MYH11 — gene · CancerIndex

Curated evidence

Clinical evidence (7)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–7 of 7 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MYH11 Fusion6
(prognostic)	Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11ALIAS	Prognostic	B	Supports Better Outcome	5	submitted	EID11788 This study evaluated the independent prognostic significance of pretreatment cytogenetics based on the large Medical Research Council (MRC) AML 10 trial which enrolled a total of 1,966 patients (364 c… (full text at CIViC) PMID 9746770 · Grimwade et al., 1998 · Open in CIViC	civic
(diagnostic)	Acute Myeloid Leukemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11ALIAS	Diagnostic	B	Supports Positive	5	accepted	EID11791 This is a Cancer and Leukemia Group B study on core binding factor (CBF) AML (2005): AML with RUNX1::RUNX1T1 (303 adult patients who received treatment) vs AML with CBFB::MYH11 (164 patients who recei…

Cohorts

Alteration frequency by cohort (34)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved34 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Pre-cancer Colorectal Polyps (HTAN Vanderbilt, Cell 2021) crc_hta11_htan_2021	Colorectal Adenocarcinoma	Ssm	11

Literature

Linked publications (4)

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study.
· J Clin Oncol · 2005 · PMID 16110030 · validated civic_curation pubmed
Individual patient data-based meta-analysis of patients aged 16 to 60 years with core binding factor acute myeloid leukemia: a survey of the German Acute Myeloid Leukemia Intergroup.
· J Clin Oncol · 2004 · PMID 15289486 · validated civic_curation pubmed
Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management.
· Am J Hematol · 2012 · PMID 22180162 · validated civic_curation pubmed
Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association.