Gene

MAML3

mastermind like transcriptional coactivator 3

Explore in graph →CI-GENE-00011908HGNC:16272 ENSG00000196782 NCBI 55534 Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CCNB3 Fusion + MAML3 FusionCCNB3 MAML31
(diagnostic)	Sarcoma with BCOR Genetic Alterations	Diagnostic	B	Supports Positive	3	accepted	EID11590 BCOR expression was evaluated in a cohort of 25 small blue round cell tumors (SBRCTs) with BCOR fusions (BCOR::MAML3, BCOR::CCNB3), BCOR exon 15 ITDs, or YWHAE-NUTM2B fusion (which is known to upregul… (full text at CIViC) PMID 27428733 · Kao et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (5)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved5 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Squamous Cell Carcinoma of the Vulva (CUK, Exp Mol Med 2018) vsc_cuk_2018	Vaginal Squamous Cell Carcinoma, Not Otherwise Specified	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

BCOR Overexpression Is a Highly Sensitive Marker in Round Cell Sarcomas With BCOR Genetic Abnormalities.
· Am J Surg Pathol · 2016 · PMID 27428733 · validated civic_curation pubmed