Invasive Carcinoma — Genomics

Invasive Carcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

65 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Adenoid Cystic Carcinoma of the Breast (MSK, J Pathol. 2015) acbc_mskcc_2015MSK

12 cases with simple somatic mutation data · 12 cases total · 2026-08-20 · mapped to Breast Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	MYB

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Breast Cancer (HTAN, 2022) brca_hta9_htan_2022HTAN

5 cases with simple somatic mutation data · 5 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
23	SH2B1	Ssm	5	5	100%	cbioportal
7	DNAH6	Ssm	5	5	100%	cbioportal
6	CRTAM	Ssm	5	5	100%	cbioportal
5	CEP55	Ssm	5	5	100%	cbioportal
4	CDK9	Ssm	5	5	100%	cbioportal
3	CCDC158	Ssm	5	5	100%	cbioportal
2	BNC2	Ssm	5	5	100%	cbioportal
1	ATP2B2	Ssm	5	5	100%	cbioportal
9	ENTHD1	Ssm	5	5	100%	cbioportal
10	FLG	Ssm	5	5	100%	cbioportal
11	GCA	Ssm	5	5	100%	cbioportal
12	GDPD2	Ssm	5	5	100%	cbioportal
13	GPM6B	Ssm	5	5	100%	cbioportal
14	HSF5	Ssm	5	5	100%	cbioportal
15	IPO13	Ssm	5	5	100%	cbioportal
16	MYO15A	Ssm	5	5	100%	cbioportal
17	PCNT	Ssm	5	5	100%	cbioportal
18	PEX5L	Ssm	5	5	100%	cbioportal
19	PKHD1L1	Ssm	5	5	100%	cbioportal
20	PLEKHM1	Ssm	5	5	100%	cbioportal
21	PREX1	Ssm	5	5	100%	cbioportal
22	SBNO2	Ssm	5	5	100%	cbioportal
24	SLC35B3	Ssm	5	5	100%	cbioportal
25	SLITRK3	Ssm	5	5	100%	cbioportal
26	TBC1D5	Ssm	5	5	100%	cbioportal
27	THOP1	Ssm	5	5	100%	cbioportal
28	ZC3H12C	Ssm	5	5	100%	cbioportal
29	ZNF648	Ssm	5	5	100%	cbioportal
8	DPM1	Ssm	5	5	100%	cbioportal
30	CFAP65	Ssm	4	5	80%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer (METABRIC, Nature 2012 & Nat Commun 2016) brca_metabricMETABRIC

2,433 cases with simple somatic mutation data · 2,509 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	975	2,433	40.1%	cbioportal
2	TP53	Ssm	864	2,433	35.5%	cbioportal
3	MUC16	Ssm	409	2,433	16.8%	cbioportal
4	AHNAK2	Ssm	395	2,433	16.2%	cbioportal
5	SYNE1	Ssm	294	2,433	12.1%	cbioportal
6	KMT2C	Ssm	280	2,433	11.5%	cbioportal
7	GATA3	Ssm	269	2,433	11.1%	cbioportal
9	MAP3K1	Ssm	236	2,433	9.7%	cbioportal
8	CDH1	Ssm	236	2,433	9.7%	cbioportal
10	DNAH11	Ssm	226	2,433	9.3%	cbioportal
11	AHNAK	Ssm	220	2,433	9%	cbioportal
12	DNAH2	Ssm	186	2,433	7.6%	cbioportal
13	KMT2D	Ssm	176	2,433	7.2%	cbioportal
14	USH2A	Ssm	170	2,433	7%	cbioportal
15	DNAH5	Ssm	167	2,433	6.9%	cbioportal
17	RYR2	Ssm	161	2,433	6.6%	cbioportal
16	HERC2	Ssm	161	2,433	6.6%	cbioportal
18	PDE4DIP	Ssm	146	2,433	6%	cbioportal
19	AKAP9	Ssm	143	2,433	5.9%	cbioportal
20	TG	Ssm	137	2,433	5.6%	cbioportal
21	BIRC6	Ssm	128	2,433	5.3%	cbioportal
22	UTRN	Ssm	124	2,433	5.1%	cbioportal
23	TBX3	Ssm	123	2,433	5.1%	cbioportal
24	COL6A3	Ssm	119	2,433	4.9%	cbioportal
25	LAMA2	Ssm	117	2,433	4.8%	cbioportal
26	NOTCH1	Ssm	116	2,433	4.8%	cbioportal
27	ARID1A	Ssm	114	2,433	4.7%	cbioportal
28	CBFB	Ssm	112	2,433	4.6%	cbioportal
29	COL12A1	Ssm	103	2,433	4.2%	cbioportal
30	NCOR2	Ssm	102	2,433	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer (MSK, Clinical Cancer Res 2020) brca_pareja_msk_2020MSK

60 cases with simple somatic mutation data · 60 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	29	60	48.3%	cbioportal
2	PIK3CA	Ssm	22	60	36.7%	cbioportal
3	GATA3	Ssm	15	60	25%	cbioportal
4	MUC16	Ssm	9	60	15%	cbioportal
5	AGGF1	Ssm	8	60	13.3%	cbioportal
8	KIF5A	Ssm	7	60	11.7%	cbioportal
6	CCAR1	Ssm	7	60	11.7%	cbioportal
7	CDC27	Ssm	7	60	11.7%	cbioportal
9	TTN	Ssm	7	60	11.7%	cbioportal
11	DNAH1	Ssm	6	60	10%	cbioportal
16	RP1	Ssm	6	60	10%	cbioportal
15	PTEN	Ssm	6	60	10%	cbioportal
14	PPL	Ssm	6	60	10%	cbioportal
13	PKHD1	Ssm	6	60	10%	cbioportal
12	KMT2A	Ssm	6	60	10%	cbioportal
10	ARHGAP22	Ssm	6	60	10%	cbioportal
23	L3MBTL1	Ssm	5	60	8.3%	cbioportal
18	APOBR	Ssm	5	60	8.3%	cbioportal
19	ARHGEF18	Ssm	5	60	8.3%	cbioportal
28	USP8	Ssm	5	60	8.3%	cbioportal
27	SPEN	Ssm	5	60	8.3%	cbioportal
26	SCN4A	Ssm	5	60	8.3%	cbioportal
25	NPAT	Ssm	5	60	8.3%	cbioportal
24	MLXIP	Ssm	5	60	8.3%	cbioportal
17	ADAMTS14	Ssm	5	60	8.3%	cbioportal
22	IFT122	Ssm	5	60	8.3%	cbioportal
21	CBFB	Ssm	5	60	8.3%	cbioportal
20	ATR	Ssm	5	60	8.3%	cbioportal
82	PER2	Ssm	4	60	6.7%	cbioportal
29	ABCB11	Ssm	4	60	6.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer (MSK, Nat Genet 2025) breast_msk_2025MSK

3,879 cases with simple somatic mutation data · 3,879 cases total · 2026-01-20 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	1,707	3,879	44%	cbioportal
2	PIK3CA	Ssm	1,401	3,879	36.1%	cbioportal
3	GATA3	Ssm	582	3,879	15%	cbioportal
4	CDH1	Ssm	566	3,879	14.6%	cbioportal
5	ESR1	Ssm	388	3,879	10%	cbioportal
6	KMT2C	Ssm	357	3,879	9.2%	cbioportal
7	MAP3K1	Ssm	314	3,879	8.1%	cbioportal
8	PTEN	Ssm	303	3,879	7.8%	cbioportal
9	ARID1A	Ssm	279	3,879	7.2%	cbioportal
10	TBX3	Ssm	237	3,879	6.1%	cbioportal
11	AKT1	Ssm	220	3,879	5.7%	cbioportal
12	NF1	Ssm	217	3,879	5.6%	cbioportal
13	FOXA1	Ssm	194	3,879	5%	cbioportal
14	KMT2D	Ssm	188	3,879	4.8%	cbioportal
15	ERBB2	Ssm	182	3,879	4.7%	cbioportal
16	MAP2K4	Ssm	169	3,879	4.4%	cbioportal
17	RB1	Ssm	169	3,879	4.4%	cbioportal
18	NCOR1	Ssm	163	3,879	4.2%	cbioportal
19	SPEN	Ssm	157	3,879	4%	cbioportal
20	CBFB	Ssm	153	3,879	3.9%	cbioportal
21	BRCA2	Ssm	152	3,879	3.9%	cbioportal
22	FAT1	Ssm	149	3,879	3.8%	cbioportal
23	RUNX1	Ssm	143	3,879	3.7%	cbioportal
24	ATM	Ssm	126	3,879	3.2%	cbioportal
25	KMT2A	Ssm	122	3,879	3.1%	cbioportal
26	ZFHX3	Ssm	110	3,508	3.1%	cbioportal
52	PREX2	Ssm	76	2,602	2.9%	cbioportal
32	MGA	Ssm	99	3,508	2.8%	cbioportal
27	PIK3R1	Ssm	106	3,879	2.7%	cbioportal
59	KMT2B	Ssm	70	2,602	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Breast Cancer (MSK, NPJ Breast Cancer 2019) brca_mskcc_2019MSK

70 cases with simple somatic mutation data · 70 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	35	70	50%	cbioportal
2	TP53	Ssm	19	70	27.1%	cbioportal
3	CDH1	Ssm	15	70	21.4%	cbioportal
5	MAP3K1	Ssm	12	70	17.1%	cbioportal
4	GATA3	Ssm	12	70	17.1%	cbioportal
6	KMT2C	Ssm	10	70	14.3%	cbioportal
7	ERBB2	Ssm	8	70	11.4%	cbioportal
8	MDC1	Ssm	8	70	11.4%	cbioportal
9	BRCA2	Ssm	7	70	10%	cbioportal
11	PTEN	Ssm	7	70	10%	cbioportal
10	MED12	Ssm	7	70	10%	cbioportal
13	ATM	Ssm	6	70	8.6%	cbioportal
12	ALK	Ssm	6	70	8.6%	cbioportal
15	TSC2	Ssm	6	70	8.6%	cbioportal
14	RUNX1	Ssm	6	70	8.6%	cbioportal
16	BRCA1	Ssm	5	70	7.1%	cbioportal
21	PTPRD	Ssm	5	70	7.1%	cbioportal
20	POLE	Ssm	5	70	7.1%	cbioportal
22	TGFBR2	Ssm	5	70	7.1%	cbioportal
19	NCOR1	Ssm	5	70	7.1%	cbioportal
18	ESR1	Ssm	5	70	7.1%	cbioportal
17	EGFR	Ssm	5	70	7.1%	cbioportal
30	SPEN	Ssm	4	70	5.7%	cbioportal
23	ATR	Ssm	4	70	5.7%	cbioportal
24	ERBB3	Ssm	4	70	5.7%	cbioportal
25	FANCA	Ssm	4	70	5.7%	cbioportal
26	FAT1	Ssm	4	70	5.7%	cbioportal
27	MAP2K4	Ssm	4	70	5.7%	cbioportal
28	NOTCH2	Ssm	4	70	5.7%	cbioportal
29	SF3B1	Ssm	4	70	5.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer (SMC 2018) brca_smc_2018

186 cases with simple somatic mutation data · 187 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	89	186	47.8%	cbioportal
2	PIK3CA	Ssm	53	186	28.5%	cbioportal
4	TTN	Ssm	23	186	12.4%	cbioportal
3	GATA3	Ssm	23	186	12.4%	cbioportal
5	MUC16	Ssm	12	186	6.5%	cbioportal
6	CSMD3	Ssm	9	186	4.8%	cbioportal
7	MAP3K1	Ssm	9	186	4.8%	cbioportal
8	MAML3	Ssm	8	186	4.3%	cbioportal
12	MUC4	Ssm	7	186	3.8%	cbioportal
13	NEB	Ssm	7	186	3.8%	cbioportal
14	NF1	Ssm	7	186	3.8%	cbioportal
15	SYNE1	Ssm	7	186	3.8%	cbioportal
16	UBR4	Ssm	7	186	3.8%	cbioportal
11	KMT2C	Ssm	7	186	3.8%	cbioportal
10	ARID1A	Ssm	7	186	3.8%	cbioportal
9	APOB	Ssm	7	186	3.8%	cbioportal
22	ZNF536	Ssm	6	186	3.2%	cbioportal
18	NEFH	Ssm	6	186	3.2%	cbioportal
17	LRP1B	Ssm	6	186	3.2%	cbioportal
20	PTEN	Ssm	6	186	3.2%	cbioportal
21	USH2A	Ssm	6	186	3.2%	cbioportal
19	PKHD1	Ssm	6	186	3.2%	cbioportal
24	AKT1	Ssm	5	186	2.7%	cbioportal
29	CDH23	Ssm	5	186	2.7%	cbioportal
28	CBFB	Ssm	5	186	2.7%	cbioportal
27	BIRC6	Ssm	5	186	2.7%	cbioportal
26	ATXN1	Ssm	5	186	2.7%	cbioportal
25	ANK3	Ssm	5	186	2.7%	cbioportal
23	ABCA13	Ssm	5	186	2.7%	cbioportal
35	HMCN1	Ssm	5	186	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer Xenografts (British Columbia, Nature 2015) brca_bccrc_xenograft_2014British Columbia

116 cases with simple somatic mutation data · 117 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	41	116	35.3%	cbioportal
3	SHOC2	Ssm	24	116	20.7%	cbioportal
2	ABCD4	Ssm	24	116	20.7%	cbioportal
5	KALRN	Ssm	22	116	19%	cbioportal
4	FAM47C	Ssm	22	116	19%	cbioportal
6	PLEC	Ssm	21	116	18.1%	cbioportal
9	ZNF415	Ssm	20	116	17.2%	cbioportal
7	NOTCH1	Ssm	20	116	17.2%	cbioportal
8	TTN	Ssm	20	116	17.2%	cbioportal
10	CCER1	Ssm	19	116	16.4%	cbioportal
11	HPS3	Ssm	17	116	14.7%	cbioportal
25	IFNGR2	Ssm	16	116	13.8%	cbioportal
12	ANKRD61	Ssm	16	116	13.8%	cbioportal
13	APOA5	Ssm	16	116	13.8%	cbioportal
14	ARMC12	Ssm	16	116	13.8%	cbioportal
15	ASIC5	Ssm	16	116	13.8%	cbioportal
16	ATXN7L3	Ssm	16	116	13.8%	cbioportal
17	BTNL3	Ssm	16	116	13.8%	cbioportal
18	C2ORF78	Ssm	16	116	13.8%	cbioportal
19	CABLES2	Ssm	16	116	13.8%	cbioportal
20	CAPN9	Ssm	16	116	13.8%	cbioportal
21	DUSP16	Ssm	16	116	13.8%	cbioportal
22	EXOC3L4	Ssm	16	116	13.8%	cbioportal
23	GABRQ	Ssm	16	116	13.8%	cbioportal
24	GRM1	Ssm	16	116	13.8%	cbioportal
26	MMP16	Ssm	16	116	13.8%	cbioportal
27	MUC4	Ssm	16	116	13.8%	cbioportal
28	MYT1	Ssm	16	116	13.8%	cbioportal
29	NOTCH3	Ssm	16	116	13.8%	cbioportal
30	NPR2	Ssm	16	116	13.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Carcinoma (MSK, NPJ Precis Oncol 2025) brca_msk_2025MSK

