Digestive System Carcinoma — Genomics

Digestive System Carcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

94 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Acinar Cell Carcinoma of the Pancreas (JHU, J Pathol 2014) paac_jhu_2014JHU

23 cases with simple somatic mutation data · 23 cases total · 2026-01-12 · mapped to Pancreatic Acinar Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMAD4

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Ampullary Carcinoma (Baylor College of Medicine, Cell Reports 2016) ampca_bcm_2016Baylor College of Medicine

160 cases with simple somatic mutation data · 160 cases total · 2026-01-05 · mapped to Ampulla of Vater Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	99	160	61.9%	cbioportal
2	KRAS	Ssm	86	160	53.8%	cbioportal
3	APC	Ssm	36	160	22.5%	cbioportal
4	TTN	Ssm	33	160	20.6%	cbioportal
5	SMAD4	Ssm	29	160	18.1%	cbioportal
6	PIK3CA	Ssm	21	160	13.1%	cbioportal
7	SYNE1	Ssm	21	160	13.1%	cbioportal
8	ARID1A	Ssm	17	160	10.6%	cbioportal
10	ATM	Ssm	17	160	10.6%	cbioportal
9	ARID2	Ssm	17	160	10.6%	cbioportal
13	LRP1B	Ssm	16	160	10%	cbioportal
12	KMT2C	Ssm	16	160	10%	cbioportal
11	CDKN2A	Ssm	16	160	10%	cbioportal
15	TGFBR2	Ssm	16	160	10%	cbioportal
14	NF1	Ssm	16	160	10%	cbioportal
17	MUC16	Ssm	15	160	9.4%	cbioportal
18	ZFHX4	Ssm	15	160	9.4%	cbioportal
16	ERBB3	Ssm	15	160	9.4%	cbioportal
20	DMD	Ssm	14	160	8.8%	cbioportal
19	CTNNB1	Ssm	14	160	8.8%	cbioportal
21	ELF3	Ssm	14	160	8.8%	cbioportal
22	FAT3	Ssm	14	160	8.8%	cbioportal
23	MUC2	Ssm	14	160	8.8%	cbioportal
24	DNAH5	Ssm	13	160	8.1%	cbioportal
25	RNF43	Ssm	13	160	8.1%	cbioportal
26	ACVR2A	Ssm	12	160	7.5%	cbioportal
27	CSMD2	Ssm	12	160	7.5%	cbioportal
28	ERICH6B	Ssm	12	160	7.5%	cbioportal
29	KMT2D	Ssm	12	160	7.5%	cbioportal
30	MUC4	Ssm	12	160	7.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Appendiceal Cancer (MSK, J Clin Oncol 2022) appendiceal_msk_2022MSK

273 cases with simple somatic mutation data · 273 cases total · 2026-01-05 · mapped to Appendix Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	161	273	59%	cbioportal
2	GNAS	Ssm	91	273	33.3%	cbioportal
3	TP53	Ssm	86	273	31.5%	cbioportal
4	SMAD4	Ssm	35	273	12.8%	cbioportal
5	PIK3CA	Ssm	26	273	9.5%	cbioportal
6	SOX9	Ssm	21	273	7.7%	cbioportal
7	SMAD2	Ssm	18	273	6.6%	cbioportal
8	ATM	Ssm	17	273	6.2%	cbioportal
9	APC	Ssm	15	273	5.5%	cbioportal
10	TGFBR2	Ssm	14	273	5.1%	cbioportal
11	RNF43	Ssm	13	273	4.8%	cbioportal
17	INPPL1	Ssm	8	177	4.5%	cbioportal
13	FBXW7	Ssm	12	273	4.4%	cbioportal
12	ARID1A	Ssm	12	273	4.4%	cbioportal
15	KMT2D	Ssm	10	273	3.7%	cbioportal
14	CDH1	Ssm	10	273	3.7%	cbioportal
18	MGA	Ssm	8	264	3%	cbioportal
19	NCOR1	Ssm	8	273	2.9%	cbioportal
20	SMAD3	Ssm	8	273	2.9%	cbioportal
16	FAT1	Ssm	8	273	2.9%	cbioportal
23	PLCG2	Ssm	7	264	2.7%	cbioportal
21	AKT1	Ssm	7	273	2.6%	cbioportal
22	CARD11	Ssm	7	273	2.6%	cbioportal
24	PTPRT	Ssm	7	273	2.6%	cbioportal
50	KMT2B	Ssm	4	177	2.3%	cbioportal
29	NOTCH1	Ssm	6	273	2.2%	cbioportal
27	KDM6A	Ssm	6	273	2.2%	cbioportal
25	ARID2	Ssm	6	273	2.2%	cbioportal
28	KDR	Ssm	6	273	2.2%	cbioportal
30	NRAS	Ssm	6	273	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Biliary Tract Tumors (MSK, 2026) biliary_tract_adc_targets_msk_2026MSK

