Gene
ADAM2
ADAM metallopeptidase domain 2
Explore in graph →CI-GENE-00000403HGNC:198 ENSG00000104755 NCBI 2515 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (12)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 26359337
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Metastatic Melanoma (DFCI, Science 2015) skcm_dfci_2015 | Cutaneous Melanoma | Ssm | 14 | 110 | 12.7% | 195 | cbioportal |
| Normal Fibroblasts (UCSF, BioRxiv 2024) normal_skin_fibroblast_2024 | unmapped | Ssm | 1 | 18 | 5.6% | 181 | cbioportal |
| Adenoid Cystic Carcinoma (JHU, Cancer Prev Res 2016) acyc_jhu_2016 | Adenoid Cystic Carcinoma | Ssm | 1 | 25 | 4% | 19 | cbioportal |
| Mantle Cell Lymphoma (IDIBIPS, PNAS 2013) mcl_idibips_2013 | Mantle Cell Lymphoma | Ssm | 1 | 29 | 3.4% | 37 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.