527 cases with simple somatic mutation data · 527 cases total · 2026-01-20 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	316	527	60%	cbioportal
2	TP53	Ssm	288	527	54.6%	cbioportal
3	CDH1	Ssm	173	527	32.8%	cbioportal
4	KMT2C	Ssm	147	527	27.9%	cbioportal
5	KMT2D	Ssm	108	527	20.5%	cbioportal
6	NF1	Ssm	103	527	19.5%	cbioportal
7	ARID1A	Ssm	92	527	17.5%	cbioportal
8	FAT1	Ssm	89	527	16.9%	cbioportal
9	SPEN	Ssm	88	527	16.7%	cbioportal
10	MAP3K1	Ssm	87	527	16.5%	cbioportal
12	ZFHX3	Ssm	73	488	15%	cbioportal
11	PTEN	Ssm	77	527	14.6%	cbioportal
25	KMT2B	Ssm	57	407	14%	cbioportal
13	FOXA1	Ssm	72	527	13.7%	cbioportal
21	MGA	Ssm	66	488	13.5%	cbioportal
14	NCOR1	Ssm	71	527	13.5%	cbioportal
15	BRCA2	Ssm	70	527	13.3%	cbioportal
16	ATM	Ssm	69	527	13.1%	cbioportal
17	ESR1	Ssm	69	527	13.1%	cbioportal
18	GATA3	Ssm	69	527	13.1%	cbioportal
19	KMT2A	Ssm	68	527	12.9%	cbioportal
20	TBX3	Ssm	67	527	12.7%	cbioportal
22	ATRX	Ssm	61	527	11.6%	cbioportal
23	APC	Ssm	60	527	11.4%	cbioportal
24	ATR	Ssm	59	527	11.2%	cbioportal
28	SETD2	Ssm	54	527	10.2%	cbioportal
27	ROS1	Ssm	54	527	10.2%	cbioportal
26	RB1	Ssm	54	527	10.2%	cbioportal
29	ARID1B	Ssm	53	527	10.1%	cbioportal
30	NOTCH4	Ssm	53	527	10.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Breast Invasive Carcinoma TCGA-BRCATCGA

1,098 cases with simple somatic mutation data · 1,098 cases total · Data Release 46.0 · mapped to Breast Invasive Carcinoma, NOS ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	OBSCN	Ssm	806	1,098	73.4%	gdc
2	PIK3C2B	Ssm	804	1,098	73.2%	gdc
6	MDM4	Ssm	803	1,098	73.1%	gdc
5	USH2A	Ssm	803	1,098	73.1%	gdc
4	NFASC	Ssm	803	1,098	73.1%	gdc
3	NID1	Ssm	803	1,098	73.1%	gdc
7	LRRN2	Ssm	803	1,098	73.1%	gdc
8	PLEKHA6	Ssm	802	1,098	73%	gdc
9	PPP1R15B	Ssm	801	1,098	73%	gdc
10	CDK18	Ssm	800	1,098	72.9%	gdc
11	ASPM	Ssm	800	1,098	72.9%	gdc
12	RYR2	Ssm	800	1,098	72.9%	gdc
16	SLC35F3	Ssm	799	1,098	72.8%	gdc
13	EXOC8	Ssm	799	1,098	72.8%	gdc
14	CHI3L1	Ssm	799	1,098	72.8%	gdc
15	LYST	Ssm	799	1,098	72.8%	gdc
17	TMEM81	Ssm	799	1,098	72.8%	gdc
18	TMCC2	Ssm	799	1,098	72.8%	gdc
19	CNTN2	Ssm	799	1,098	72.8%	gdc
20	DSTYK	Ssm	799	1,098	72.8%	gdc
30	NUAK2	Ssm	798	1,098	72.7%	gdc
21	RBBP5	Ssm	798	1,098	72.7%	gdc
22	GNPAT	Ssm	798	1,098	72.7%	gdc
23	GOLT1A	Ssm	798	1,098	72.7%	gdc
24	BLACAT1	Ssm	798	1,098	72.7%	gdc
25	ZC3H11A	Ssm	798	1,098	72.7%	gdc
26	KISS1	Ssm	798	1,098	72.7%	gdc
27	ATP2B4	Ssm	798	1,098	72.7%	gdc
28	LEMD1	Ssm	798	1,098	72.7%	gdc
29	RAB29	Ssm	798	1,098	72.7%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Breast Invasive Carcinoma (British Columbia, Nature 2012) brca_bccrcBritish Columbia

65 cases with simple somatic mutation data · 65 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	35	65	53.8%	cbioportal
2	PIK3CA	Ssm	7	65	10.8%	cbioportal
4	USH2A	Ssm	6	65	9.2%	cbioportal
3	MYO3A	Ssm	6	65	9.2%	cbioportal
5	PTEN	Ssm	5	65	7.7%	cbioportal
6	ADGRG4	Ssm	4	65	6.2%	cbioportal
7	ATR	Ssm	4	65	6.2%	cbioportal
8	COL6A3	Ssm	4	65	6.2%	cbioportal
9	LRP2	Ssm	4	65	6.2%	cbioportal
10	MDN1	Ssm	4	65	6.2%	cbioportal
11	RB1	Ssm	4	65	6.2%	cbioportal
12	SYNE1	Ssm	4	65	6.2%	cbioportal
13	TTN	Ssm	4	65	6.2%	cbioportal
14	UBR5	Ssm	4	65	6.2%	cbioportal
15	ZNF142	Ssm	4	65	6.2%	cbioportal
28	KATNIP	Ssm	3	65	4.6%	cbioportal
29	LAMA2	Ssm	3	65	4.6%	cbioportal
16	ADGRL2	Ssm	3	65	4.6%	cbioportal
17	ARHGAP5	Ssm	3	65	4.6%	cbioportal
18	BRCA2	Ssm	3	65	4.6%	cbioportal
19	CELSR1	Ssm	3	65	4.6%	cbioportal
20	CEP192	Ssm	3	65	4.6%	cbioportal
21	DLG5	Ssm	3	65	4.6%	cbioportal
33	NR3C1	Ssm	3	65	4.6%	cbioportal
22	DNAH5	Ssm	3	65	4.6%	cbioportal
23	EMSY	Ssm	3	65	4.6%	cbioportal
24	FMN2	Ssm	3	65	4.6%	cbioportal
25	GH1	Ssm	3	65	4.6%	cbioportal
26	HECW1	Ssm	3	65	4.6%	cbioportal
27	HRNR	Ssm	3	65	4.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (Broad, Nature 2012) brca_broadBroad

103 cases with simple somatic mutation data · 103 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	TP53	Ssm	28	103	27.2%	cbioportal
1	PIK3CA	Ssm	28	103	27.2%	cbioportal
3	TTN	Ssm	12	103	11.7%	cbioportal
4	KMT2C	Ssm	7	103	6.8%	cbioportal
8	MUC2	Ssm	6	103	5.8%	cbioportal
5	AKT1	Ssm	6	103	5.8%	cbioportal
6	FLG	Ssm	6	103	5.8%	cbioportal
7	MUC16	Ssm	6	103	5.8%	cbioportal
9	DMD	Ssm	5	103	4.9%	cbioportal
15	CSMD3	Ssm	4	103	3.9%	cbioportal
16	DNAH8	Ssm	4	103	3.9%	cbioportal
17	DST	Ssm	4	103	3.9%	cbioportal
18	GATA3	Ssm	4	103	3.9%	cbioportal
19	HMCN1	Ssm	4	103	3.9%	cbioportal
26	SYNE1	Ssm	4	103	3.9%	cbioportal
25	SRRM2	Ssm	4	103	3.9%	cbioportal
24	SI	Ssm	4	103	3.9%	cbioportal
23	SCN3A	Ssm	4	103	3.9%	cbioportal
22	RYR3	Ssm	4	103	3.9%	cbioportal
20	LRP1B	Ssm	4	103	3.9%	cbioportal
21	RYR2	Ssm	4	103	3.9%	cbioportal
10	ADAMTS7	Ssm	4	103	3.9%	cbioportal
11	AGRN	Ssm	4	103	3.9%	cbioportal
12	ATM	Ssm	4	103	3.9%	cbioportal
13	CACNA1E	Ssm	4	103	3.9%	cbioportal
14	CBFB	Ssm	4	103	3.9%	cbioportal
29	ADGRG4	Ssm	3	103	2.9%	cbioportal
27	ACE	Ssm	3	103	2.9%	cbioportal
28	ADAMTS20	Ssm	3	103	2.9%	cbioportal
30	AHNAK	Ssm	3	103	2.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (Sanger, Nature 2012) brca_sangerSanger

100 cases with simple somatic mutation data · 100 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	37	100	37%	cbioportal
2	PIK3CA	Ssm	30	100	30%	cbioportal
3	TTN	Ssm	26	100	26%	cbioportal
4	GATA3	Ssm	15	100	15%	cbioportal
5	KMT2C	Ssm	11	100	11%	cbioportal
6	MUC16	Ssm	10	100	10%	cbioportal
7	CDH1	Ssm	8	100	8%	cbioportal
10	SYNE1	Ssm	7	100	7%	cbioportal
8	BIRC6	Ssm	7	100	7%	cbioportal
9	FSIP2	Ssm	7	100	7%	cbioportal
15	NCOR1	Ssm	6	100	6%	cbioportal
14	MAP3K1	Ssm	6	100	6%	cbioportal
13	DST	Ssm	6	100	6%	cbioportal
12	DNAH11	Ssm	6	100	6%	cbioportal
11	CSMD1	Ssm	6	100	6%	cbioportal
17	VPS13C	Ssm	6	100	6%	cbioportal
16	STAB2	Ssm	6	100	6%	cbioportal
19	AKT1	Ssm	5	100	5%	cbioportal
29	TENM1	Ssm	5	100	5%	cbioportal
28	PRRC2B	Ssm	5	100	5%	cbioportal
27	NBAS	Ssm	5	100	5%	cbioportal
26	MAP2K4	Ssm	5	100	5%	cbioportal
25	LRP2	Ssm	5	100	5%	cbioportal
24	HYDIN2	Ssm	5	100	5%	cbioportal
23	HERC1	Ssm	5	100	5%	cbioportal
22	DIDO1	Ssm	5	100	5%	cbioportal
21	BRCA2	Ssm	5	100	5%	cbioportal
20	ARID1B	Ssm	5	100	5%	cbioportal
18	ADGRG4	Ssm	5	100	5%	cbioportal
30	AHNAK	Ssm	4	100	4%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (TCGA, Cell 2015) brca_tcga_pub2015TCGA

817 cases with simple somatic mutation data · 818 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	282	817	34.5%	cbioportal
2	TP53	Ssm	280	817	34.3%	cbioportal
3	TTN	Ssm	135	817	16.5%	cbioportal
4	CDH1	Ssm	107	817	13.1%	cbioportal
5	GATA3	Ssm	96	817	11.8%	cbioportal
6	MUC16	Ssm	71	817	8.7%	cbioportal
7	MAP3K1	Ssm	69	817	8.4%	cbioportal
8	KMT2C	Ssm	62	817	7.6%	cbioportal
9	MUC4	Ssm	50	817	6.1%	cbioportal
10	MUC12	Ssm	47	817	5.8%	cbioportal
11	PTEN	Ssm	42	817	5.1%	cbioportal
13	NCOA3	Ssm	41	817	5%	cbioportal
14	SYNE1	Ssm	41	817	5%	cbioportal
12	FLG	Ssm	41	817	5%	cbioportal
16	USH2A	Ssm	38	817	4.7%	cbioportal
15	NCOR1	Ssm	38	817	4.7%	cbioportal
17	NEB	Ssm	37	817	4.5%	cbioportal
18	RYR2	Ssm	36	817	4.4%	cbioportal
19	ARID1A	Ssm	33	817	4%	cbioportal
20	DMD	Ssm	33	817	4%	cbioportal
21	RYR3	Ssm	33	817	4%	cbioportal
22	MUC5B	Ssm	32	817	3.9%	cbioportal
23	SPEN	Ssm	32	817	3.9%	cbioportal
24	RUNX1	Ssm	31	817	3.8%	cbioportal
28	LRP2	Ssm	30	817	3.7%	cbioportal
29	MAP2K4	Ssm	30	817	3.7%	cbioportal
30	SPTA1	Ssm	30	817	3.7%	cbioportal
27	HMCN1	Ssm	30	817	3.7%	cbioportal
25	FAT3	Ssm	30	817	3.7%	cbioportal
26	FOXA1	Ssm	30	817	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (TCGA, Firehose Legacy) brca_tcgaTCGA

982 cases with simple somatic mutation data · 1,108 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	319	982	32.5%	cbioportal
2	TP53	Ssm	301	982	30.7%	cbioportal
3	TTN	Ssm	161	982	16.4%	cbioportal
4	CDH1	Ssm	112	982	11.4%	cbioportal
5	GATA3	Ssm	97	982	9.9%	cbioportal
6	MUC16	Ssm	74	982	7.5%	cbioportal
7	MAP3K1	Ssm	71	982	7.2%	cbioportal
8	KMT2C	Ssm	70	982	7.1%	cbioportal
9	MUC12	Ssm	54	982	5.5%	cbioportal
10	MUC4	Ssm	53	982	5.4%	cbioportal
12	USH2A	Ssm	45	982	4.6%	cbioportal
11	FLG	Ssm	45	982	4.6%	cbioportal
13	SYNE1	Ssm	43	982	4.4%	cbioportal
14	RYR2	Ssm	42	982	4.3%	cbioportal
15	NCOR1	Ssm	40	982	4.1%	cbioportal
16	DMD	Ssm	39	982	4%	cbioportal
19	RYR3	Ssm	37	982	3.8%	cbioportal
17	HMCN1	Ssm	37	982	3.8%	cbioportal
18	NEB	Ssm	37	982	3.8%	cbioportal
20	SYNE2	Ssm	37	982	3.8%	cbioportal
21	MUC5B	Ssm	36	982	3.7%	cbioportal
23	HUWE1	Ssm	35	982	3.6%	cbioportal
22	FAT3	Ssm	35	982	3.6%	cbioportal
24	PTEN	Ssm	35	982	3.6%	cbioportal
26	LRP2	Ssm	34	982	3.5%	cbioportal
25	HRNR	Ssm	34	982	3.5%	cbioportal
30	ZFHX4	Ssm	33	982	3.4%	cbioportal
27	OBSCN	Ssm	33	982	3.4%	cbioportal
28	SPEN	Ssm	33	982	3.4%	cbioportal
29	SPTA1	Ssm	33	982	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (TCGA, Nature 2012) brca_tcga_pubTCGA

507 cases with simple somatic mutation data · 825 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	190	507	37.5%	cbioportal
2	PIK3CA	Ssm	179	507	35.3%	cbioportal
3	TTN	Ssm	75	507	14.8%	cbioportal
4	GATA3	Ssm	54	507	10.7%	cbioportal
5	MAP3K1	Ssm	39	507	7.7%	cbioportal
6	KMT2C	Ssm	38	507	7.5%	cbioportal
7	MUC16	Ssm	38	507	7.5%	cbioportal
8	CDH1	Ssm	34	507	6.7%	cbioportal
9	USH2A	Ssm	27	507	5.3%	cbioportal
10	BRCA2	Ssm	24	507	4.7%	cbioportal
11	RYR2	Ssm	23	507	4.5%	cbioportal
12	FLG	Ssm	22	507	4.3%	cbioportal
13	MAP2K4	Ssm	21	507	4.1%	cbioportal
15	FAT3	Ssm	20	507	3.9%	cbioportal
14	ATM	Ssm	20	507	3.9%	cbioportal
18	OBSCN	Ssm	19	507	3.7%	cbioportal
16	HMCN1	Ssm	19	507	3.7%	cbioportal
17	NEB	Ssm	19	507	3.7%	cbioportal
21	PTEN	Ssm	18	507	3.6%	cbioportal
22	RUNX1	Ssm	18	507	3.6%	cbioportal
19	BRCA1	Ssm	18	507	3.6%	cbioportal
20	MUC17	Ssm	18	507	3.6%	cbioportal
25	NCOR1	Ssm	17	507	3.4%	cbioportal
26	SYNE1	Ssm	17	507	3.4%	cbioportal
23	LRP2	Ssm	17	507	3.4%	cbioportal
24	MUC4	Ssm	17	507	3.4%	cbioportal
27	CSMD1	Ssm	16	507	3.2%	cbioportal
29	ZFHX4	Ssm	16	507	3.2%	cbioportal
28	SYNE2	Ssm	16	507	3.2%	cbioportal
30	APOB	Ssm	15	507	3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (TCGA, PanCancer Atlas) brca_tcga_pan_can_atlas_2018TCGA

