TYK2 — gene · CancerIndex

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TYK2 Fusion1
(diagnostic)	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	Diagnostic	C	Supports Positive	3	accepted	EID12810 In this 2014 genomic profiling study of 1,725 patients with precursor B-cell acute lymphoblastic leukemia (B-ALL), the authors define the high-risk "Philadelphia chromosome-like" (Ph-like or BCR::ABL1… (full text at CIViC) PMID 25207766 · Roberts et al., 2014 · Open in CIViC	civic
TYK2 Pro1104Ala1
(oncogenic)	Malignant Peripheral Nerve Sheath Tumor	Oncogenic	B	Supports Oncogenicity	2	submitted	EID9218 TYK2 protein overexpression was observed in 60% of MPNST cases using an independently generated tissue microarray, regardless of NF1 status. A total of 3 women and 4 men with NF1-MPNST were studied (m… (full text at CIViC)

Cohorts

Alteration frequency by cohort (10)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved10 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Basal Cell Carcinoma (UNIGE, Nat Genet 2016) bcc_unige_2016	Skin Basal Cell Carcinoma	Ssm	50	293

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
· N Engl J Med · 2014 · PMID 25207766 · validated civic_curation pubmed
Exploring the oncogenic and therapeutic target potential of the MYB-TYK2 fusion gene in B-cell acute lymphoblastic leukemia.
· Cancer Gene Ther · 2022 · PMID 35022522 · validated civic_curation pubmed