Gene

HIF1A

hypoxia inducible factor 1 subunit alpha

Explore in graph →CI-GENE-00004385HGNC:4910 ENSG00000100644 NCBI 3091 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
HIF1A 3' UTR Polymorphism1
(prognostic)	Pancreatic Adenocarcinoma	Prognostic	B	Supports Poor Outcome	2	accepted	EID1031 The HIF1A rs2057482 SNP was genotyped in 410 pancreatic ductal adenocarcinoma cases and 490 healthy controls. The CC genotype was significantly correlated with PDAC risk (OR = 1.719, 95% CI: 1.293-2.2…

Cohorts

Alteration frequency by cohort (8)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved8 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cutaneous Squamous Cell Carcinoma (DFCI, Clin Cancer Res 2015) cscc_dfarber_2015	Skin Squamous Cell Carcinoma	Ssm	3

Literature

Linked publications (4)

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers.
· Am J Pathol · 2010 · PMID 20363910 · validated civic_curation pubmed
Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes.
· Oncotarget · 2016 · PMID 26872370 · validated civic_curation pubmed
Expression of hypoxia-inducible factor (HIF)-1alpha as a biomarker of outcome in soft-tissue sarcomas.
· Virchows Arch · 2006 · PMID 17103226 · validated civic_curation pubmed
The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma.
· Clin Cancer Res · 2013 · PMID 23881929

HIF1A OVEREXPRESSION2
(prognostic)	Malignant Colorectal NeoplasmCURATED_BROADER	Prognostic	B	Supports Poor Outcome	3	accepted	EID1032 HIF1A overexpression was assessed by IHC in 731 colorectal cancers from two prospective cohort studies. 142 (19%) tumors showed HIF1A overexpression. Overexpression of HIF1A was associated with higher… (full text at CIViC) PMID 20363910 · Baba et al., 2010 · Open in CIViC	civic
〃	Sarcoma	Prognostic	B	Supports Poor Outcome	2	accepted	EID1034 Expression of HIF1A was analyzed by IHC in 49 soft-tissue sarcomas (29 malignant fibrous histiocytomas, 12 synovial sarcomas, 4 leiomyosarcomas and 4 malignant peripheral nerve sheath tumors). High (1… (full text at CIViC) PMID 17103226 · Shintani et al., 2006 · Open in CIViC	civic