33 cases with simple somatic mutation data · 33 cases total · 2026-08-24 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	11	33	33.3%	cbioportal
2	ELF3	Ssm	8	33	24.2%	cbioportal
3	SMAD4	Ssm	7	33	21.2%	cbioportal
5	BAP1	Ssm	5	33	15.2%	cbioportal
4	ARID1A	Ssm	5	33	15.2%	cbioportal
6	CDKN2A	Ssm	5	33	15.2%	cbioportal
7	FGFR2	Ssm	4	33	12.1%	cbioportal
9	KMT2C	Ssm	3	33	9.1%	cbioportal
11	SF3B1	Ssm	3	33	9.1%	cbioportal
10	KRAS	Ssm	3	33	9.1%	cbioportal
8	BRAF	Ssm	3	33	9.1%	cbioportal
12	TCF7L2	Ssm	3	33	9.1%	cbioportal
18	EZH1	Ssm	2	33	6.1%	cbioportal
19	FAT1	Ssm	2	33	6.1%	cbioportal
20	IDH2	Ssm	2	33	6.1%	cbioportal
21	KMT2A	Ssm	2	33	6.1%	cbioportal
13	APC	Ssm	2	33	6.1%	cbioportal
30	TET1	Ssm	2	33	6.1%	cbioportal
31	TSC1	Ssm	2	33	6.1%	cbioportal
22	KMT2D	Ssm	2	33	6.1%	cbioportal
23	MAP3K13	Ssm	2	33	6.1%	cbioportal
24	NTRK1	Ssm	2	33	6.1%	cbioportal
25	PIK3CA	Ssm	2	33	6.1%	cbioportal
14	ATM	Ssm	2	33	6.1%	cbioportal
15	CDK12	Ssm	2	33	6.1%	cbioportal
16	ERBB3	Ssm	2	33	6.1%	cbioportal
17	ERBB4	Ssm	2	33	6.1%	cbioportal
27	PIK3CG	Ssm	2	33	6.1%	cbioportal
28	RRAS2	Ssm	2	33	6.1%	cbioportal
29	RTEL1	Ssm	2	33	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-08-24

