Gene

DUSP6

dual specificity phosphatase 6

Explore in graph →CI-GENE-00043966HGNC:3072 ENSG00000139318 NCBI 1848 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
DUSP6 EXPRESSION1
Trametinib	Malignant NeoplasmALIAS	Predictive	D	Supports Sensitivity Response	3	accepted	EID934 Expression of DUSP6 was associated with sensitivity to MEK inhibitor GSK1120212 (Sensitivity: 79%; specificity: 82%: P = 0.0027) in 218 solid cancer cell lines. PMID 22169769 · Jing et al., 2012 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Metaplastic Breast Cancer (MSK,NPJ Breast Cancer 2021) mbc_msk_2021	Breast Metaplastic Carcinoma	Ssm	1

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Comprehensive predictive biomarker analysis for MEK inhibitor GSK1120212.
· Mol Cancer Ther · 2012 · PMID 22169769 · validated civic_curation pubmed