1,066 cases with simple somatic mutation data · 1,084 cases total · 2026-06-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	347	1,066	32.6%	cbioportal
2	TP53	Ssm	347	1,066	32.6%	cbioportal
3	TTN	Ssm	187	1,066	17.5%	cbioportal
4	CDH1	Ssm	130	1,066	12.2%	cbioportal
5	GATA3	Ssm	127	1,066	11.9%	cbioportal
6	MUC16	Ssm	109	1,066	10.2%	cbioportal
7	KMT2C	Ssm	99	1,066	9.3%	cbioportal
8	MAP3K1	Ssm	89	1,066	8.3%	cbioportal
9	FLG	Ssm	66	1,066	6.2%	cbioportal
10	RYR2	Ssm	66	1,066	6.2%	cbioportal
11	SYNE1	Ssm	63	1,066	5.9%	cbioportal
12	USH2A	Ssm	62	1,066	5.8%	cbioportal
13	HMCN1	Ssm	61	1,066	5.7%	cbioportal
14	PTEN	Ssm	58	1,066	5.4%	cbioportal
15	SPTA1	Ssm	54	1,066	5.1%	cbioportal
16	ZFHX4	Ssm	53	1,066	5%	cbioportal
17	NEB	Ssm	52	1,066	4.9%	cbioportal
18	DMD	Ssm	51	1,066	4.8%	cbioportal
19	NCOR1	Ssm	50	1,066	4.7%	cbioportal
20	MUC4	Ssm	46	1,066	4.3%	cbioportal
21	SYNE2	Ssm	46	1,066	4.3%	cbioportal
22	MUC17	Ssm	45	1,066	4.2%	cbioportal
23	CSMD3	Ssm	44	1,066	4.1%	cbioportal
24	OBSCN	Ssm	44	1,066	4.1%	cbioportal
25	RYR3	Ssm	44	1,066	4.1%	cbioportal
26	FAT3	Ssm	43	1,066	4%	cbioportal
28	MAP2K4	Ssm	42	1,066	3.9%	cbioportal
27	CSMD1	Ssm	42	1,066	3.9%	cbioportal
30	PKHD1L1	Ssm	41	1,066	3.8%	cbioportal
29	MACF1	Ssm	41	1,066	3.8%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

High-Grade Serous Ovarian Cancer (MSK, NPJ Genome Med 2021) hgsoc_msk_2021MSK

45 cases with simple somatic mutation data · 45 cases total · 2026-01-07 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	44	45	97.8%	cbioportal
2	BRCA2	Ssm	5	45	11.1%	cbioportal
3	KMT2D	Ssm	4	45	8.9%	cbioportal
9	AGO2	Ssm	2	28	7.1%	cbioportal
7	KMT2C	Ssm	3	45	6.7%	cbioportal
5	BRD4	Ssm	3	45	6.7%	cbioportal
6	KDM5A	Ssm	3	45	6.7%	cbioportal
4	BRCA1	Ssm	3	45	6.7%	cbioportal
8	NTRK3	Ssm	3	45	6.7%	cbioportal
18	MGA	Ssm	2	36	5.6%	cbioportal
10	APC	Ssm	2	45	4.4%	cbioportal
21	PDGFRA	Ssm	2	45	4.4%	cbioportal
24	PPP2R1A	Ssm	2	45	4.4%	cbioportal
23	PIK3R2	Ssm	2	45	4.4%	cbioportal
22	PIK3CA	Ssm	2	45	4.4%	cbioportal
20	NCOR1	Ssm	2	45	4.4%	cbioportal
19	MRE11	Ssm	2	45	4.4%	cbioportal
17	KIT	Ssm	2	45	4.4%	cbioportal
16	INPP4B	Ssm	2	45	4.4%	cbioportal
15	FLT1	Ssm	2	45	4.4%	cbioportal
14	EPHA5	Ssm	2	45	4.4%	cbioportal
13	CDK12	Ssm	2	45	4.4%	cbioportal
11	AR	Ssm	2	45	4.4%	cbioportal
12	ATRX	Ssm	2	45	4.4%	cbioportal
45	EZH1	Ssm	1	28	3.6%	cbioportal
90	RRAGC	Ssm	1	28	3.6%	cbioportal
79	PREX2	Ssm	1	28	3.6%	cbioportal
80	PRKCI	Ssm	1	28	3.6%	cbioportal
93	SESN1	Ssm	1	28	3.6%	cbioportal
61	INPPL1	Ssm	1	28	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

High-Grade Serous Ovarian Cancer (TCGA GDC, 2025) hgsoc_tcga_gdcTCGA GDC

405 cases with simple somatic mutation data · 604 cases total · 2026-01-13 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	369	405	91.1%	cbioportal
2	TTN	Ssm	96	405	23.7%	cbioportal
3	CSMD3	Ssm	36	405	8.9%	cbioportal
4	USH2A	Ssm	31	405	7.7%	cbioportal
5	NF1	Ssm	29	405	7.2%	cbioportal
6	RYR2	Ssm	28	405	6.9%	cbioportal
8	MUC16	Ssm	26	405	6.4%	cbioportal
7	HMCN1	Ssm	26	405	6.4%	cbioportal
9	FAT3	Ssm	23	405	5.7%	cbioportal
10	MACF1	Ssm	22	405	5.4%	cbioportal
11	SI	Ssm	22	405	5.4%	cbioportal
15	MUC17	Ssm	21	405	5.2%	cbioportal
13	APOB	Ssm	21	405	5.2%	cbioportal
14	FLG2	Ssm	21	405	5.2%	cbioportal
12	AHNAK	Ssm	21	405	5.2%	cbioportal
19	LRP1B	Ssm	20	405	4.9%	cbioportal
17	DNAH3	Ssm	20	405	4.9%	cbioportal
18	FLG	Ssm	20	405	4.9%	cbioportal
16	CDK12	Ssm	20	405	4.9%	cbioportal
23	LRP1	Ssm	19	405	4.7%	cbioportal
21	DNAH5	Ssm	19	405	4.7%	cbioportal
22	DST	Ssm	19	405	4.7%	cbioportal
20	BRCA1	Ssm	19	405	4.7%	cbioportal
26	SYNE1	Ssm	18	405	4.4%	cbioportal
24	COL6A3	Ssm	18	405	4.4%	cbioportal
28	TG	Ssm	18	405	4.4%	cbioportal
27	SYNE2	Ssm	18	405	4.4%	cbioportal
25	FCGBP	Ssm	18	405	4.4%	cbioportal
30	DNAH8	Ssm	17	405	4.2%	cbioportal
31	MDN1	Ssm	17	405	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Invasive Breast Carcinoma (TCGA GDC, 2025) brca_tcga_gdcTCGA GDC

971 cases with simple somatic mutation data · 1,102 cases total · 2026-01-13 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	334	971	34.4%	cbioportal
2	PIK3CA	Ssm	331	971	34.1%	cbioportal
3	TTN	Ssm	166	971	17.1%	cbioportal
4	CDH1	Ssm	130	971	13.4%	cbioportal
5	GATA3	Ssm	124	971	12.8%	cbioportal
6	MUC16	Ssm	98	971	10.1%	cbioportal
7	KMT2C	Ssm	86	971	8.9%	cbioportal
8	MAP3K1	Ssm	82	971	8.4%	cbioportal
9	HMCN1	Ssm	58	971	6%	cbioportal
10	FLG	Ssm	56	971	5.8%	cbioportal
11	RYR2	Ssm	56	971	5.8%	cbioportal
12	SYNE1	Ssm	53	971	5.5%	cbioportal
14	USH2A	Ssm	52	971	5.4%	cbioportal
13	PTEN	Ssm	52	971	5.4%	cbioportal
15	NCOR1	Ssm	49	971	5%	cbioportal
17	ZFHX4	Ssm	47	971	4.8%	cbioportal
16	SPTA1	Ssm	47	971	4.8%	cbioportal
18	DMD	Ssm	45	971	4.6%	cbioportal
19	MUC17	Ssm	43	971	4.4%	cbioportal
20	NEB	Ssm	42	971	4.3%	cbioportal
21	LRP2	Ssm	40	971	4.1%	cbioportal
22	FAT3	Ssm	39	971	4%	cbioportal
23	NF1	Ssm	39	971	4%	cbioportal
27	SYNE2	Ssm	38	971	3.9%	cbioportal
24	CSMD3	Ssm	38	971	3.9%	cbioportal
25	DST	Ssm	38	971	3.9%	cbioportal
26	MAP2K4	Ssm	38	971	3.9%	cbioportal
29	RYR3	Ssm	37	971	3.8%	cbioportal
28	RUNX1	Ssm	37	971	3.8%	cbioportal
30	APOB	Ssm	36	971	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Juvenile Papillomatosis and Breast Cancer (MSK,J Pathol. 2015) brca_jup_msk_2020MSK

5 cases with simple somatic mutation data · 5 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	4	5	80%	cbioportal
3	SMG1	Ssm	3	5	60%	cbioportal
2	CES1	Ssm	3	5	60%	cbioportal
17	NUTM2F	Ssm	2	5	40%	cbioportal
4	AKAP12	Ssm	2	5	40%	cbioportal
5	ARID1A	Ssm	2	5	40%	cbioportal
6	CKAP2L	Ssm	2	5	40%	cbioportal
7	CLEC12B	Ssm	2	5	40%	cbioportal
8	CTSW	Ssm	2	5	40%	cbioportal
9	ENOX1	Ssm	2	5	40%	cbioportal
10	FAM83G	Ssm	2	5	40%	cbioportal
11	KEAP1	Ssm	2	5	40%	cbioportal
12	KLF2	Ssm	2	5	40%	cbioportal
13	KMT2C	Ssm	2	5	40%	cbioportal
14	MARCHF11	Ssm	2	5	40%	cbioportal
15	MED13	Ssm	2	5	40%	cbioportal
16	NUP93	Ssm	2	5	40%	cbioportal
18	PIK3C2A	Ssm	2	5	40%	cbioportal
19	PIK3CB	Ssm	2	5	40%	cbioportal
20	PPP6R3	Ssm	2	5	40%	cbioportal
21	SLC24A4	Ssm	2	5	40%	cbioportal
22	TINAG	Ssm	2	5	40%	cbioportal
23	TLN1	Ssm	2	5	40%	cbioportal
24	VPS41	Ssm	2	5	40%	cbioportal
29	CD33	Ssm	1	5	20%	cbioportal
33	CRACDL	Ssm	1	5	20%	cbioportal
25	ACIN1	Ssm	1	5	20%	cbioportal
26	ANKS1A	Ssm	1	5	20%	cbioportal
27	BRWD1	Ssm	1	5	20%	cbioportal
28	BTBD17	Ssm	1	5	20%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Low-Grade Serous Ovarian Cancer (MSK, Clin Cancer Res 2022) lgsoc_mapk_msk_2022MSK

119 cases with simple somatic mutation data · 119 cases total · 2026-01-16 · mapped to Low-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	38	119	31.9%	cbioportal
2	NRAS	Ssm	13	119	10.9%	cbioportal
3	BRAF	Ssm	11	119	9.2%	cbioportal
4	EIF1AX	Ssm	11	119	9.2%	cbioportal
5	KMT2D	Ssm	5	119	4.2%	cbioportal
6	ERBB2	Ssm	4	119	3.4%	cbioportal
7	ANKRD11	Ssm	3	111	2.7%	cbioportal
8	ARID1B	Ssm	3	119	2.5%	cbioportal
15	MET	Ssm	2	119	1.7%	cbioportal
16	NF1	Ssm	2	119	1.7%	cbioportal
17	NF2	Ssm	2	119	1.7%	cbioportal
24	TP53	Ssm	2	119	1.7%	cbioportal
23	TERT	Ssm	2	119	1.7%	cbioportal
22	TBX3	Ssm	2	119	1.7%	cbioportal
18	PTPRS	Ssm	2	119	1.7%	cbioportal
9	ATRX	Ssm	2	119	1.7%	cbioportal
10	BARD1	Ssm	2	119	1.7%	cbioportal
19	RB1	Ssm	2	119	1.7%	cbioportal
14	MAP3K1	Ssm	2	119	1.7%	cbioportal
13	KMT2C	Ssm	2	119	1.7%	cbioportal
12	KMT2A	Ssm	2	119	1.7%	cbioportal
11	CTCF	Ssm	2	119	1.7%	cbioportal
21	RUNX1	Ssm	2	119	1.7%	cbioportal
20	ROS1	Ssm	2	119	1.7%	cbioportal
48	EPAS1	Ssm	1	88	1.1%	cbioportal
71	MSH3	Ssm	1	88	1.1%	cbioportal
88	RTEL1	Ssm	1	88	1.1%	cbioportal
52	ERF	Ssm	1	88	1.1%	cbioportal
36	CARM1	Ssm	1	88	1.1%	cbioportal
83	PPP6C	Ssm	1	111	0.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

MAPK on resistance to anti-HER2 therapy for breast cancer (MSK, Nat Commun. 2022) brca_mapk_hp_msk_2021MSK

145 cases with simple somatic mutation data · 145 cases total · 2026-04-07 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	88	145	60.7%	cbioportal
2	PIK3CA	Ssm	42	145	29%	cbioportal
3	GATA3	Ssm	17	145	11.7%	cbioportal
4	CDH1	Ssm	12	145	8.3%	cbioportal
5	ERBB2	Ssm	11	145	7.6%	cbioportal
6	NF1	Ssm	10	145	6.9%	cbioportal
7	KMT2C	Ssm	9	145	6.2%	cbioportal
8	TBX3	Ssm	9	145	6.2%	cbioportal
9	ARID2	Ssm	8	145	5.5%	cbioportal
12	ERBB3	Ssm	7	145	4.8%	cbioportal
14	RARA	Ssm	7	145	4.8%	cbioportal
10	ARID1A	Ssm	7	145	4.8%	cbioportal
11	ATM	Ssm	7	145	4.8%	cbioportal
13	PTPRD	Ssm	7	145	4.8%	cbioportal
15	KMT2D	Ssm	6	145	4.1%	cbioportal
23	ZFHX3	Ssm	5	122	4.1%	cbioportal
16	ALK	Ssm	5	145	3.4%	cbioportal
17	FAT1	Ssm	5	145	3.4%	cbioportal
18	PIK3R1	Ssm	5	145	3.4%	cbioportal
19	PTEN	Ssm	5	145	3.4%	cbioportal
20	RECQL4	Ssm	5	145	3.4%	cbioportal
21	RUNX1	Ssm	5	145	3.4%	cbioportal
22	TET1	Ssm	5	145	3.4%	cbioportal
24	BRD4	Ssm	4	145	2.8%	cbioportal
30	PTPRS	Ssm	4	145	2.8%	cbioportal
29	NOTCH4	Ssm	4	145	2.8%	cbioportal
28	NCOR1	Ssm	4	145	2.8%	cbioportal
26	ESR1	Ssm	4	145	2.8%	cbioportal
25	EPHA5	Ssm	4	145	2.8%	cbioportal
27	KMT2A	Ssm	4	145	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Metaplastic Breast Cancer (MSK,NPJ Breast Cancer 2021) mbc_msk_2021MSK

19 cases with simple somatic mutation data · 19 cases total · 2026-01-16 · mapped to Breast Metaplastic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	16	19	84.2%	cbioportal
4	ZFHX4	Ssm	3	5	60%	cbioportal
13	RYR2	Ssm	2	5	40%	cbioportal
8	KIF26A	Ssm	2	5	40%	cbioportal
14	VPS9D1	Ssm	2	5	40%	cbioportal
6	DPYD	Ssm	2	5	40%	cbioportal
5	APOBR	Ssm	2	5	40%	cbioportal
10	MUC22	Ssm	2	5	40%	cbioportal
2	PIK3CA	Ssm	5	19	26.3%	cbioportal
26	ADRA2B	Ssm	1	5	20%	cbioportal
35	ANO4	Ssm	1	5	20%	cbioportal
34	ANKRD13B	Ssm	1	5	20%	cbioportal
32	AKR1E2	Ssm	1	5	20%	cbioportal
31	AKAP8	Ssm	1	5	20%	cbioportal
30	AKAP6	Ssm	1	5	20%	cbioportal
29	AKAP4	Ssm	1	5	20%	cbioportal
28	AIDA	Ssm	1	5	20%	cbioportal
27	AGRN	Ssm	1	5	20%	cbioportal
25	ADGRB1	Ssm	1	5	20%	cbioportal
24	ADAMTS4	Ssm	1	5	20%	cbioportal
23	ADAMTS3	Ssm	1	5	20%	cbioportal
22	ADAM21	Ssm	1	5	20%	cbioportal
21	ACTN4	Ssm	1	5	20%	cbioportal
20	ACSF3	Ssm	1	5	20%	cbioportal
19	ABCC12	Ssm	1	5	20%	cbioportal
18	ABCA4	Ssm	1	5	20%	cbioportal
17	ABCA3	Ssm	1	5	20%	cbioportal
16	ABCA2	Ssm	1	5	20%	cbioportal
15	AAAS	Ssm	1	5	20%	cbioportal
148	DUSP6	Ssm	1	5	20%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Breast Cancer (AURORA US Network, Nat Cancer 2023) brca_aurora_2023AURORA US Network

