MYB — gene · CancerIndex

Curated evidence

Clinical evidence (7)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–7 of 7 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MYB AMPLIFICATION1
(prognostic)	Childhood Low Grade Glioma	Prognostic	B	Supports Better Outcome	4	accepted	EID7194 MYB amplification was detected in 28 of 263 patients with PLGGs using Fluorescence In situ hybridization (FISH) analysis. The amplification of MYB was strongly associated with greater progression-free… (full text at CIViC) PMID 29948154 · Yang et al., 2018 · Open in CIViC	civic
MYB Rearrangement5
(diagnostic)	Diffuse AstrocytomaALIAS	Diagnostic	B	Supports Positive	3	accepted	EID11777 Comprehensive molecular studies (through whole genome, whole exome, transcriptome sequencing, genome-wide copy number analysis, clustering analysis by DNA methylation profiling, mutation hotspot analy…

Cohorts

Alteration frequency by cohort (12)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved12 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Adenoid Cystic Carcinoma of the Breast (MSK, J Pathol. 2015) acbc_mskcc_2015	Breast Adenoid Cystic Carcinoma	Ssm	2

Literature

Linked publications (6)

25 per page, newest first.

pubmedPublishedShowing 1–6 of 6 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Pediatric low-grade gliomas can be molecularly stratified for risk.
· Acta Neuropathol · 2018 · PMID 29948154 · validated civic_curation pubmed
A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.
· Acta Neuropathol · 2019 · PMID 31595312 · validated civic_curation pubmed
Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.
· Acta Neuropathol · 2020 · PMID 31563982 · validated civic_curation pubmed
Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.
· Proc Natl Acad Sci U S A · 2013 · PMID 23633565 · validated