Gene

CDK9

cyclin dependent kinase 9

Explore in graph →CI-GENE-00040753HGNC:1780 ENSG00000136807 NCBI 1025 CIViC Approved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CDK9 Overexpression3
Alvocidib + CAN508Combination	Malignant Esophageal Neoplasm	Predictive	D	Supports Sensitivity Response	4	submitted	EID9311 Cyclin-dependent kinase 9 (CDK9) was predominantly overexpressed in esophageal carcinoma tumor samples compared to normal esophageal cell lines. This high expression was also found in 90% of invasive … (full text at CIViC) PMID 28404924 · Tong et al., 2017 · Open in CIViC	civic
Dinaciclib	Neuroblastoma	Predictive	D	Supports Sensitivity Response	3	submitted	EID7012 As shown in Fig. 3a, all six NB cells showed relatively high expression levels of RNAP II, CDK2, and CDK9, suggesting that CDK2 and CDK9 may be ideal targets in NB therapy...Therefore, we hypothesize … (full text at CIViC) PMID 27378523 ·

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Breast Cancer (HTAN, 2022) brca_hta9_htan_2022	Invasive Breast Carcinoma	Ssm	5	5	100%	4

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.