Gene
MDM4
MDM4 regulator of p53
Explore in graph →CI-GENE-00012271HGNC:6974 ENSG00000198625 NCBI 4194 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (2)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28351930
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MDM4 Amplification1 | ||||||||
| Atezolizumab + Nivolumab + PembrolizumabSubstitutes | Malignant NeoplasmALIAS | Predictive | B | Supports Adverse Response | 3 | submitted | EID2925A subset of patients receiving PD1/PD-L1 inhibition appear to be "hyper-progressors," with a greatly accelerated rate of tumor growth and clinical deterioration compared to pre-therapy. The current st… (full text at CIViC) PMID 28351930 · Kato et al., 2017 · Open in CIViC | civic |
| MDM4 EXPRESSION1 | ||||||||
| Atezolizumab + Nivolumab + PembrolizumabSubstitutes | Malignant NeoplasmALIAS | Predictive | ||||||
Cohorts
Alteration frequency by cohort (26)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
gdcProvenance
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Breast Invasive Carcinoma TCGA-BRCA | Breast Invasive Carcinoma, NOS | Ssm |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.