134 cases with simple somatic mutation data · 155 cases total · 2026-01-29 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	58	134	43.3%	cbioportal
2	TTN	Ssm	51	134	38.1%	cbioportal
3	SYNE1	Ssm	41	134	30.6%	cbioportal
4	MUC16	Ssm	40	134	29.9%	cbioportal
5	RYR2	Ssm	30	134	22.4%	cbioportal
6	VPS13B	Ssm	30	134	22.4%	cbioportal
7	USH2A	Ssm	29	134	21.6%	cbioportal
8	SYNE2	Ssm	27	134	20.1%	cbioportal
11	NEB	Ssm	26	134	19.4%	cbioportal
9	HUWE1	Ssm	26	134	19.4%	cbioportal
10	MUC19	Ssm	26	134	19.4%	cbioportal
12	DST	Ssm	25	134	18.7%	cbioportal
13	LRTM3	Ssm	25	134	18.7%	cbioportal
14	OBSCN	Ssm	25	134	18.7%	cbioportal
19	RUNX1T1	Ssm	24	134	17.9%	cbioportal
16	DYNC1H1	Ssm	24	134	17.9%	cbioportal
15	ASPM	Ssm	24	134	17.9%	cbioportal
17	HMCN1	Ssm	24	134	17.9%	cbioportal
18	PLEC	Ssm	24	134	17.9%	cbioportal
21	MYH15	Ssm	23	134	17.2%	cbioportal
20	BLTP1	Ssm	23	134	17.2%	cbioportal
27	TCHH	Ssm	22	134	16.4%	cbioportal
28	VPS13D	Ssm	22	134	16.4%	cbioportal
22	ABCA13	Ssm	22	134	16.4%	cbioportal
23	CSMD3	Ssm	22	134	16.4%	cbioportal
24	KMT2A	Ssm	22	134	16.4%	cbioportal
25	RYR3	Ssm	22	134	16.4%	cbioportal
26	SPEN	Ssm	22	134	16.4%	cbioportal
30	FAM186A	Ssm	21	134	15.7%	cbioportal
29	DNAH5	Ssm	21	134	15.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-29

Metastatic Breast Cancer (DFCI, Cancer Discov 2020) brca_dfci_2020DFCI

59 cases with simple somatic mutation data · 59 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	26	59	44.1%	cbioportal
2	TP53	Ssm	21	59	35.6%	cbioportal
3	TTN	Ssm	18	59	30.5%	cbioportal
4	ESR1	Ssm	17	59	28.8%	cbioportal
5	GATA3	Ssm	11	59	18.6%	cbioportal
6	MUC16	Ssm	10	59	16.9%	cbioportal
9	KMT2C	Ssm	8	59	13.6%	cbioportal
7	CDH1	Ssm	8	59	13.6%	cbioportal
13	TBX3	Ssm	8	59	13.6%	cbioportal
12	OBSCN	Ssm	8	59	13.6%	cbioportal
11	NEB	Ssm	8	59	13.6%	cbioportal
10	MYO9B	Ssm	8	59	13.6%	cbioportal
8	FLG	Ssm	8	59	13.6%	cbioportal
17	ATAD5	Ssm	7	59	11.9%	cbioportal
18	MAP2K4	Ssm	7	59	11.9%	cbioportal
14	AHNAK	Ssm	7	59	11.9%	cbioportal
19	PLEC	Ssm	7	59	11.9%	cbioportal
16	ARID2	Ssm	7	59	11.9%	cbioportal
15	ARID1A	Ssm	7	59	11.9%	cbioportal
26	TCHH	Ssm	6	59	10.2%	cbioportal
21	DCC	Ssm	6	59	10.2%	cbioportal
25	RIMS2	Ssm	6	59	10.2%	cbioportal
24	PKHD1	Ssm	6	59	10.2%	cbioportal
23	MED23	Ssm	6	59	10.2%	cbioportal
22	DCHS2	Ssm	6	59	10.2%	cbioportal
27	ZFHX4	Ssm	6	59	10.2%	cbioportal
20	ADGRV1	Ssm	6	59	10.2%	cbioportal
48	MYH9	Ssm	5	59	8.5%	cbioportal
47	MYH11	Ssm	5	59	8.5%	cbioportal
49	NBAS	Ssm	5	59	8.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Metastatic Breast Cancer (INSERM, PLoS Med 2016) brca_igr_2015INSERM

216 cases with simple somatic mutation data · 216 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	84	216	38.9%	cbioportal
2	PIK3CA	Ssm	66	216	30.6%	cbioportal
3	TTN	Ssm	40	216	18.5%	cbioportal
4	GATA3	Ssm	26	216	12%	cbioportal
5	ESR1	Ssm	22	216	10.2%	cbioportal
6	RYR2	Ssm	20	216	9.3%	cbioportal
7	MAP3K1	Ssm	18	216	8.3%	cbioportal
9	FSIP2	Ssm	16	216	7.4%	cbioportal
8	CDH1	Ssm	16	216	7.4%	cbioportal
13	USH2A	Ssm	15	216	6.9%	cbioportal
10	FRAS1	Ssm	15	216	6.9%	cbioportal
11	HMCN1	Ssm	15	216	6.9%	cbioportal
12	OBSCN	Ssm	15	216	6.9%	cbioportal
14	KMT2C	Ssm	14	216	6.5%	cbioportal
17	SYNE1	Ssm	14	216	6.5%	cbioportal
16	RYR3	Ssm	14	216	6.5%	cbioportal
15	MUC16	Ssm	14	216	6.5%	cbioportal
22	NEB	Ssm	13	216	6%	cbioportal
23	PKHD1L1	Ssm	13	216	6%	cbioportal
21	FLG	Ssm	13	216	6%	cbioportal
20	DNAH9	Ssm	13	216	6%	cbioportal
19	DNAH6	Ssm	13	216	6%	cbioportal
18	DMD	Ssm	13	216	6%	cbioportal
27	PCLO	Ssm	12	216	5.6%	cbioportal
28	RYR1	Ssm	12	216	5.6%	cbioportal
29	TENM3	Ssm	12	216	5.6%	cbioportal
30	XIRP2	Ssm	12	216	5.6%	cbioportal
26	NF1	Ssm	12	216	5.6%	cbioportal
25	CACNA1E	Ssm	12	216	5.6%	cbioportal
24	ANK3	Ssm	12	216	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Metastatic castration-sensitive prostate cancer (MSK, Clin Cancer Res 2020) prad_mcspc_mskcc_2020MSK

424 cases with simple somatic mutation data · 424 cases total · 2026-04-07 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	129	424	30.4%	cbioportal
2	SPOP	Ssm	53	424	12.5%	cbioportal
3	FOXA1	Ssm	50	424	11.8%	cbioportal
4	PTEN	Ssm	46	424	10.8%	cbioportal
5	APC	Ssm	36	424	8.5%	cbioportal
6	KMT2C	Ssm	34	424	8%	cbioportal
7	KMT2D	Ssm	30	424	7.1%	cbioportal
8	ZFHX3	Ssm	25	387	6.5%	cbioportal
11	PIK3CA	Ssm	24	424	5.7%	cbioportal
10	CDK12	Ssm	24	424	5.7%	cbioportal
9	ATM	Ssm	24	424	5.7%	cbioportal
12	CTNNB1	Ssm	23	424	5.4%	cbioportal
13	BRCA2	Ssm	19	424	4.5%	cbioportal
15	MGA	Ssm	14	387	3.6%	cbioportal
14	SPEN	Ssm	15	424	3.5%	cbioportal
16	NCOR1	Ssm	13	424	3.1%	cbioportal
57	TP53BP1	Ssm	7	233	3%	cbioportal
17	BRAF	Ssm	12	424	2.8%	cbioportal
18	CREBBP	Ssm	12	424	2.8%	cbioportal
19	JAK1	Ssm	12	424	2.8%	cbioportal
21	GRIN2A	Ssm	11	424	2.6%	cbioportal
22	PTPRT	Ssm	11	424	2.6%	cbioportal
20	FAT1	Ssm	11	424	2.6%	cbioportal
28	NF1	Ssm	10	424	2.4%	cbioportal
23	ARID1A	Ssm	10	424	2.4%	cbioportal
27	KMT2A	Ssm	10	424	2.4%	cbioportal
26	ASXL2	Ssm	10	424	2.4%	cbioportal
29	NOTCH1	Ssm	10	424	2.4%	cbioportal
24	ARID1B	Ssm	10	424	2.4%	cbioportal
25	ASXL1	Ssm	10	424	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Metastatic Prostate Adenocarcinoma (MCTP, Nature 2012) prad_michMCTP

61 cases with simple somatic mutation data · 121 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	25	61	41%	cbioportal
2	TTN	Ssm	8	61	13.1%	cbioportal
3	ZFHX3	Ssm	8	61	13.1%	cbioportal
4	ABCA13	Ssm	7	61	11.5%	cbioportal
5	RYR3	Ssm	7	61	11.5%	cbioportal
9	MUC16	Ssm	6	61	9.8%	cbioportal
11	RB1	Ssm	6	61	9.8%	cbioportal
10	PTEN	Ssm	6	61	9.8%	cbioportal
8	KMT2D	Ssm	6	61	9.8%	cbioportal
7	DNAH11	Ssm	6	61	9.8%	cbioportal
6	APC	Ssm	6	61	9.8%	cbioportal
14	USH2A	Ssm	5	61	8.2%	cbioportal
12	AR	Ssm	5	61	8.2%	cbioportal
13	CSMD1	Ssm	5	61	8.2%	cbioportal
30	RYR1	Ssm	4	61	6.6%	cbioportal
19	DGKB	Ssm	4	61	6.6%	cbioportal
18	COL6A3	Ssm	4	61	6.6%	cbioportal
17	CDC42EP1	Ssm	4	61	6.6%	cbioportal
16	ATM	Ssm	4	61	6.6%	cbioportal
15	ASXL2	Ssm	4	61	6.6%	cbioportal
25	LPAR1	Ssm	4	61	6.6%	cbioportal
26	MAGI3	Ssm	4	61	6.6%	cbioportal
27	NAALADL2	Ssm	4	61	6.6%	cbioportal
28	NEB	Ssm	4	61	6.6%	cbioportal
29	PLEC	Ssm	4	61	6.6%	cbioportal
24	JARID2	Ssm	4	61	6.6%	cbioportal
23	HSPG2	Ssm	4	61	6.6%	cbioportal
22	GRIA1	Ssm	4	61	6.6%	cbioportal
21	FREM2	Ssm	4	61	6.6%	cbioportal
20	FAT4	Ssm	4	61	6.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, PNAS 2019) prad_su2c_2019SU2C/PCF Dream Team

444 cases with simple somatic mutation data · 444 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	163	444	36.7%	cbioportal
2	TTN	Ssm	88	444	19.8%	cbioportal
3	MUC16	Ssm	67	444	15.1%	cbioportal
4	AR	Ssm	61	444	13.7%	cbioportal
5	SYNE1	Ssm	49	444	11%	cbioportal
6	CSMD3	Ssm	43	444	9.7%	cbioportal
7	FOXA1	Ssm	41	444	9.2%	cbioportal
8	KMT2C	Ssm	40	444	9%	cbioportal
10	KMT2D	Ssm	37	444	8.3%	cbioportal
9	BRCA2	Ssm	37	444	8.3%	cbioportal
11	AHNAK2	Ssm	35	444	7.9%	cbioportal
12	HMCN1	Ssm	32	444	7.2%	cbioportal
13	APC	Ssm	31	444	7%	cbioportal
14	USH2A	Ssm	31	444	7%	cbioportal
15	CACNA1E	Ssm	29	444	6.5%	cbioportal
16	OBSCN	Ssm	29	444	6.5%	cbioportal
17	LRP1B	Ssm	28	444	6.3%	cbioportal
20	RYR1	Ssm	28	444	6.3%	cbioportal
19	PTEN	Ssm	28	444	6.3%	cbioportal
18	PLEC	Ssm	28	444	6.3%	cbioportal
23	FAT3	Ssm	27	444	6.1%	cbioportal
21	ATM	Ssm	27	444	6.1%	cbioportal
22	DCHS2	Ssm	27	444	6.1%	cbioportal
25	MUC4	Ssm	26	444	5.9%	cbioportal
26	RYR3	Ssm	26	444	5.9%	cbioportal
24	CDK12	Ssm	26	444	5.9%	cbioportal
30	SPOP	Ssm	25	444	5.6%	cbioportal
27	ABCA13	Ssm	25	444	5.6%	cbioportal
28	MACF1	Ssm	25	444	5.6%	cbioportal
29	RYR2	Ssm	25	444	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Prostate Cancer (SU2C/PCF Dream Team, Cell 2015) prad_su2c_2015SU2C/PCF Dream Team

150 cases with simple somatic mutation data · 150 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	60	150	40%	cbioportal
2	TP53	Ssm	58	150	38.7%	cbioportal
3	TTN	Ssm	41	150	27.3%	cbioportal
4	MUC16	Ssm	35	150	23.3%	cbioportal
5	AR	Ssm	27	150	18%	cbioportal
6	KMT2C	Ssm	23	150	15.3%	cbioportal
7	SYNE1	Ssm	21	150	14%	cbioportal
8	KMT2D	Ssm	18	150	12%	cbioportal
9	FOXA1	Ssm	16	150	10.7%	cbioportal
10	MUC2	Ssm	15	150	10%	cbioportal
14	USH2A	Ssm	14	150	9.3%	cbioportal
13	PIEZO1	Ssm	14	150	9.3%	cbioportal
12	FAT4	Ssm	14	150	9.3%	cbioportal
11	CSMD3	Ssm	14	150	9.3%	cbioportal
16	PLEC	Ssm	13	150	8.7%	cbioportal
15	CSMD1	Ssm	13	150	8.7%	cbioportal
17	APC	Ssm	12	150	8%	cbioportal
18	LRP1B	Ssm	12	150	8%	cbioportal
19	SPOP	Ssm	12	150	8%	cbioportal
21	CNTNAP5	Ssm	11	150	7.3%	cbioportal
22	DCHS2	Ssm	11	150	7.3%	cbioportal
23	DNAH3	Ssm	11	150	7.3%	cbioportal
24	HMCN1	Ssm	11	150	7.3%	cbioportal
25	MUC5B	Ssm	11	150	7.3%	cbioportal
26	OBSCN	Ssm	11	150	7.3%	cbioportal
27	PKHD1L1	Ssm	11	150	7.3%	cbioportal
28	PREX2	Ssm	11	150	7.3%	cbioportal
29	PTEN	Ssm	11	150	7.3%	cbioportal
30	RYR1	Ssm	11	150	7.3%	cbioportal
20	ABCA13	Ssm	11	150	7.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Triple Negative Breast Cancer (UNC Phase II Trial, J Immunother Cancer 2022) - iAtlas Harmonized brca_iatlas_anders_2022

25 cases with simple somatic mutation data · 31 cases total · 2026-02-11 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	18	25	72%	cbioportal
2	TTN	Ssm	7	25	28%	cbioportal
4	FAT1	Ssm	6	25	24%	cbioportal
6	OBSCN	Ssm	6	25	24%	cbioportal
7	RYR2	Ssm	6	25	24%	cbioportal
8	SPTA1	Ssm	6	25	24%	cbioportal
3	DST	Ssm	6	25	24%	cbioportal
5	LAMA5	Ssm	6	25	24%	cbioportal
11	PAPPA2	Ssm	5	25	20%	cbioportal
13	PLEC	Ssm	5	25	20%	cbioportal
14	RYR1	Ssm	5	25	20%	cbioportal
12	PKHD1L1	Ssm	5	25	20%	cbioportal
15	SRCAP	Ssm	5	25	20%	cbioportal
16	SYNE1	Ssm	5	25	20%	cbioportal
9	AEBP1	Ssm	5	25	20%	cbioportal
10	FASN	Ssm	5	25	20%	cbioportal
27	FGFR3	Ssm	4	25	16%	cbioportal
33	MAG	Ssm	4	25	16%	cbioportal
32	LRP2	Ssm	4	25	16%	cbioportal
31	LAMA1	Ssm	4	25	16%	cbioportal
34	MAP1B	Ssm	4	25	16%	cbioportal
30	KMT2B	Ssm	4	25	16%	cbioportal
35	MTCL1	Ssm	4	25	16%	cbioportal
36	MYO9B	Ssm	4	25	16%	cbioportal
37	P2RY2	Ssm	4	25	16%	cbioportal
29	KMT2A	Ssm	4	25	16%	cbioportal
24	DNAH9	Ssm	4	25	16%	cbioportal
25	ERICH3	Ssm	4	25	16%	cbioportal
26	FAT4	Ssm	4	25	16%	cbioportal
28	GOLGA2	Ssm	4	25	16%	cbioportal

