Gene
MYH9
myosin heavy chain 9
Explore in graph →CI-GENE-00015989HGNC:7579 ENSG00000100345 NCBI 4627 Cancer geneApproved
Curated evidence
Clinical evidence (1)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 25207766
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MYH9 Fusion1 | ||||||||
| (diagnostic) | Childhood B-cell Acute Lymphoblastic LeukemiaUNRESOLVED | Diagnostic | C | Supports Positive | 2 | submitted | EID7259In a cohort of 264 patients with Ph-like B-ALL, a high risk female had a IL2RB-MYH9 rearrangement. MYH9 as a fusion partner had not been previously reported. PMID 25207766 · Roberts et al., 2014 · Open in CIViC | civic |
Cohorts
Alteration frequency by cohort (36)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 26950094
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Basal Cell Carcinoma (UNIGE, Nat Genet 2016) bcc_unige_2016 | Skin Basal Cell Carcinoma | Ssm | 82 | 293 |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.