Cholangiocarcinoma TCGA-CHOLTCGA

51 cases with simple somatic mutation data · 51 cases total · Data Release 46.0 · mapped to Cholangiocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ARID1A	Ssm	43	51	84.3%	gdc
4	KLHDC7A	Ssm	42	51	82.4%	gdc
2	TAS1R2	Ssm	42	51	82.4%	gdc
3	MRTO4	Ssm	42	51	82.4%	gdc
6	HTR6	Ssm	42	51	82.4%	gdc
5	TMCO4	Ssm	42	51	82.4%	gdc
19	DNAJC11	Ssm	41	51	80.4%	gdc
36	HNRNPCL4	Ssm	41	51	80.4%	gdc
35	PRAMEF20	Ssm	41	51	80.4%	gdc
34	CAPZB	Ssm	41	51	80.4%	gdc
33	MFAP2	Ssm	41	51	80.4%	gdc
32	RNF186	Ssm	41	51	80.4%	gdc
31	ZNF436	Ssm	41	51	80.4%	gdc
30	RPL11	Ssm	41	51	80.4%	gdc
29	THAP3	Ssm	41	51	80.4%	gdc
28	PRAMEF27	Ssm	41	51	80.4%	gdc
27	PADI4	Ssm	41	51	80.4%	gdc
26	PRAMEF12	Ssm	41	51	80.4%	gdc
25	ACTL8	Ssm	41	51	80.4%	gdc
24	CAMK2N1	Ssm	41	51	80.4%	gdc
23	TEX46	Ssm	41	51	80.4%	gdc
22	EIF4G3	Ssm	41	51	80.4%	gdc
21	VWA5B1	Ssm	41	51	80.4%	gdc
20	LACTBL1	Ssm	41	51	80.4%	gdc
18	PITHD1	Ssm	41	51	80.4%	gdc
17	HTR1D	Ssm	41	51	80.4%	gdc
16	AADACL4	Ssm	41	51	80.4%	gdc
15	NBL1	Ssm	41	51	80.4%	gdc
14	OTUD3	Ssm	41	51	80.4%	gdc
13	PADI6	Ssm	41	51	80.4%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Cholangiocarcinoma (ICGC, Cancer Discov 2017) chol_icgc_2017ICGC

417 cases with simple somatic mutation data · 489 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	147	417	35.3%	cbioportal
2	ARID1A	Ssm	80	417	19.2%	cbioportal
3	KRAS	Ssm	76	417	18.2%	cbioportal
4	SMAD4	Ssm	60	417	14.4%	cbioportal
5	SYNE1	Ssm	46	417	11%	cbioportal
6	MUC16	Ssm	44	417	10.6%	cbioportal
8	LRP1B	Ssm	39	417	9.4%	cbioportal
7	BAP1	Ssm	39	417	9.4%	cbioportal
9	FSIP2	Ssm	37	417	8.9%	cbioportal
10	EPHA2	Ssm	36	417	8.6%	cbioportal
11	PCLO	Ssm	36	417	8.6%	cbioportal
12	CSMD3	Ssm	34	417	8.2%	cbioportal
13	SACS	Ssm	34	417	8.2%	cbioportal
14	APC	Ssm	33	417	7.9%	cbioportal
15	RYR2	Ssm	32	417	7.7%	cbioportal
16	OBSCN	Ssm	31	417	7.4%	cbioportal
18	KMT2D	Ssm	30	417	7.2%	cbioportal
17	HMCN1	Ssm	30	417	7.2%	cbioportal
19	ELF3	Ssm	29	417	7%	cbioportal
20	KMT2C	Ssm	29	417	7%	cbioportal
21	PBRM1	Ssm	29	417	7%	cbioportal
22	LRP2	Ssm	28	417	6.7%	cbioportal
23	MUC6	Ssm	28	417	6.7%	cbioportal
24	FAT3	Ssm	27	417	6.5%	cbioportal
25	ARID2	Ssm	25	417	6%	cbioportal
29	PLEC	Ssm	24	417	5.8%	cbioportal
28	NEB	Ssm	24	417	5.8%	cbioportal
26	ADGRV1	Ssm	24	417	5.8%	cbioportal
27	CSMD1	Ssm	24	417	5.8%	cbioportal
30	SPTA1	Ssm	24	417	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Cholangiocarcinoma (MSK, Clin Cancer Res 2018) chol_msk_2018MSK

