AFF2

ALF transcription elongation factor 2

Explore in graph →CI-GENE-00000636HGNC:3776 ENSG00000155966 NCBI 2334 Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
AFF2 Fusion1
Pembrolizumab	Head and Neck Squamous Cell Carcinoma	Predictive	C	Supports Sensitivity Response	2	submitted	EID7304 The primary tumor of A patient with head and neck squamous cell carcinoma with lung metastasis was not surgically resectable. Initial treatments led to stable disease and progression after 1 year. The… (full text at CIViC) PMID 31011208 · Yang et al., 2019 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (55)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved55 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Uterine Carcinosarcoma (Johns Hopkins, Nat Commun 2014) ucs_jhu_2014	Uterine Malignant Mixed Mesodermal (Mullerian) Tumor

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.