Gene
DPYD
dihydropyrimidine dehydrogenase
Explore in graph →CI-GENE-00043841HGNC:3012 ENSG00000188641 NCBI 1806 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (4)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23988873
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DPYD DPYD*13 HOMOZYGOSITY1 | ||||||||
| Capecitabine + Fluorouracil + TegafurSubstitutes | Malignant NeoplasmALIAS | Predictive | A | Supports Adverse Response | 5 | accepted | EID1801The Clinical Pharmacogenomics Implementation Consortium Guidelines for DPYD genotype and 5-FU dosing does not recommend the use of 5-FU or capecitabine in patients with homozygous DPYD*2A, *13 or rs67… (full text at CIViC) PMID 23988873 · Caudle et al., 2013 · Open in CIViC | civic |
| DPYD DPYD*2A HOMOZYGOSITY1 | ||||||||
| Capecitabine + Fluorouracil + TegafurSubstitutes | Malignant NeoplasmALIAS | Predictive | ||||||
Cohorts
Alteration frequency by cohort (28)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 33863915
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Metaplastic Breast Cancer (MSK,NPJ Breast Cancer 2021) mbc_msk_2021 | Breast Metaplastic Carcinoma | Ssm | 2 |
Literature
Linked publications (2)
25 per page, newest first.
pubmedProvenance
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)