195 cases with simple somatic mutation data · 195 cases total · 2026-04-07 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	48	195	24.6%	cbioportal
2	TP53	Ssm	46	195	23.6%	cbioportal
3	ARID1A	Ssm	40	195	20.5%	cbioportal
4	BAP1	Ssm	26	195	13.3%	cbioportal
5	KRAS	Ssm	23	195	11.8%	cbioportal
6	PBRM1	Ssm	20	195	10.3%	cbioportal
7	SMAD4	Ssm	16	195	8.2%	cbioportal
8	ATM	Ssm	15	195	7.7%	cbioportal
9	KMT2C	Ssm	13	195	6.7%	cbioportal
10	PIK3CA	Ssm	13	195	6.7%	cbioportal
11	RASA1	Ssm	10	195	5.1%	cbioportal
14	NF1	Ssm	9	195	4.6%	cbioportal
12	BRAF	Ssm	9	195	4.6%	cbioportal
13	KMT2D	Ssm	9	195	4.6%	cbioportal
15	TERT	Ssm	8	195	4.1%	cbioportal
17	NRAS	Ssm	7	195	3.6%	cbioportal
16	ERBB3	Ssm	7	195	3.6%	cbioportal
18	SMARCA4	Ssm	6	195	3.1%	cbioportal
19	ABL1	Ssm	5	195	2.6%	cbioportal
21	ARID2	Ssm	5	195	2.6%	cbioportal
20	ARID1B	Ssm	5	195	2.6%	cbioportal
22	ASXL1	Ssm	5	195	2.6%	cbioportal
23	CTNNB1	Ssm	5	195	2.6%	cbioportal
24	DOT1L	Ssm	5	195	2.6%	cbioportal
25	KMT2A	Ssm	5	195	2.6%	cbioportal
26	PTPRS	Ssm	5	195	2.6%	cbioportal
27	SF3B1	Ssm	5	195	2.6%	cbioportal
28	STK11	Ssm	5	195	2.6%	cbioportal
48	CSF3R	Ssm	3	141	2.1%	cbioportal
43	ANKRD11	Ssm	3	141	2.1%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Cholangiocarcinoma (National Cancer Centre of Singapore, Nat Genet 2013) chol_nccs_2013National Cancer Centre of Singapore

15 cases with simple somatic mutation data · 15 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	BAP1	Ssm	4	15	26.7%	cbioportal
1	ARID1A	Ssm	4	15	26.7%	cbioportal
4	KRAS	Ssm	3	15	20%	cbioportal
3	IDH1	Ssm	3	15	20%	cbioportal
5	TP53	Ssm	3	15	20%	cbioportal
9	CCT8L2	Ssm	2	15	13.3%	cbioportal
12	LRRIQ1	Ssm	2	15	13.3%	cbioportal
11	HMCN1	Ssm	2	15	13.3%	cbioportal
6	ADGRG4	Ssm	2	15	13.3%	cbioportal
7	ATP10A	Ssm	2	15	13.3%	cbioportal
8	BRPF3	Ssm	2	15	13.3%	cbioportal
10	GPAT4	Ssm	2	15	13.3%	cbioportal
91	GFRA1	Ssm	1	15	6.7%	cbioportal
89	GCDH	Ssm	1	15	6.7%	cbioportal
90	GDPD5	Ssm	1	15	6.7%	cbioportal
97	GPBP1L1	Ssm	1	15	6.7%	cbioportal
92	GIT2	Ssm	1	15	6.7%	cbioportal
93	GLI3	Ssm	1	15	6.7%	cbioportal
94	GLRB	Ssm	1	15	6.7%	cbioportal
95	GLYATL2	Ssm	1	15	6.7%	cbioportal
96	GNPAT	Ssm	1	15	6.7%	cbioportal
102	HMGCR	Ssm	1	15	6.7%	cbioportal
101	HIF3A	Ssm	1	15	6.7%	cbioportal
100	HECTD3	Ssm	1	15	6.7%	cbioportal
99	GRIN2A	Ssm	1	15	6.7%	cbioportal
98	GRID2	Ssm	1	15	6.7%	cbioportal
85	FRMD4A	Ssm	1	15	6.7%	cbioportal
86	FSCN3	Ssm	1	15	6.7%	cbioportal
87	FZD2	Ssm	1	15	6.7%	cbioportal
88	GAPDH	Ssm	1	15	6.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Cholangiocarcinoma (National University of Singapore, Nat Genet 2012) chol_nus_2012National University of Singapore

