Gene

PRKN

parkin RBR E3 ubiquitin protein ligase

Explore in graph →CI-GENE-00021022HGNC:8607 ENSG00000185345 NCBI 5071 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PRKN Loss1
Phosphatidylinositide 3-Kinase Inhibitor	Malignant NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	2	submitted	EID7440 Loss of function of PARK2 has been shown to result in enhanced phosphatidylinositol 3-kinase/Akt (PI3K/Akt) activation and increased vulnerability to PI3K/Akt/mTOR inhibitors in vitro. PMID 28306514 · Gupta et al., 2017 · Open in CIViC	civic
PRKN R275W1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	2	submitted	EID7439 Experimental studies have shown that this variant impairs the function of the PARK2 protein by causing defects in solubility, aggregation, enzymatic activity or targeting proteins to the proteasome fo…

Cohorts

Alteration frequency by cohort (56)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved56 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.