Data updated 22 days agoSource updated 2026-02-11

Neuroendocrine Prostate Cancer (Multi-Institute, Nat Med 2016) nepc_wcm_2016Multi-Institute

114 cases with simple somatic mutation data · 114 cases total · 2026-01-08 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	27	114	23.7%	cbioportal
2	TTN	Ssm	21	114	18.4%	cbioportal
3	SPOP	Ssm	13	114	11.4%	cbioportal
4	MUC16	Ssm	11	114	9.6%	cbioportal
5	OBSCN	Ssm	10	114	8.8%	cbioportal
8	SHANK1	Ssm	9	114	7.9%	cbioportal
7	HMCN1	Ssm	9	114	7.9%	cbioportal
12	ZNF729	Ssm	9	114	7.9%	cbioportal
6	FOXA1	Ssm	9	114	7.9%	cbioportal
11	ZNF626	Ssm	9	114	7.9%	cbioportal
10	ZNF208	Ssm	9	114	7.9%	cbioportal
9	TMC8	Ssm	9	114	7.9%	cbioportal
20	RB1	Ssm	8	114	7%	cbioportal
13	CPD	Ssm	8	114	7%	cbioportal
14	DNAH3	Ssm	8	114	7%	cbioportal
15	DYNC1H1	Ssm	8	114	7%	cbioportal
16	FSIP2	Ssm	8	114	7%	cbioportal
17	KMO	Ssm	8	114	7%	cbioportal
18	LTBP1	Ssm	8	114	7%	cbioportal
19	METTL24	Ssm	8	114	7%	cbioportal
21	ZNFX1	Ssm	8	114	7%	cbioportal
28	OR9A4	Ssm	7	114	6.1%	cbioportal
30	SLC44A5	Ssm	7	114	6.1%	cbioportal
23	CHRNA3	Ssm	7	114	6.1%	cbioportal
24	COL14A1	Ssm	7	114	6.1%	cbioportal
25	CSMD3	Ssm	7	114	6.1%	cbioportal
26	NBPF3	Ssm	7	114	6.1%	cbioportal
27	NR2E1	Ssm	7	114	6.1%	cbioportal
29	PIWIL2	Ssm	7	114	6.1%	cbioportal
22	ADRM1	Ssm	7	114	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Ovarian Serous Cystadenocarcinoma TCGA-OVTCGA

603 cases with simple somatic mutation data · 608 cases total · Data Release 46.0 · mapped to Ovarian Serous Cystadenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	483	603	80.1%	gdc
2	MYC	Ssm	455	603	75.5%	gdc
3	POU5F1B	Ssm	449	603	74.5%	gdc
4	FAM135B	Ssm	449	603	74.5%	gdc
5	ACTRT3	Ssm	447	603	74.1%	gdc
8	MYNN	Ssm	446	603	74%	gdc
7	ADCY8	Ssm	446	603	74%	gdc
6	AGO2	Ssm	446	603	74%	gdc
10	LRRC34	Ssm	446	603	74%	gdc
9	PTK2	Ssm	446	603	74%	gdc
11	GSDMC	Ssm	445	603	73.8%	gdc
15	LRRIQ4	Ssm	445	603	73.8%	gdc
16	LRATD2	Ssm	445	603	73.8%	gdc
13	LRRC31	Ssm	445	603	73.8%	gdc
12	PTP4A3	Ssm	445	603	73.8%	gdc
14	GPR20	Ssm	445	603	73.8%	gdc
19	AC138647.1	Ssm	444	603	73.6%	gdc
18	SLC45A4	Ssm	444	603	73.6%	gdc
17	SAMD7	Ssm	444	603	73.6%	gdc
24	TG	Ssm	444	603	73.6%	gdc
20	TRIB1	Ssm	444	603	73.6%	gdc
21	ASAP1	Ssm	444	603	73.6%	gdc
22	SEC62	Ssm	444	603	73.6%	gdc
23	CHRAC1	Ssm	444	603	73.6%	gdc
28	KCNK9	Ssm	443	603	73.5%	gdc
25	GPR160	Ssm	443	603	73.5%	gdc
32	ZFAT	Ssm	443	603	73.5%	gdc
30	SCRIB	Ssm	443	603	73.5%	gdc
29	MECOM	Ssm	443	603	73.5%	gdc
33	CYRIB	Ssm	443	603	73.5%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Ovarian Serous Cystadenocarcinoma (TCGA, Firehose Legacy) ov_tcgaTCGA

316 cases with simple somatic mutation data · 617 cases total · 2026-01-12 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	277	316	87.7%	cbioportal
2	TTN	Ssm	56	316	17.7%	cbioportal
3	USH2A	Ssm	20	316	6.3%	cbioportal
4	FAT3	Ssm	19	316	6%	cbioportal
5	CSMD3	Ssm	18	316	5.7%	cbioportal
6	MUC16	Ssm	18	316	5.7%	cbioportal
7	HMCN1	Ssm	15	316	4.7%	cbioportal
8	LRP2	Ssm	15	316	4.7%	cbioportal
9	NF1	Ssm	14	316	4.4%	cbioportal
10	RYR2	Ssm	14	316	4.4%	cbioportal
11	DNAH5	Ssm	13	316	4.1%	cbioportal
12	LRP1B	Ssm	13	316	4.1%	cbioportal
16	COL6A3	Ssm	12	316	3.8%	cbioportal
15	BRCA1	Ssm	12	316	3.8%	cbioportal
14	AHNAK2	Ssm	12	316	3.8%	cbioportal
13	AHNAK	Ssm	12	316	3.8%	cbioportal
21	HUWE1	Ssm	11	316	3.5%	cbioportal
24	RYR1	Ssm	11	316	3.5%	cbioportal
23	MUC17	Ssm	11	316	3.5%	cbioportal
22	HYDIN	Ssm	11	316	3.5%	cbioportal
20	FAT1	Ssm	11	316	3.5%	cbioportal
19	DNAH3	Ssm	11	316	3.5%	cbioportal
18	BRCA2	Ssm	11	316	3.5%	cbioportal
17	APOB	Ssm	11	316	3.5%	cbioportal
25	LRRK2	Ssm	10	316	3.2%	cbioportal
28	TENM1	Ssm	10	316	3.2%	cbioportal
27	SI	Ssm	10	316	3.2%	cbioportal
26	PKHD1	Ssm	10	316	3.2%	cbioportal
30	COL22A1	Ssm	9	316	2.8%	cbioportal
29	CDK12	Ssm	9	316	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Ovarian Serous Cystadenocarcinoma (TCGA, Nature 2011) ov_tcga_pubTCGA

316 cases with simple somatic mutation data · 489 cases total · 2026-01-21 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	303	316	95.9%	cbioportal
2	TTN	Ssm	55	316	17.4%	cbioportal
3	BRCA1	Ssm	37	316	11.7%	cbioportal
4	BRCA2	Ssm	34	316	10.8%	cbioportal
5	USH2A	Ssm	20	316	6.3%	cbioportal
6	CSMD3	Ssm	19	316	6%	cbioportal
8	MUC16	Ssm	18	316	5.7%	cbioportal
7	FAT3	Ssm	18	316	5.7%	cbioportal
9	LRP2	Ssm	15	316	4.7%	cbioportal
11	RYR2	Ssm	14	316	4.4%	cbioportal
10	HMCN1	Ssm	14	316	4.4%	cbioportal
12	LRP1B	Ssm	13	316	4.1%	cbioportal
15	DNAH5	Ssm	12	316	3.8%	cbioportal
14	DNAH3	Ssm	12	316	3.8%	cbioportal
13	AHNAK	Ssm	12	316	3.8%	cbioportal
16	NF1	Ssm	12	316	3.8%	cbioportal
18	APOB	Ssm	11	316	3.5%	cbioportal
17	AHNAK2	Ssm	11	316	3.5%	cbioportal
22	TENM1	Ssm	11	316	3.5%	cbioportal
21	MUC17	Ssm	11	316	3.5%	cbioportal
20	HYDIN	Ssm	11	316	3.5%	cbioportal
19	FAT1	Ssm	11	316	3.5%	cbioportal
25	LRRK2	Ssm	10	316	3.2%	cbioportal
23	COL6A3	Ssm	10	316	3.2%	cbioportal
26	RYR1	Ssm	10	316	3.2%	cbioportal
24	HUWE1	Ssm	10	316	3.2%	cbioportal
29	COL22A1	Ssm	9	316	2.8%	cbioportal
30	DST	Ssm	9	316	2.8%	cbioportal
27	ADGRB3	Ssm	9	316	2.8%	cbioportal
28	CDK12	Ssm	9	316	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-21

Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas) ov_tcga_pan_can_atlas_2018TCGA

523 cases with simple somatic mutation data · 585 cases total · 2026-06-04 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	373	523	71.3%	cbioportal
2	TTN	Ssm	110	523	21%	cbioportal
3	FLG2	Ssm	41	523	7.8%	cbioportal
4	MUC16	Ssm	41	523	7.8%	cbioportal
5	CSMD3	Ssm	38	523	7.3%	cbioportal
6	HMCN1	Ssm	34	523	6.5%	cbioportal
7	USH2A	Ssm	32	523	6.1%	cbioportal
8	AHNAK2	Ssm	30	523	5.7%	cbioportal
9	FLG	Ssm	30	523	5.7%	cbioportal
10	NF1	Ssm	30	523	5.7%	cbioportal
11	MACF1	Ssm	29	523	5.5%	cbioportal
12	RYR2	Ssm	28	523	5.4%	cbioportal
14	SYNE1	Ssm	26	523	5%	cbioportal
13	AHNAK	Ssm	26	523	5%	cbioportal
20	MUC17	Ssm	24	523	4.6%	cbioportal
16	DNAH3	Ssm	24	523	4.6%	cbioportal
17	FAT3	Ssm	24	523	4.6%	cbioportal
15	APOB	Ssm	24	523	4.6%	cbioportal
18	KMT2C	Ssm	24	523	4.6%	cbioportal
19	LRP2	Ssm	24	523	4.6%	cbioportal
21	RYR1	Ssm	23	523	4.4%	cbioportal
22	COL6A3	Ssm	22	523	4.2%	cbioportal
24	MDN1	Ssm	22	523	4.2%	cbioportal
25	SI	Ssm	22	523	4.2%	cbioportal
23	DST	Ssm	22	523	4.2%	cbioportal
28	LRP1B	Ssm	21	523	4%	cbioportal
29	MYH1	Ssm	21	523	4%	cbioportal
26	DNAH5	Ssm	21	523	4%	cbioportal
27	FCGBP	Ssm	21	523	4%	cbioportal
30	FAT4	Ssm	20	523	3.8%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Prostate Adenocarcinoma TCGA-PRADTCGA

500 cases with simple somatic mutation data · 500 cases total · Data Release 46.0 · mapped to Prostate Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CCAR2	Ssm	298	500	59.6%	gdc
4	C8orf58	Ssm	297	500	59.4%	gdc
2	XPO7	Ssm	297	500	59.4%	gdc
3	BIN3	Ssm	297	500	59.4%	gdc
11	AC037459.1	Ssm	296	500	59.2%	gdc
10	TNFRSF10C	Ssm	296	500	59.2%	gdc
9	PPP3CC	Ssm	296	500	59.2%	gdc
8	BMP1	Ssm	296	500	59.2%	gdc
12	PEBP4	Ssm	296	500	59.2%	gdc
6	RHOBTB2	Ssm	296	500	59.2%	gdc
5	SORBS3	Ssm	296	500	59.2%	gdc
7	PIWIL2	Ssm	296	500	59.2%	gdc
23	TNFRSF10A	Ssm	295	500	59%	gdc
13	HR	Ssm	295	500	59%	gdc
21	FAM160B2	Ssm	295	500	59%	gdc
22	PDLIM2	Ssm	295	500	59%	gdc
20	TNFRSF10D	Ssm	295	500	59%	gdc
19	POLR3D	Ssm	295	500	59%	gdc
18	DOK2	Ssm	295	500	59%	gdc
17	DMTN	Ssm	295	500	59%	gdc
16	REEP4	Ssm	295	500	59%	gdc
15	EGR3	Ssm	295	500	59%	gdc
14	AC107959.5	Ssm	295	500	59%	gdc
26	NKX3-1	Ssm	294	500	58.8%	gdc
29	R3HCC1	Ssm	294	500	58.8%	gdc
28	NPM2	Ssm	294	500	58.8%	gdc
27	LGI3	Ssm	294	500	58.8%	gdc
25	TNFRSF10B	Ssm	294	500	58.8%	gdc
24	CHMP7	Ssm	294	500	58.8%	gdc
30	SLC25A37	Ssm	294	500	58.8%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Prostate Adenocarcinoma (Broad/Cornell, Cell 2013) prad_broad_2013Broad/Cornell

57 cases with simple somatic mutation data · 82 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	7	57	12.3%	cbioportal
4	TP53	Ssm	6	57	10.5%	cbioportal
2	ATM	Ssm	6	57	10.5%	cbioportal
3	MUC16	Ssm	6	57	10.5%	cbioportal
5	FOXA1	Ssm	5	57	8.8%	cbioportal
7	MACF1	Ssm	5	57	8.8%	cbioportal
6	KMT2C	Ssm	5	57	8.8%	cbioportal
12	TTN	Ssm	4	57	7%	cbioportal
13	ZAN	Ssm	4	57	7%	cbioportal
11	SPOP	Ssm	4	57	7%	cbioportal
8	BRINP2	Ssm	4	57	7%	cbioportal
10	PLCB3	Ssm	4	57	7%	cbioportal
9	FLG	Ssm	4	57	7%	cbioportal
35	SUZ12	Ssm	3	57	5.3%	cbioportal
26	FASN	Ssm	3	57	5.3%	cbioportal
25	DYNC2I1	Ssm	3	57	5.3%	cbioportal
23	CSMD3	Ssm	3	57	5.3%	cbioportal
24	DMD	Ssm	3	57	5.3%	cbioportal
22	CS	Ssm	3	57	5.3%	cbioportal
18	C10ORF90	Ssm	3	57	5.3%	cbioportal
17	BICD2	Ssm	3	57	5.3%	cbioportal
16	APC	Ssm	3	57	5.3%	cbioportal
15	ANK2	Ssm	3	57	5.3%	cbioportal
14	ABCC9	Ssm	3	57	5.3%	cbioportal
21	CREB3L4	Ssm	3	57	5.3%	cbioportal
20	CLIC6	Ssm	3	57	5.3%	cbioportal
19	CD8B	Ssm	3	57	5.3%	cbioportal
36	TNXB	Ssm	3	57	5.3%	cbioportal
33	PRDM9	Ssm	3	57	5.3%	cbioportal
34	SIPA1L1	Ssm	3	57	5.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (Broad/Cornell, Nat Genet 2012) prad_broadBroad/Cornell