8 cases with simple somatic mutation data · 8 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMAD4	Ssm	4	8	50%	cbioportal
2	TP53	Ssm	4	8	50%	cbioportal
4	RNF43	Ssm	3	8	37.5%	cbioportal
3	KRAS	Ssm	3	8	37.5%	cbioportal
13	XIRP2	Ssm	2	8	25%	cbioportal
5	GNAS	Ssm	2	8	25%	cbioportal
12	ROBO2	Ssm	2	8	25%	cbioportal
11	RADIL	Ssm	2	8	25%	cbioportal
10	PEG3	Ssm	2	8	25%	cbioportal
7	LAMA2	Ssm	2	8	25%	cbioportal
8	NDC80	Ssm	2	8	25%	cbioportal
9	PCDHA13	Ssm	2	8	25%	cbioportal
6	KMT2C	Ssm	2	8	25%	cbioportal
29	CCDC183	Ssm	1	8	12.5%	cbioportal
107	NPY5R	Ssm	1	8	12.5%	cbioportal
14	ADAM12	Ssm	1	8	12.5%	cbioportal
15	AFF1	Ssm	1	8	12.5%	cbioportal
16	AGO1	Ssm	1	8	12.5%	cbioportal
17	ALPP	Ssm	1	8	12.5%	cbioportal
18	ANK2	Ssm	1	8	12.5%	cbioportal
19	ANKRD35	Ssm	1	8	12.5%	cbioportal
20	ANO4	Ssm	1	8	12.5%	cbioportal
21	ARAF	Ssm	1	8	12.5%	cbioportal
22	ARID1A	Ssm	1	8	12.5%	cbioportal
23	ARL6IP5	Ssm	1	8	12.5%	cbioportal
24	ASAP3	Ssm	1	8	12.5%	cbioportal
25	BBS4	Ssm	1	8	12.5%	cbioportal
26	BCAS2	Ssm	1	8	12.5%	cbioportal
27	CALML5	Ssm	1	8	12.5%	cbioportal
28	CALN1	Ssm	1	8	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Cholangiocarcinoma (TCGA, Firehose Legacy) chol_tcgaTCGA

35 cases with simple somatic mutation data · 51 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	14	35	40%	cbioportal
2	TTN	Ssm	10	35	28.6%	cbioportal
4	PBRM1	Ssm	8	35	22.9%	cbioportal
3	BAP1	Ssm	8	35	22.9%	cbioportal
6	CDC27	Ssm	7	35	20%	cbioportal
5	ANKRD36C	Ssm	7	35	20%	cbioportal
7	KMT2C	Ssm	7	35	20%	cbioportal
8	MUC2	Ssm	7	35	20%	cbioportal
11	TCHH	Ssm	6	35	17.1%	cbioportal
10	MUC5B	Ssm	6	35	17.1%	cbioportal
9	DNAH5	Ssm	6	35	17.1%	cbioportal
24	TP53	Ssm	5	35	14.3%	cbioportal
23	RYR3	Ssm	5	35	14.3%	cbioportal
12	ABCA13	Ssm	5	35	14.3%	cbioportal
14	AHNAK	Ssm	5	35	14.3%	cbioportal
15	ARID1A	Ssm	5	35	14.3%	cbioportal
16	ATM	Ssm	5	35	14.3%	cbioportal
17	BIRC6	Ssm	5	35	14.3%	cbioportal
18	BLTP1	Ssm	5	35	14.3%	cbioportal
19	HLA-B	Ssm	5	35	14.3%	cbioportal
20	MUC16	Ssm	5	35	14.3%	cbioportal
21	PLXNA4	Ssm	5	35	14.3%	cbioportal
22	POLE	Ssm	5	35	14.3%	cbioportal
13	ADGRV1	Ssm	5	35	14.3%	cbioportal
25	AHNAK2	Ssm	4	35	11.4%	cbioportal
26	ANKRD17	Ssm	4	35	11.4%	cbioportal
27	APC	Ssm	4	35	11.4%	cbioportal
28	ARID1B	Ssm	4	35	11.4%	cbioportal
29	CLIP4	Ssm	4	35	11.4%	cbioportal
30	COL6A3	Ssm	4	35	11.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Cholangiocarcinoma (TCGA GDC, 2025) chol_tcga_gdcTCGA GDC

