Gene

PPP2R1A

protein phosphatase 2 scaffold subunit Aalpha

Explore in graph →CI-GENE-00020757HGNC:9302 ENSG00000105568 NCBI 5518 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PPP2R1A Mutation1
Durvalumab/Tremelimumab Regimen + Ipilimumab/Nivolumab RegimenSubstitutes	Ovarian Clear Cell CarcinomaUNRESOLVED	Predictive	B	Supports Sensitivity Response	3	submitted	EID12745 In an open-label adaptively randomized phase II trial of dual immune checkpoint blockade in platinum-resistant ovarian clear cell carcinoma (NCT03026062 plus 1 patient from NCT01928394; n = 34, PPP2R1… (full text at CIViC) PMID 40604275 · Dai et al., 2025 · Open in CIViC	civic
PPP2R1A P179R1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	4

Cohorts

Alteration frequency by cohort (76)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved76 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis.
· Cancer Res · 2019 · PMID 31142515 · validated civic_curation pubmed