112 cases with simple somatic mutation data · 123 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	14	112	12.5%	cbioportal
2	TTN	Ssm	11	112	9.8%	cbioportal
4	TP53	Ssm	7	112	6.3%	cbioportal
3	THSD7B	Ssm	7	112	6.3%	cbioportal
7	MED12	Ssm	6	112	5.4%	cbioportal
8	SCN11A	Ssm	6	112	5.4%	cbioportal
9	SPTA1	Ssm	6	112	5.4%	cbioportal
5	FAT4	Ssm	6	112	5.4%	cbioportal
6	HMCN1	Ssm	6	112	5.4%	cbioportal
17	SYNE3	Ssm	5	112	4.5%	cbioportal
10	ABCA13	Ssm	5	112	4.5%	cbioportal
11	FAT1	Ssm	5	112	4.5%	cbioportal
12	FLG	Ssm	5	112	4.5%	cbioportal
13	MDN1	Ssm	5	112	4.5%	cbioportal
14	NBAS	Ssm	5	112	4.5%	cbioportal
15	OBSCN	Ssm	5	112	4.5%	cbioportal
16	PTEN	Ssm	5	112	4.5%	cbioportal
28	LRP1B	Ssm	4	112	3.6%	cbioportal
18	CACNA1E	Ssm	4	112	3.6%	cbioportal
19	CD1A	Ssm	4	112	3.6%	cbioportal
20	CTNNA2	Ssm	4	112	3.6%	cbioportal
21	CUX1	Ssm	4	112	3.6%	cbioportal
22	DISP3	Ssm	4	112	3.6%	cbioportal
23	FMN2	Ssm	4	112	3.6%	cbioportal
24	FNDC1	Ssm	4	112	3.6%	cbioportal
25	FOXA1	Ssm	4	112	3.6%	cbioportal
26	FRAS1	Ssm	4	112	3.6%	cbioportal
27	ITPR1	Ssm	4	112	3.6%	cbioportal
29	MUC16	Ssm	4	112	3.6%	cbioportal
30	MYO18B	Ssm	4	112	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (CPC-GENE, Nature 2017) prad_cpcg_2017CPC-GENE

477 cases with simple somatic mutation data · 477 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	38	477	8%	cbioportal
2	TTN	Ssm	21	477	4.4%	cbioportal
3	TP53	Ssm	16	477	3.4%	cbioportal
4	MUC16	Ssm	12	477	2.5%	cbioportal
5	FOXA1	Ssm	11	477	2.3%	cbioportal
6	MED12	Ssm	11	477	2.3%	cbioportal
9	QRICH2	Ssm	9	477	1.9%	cbioportal
7	C6	Ssm	9	477	1.9%	cbioportal
8	PRB4	Ssm	9	477	1.9%	cbioportal
10	RYR2	Ssm	9	477	1.9%	cbioportal
11	ATM	Ssm	8	477	1.7%	cbioportal
12	KMT2C	Ssm	8	477	1.7%	cbioportal
13	PCDH15	Ssm	7	477	1.5%	cbioportal
14	SYNE1	Ssm	7	477	1.5%	cbioportal
15	TPTE	Ssm	7	477	1.5%	cbioportal
18	C9	Ssm	6	477	1.3%	cbioportal
21	SPTA1	Ssm	6	477	1.3%	cbioportal
20	FAT3	Ssm	6	477	1.3%	cbioportal
19	CSMD3	Ssm	6	477	1.3%	cbioportal
16	ADAMTS20	Ssm	6	477	1.3%	cbioportal
17	AHNAK2	Ssm	6	477	1.3%	cbioportal
25	CFAP65	Ssm	5	477	1%	cbioportal
24	C7	Ssm	5	477	1%	cbioportal
23	C3	Ssm	5	477	1%	cbioportal
22	ANK2	Ssm	5	477	1%	cbioportal
30	FNDC1	Ssm	5	477	1%	cbioportal
29	FAT1	Ssm	5	477	1%	cbioportal
28	DCAF4L2	Ssm	5	477	1%	cbioportal
27	COL11A1	Ssm	5	477	1%	cbioportal
26	CNTNAP5	Ssm	5	477	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (Fred Hutchinson CRC, Nat Med 2016) prad_fhcrcFred Hutchinson CRC

141 cases with simple somatic mutation data · 176 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	57	141	40.4%	cbioportal
2	CSMD3	Ssm	18	141	12.8%	cbioportal
3	MUC16	Ssm	18	141	12.8%	cbioportal
4	RNF213	Ssm	18	141	12.8%	cbioportal
5	TTN	Ssm	18	141	12.8%	cbioportal
6	DCHS2	Ssm	17	141	12.1%	cbioportal
7	OBSCN	Ssm	17	141	12.1%	cbioportal
11	RYR2	Ssm	16	141	11.3%	cbioportal
10	LRP1B	Ssm	16	141	11.3%	cbioportal
9	HERC2	Ssm	16	141	11.3%	cbioportal
8	ATM	Ssm	16	141	11.3%	cbioportal
12	CDH11	Ssm	15	141	10.6%	cbioportal
13	DNAH6	Ssm	15	141	10.6%	cbioportal
14	TICRR	Ssm	15	141	10.6%	cbioportal
15	ZFHX3	Ssm	15	141	10.6%	cbioportal
21	SPTA1	Ssm	14	141	9.9%	cbioportal
16	ABCA13	Ssm	14	141	9.9%	cbioportal
18	KMT2D	Ssm	14	141	9.9%	cbioportal
19	PCDHA6	Ssm	14	141	9.9%	cbioportal
20	PLCG1	Ssm	14	141	9.9%	cbioportal
17	CENPF	Ssm	14	141	9.9%	cbioportal
23	HECTD1	Ssm	13	141	9.2%	cbioportal
26	SYNE1	Ssm	13	141	9.2%	cbioportal
25	SKIC3	Ssm	13	141	9.2%	cbioportal
24	LRRK2	Ssm	13	141	9.2%	cbioportal
22	DNAH1	Ssm	13	141	9.2%	cbioportal
36	USH2A	Ssm	12	141	8.5%	cbioportal
32	KMT2C	Ssm	12	141	8.5%	cbioportal
35	PPFIA2	Ssm	12	141	8.5%	cbioportal
27	APOBEC3G	Ssm	12	141	8.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (MSK, 2025) prad_msk_2025MSK

120 cases with simple somatic mutation data · 120 cases total · 2026-03-04 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	31	120	25.8%	cbioportal
2	BRCA2	Ssm	22	120	18.3%	cbioportal
3	ZFHX3	Ssm	15	116	12.9%	cbioportal
4	FOXA1	Ssm	14	120	11.7%	cbioportal
5	KMT2C	Ssm	14	120	11.7%	cbioportal
6	CDK12	Ssm	12	120	10%	cbioportal
7	ATM	Ssm	10	120	8.3%	cbioportal
8	KMT2D	Ssm	9	120	7.5%	cbioportal
9	SPOP	Ssm	9	120	7.5%	cbioportal
10	SPEN	Ssm	8	120	6.7%	cbioportal
14	MGA	Ssm	7	116	6%	cbioportal
11	APC	Ssm	7	120	5.8%	cbioportal
13	BRCA1	Ssm	7	120	5.8%	cbioportal
12	AR	Ssm	7	120	5.8%	cbioportal
27	TP53BP1	Ssm	5	90	5.6%	cbioportal
16	KMT2A	Ssm	6	120	5%	cbioportal
17	NCOR1	Ssm	6	120	5%	cbioportal
18	PTCH1	Ssm	6	120	5%	cbioportal
20	PTPRD	Ssm	6	120	5%	cbioportal
15	CTNNB1	Ssm	6	120	5%	cbioportal
19	PTEN	Ssm	6	120	5%	cbioportal
184	GNB1	Ssm	1	22	4.5%	cbioportal
150	ARHGAP35	Ssm	1	22	4.5%	cbioportal
31	CARM1	Ssm	4	90	4.4%	cbioportal
35	ERF	Ssm	4	90	4.4%	cbioportal
21	ANKRD11	Ssm	5	116	4.3%	cbioportal
23	MED12	Ssm	5	120	4.2%	cbioportal
25	SETD2	Ssm	5	120	4.2%	cbioportal
22	KDM6A	Ssm	5	120	4.2%	cbioportal
24	NOTCH2	Ssm	5	120	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-03-04

Prostate Adenocarcinoma (MSK, Cancer Cell 2010) prad_mskccMSK

182 cases with simple somatic mutation data · 240 cases total · 2026-02-19 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
69	STAT5B	Ssm	2	9	22.2%	cbioportal
66	ROS1	Ssm	2	9	22.2%	cbioportal
115	RAC3	Ssm	1	9	11.1%	cbioportal
114	PTPN6	Ssm	1	9	11.1%	cbioportal
121	TYK2	Ssm	1	9	11.1%	cbioportal
120	STAT1	Ssm	1	9	11.1%	cbioportal
90	IDH2	Ssm	1	9	11.1%	cbioportal
119	SRC	Ssm	1	9	11.1%	cbioportal
89	FGF1	Ssm	1	9	11.1%	cbioportal
88	FES	Ssm	1	9	11.1%	cbioportal
92	JAK2	Ssm	1	9	11.1%	cbioportal
97	LCK	Ssm	1	9	11.1%	cbioportal
85	ETS2	Ssm	1	9	11.1%	cbioportal
100	MAPK7	Ssm	1	9	11.1%	cbioportal
103	MUTYH	Ssm	1	9	11.1%	cbioportal
106	NSD1	Ssm	1	9	11.1%	cbioportal
81	ELK1	Ssm	1	9	11.1%	cbioportal
80	EGF	Ssm	1	9	11.1%	cbioportal
107	PDGFRB	Ssm	1	9	11.1%	cbioportal
78	CASP9	Ssm	1	9	11.1%	cbioportal
110	PRKCZ	Ssm	1	9	11.1%	cbioportal
111	PTK2	Ssm	1	9	11.1%	cbioportal
75	BLK	Ssm	1	9	11.1%	cbioportal
1	PTPRF	Ssm	9	106	8.5%	cbioportal
2	EP300	Ssm	7	106	6.6%	cbioportal
4	FLT4	Ssm	6	106	5.7%	cbioportal
3	AR	Ssm	6	106	5.7%	cbioportal
9	NCOR2	Ssm	5	106	4.7%	cbioportal
10	PTK7	Ssm	5	106	4.7%	cbioportal
8	JAK1	Ssm	5	106	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Prostate Adenocarcinoma (MSK, Clin Cancer Res. 2022) prad_pik3r1_msk_2021MSK

1,417 cases with simple somatic mutation data · 1,417 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	411	1,417	29%	cbioportal
2	SPOP	Ssm	200	1,417	14.1%	cbioportal
3	FOXA1	Ssm	197	1,417	13.9%	cbioportal
4	APC	Ssm	124	1,417	8.8%	cbioportal
5	PTEN	Ssm	119	1,417	8.4%	cbioportal
6	KMT2C	Ssm	81	1,417	5.7%	cbioportal
8	ZFHX3	Ssm	75	1,361	5.5%	cbioportal
7	KMT2D	Ssm	76	1,417	5.4%	cbioportal
9	CDK12	Ssm	67	1,417	4.7%	cbioportal
10	CTNNB1	Ssm	61	1,417	4.3%	cbioportal
11	PIK3CA	Ssm	60	1,417	4.2%	cbioportal
12	ATM	Ssm	59	1,417	4.2%	cbioportal
13	BRCA2	Ssm	56	1,417	4%	cbioportal
14	AR	Ssm	53	1,417	3.7%	cbioportal
15	PIK3R1	Ssm	48	1,417	3.4%	cbioportal
16	KDM6A	Ssm	44	1,417	3.1%	cbioportal
17	MGA	Ssm	39	1,361	2.9%	cbioportal
18	RB1	Ssm	36	1,417	2.5%	cbioportal
19	MED12	Ssm	35	1,417	2.5%	cbioportal
20	PTPRD	Ssm	31	1,417	2.2%	cbioportal
21	GRIN2A	Ssm	28	1,417	2%	cbioportal
22	ASXL2	Ssm	27	1,417	1.9%	cbioportal
23	EPHB1	Ssm	26	1,417	1.8%	cbioportal
24	JAK1	Ssm	26	1,417	1.8%	cbioportal
25	SPEN	Ssm	26	1,417	1.8%	cbioportal
27	SF3B1	Ssm	25	1,417	1.8%	cbioportal
26	NCOR1	Ssm	25	1,417	1.8%	cbioportal
28	ARID1A	Ssm	23	1,417	1.6%	cbioportal
29	ASXL1	Ssm	22	1,417	1.6%	cbioportal
30	BRAF	Ssm	22	1,417	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (MSK/DFCI, Nature Genetics 2018) prad_p1000MSK/DFCI

1,013 cases with simple somatic mutation data · 1,013 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	189	1,013	18.7%	cbioportal
2	TTN	Ssm	151	1,013	14.9%	cbioportal
3	MUC16	Ssm	113	1,013	11.2%	cbioportal
4	SPOP	Ssm	92	1,013	9.1%	cbioportal
5	SYNE1	Ssm	73	1,013	7.2%	cbioportal
6	FOXA1	Ssm	69	1,013	6.8%	cbioportal
7	KMT2C	Ssm	66	1,013	6.5%	cbioportal
8	KMT2D	Ssm	65	1,013	6.4%	cbioportal
9	CSMD3	Ssm	61	1,013	6%	cbioportal
10	HMCN1	Ssm	55	1,013	5.4%	cbioportal
11	LRP1B	Ssm	54	1,013	5.3%	cbioportal
12	OBSCN	Ssm	53	1,013	5.2%	cbioportal
13	AR	Ssm	48	1,013	4.7%	cbioportal
14	SPTA1	Ssm	47	1,013	4.6%	cbioportal
15	USH2A	Ssm	46	1,013	4.5%	cbioportal
16	RYR1	Ssm	45	1,013	4.4%	cbioportal
17	PTEN	Ssm	44	1,013	4.3%	cbioportal
18	RYR2	Ssm	44	1,013	4.3%	cbioportal
19	ABCA13	Ssm	43	1,013	4.2%	cbioportal
20	FAT3	Ssm	41	1,013	4%	cbioportal
21	ZFHX3	Ssm	41	1,013	4%	cbioportal
22	DCHS2	Ssm	40	1,013	3.9%	cbioportal
23	FAT4	Ssm	39	1,013	3.8%	cbioportal
24	ATM	Ssm	38	1,013	3.8%	cbioportal
26	CSMD1	Ssm	37	1,013	3.7%	cbioportal
25	CACNA1E	Ssm	37	1,013	3.7%	cbioportal
27	DNAH3	Ssm	36	1,013	3.6%	cbioportal
29	MYO15A	Ssm	34	1,013	3.4%	cbioportal
28	MUC4	Ssm	34	1,013	3.4%	cbioportal
30	XIRP2	Ssm	34	1,013	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (MSK, Eur Urol 2020) prad_cdk12_mskcc_2020MSK

1,465 cases with simple somatic mutation data · 1,465 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	391	1,465	26.7%	cbioportal
2	FOXA1	Ssm	179	1,465	12.2%	cbioportal
3	SPOP	Ssm	166	1,465	11.3%	cbioportal
4	PTEN	Ssm	97	1,465	6.6%	cbioportal
5	KMT2C	Ssm	89	1,465	6.1%	cbioportal
6	CDK12	Ssm	88	1,465	6%	cbioportal
7	APC	Ssm	86	1,465	5.9%	cbioportal
8	KMT2D	Ssm	74	1,465	5.1%	cbioportal
9	AR	Ssm	56	1,465	3.8%	cbioportal
13	ZFHX3	Ssm	51	1,337	3.8%	cbioportal
10	CTNNB1	Ssm	55	1,465	3.8%	cbioportal
12	PIK3CA	Ssm	52	1,465	3.5%	cbioportal
11	ATM	Ssm	52	1,465	3.5%	cbioportal
14	BRCA2	Ssm	45	1,465	3.1%	cbioportal
15	KDM6A	Ssm	38	1,465	2.6%	cbioportal
16	GRIN2A	Ssm	36	1,465	2.5%	cbioportal
17	MED12	Ssm	31	1,465	2.1%	cbioportal
18	PTPRD	Ssm	30	1,465	2%	cbioportal
19	SPEN	Ssm	28	1,465	1.9%	cbioportal
20	RB1	Ssm	27	1,465	1.8%	cbioportal
24	MGA	Ssm	24	1,337	1.8%	cbioportal
21	BRAF	Ssm	26	1,465	1.8%	cbioportal
48	ERF	Ssm	14	809	1.7%	cbioportal
22	PIK3R1	Ssm	25	1,465	1.7%	cbioportal
23	ASXL1	Ssm	24	1,465	1.6%	cbioportal
25	NCOR1	Ssm	24	1,465	1.6%	cbioportal
26	ARID1A	Ssm	23	1,465	1.6%	cbioportal
29	NF1	Ssm	23	1,465	1.6%	cbioportal
27	JAK1	Ssm	23	1,465	1.6%	cbioportal
28	KMT2A	Ssm	23	1,465	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma Organoids (MSK, Cell 2014) prad_mskcc_cheny1_organoids_2014MSK