51 cases with simple somatic mutation data · 51 cases total · 2026-01-13 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PBRM1	Ssm	10	51	19.6%	cbioportal
2	ARID1A	Ssm	9	51	17.6%	cbioportal
3	BAP1	Ssm	8	51	15.7%	cbioportal
5	IDH1	Ssm	7	51	13.7%	cbioportal
4	EPHA2	Ssm	7	51	13.7%	cbioportal
9	TP53	Ssm	5	51	9.8%	cbioportal
8	MUC16	Ssm	5	51	9.8%	cbioportal
7	LRP1B	Ssm	5	51	9.8%	cbioportal
6	KRAS	Ssm	5	51	9.8%	cbioportal
12	DNAH5	Ssm	4	51	7.8%	cbioportal
10	CHD7	Ssm	4	51	7.8%	cbioportal
11	CSMD3	Ssm	4	51	7.8%	cbioportal
13	DNAH8	Ssm	4	51	7.8%	cbioportal
14	ELF3	Ssm	4	51	7.8%	cbioportal
15	FGFR2	Ssm	4	51	7.8%	cbioportal
16	KMT2C	Ssm	4	51	7.8%	cbioportal
17	MUC5B	Ssm	4	51	7.8%	cbioportal
18	NEB	Ssm	4	51	7.8%	cbioportal
19	PCLO	Ssm	4	51	7.8%	cbioportal
20	PIK3CA	Ssm	4	51	7.8%	cbioportal
21	TENM1	Ssm	4	51	7.8%	cbioportal
30	DCAF4L2	Ssm	3	51	5.9%	cbioportal
22	ADAM30	Ssm	3	51	5.9%	cbioportal
23	AHNAK	Ssm	3	51	5.9%	cbioportal
24	ALB	Ssm	3	51	5.9%	cbioportal
25	ANK2	Ssm	3	51	5.9%	cbioportal
26	APOB	Ssm	3	51	5.9%	cbioportal
27	BIRC6	Ssm	3	51	5.9%	cbioportal
28	C3	Ssm	3	51	5.9%	cbioportal
29	CTNNA2	Ssm	3	51	5.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Cholangiocarcinoma (TCGA, PanCancer Atlas) chol_tcga_pan_can_atlas_2018TCGA

36 cases with simple somatic mutation data · 36 cases total · 2026-06-05 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	PBRM1	Ssm	7	36	19.4%	cbioportal
1	BAP1	Ssm	7	36	19.4%	cbioportal
3	IDH1	Ssm	5	36	13.9%	cbioportal
9	TTN	Ssm	4	36	11.1%	cbioportal
4	ARID1A	Ssm	4	36	11.1%	cbioportal
5	DNAH5	Ssm	4	36	11.1%	cbioportal
6	EPHA2	Ssm	4	36	11.1%	cbioportal
7	KMT2C	Ssm	4	36	11.1%	cbioportal
8	TP53	Ssm	4	36	11.1%	cbioportal
20	CSMD2	Ssm	3	36	8.3%	cbioportal
15	ARID1B	Ssm	3	36	8.3%	cbioportal
16	BCOR	Ssm	3	36	8.3%	cbioportal
17	BIRC6	Ssm	3	36	8.3%	cbioportal
18	CHD7	Ssm	3	36	8.3%	cbioportal
19	COL6A3	Ssm	3	36	8.3%	cbioportal
21	FMN2	Ssm	3	36	8.3%	cbioportal
23	MACF1	Ssm	3	36	8.3%	cbioportal
22	LRP1	Ssm	3	36	8.3%	cbioportal
24	MPDZ	Ssm	3	36	8.3%	cbioportal
25	MUC16	Ssm	3	36	8.3%	cbioportal
26	MUC5B	Ssm	3	36	8.3%	cbioportal
27	PLXNA4	Ssm	3	36	8.3%	cbioportal
28	RYR1	Ssm	3	36	8.3%	cbioportal
10	ADAM30	Ssm	3	36	8.3%	cbioportal
11	ADGRV1	Ssm	3	36	8.3%	cbioportal
12	AHNAK	Ssm	3	36	8.3%	cbioportal
13	ALB	Ssm	3	36	8.3%	cbioportal
14	APOB	Ssm	3	36	8.3%	cbioportal
30	AFDN	Ssm	2	36	5.6%	cbioportal
29	ABCA13	Ssm	2	36	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Colon Adenocarcinoma TCGA-COADTCGA

