Gene
ACTN4
actinin alpha 4
Explore in graph →CI-GENE-00000348HGNC:166 ENSG00000130402 NCBI 81 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (8)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 33863915
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Metaplastic Breast Cancer (MSK,NPJ Breast Cancer 2021) mbc_msk_2021 | Breast Metaplastic Carcinoma | Ssm | 1 | 5 | 20% | 21 | cbioportal |
| Esophagogastric Cancer (MSK, Clin Cancer Res 2023) egc_trap_ccr_msk_2023 | Gastroesophageal Junction Adenocarcinoma | Ssm | 5 | 64 | 7.8% | 102 | cbioportal |
| Esophageal Cancer-TRAP Project (MSK, Lancet Oncol 2020) egc_trap_msk_2020 | Gastroesophageal Junction Adenocarcinoma | Ssm | 2 | 31 | 6.5% | 142 | cbioportal |
| Rhabdoid Cancer (BCGSC, Cancer Cell 2016) mrt_bcgsc_2016 | Rhabdoid Tumor | Ssm | 1 | 40 | 2.5% | 8 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.