12 cases with simple somatic mutation data · 12 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	12	58.3%	cbioportal
2	TBP	Ssm	6	12	50%	cbioportal
3	LCE4A	Ssm	4	12	33.3%	cbioportal
16	TRIOBP	Ssm	3	12	25%	cbioportal
7	FOXA1	Ssm	3	12	25%	cbioportal
11	KRT72	Ssm	3	12	25%	cbioportal
15	SPATA31D1	Ssm	3	12	25%	cbioportal
14	SPATA3	Ssm	3	12	25%	cbioportal
13	SCN5A	Ssm	3	12	25%	cbioportal
12	NKX6-2	Ssm	3	12	25%	cbioportal
10	KRT1	Ssm	3	12	25%	cbioportal
9	KIRREL1	Ssm	3	12	25%	cbioportal
6	CRACD	Ssm	3	12	25%	cbioportal
8	GIT2	Ssm	3	12	25%	cbioportal
5	ATXN1	Ssm	3	12	25%	cbioportal
4	ABHD15	Ssm	3	12	25%	cbioportal
104	PIK3R1	Ssm	2	12	16.7%	cbioportal
94	OLFM1	Ssm	2	12	16.7%	cbioportal
95	OPCML	Ssm	2	12	16.7%	cbioportal
96	OR10H3	Ssm	2	12	16.7%	cbioportal
97	OR10J1	Ssm	2	12	16.7%	cbioportal
98	OR1S2	Ssm	2	12	16.7%	cbioportal
99	OTOF	Ssm	2	12	16.7%	cbioportal
100	PCARE	Ssm	2	12	16.7%	cbioportal
101	PEG3	Ssm	2	12	16.7%	cbioportal
102	PEX39	Ssm	2	12	16.7%	cbioportal
103	PHLPP1	Ssm	2	12	16.7%	cbioportal
105	PITRM1	Ssm	2	12	16.7%	cbioportal
106	PJA1	Ssm	2	12	16.7%	cbioportal
107	PLD2	Ssm	2	12	16.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (SMMU, Eur Urol 2017) prad_eururol_2017SMMU

65 cases with simple somatic mutation data · 65 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	11	65	16.9%	cbioportal
2	KDM6A	Ssm	5	65	7.7%	cbioportal
3	KMT2D	Ssm	4	65	6.2%	cbioportal
7	RYR1	Ssm	3	65	4.6%	cbioportal
8	SEMA5A	Ssm	3	65	4.6%	cbioportal
6	PTEN	Ssm	3	65	4.6%	cbioportal
9	TP53	Ssm	3	65	4.6%	cbioportal
5	MYH2	Ssm	3	65	4.6%	cbioportal
4	COL22A1	Ssm	3	65	4.6%	cbioportal
17	CAMTA1	Ssm	2	65	3.1%	cbioportal
10	ADAM2	Ssm	2	65	3.1%	cbioportal
11	ADCY8	Ssm	2	65	3.1%	cbioportal
12	AKR1A1	Ssm	2	65	3.1%	cbioportal
13	ALOX5	Ssm	2	65	3.1%	cbioportal
14	ATM	Ssm	2	65	3.1%	cbioportal
15	BOC	Ssm	2	65	3.1%	cbioportal
16	C2	Ssm	2	65	3.1%	cbioportal
18	CDK12	Ssm	2	65	3.1%	cbioportal
19	CFAP69	Ssm	2	65	3.1%	cbioportal
20	CHD6	Ssm	2	65	3.1%	cbioportal
21	CLCNKA	Ssm	2	65	3.1%	cbioportal
22	COL16A1	Ssm	2	65	3.1%	cbioportal
23	COL4A1	Ssm	2	65	3.1%	cbioportal
24	COL4A2	Ssm	2	65	3.1%	cbioportal
25	CPOX	Ssm	2	65	3.1%	cbioportal
26	CSF1R	Ssm	2	65	3.1%	cbioportal
27	CSMD1	Ssm	2	65	3.1%	cbioportal
28	CTNNB1	Ssm	2	65	3.1%	cbioportal
29	CUL3	Ssm	2	65	3.1%	cbioportal
30	DNAH10	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (TCGA, Cell 2015) prad_tcga_pubTCGA

333 cases with simple somatic mutation data · 333 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	TTN	Ssm	37	333	11.1%	cbioportal
1	SPOP	Ssm	37	333	11.1%	cbioportal
3	TP53	Ssm	23	333	6.9%	cbioportal
4	MUC16	Ssm	20	333	6%	cbioportal
5	MUC17	Ssm	17	333	5.1%	cbioportal
6	SPTA1	Ssm	15	333	4.5%	cbioportal
9	KMT2C	Ssm	13	333	3.9%	cbioportal
8	FOXA1	Ssm	13	333	3.9%	cbioportal
7	ATM	Ssm	13	333	3.9%	cbioportal
12	LRP1B	Ssm	12	333	3.6%	cbioportal
10	AHNAK2	Ssm	12	333	3.6%	cbioportal
11	CSMD3	Ssm	12	333	3.6%	cbioportal
14	OBSCN	Ssm	11	333	3.3%	cbioportal
13	KMT2D	Ssm	11	333	3.3%	cbioportal
17	HMCN1	Ssm	10	333	3%	cbioportal
15	AHNAK	Ssm	10	333	3%	cbioportal
18	RP1	Ssm	10	333	3%	cbioportal
16	FAT3	Ssm	10	333	3%	cbioportal
22	PTEN	Ssm	9	333	2.7%	cbioportal
19	BRCA2	Ssm	9	333	2.7%	cbioportal
21	FLG2	Ssm	9	333	2.7%	cbioportal
20	DCHS2	Ssm	9	333	2.7%	cbioportal
24	ADGRV1	Ssm	8	333	2.4%	cbioportal
23	ADGRB3	Ssm	8	333	2.4%	cbioportal
25	BRAF	Ssm	8	333	2.4%	cbioportal
29	MACF1	Ssm	8	333	2.4%	cbioportal
28	FLG	Ssm	8	333	2.4%	cbioportal
27	DNAH9	Ssm	8	333	2.4%	cbioportal
26	CTNNB1	Ssm	8	333	2.4%	cbioportal
30	PCDH18	Ssm	8	333	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (TCGA, Firehose Legacy) prad_tcgaTCGA

499 cases with simple somatic mutation data · 501 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FRG1BP	Ssm	97	499	19.4%	cbioportal
2	TTN	Ssm	63	499	12.6%	cbioportal
3	TP53	Ssm	61	499	12.2%	cbioportal
4	SPOP	Ssm	57	499	11.4%	cbioportal
5	MUC16	Ssm	38	499	7.6%	cbioportal
6	MUC17	Ssm	33	499	6.6%	cbioportal
7	KMT2C	Ssm	30	499	6%	cbioportal
8	KMT2D	Ssm	29	499	5.8%	cbioportal
9	FOXA1	Ssm	28	499	5.6%	cbioportal
11	SYNE1	Ssm	27	499	5.4%	cbioportal
10	NBPF1	Ssm	27	499	5.4%	cbioportal
12	SPTA1	Ssm	26	499	5.2%	cbioportal
13	KRTAP4-11	Ssm	24	499	4.8%	cbioportal
14	LRP1B	Ssm	24	499	4.8%	cbioportal
15	NBPF10	Ssm	23	499	4.6%	cbioportal
16	ATM	Ssm	22	499	4.4%	cbioportal
18	ZAN	Ssm	22	499	4.4%	cbioportal
17	CSMD3	Ssm	22	499	4.4%	cbioportal
20	MUC4	Ssm	21	499	4.2%	cbioportal
19	CHEK2	Ssm	21	499	4.2%	cbioportal
22	HMCN1	Ssm	19	499	3.8%	cbioportal
21	FAT3	Ssm	19	499	3.8%	cbioportal
23	RYR1	Ssm	19	499	3.8%	cbioportal
24	CACNA1E	Ssm	18	499	3.6%	cbioportal
27	USH2A	Ssm	18	499	3.6%	cbioportal
26	RGPD8	Ssm	18	499	3.6%	cbioportal
25	OBSCN	Ssm	18	499	3.6%	cbioportal
29	PTEN	Ssm	17	499	3.4%	cbioportal
28	MACF1	Ssm	17	499	3.4%	cbioportal
30	RYR2	Ssm	17	499	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (TCGA GDC, 2025) prad_tcga_gdcTCGA GDC

491 cases with simple somatic mutation data · 501 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	55	491	11.2%	cbioportal
2	SPOP	Ssm	54	491	11%	cbioportal
3	TTN	Ssm	47	491	9.6%	cbioportal
4	FOXA1	Ssm	29	491	5.9%	cbioportal
5	KMT2D	Ssm	28	491	5.7%	cbioportal
6	MUC16	Ssm	26	491	5.3%	cbioportal
7	SYNE1	Ssm	22	491	4.5%	cbioportal
8	KMT2C	Ssm	21	491	4.3%	cbioportal
9	LRP1B	Ssm	20	491	4.1%	cbioportal
10	SPTA1	Ssm	20	491	4.1%	cbioportal
11	ATM	Ssm	18	491	3.7%	cbioportal
12	CSMD3	Ssm	17	491	3.5%	cbioportal
13	RYR2	Ssm	17	491	3.5%	cbioportal
14	PTEN	Ssm	16	491	3.3%	cbioportal
15	KDM6A	Ssm	15	491	3.1%	cbioportal
17	HMCN1	Ssm	14	491	2.9%	cbioportal
18	MUC17	Ssm	14	491	2.9%	cbioportal
16	CACNA1E	Ssm	14	491	2.9%	cbioportal
20	USH2A	Ssm	13	491	2.6%	cbioportal
19	RP1	Ssm	13	491	2.6%	cbioportal
23	RYR1	Ssm	12	491	2.4%	cbioportal
22	MYO15A	Ssm	12	491	2.4%	cbioportal
21	FAT3	Ssm	12	491	2.4%	cbioportal
25	ADGRB3	Ssm	11	491	2.2%	cbioportal
24	ABCA13	Ssm	11	491	2.2%	cbioportal
30	ZMYM3	Ssm	11	491	2.2%	cbioportal
29	OBSCN	Ssm	11	491	2.2%	cbioportal
28	MACF1	Ssm	11	491	2.2%	cbioportal
27	CNTNAP5	Ssm	11	491	2.2%	cbioportal
26	APC	Ssm	11	491	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (TCGA, PanCancer Atlas) prad_tcga_pan_can_atlas_2018TCGA

494 cases with simple somatic mutation data · 494 cases total · 2026-06-04 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	57	494	11.5%	cbioportal
2	SPOP	Ssm	55	494	11.1%	cbioportal
3	TTN	Ssm	54	494	10.9%	cbioportal
4	MUC16	Ssm	31	494	6.3%	cbioportal
5	FOXA1	Ssm	28	494	5.7%	cbioportal
6	KMT2D	Ssm	28	494	5.7%	cbioportal
7	KMT2C	Ssm	25	494	5.1%	cbioportal
8	SPTA1	Ssm	23	494	4.7%	cbioportal
9	SYNE1	Ssm	23	494	4.7%	cbioportal
10	LRP1B	Ssm	22	494	4.5%	cbioportal
11	ATM	Ssm	20	494	4%	cbioportal
12	CSMD3	Ssm	19	494	3.8%	cbioportal
14	PTEN	Ssm	18	494	3.6%	cbioportal
13	FAT3	Ssm	18	494	3.6%	cbioportal
15	RYR2	Ssm	18	494	3.6%	cbioportal
16	HMCN1	Ssm	16	494	3.2%	cbioportal
17	OBSCN	Ssm	16	494	3.2%	cbioportal
21	RYR1	Ssm	15	494	3%	cbioportal
18	CACNA1E	Ssm	15	494	3%	cbioportal
19	COL11A1	Ssm	15	494	3%	cbioportal
20	MUC17	Ssm	15	494	3%	cbioportal
22	USH2A	Ssm	15	494	3%	cbioportal
23	MACF1	Ssm	14	494	2.8%	cbioportal
24	MYO15A	Ssm	14	494	2.8%	cbioportal
25	RP1	Ssm	13	494	2.6%	cbioportal
26	ZFHX3	Ssm	13	494	2.6%	cbioportal
29	DCHS2	Ssm	12	494	2.4%	cbioportal
27	ABCA13	Ssm	12	494	2.4%	cbioportal
28	CSMD1	Ssm	12	494	2.4%	cbioportal
30	DNAH17	Ssm	12	494	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Prostate Cancer-IDH Driver Mutant Cohort (MSK, 2024) prad_idhmut_msk_2025MSK

99 cases with simple somatic mutation data · 99 cases total · 2026-08-20 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	29	99	29.3%	cbioportal
2	TP53	Ssm	17	99	17.2%	cbioportal
4	SPOP	Ssm	12	99	12.1%	cbioportal
3	FOXA1	Ssm	12	99	12.1%	cbioportal
7	PIK3CA	Ssm	6	99	6.1%	cbioportal
5	BRCA2	Ssm	6	99	6.1%	cbioportal
6	CTNNB1	Ssm	6	99	6.1%	cbioportal
8	ATM	Ssm	5	99	5.1%	cbioportal
9	KMT2D	Ssm	5	99	5.1%	cbioportal
11	CDK12	Ssm	4	99	4%	cbioportal
13	PTEN	Ssm	4	99	4%	cbioportal
10	APC	Ssm	4	99	4%	cbioportal
12	IDH2	Ssm	4	99	4%	cbioportal
22	ZFHX3	Ssm	3	96	3.1%	cbioportal
19	MGA	Ssm	3	96	3.1%	cbioportal
20	PTPRD	Ssm	3	99	3%	cbioportal
18	KMT2A	Ssm	3	99	3%	cbioportal
14	BCOR	Ssm	3	99	3%	cbioportal
15	DNMT3B	Ssm	3	99	3%	cbioportal
16	JAK1	Ssm	3	99	3%	cbioportal
17	KDM6A	Ssm	3	99	3%	cbioportal
21	TSC2	Ssm	3	99	3%	cbioportal
40	NSD2	Ssm	2	89	2.2%	cbioportal
119	MAP3K7	Ssm	1	45	2.2%	cbioportal
117	LRP1B	Ssm	1	45	2.2%	cbioportal
93	FANCL	Ssm	1	45	2.2%	cbioportal
124	MLH3	Ssm	1	45	2.2%	cbioportal
51	ACVR1B	Ssm	1	45	2.2%	cbioportal
43	POLD1	Ssm	2	96	2.1%	cbioportal
31	FBXW7	Ssm	2	99	2%	cbioportal