461 cases with simple somatic mutation data · 461 cases total · Data Release 46.0 · mapped to Colon Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	PTPRT	Ssm	348	461	75.5%	gdc
1	ZNF831	Ssm	348	461	75.5%	gdc
3	DIDO1	Ssm	345	461	74.8%	gdc
4	KCNB1	Ssm	343	461	74.4%	gdc
5	APC	Ssm	341	461	74%	gdc
6	LAMA5	Ssm	340	461	73.8%	gdc
7	CHD6	Ssm	339	461	73.5%	gdc
8	ZMYND8	Ssm	338	461	73.3%	gdc
9	SLC12A5	Ssm	338	461	73.3%	gdc
10	TSHZ2	Ssm	338	461	73.3%	gdc
12	CDH4	Ssm	337	461	73.1%	gdc
11	RALGAPB	Ssm	337	461	73.1%	gdc
14	ARFGEF2	Ssm	336	461	72.9%	gdc
13	NCOA6	Ssm	336	461	72.9%	gdc
15	ZNFX1	Ssm	335	461	72.7%	gdc
16	ASXL1	Ssm	334	461	72.5%	gdc
18	SYCP2	Ssm	334	461	72.5%	gdc
17	KCNQ2	Ssm	334	461	72.5%	gdc
21	DDX27	Ssm	334	461	72.5%	gdc
20	ZNF335	Ssm	334	461	72.5%	gdc
19	CEP250	Ssm	334	461	72.5%	gdc
22	KIAA1755	Ssm	333	461	72.2%	gdc
26	GNAS	Ssm	332	461	72%	gdc
23	HELZ2	Ssm	332	461	72%	gdc
24	SALL4	Ssm	332	461	72%	gdc
25	PREX1	Ssm	332	461	72%	gdc
28	ATP9A	Ssm	331	461	71.8%	gdc
27	MYH7B	Ssm	331	461	71.8%	gdc
30	TGM2	Ssm	331	461	71.8%	gdc
29	PLCG1	Ssm	331	461	71.8%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Colon Adenocarcinoma (CaseCCC, PNAS 2015) coad_caseccc_2015CaseCCC

29 cases with simple somatic mutation data · 29 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	22	29	75.9%	cbioportal
2	TP53	Ssm	20	29	69%	cbioportal
3	KRAS	Ssm	16	29	55.2%	cbioportal
4	TTN	Ssm	11	29	37.9%	cbioportal
5	FLG	Ssm	8	29	27.6%	cbioportal
6	SMAD4	Ssm	7	29	24.1%	cbioportal
7	HYDIN	Ssm	6	29	20.7%	cbioportal
11	PIK3CA	Ssm	5	29	17.2%	cbioportal
9	CSMD1	Ssm	5	29	17.2%	cbioportal
8	COL11A1	Ssm	5	29	17.2%	cbioportal
10	NEB	Ssm	5	29	17.2%	cbioportal
17	FBXW7	Ssm	4	29	13.8%	cbioportal
25	TENM1	Ssm	4	29	13.8%	cbioportal
16	DNAH3	Ssm	4	29	13.8%	cbioportal
12	AHNAK2	Ssm	4	29	13.8%	cbioportal
13	APOB	Ssm	4	29	13.8%	cbioportal
14	CSMD2	Ssm	4	29	13.8%	cbioportal
15	CYP19A1	Ssm	4	29	13.8%	cbioportal
24	SYNE1	Ssm	4	29	13.8%	cbioportal
23	SPATA31A3	Ssm	4	29	13.8%	cbioportal
22	PXDNL	Ssm	4	29	13.8%	cbioportal
21	PCLO	Ssm	4	29	13.8%	cbioportal
20	PCDH17	Ssm	4	29	13.8%	cbioportal
19	KMT2D	Ssm	4	29	13.8%	cbioportal
18	FRAS1	Ssm	4	29	13.8%	cbioportal
29	ANK2	Ssm	3	29	10.3%	cbioportal
30	ANKRD36	Ssm	3	29	10.3%	cbioportal
28	AHCTF1	Ssm	3	29	10.3%	cbioportal
27	ABCA13	Ssm	3	29	10.3%	cbioportal
26	ABCA12	Ssm	3	29	10.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colon Adenocarcinoma (CPTAC GDC, 2025) coad_cptac_gdcCPTAC GDC

