Gene
ALOX5
arachidonate 5-lipoxygenase
Explore in graph →CI-GENE-00000958HGNC:435 ENSG00000012779 NCBI 240 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (8)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 25765070
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Non-Small Cell Lung Cancer (MSK, Science 2015) nsclc_mskcc_2015 | Lung Non-Small Cell Carcinoma | Ssm | 2 | 16 | 12.5% | 142 | cbioportal |
| Adrenocortical Carcinoma (TCGA GDC, 2025) acc_tcga_gdc | Adrenal Cortical Carcinoma | Ssm | 3 | 90 | 3.3% | 78 | cbioportal |
| Adrenocortical Carcinoma (TCGA, PanCancer Atlas) acc_tcga_pan_can_atlas_2018 | Adrenal Cortical Carcinoma | Ssm | 3 | 91 | 3.3% | 124 | cbioportal |
| Prostate Adenocarcinoma (SMMU, Eur Urol 2017) prad_eururol_2017 | Prostate Adenocarcinoma | Ssm | 2 | 65 | 3.1% | 13 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.