Gene

SPOP

speckle type BTB/POZ protein

Explore in graph →CI-GENE-00033620HGNC:11254 ENSG00000121067 NCBI 8405 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (9)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–9 of 9 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SPOP D140G1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	2	accepted	EID9338 SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC	civic
SPOP E47K1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	2	accepted	EID9332 SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of…

Cohorts

Alteration frequency by cohort (72)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved72 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover.
· Cell Death Dis · 2015 · PMID 25766326 · validated civic_curation pubmed

SPOP E50K1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	2	accepted	EID9334 SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC	civic

SPOP E50K1

(functional)

—UNRESOLVED

Functional

Supports Loss Of Function

accepted

EID9334

SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC)

PMID 25766326 · Zhang et al., 2015 · Open in CIViC

civic

SPOP G75R1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	2	accepted	EID9335 SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC	civic

SPOP G75R1

(functional)

—UNRESOLVED

Functional

Supports Loss Of Function

accepted

EID9335

PMID 25766326 · Zhang et al., 2015 · Open in CIViC

civic

SPOP M117I1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	accepted	EID9216 The ubiquitin ligase complex adaptor protein SPOP was shown to directly interact with ER-alpha in co-immunoprecipitation (co-IP) experiments when ectopically expressed in 293T cells and under endogeno… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC	civic

SPOP M117I1

(functional)

—UNRESOLVED

Functional

Supports Loss Of Function

accepted

EID9216

The ubiquitin ligase complex adaptor protein SPOP was shown to directly interact with ER-alpha in co-immunoprecipitation (co-IP) experiments when ectopically expressed in 293T cells and under endogeno… (full text at CIViC)

PMID 25766326 · Zhang et al., 2015 · Open in CIViC

civic

SPOP M117V1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	accepted	EID9131 SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC	civic

SPOP M117V1

(functional)

—UNRESOLVED

Functional

Supports Loss Of Function

accepted

EID9131

PMID 25766326 · Zhang et al., 2015 · Open in CIViC

civic

SPOP P94A1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	2	submitted	EID9337 SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC	civic

SPOP P94A1

(functional)

—UNRESOLVED

Functional

Supports Loss Of Function

submitted

EID9337

PMID 25766326 · Zhang et al., 2015 · Open in CIViC

civic

SPOP R121Q1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	accepted	EID9215 The ubiquitin ligase complex adaptor protein SPOP was shown to directly interact with ER-alpha in co-immunoprecipitation (co-IP) experiments when ectopically expressed in 293T cells and under endogeno… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC	civic

SPOP R121Q1

(functional)

—UNRESOLVED

Functional

Supports Loss Of Function

accepted

EID9215

PMID 25766326 · Zhang et al., 2015 · Open in CIViC

civic

SPOP S80R1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	2	accepted	EID9336 SPOP is a ubiquitin ligase complex adapter protein capable of targeting ER-alpha (encoded by ESR1) for ubiquitination and subsequent degradation. Preclinical experiments showed that the MATH domain of… (full text at CIViC) PMID 25766326 · Zhang et al., 2015 · Open in CIViC	civic

SPOP S80R1

(functional)

—UNRESOLVED

Functional

Supports Loss Of Function

accepted

EID9336

PMID 25766326 · Zhang et al., 2015 · Open in CIViC

civic