Data updated 22 days agoSource updated 2026-08-20

Prostate Cancer (MSK, JCO Precis Oncol 2017) prad_mskcc_2017MSK

504 cases with simple somatic mutation data · 504 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	166	504	32.9%	cbioportal
2	FOXA1	Ssm	58	504	11.5%	cbioportal
3	SPOP	Ssm	47	504	9.3%	cbioportal
4	APC	Ssm	40	504	7.9%	cbioportal
5	KMT2C	Ssm	34	504	6.7%	cbioportal
6	PTEN	Ssm	28	504	5.6%	cbioportal
7	CDK12	Ssm	27	504	5.4%	cbioportal
9	KMT2D	Ssm	25	504	5%	cbioportal
8	AR	Ssm	25	504	5%	cbioportal
10	BRCA2	Ssm	24	504	4.8%	cbioportal
11	SPEN	Ssm	21	504	4.2%	cbioportal
12	GRIN2A	Ssm	19	504	3.8%	cbioportal
13	ATM	Ssm	18	504	3.6%	cbioportal
15	PIK3CA	Ssm	17	504	3.4%	cbioportal
14	CTNNB1	Ssm	17	504	3.4%	cbioportal
16	JAK1	Ssm	15	504	3%	cbioportal
30	ZFHX3	Ssm	10	345	2.9%	cbioportal
27	MGA	Ssm	10	345	2.9%	cbioportal
17	FAT1	Ssm	14	504	2.8%	cbioportal
18	RB1	Ssm	14	504	2.8%	cbioportal
20	MED12	Ssm	12	504	2.4%	cbioportal
21	NCOR1	Ssm	12	504	2.4%	cbioportal
19	KMT2A	Ssm	12	504	2.4%	cbioportal
25	PTPRS	Ssm	11	504	2.2%	cbioportal
23	KDM6A	Ssm	11	504	2.2%	cbioportal
22	ASXL1	Ssm	11	504	2.2%	cbioportal
24	NOTCH1	Ssm	11	504	2.2%	cbioportal
28	NSD1	Ssm	10	504	2%	cbioportal
26	BRAF	Ssm	10	504	2%	cbioportal
29	PIK3R1	Ssm	10	504	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Cancer (MSK, Science 2022) prad_organoids_msk_2022MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	32	47	68.1%	cbioportal
5	MUC16	Ssm	7	24	29.2%	cbioportal
7	AEBP1	Ssm	6	24	25%	cbioportal
10	TTN	Ssm	6	24	25%	cbioportal
17	HERC1	Ssm	5	24	20.8%	cbioportal
21	OBSCN	Ssm	5	24	20.8%	cbioportal
16	DNAH2	Ssm	5	24	20.8%	cbioportal
14	CDH23	Ssm	5	24	20.8%	cbioportal
26	TRIOBP	Ssm	5	24	20.8%	cbioportal
11	ABHD15	Ssm	5	24	20.8%	cbioportal
19	MACF1	Ssm	5	24	20.8%	cbioportal
20	MUC5B	Ssm	5	24	20.8%	cbioportal
18	LRP1B	Ssm	5	24	20.8%	cbioportal
2	FOXA1	Ssm	8	47	17%	cbioportal
48	ITPRID1	Ssm	4	24	16.7%	cbioportal
47	ITGA10	Ssm	4	24	16.7%	cbioportal
74	SYNE3	Ssm	4	24	16.7%	cbioportal
28	AHNAK	Ssm	4	24	16.7%	cbioportal
53	MYO10	Ssm	4	24	16.7%	cbioportal
52	MUC6	Ssm	4	24	16.7%	cbioportal
75	TRIM67	Ssm	4	24	16.7%	cbioportal
66	RNF213	Ssm	4	24	16.7%	cbioportal
68	RYR1	Ssm	4	24	16.7%	cbioportal
29	ANK2	Ssm	4	24	16.7%	cbioportal
69	RYR2	Ssm	4	24	16.7%	cbioportal
70	RYR3	Ssm	4	24	16.7%	cbioportal
71	SPATA31D1	Ssm	4	24	16.7%	cbioportal
51	MCF2L2	Ssm	4	24	16.7%	cbioportal
50	LAMA3	Ssm	4	24	16.7%	cbioportal
49	KCNQ5	Ssm	4	24	16.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Proteogenomic landscape of breast cancer (CPTAC, Cell 2020) brca_cptac_2020CPTAC

122 cases with simple somatic mutation data · 122 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	51	122	41.8%	cbioportal
2	PIK3CA	Ssm	40	122	32.8%	cbioportal
3	TTN	Ssm	33	122	27%	cbioportal
4	MUC16	Ssm	15	122	12.3%	cbioportal
5	ABCA13	Ssm	13	122	10.7%	cbioportal
7	HMCN1	Ssm	13	122	10.7%	cbioportal
6	AHNAK	Ssm	13	122	10.7%	cbioportal
8	OBSCN	Ssm	13	122	10.7%	cbioportal
9	FLG	Ssm	12	122	9.8%	cbioportal
10	HERC1	Ssm	11	122	9%	cbioportal
12	RYR1	Ssm	11	122	9%	cbioportal
11	MAP3K1	Ssm	11	122	9%	cbioportal
14	MUC5B	Ssm	10	122	8.2%	cbioportal
13	KMT2C	Ssm	10	122	8.2%	cbioportal
15	XIRP2	Ssm	10	122	8.2%	cbioportal
24	PCLO	Ssm	9	122	7.4%	cbioportal
29	ZFHX4	Ssm	9	122	7.4%	cbioportal
28	TENM4	Ssm	9	122	7.4%	cbioportal
27	SPTA1	Ssm	9	122	7.4%	cbioportal
26	RYR2	Ssm	9	122	7.4%	cbioportal
16	ADGRV1	Ssm	9	122	7.4%	cbioportal
17	AHNAK2	Ssm	9	122	7.4%	cbioportal
18	BLTP1	Ssm	9	122	7.4%	cbioportal
19	CDH1	Ssm	9	122	7.4%	cbioportal
20	DNAH11	Ssm	9	122	7.4%	cbioportal
21	DNAH9	Ssm	9	122	7.4%	cbioportal
22	FSIP2	Ssm	9	122	7.4%	cbioportal
23	NEB	Ssm	9	122	7.4%	cbioportal
25	PTEN	Ssm	9	122	7.4%	cbioportal
30	ADGRB1	Ssm	8	122	6.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Race Differences in Prostate Cancer (MSK, 2021) prad_msk_stopsack_2021MSK

2,069 cases with simple somatic mutation data · 2,069 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	551	2,069	26.6%	cbioportal
2	FOXA1	Ssm	273	2,069	13.2%	cbioportal
3	SPOP	Ssm	260	2,069	12.6%	cbioportal
4	PTEN	Ssm	155	2,069	7.5%	cbioportal
5	KMT2C	Ssm	140	2,069	6.8%	cbioportal
6	APC	Ssm	138	2,069	6.7%	cbioportal
7	KMT2D	Ssm	133	2,069	6.4%	cbioportal
9	ZFHX3	Ssm	110	1,924	5.7%	cbioportal
8	CDK12	Ssm	118	2,069	5.7%	cbioportal
10	PIK3CA	Ssm	92	2,069	4.4%	cbioportal
11	ATM	Ssm	86	2,069	4.2%	cbioportal
12	AR	Ssm	80	2,069	3.9%	cbioportal
13	CTNNB1	Ssm	78	2,069	3.8%	cbioportal
14	BRCA2	Ssm	74	2,069	3.6%	cbioportal
15	SPEN	Ssm	70	2,069	3.4%	cbioportal
27	ERF	Ssm	47	1,402	3.4%	cbioportal
16	KDM6A	Ssm	69	2,069	3.3%	cbioportal
20	MGA	Ssm	61	1,924	3.2%	cbioportal
17	JAK1	Ssm	64	2,069	3.1%	cbioportal
18	RB1	Ssm	63	2,069	3%	cbioportal
19	GRIN2A	Ssm	61	2,069	2.9%	cbioportal
21	FAT1	Ssm	56	2,069	2.7%	cbioportal
22	KMT2A	Ssm	52	2,069	2.5%	cbioportal
23	MED12	Ssm	52	2,069	2.5%	cbioportal
24	ASXL1	Ssm	50	2,069	2.4%	cbioportal
25	NCOR1	Ssm	50	2,069	2.4%	cbioportal
26	PTPRD	Ssm	49	2,069	2.4%	cbioportal
44	KMT2B	Ssm	32	1,402	2.3%	cbioportal
28	ARID1A	Ssm	43	2,069	2.1%	cbioportal
29	PIK3R1	Ssm	41	2,069	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Small Cell Carcinoma of the Ovary (MSK, Nat Genet 2014) scco_mskccMSK

12 cases with simple somatic mutation data · 12 cases total · 2026-01-13 · mapped to Ovarian Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved5 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMARCA4	Ssm	11	12	91.7%	cbioportal
5	WT1	Ssm	1	12	8.3%	cbioportal
2	ASXL1	Ssm	1	12	8.3%	cbioportal
3	JAK3	Ssm	1	12	8.3%	cbioportal
4	NOTCH2	Ssm	1	12	8.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

The Metastatic Breast Cancer Project (Archived, 2020) brca_mbcproject_wagle_2017Archived

237 cases with simple somatic mutation data · 237 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	TP53	Ssm	76	237	32.1%	cbioportal
1	PIK3CA	Ssm	76	237	32.1%	cbioportal
3	TTN	Ssm	51	237	21.5%	cbioportal
4	CDH1	Ssm	34	237	14.3%	cbioportal
5	HMCN1	Ssm	24	237	10.1%	cbioportal
6	GATA3	Ssm	23	237	9.7%	cbioportal
7	MUC16	Ssm	21	237	8.9%	cbioportal
8	PTEN	Ssm	19	237	8%	cbioportal
9	KMT2C	Ssm	17	237	7.2%	cbioportal
10	CSMD3	Ssm	16	237	6.8%	cbioportal
11	DMD	Ssm	16	237	6.8%	cbioportal
13	USH2A	Ssm	15	237	6.3%	cbioportal
12	DNAH5	Ssm	15	237	6.3%	cbioportal
15	HUWE1	Ssm	14	237	5.9%	cbioportal
14	CSMD1	Ssm	14	237	5.9%	cbioportal
17	TENM2	Ssm	14	237	5.9%	cbioportal
16	STAB2	Ssm	14	237	5.9%	cbioportal
19	MUC5B	Ssm	13	237	5.5%	cbioportal
18	BLTP1	Ssm	13	237	5.5%	cbioportal
23	SPTA1	Ssm	12	237	5.1%	cbioportal
20	ARID1A	Ssm	12	237	5.1%	cbioportal
21	DST	Ssm	12	237	5.1%	cbioportal
22	FMN2	Ssm	12	237	5.1%	cbioportal
24	SYNE1	Ssm	12	237	5.1%	cbioportal
25	TBX3	Ssm	12	237	5.1%	cbioportal
30	PKD1	Ssm	11	237	4.6%	cbioportal
29	MYT1L	Ssm	11	237	4.6%	cbioportal
28	KDM6B	Ssm	11	237	4.6%	cbioportal
27	ESR1	Ssm	11	237	4.6%	cbioportal
26	CSMD2	Ssm	11	237	4.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

The Metastatic Breast Cancer Project (Provisional, December 2021) brca_mbcproject_2022Provisional

379 cases with simple somatic mutation data · 379 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	113	379	29.8%	cbioportal
2	TTN	Ssm	82	379	21.6%	cbioportal
3	PIK3CA	Ssm	76	379	20.1%	cbioportal
4	CDH1	Ssm	55	379	14.5%	cbioportal
5	IGDCC4	Ssm	50	379	13.2%	cbioportal
6	ESR1	Ssm	43	379	11.3%	cbioportal
7	MUC16	Ssm	43	379	11.3%	cbioportal
8	HMCN1	Ssm	38	379	10%	cbioportal
9	ZKSCAN1	Ssm	37	379	9.8%	cbioportal
10	GIMAP6	Ssm	36	379	9.5%	cbioportal
11	SYNE1	Ssm	32	379	8.4%	cbioportal
12	RYR2	Ssm	31	379	8.2%	cbioportal
13	GATA3	Ssm	30	379	7.9%	cbioportal
14	RYR1	Ssm	29	379	7.7%	cbioportal
15	ZNF208	Ssm	28	379	7.4%	cbioportal
18	OBSCN	Ssm	27	379	7.1%	cbioportal
17	KMT2C	Ssm	27	379	7.1%	cbioportal
16	CSMD3	Ssm	27	379	7.1%	cbioportal
19	PTEN	Ssm	24	379	6.3%	cbioportal
23	RGPD4	Ssm	23	379	6.1%	cbioportal
21	DNAH5	Ssm	23	379	6.1%	cbioportal
20	ANK2	Ssm	23	379	6.1%	cbioportal
22	LPIN1	Ssm	23	379	6.1%	cbioportal
24	SPTBN4	Ssm	23	379	6.1%	cbioportal
29	PKD1	Ssm	22	379	5.8%	cbioportal
30	ZNF195	Ssm	22	379	5.8%	cbioportal
28	LCN9	Ssm	22	379	5.8%	cbioportal
27	CHD9	Ssm	22	379	5.8%	cbioportal
26	ANO6	Ssm	22	379	5.8%	cbioportal
25	ABCA13	Ssm	22	379	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Triple Negative Breast Cancer (DLDCCC, Cancer Discov 2022) brca_dldccc_2022DLDCCC

75 cases with simple somatic mutation data · 75 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	53	75	70.7%	cbioportal
2	TTN	Ssm	19	75	25.3%	cbioportal
3	MUC16	Ssm	14	75	18.7%	cbioportal
4	DNAH8	Ssm	13	75	17.3%	cbioportal
5	OBSCN	Ssm	13	75	17.3%	cbioportal
6	FLG	Ssm	12	75	16%	cbioportal
7	TNXB	Ssm	12	75	16%	cbioportal
8	ADCY10	Ssm	11	75	14.7%	cbioportal
9	DNAH11	Ssm	11	75	14.7%	cbioportal
10	FBN3	Ssm	11	75	14.7%	cbioportal
11	LORICRIN	Ssm	11	75	14.7%	cbioportal
13	FAM83H	Ssm	10	75	13.3%	cbioportal
18	TG	Ssm	10	75	13.3%	cbioportal
17	MYO15A	Ssm	10	75	13.3%	cbioportal
16	LAMA5	Ssm	10	75	13.3%	cbioportal
15	HEATR1	Ssm	10	75	13.3%	cbioportal
14	FCGBP	Ssm	10	75	13.3%	cbioportal
12	CACNA1H	Ssm	10	75	13.3%	cbioportal
19	ABCA13	Ssm	9	75	12%	cbioportal
20	AHNAK2	Ssm	9	75	12%	cbioportal
21	COL18A1	Ssm	9	75	12%	cbioportal
22	DNAH10	Ssm	9	75	12%	cbioportal
23	DNAH3	Ssm	9	75	12%	cbioportal
24	EPPK1	Ssm	9	75	12%	cbioportal
25	F5	Ssm	9	75	12%	cbioportal
26	GPRIN2	Ssm	9	75	12%	cbioportal
27	GREB1	Ssm	9	75	12%	cbioportal
28	LAMA1	Ssm	9	75	12%	cbioportal
29	LAMC3	Ssm	9	75	12%	cbioportal
30	MKI67	Ssm	9	75	12%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Triple-Negative Breast Cancer (FUSCC, Cell Research 2020) brca_fuscc_2020FUSCC

69 cases with simple somatic mutation data · 69 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	48	69	69.6%	cbioportal
2	PIK3CA	Ssm	12	69	17.4%	cbioportal
3	PKD1	Ssm	8	69	11.6%	cbioportal
4	PTEN	Ssm	7	69	10.1%	cbioportal
5	KMT2D	Ssm	6	69	8.7%	cbioportal
6	PTPRD	Ssm	6	69	8.7%	cbioportal
7	TSC2	Ssm	6	69	8.7%	cbioportal
8	USH2A	Ssm	6	69	8.7%	cbioportal
9	ARID1B	Ssm	5	69	7.2%	cbioportal
10	CREBBP	Ssm	5	69	7.2%	cbioportal
11	EHMT2	Ssm	5	69	7.2%	cbioportal
12	FAM47C	Ssm	5	69	7.2%	cbioportal
13	KMT2C	Ssm	5	69	7.2%	cbioportal
14	PLCG1	Ssm	5	69	7.2%	cbioportal
15	AFF2	Ssm	4	69	5.8%	cbioportal
16	AKT1	Ssm	4	69	5.8%	cbioportal
17	ANKRD11	Ssm	4	69	5.8%	cbioportal
18	ARID1A	Ssm	4	69	5.8%	cbioportal
19	CDH1	Ssm	4	69	5.8%	cbioportal
20	COL2A1	Ssm	4	69	5.8%	cbioportal
21	ERBB2	Ssm	4	69	5.8%	cbioportal
22	ERBB3	Ssm	4	69	5.8%	cbioportal
23	ERCC4	Ssm	4	69	5.8%	cbioportal
24	FASN	Ssm	4	69	5.8%	cbioportal
25	FGFR2	Ssm	4	69	5.8%	cbioportal
26	INSR	Ssm	4	69	5.8%	cbioportal
27	ITGB4	Ssm	4	69	5.8%	cbioportal
28	KCNB2	Ssm	4	69	5.8%	cbioportal
29	MAP3K1	Ssm	4	69	5.8%	cbioportal
30	PIK3R1	Ssm	4	69	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05