104 cases with simple somatic mutation data · 109 cases total · 2026-01-14 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	79	104	76%	cbioportal
2	TP53	Ssm	57	104	54.8%	cbioportal
3	TTN	Ssm	50	104	48.1%	cbioportal
4	KRAS	Ssm	36	104	34.6%	cbioportal
5	MUC16	Ssm	28	104	26.9%	cbioportal
6	SYNE1	Ssm	27	104	26%	cbioportal
7	CSMD3	Ssm	25	104	24%	cbioportal
8	FAT3	Ssm	25	104	24%	cbioportal
9	RYR1	Ssm	24	104	23.1%	cbioportal
10	FAT4	Ssm	23	104	22.1%	cbioportal
11	HMCN1	Ssm	23	104	22.1%	cbioportal
14	ZNF469	Ssm	22	104	21.2%	cbioportal
12	OBSCN	Ssm	22	104	21.2%	cbioportal
13	PIK3CA	Ssm	22	104	21.2%	cbioportal
17	LRTM3	Ssm	21	104	20.2%	cbioportal
15	ACVR2A	Ssm	21	104	20.2%	cbioportal
16	DNAH5	Ssm	21	104	20.2%	cbioportal
20	SPEG	Ssm	20	104	19.2%	cbioportal
19	SOX9	Ssm	20	104	19.2%	cbioportal
18	COL5A1	Ssm	20	104	19.2%	cbioportal
21	ARID1A	Ssm	19	104	18.3%	cbioportal
22	DMD	Ssm	19	104	18.3%	cbioportal
23	MYCBP2	Ssm	19	104	18.3%	cbioportal
24	NBEA	Ssm	19	104	18.3%	cbioportal
25	RYR2	Ssm	19	104	18.3%	cbioportal
27	FSIP2	Ssm	18	104	17.3%	cbioportal
28	HERC2	Ssm	18	104	17.3%	cbioportal
29	PCLO	Ssm	18	104	17.3%	cbioportal
30	PLEC	Ssm	18	104	17.3%	cbioportal
26	ADGRV1	Ssm	18	104	17.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Colon Adenocarcinoma (TCGA GDC, 2025) coad_tcga_gdcTCGA GDC

429 cases with simple somatic mutation data · 463 cases total · 2026-01-19 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	308	429	71.8%	cbioportal
2	TP53	Ssm	237	429	55.2%	cbioportal
3	TTN	Ssm	202	429	47.1%	cbioportal
4	KRAS	Ssm	183	429	42.7%	cbioportal
5	PIK3CA	Ssm	127	429	29.6%	cbioportal
6	SYNE1	Ssm	122	429	28.4%	cbioportal
7	MUC16	Ssm	121	429	28.2%	cbioportal
8	FAT4	Ssm	99	429	23.1%	cbioportal
9	RYR2	Ssm	86	429	20%	cbioportal
10	ZFHX4	Ssm	86	429	20%	cbioportal
11	OBSCN	Ssm	84	429	19.6%	cbioportal
13	DNAH5	Ssm	80	429	18.6%	cbioportal
12	CSMD3	Ssm	80	429	18.6%	cbioportal
14	LRP1B	Ssm	75	429	17.5%	cbioportal
15	PCLO	Ssm	73	429	17%	cbioportal
16	RYR3	Ssm	71	429	16.6%	cbioportal
17	FBXW7	Ssm	70	429	16.3%	cbioportal
19	USH2A	Ssm	69	429	16.1%	cbioportal
18	DNAH11	Ssm	69	429	16.1%	cbioportal
21	RYR1	Ssm	67	429	15.6%	cbioportal
20	CSMD1	Ssm	67	429	15.6%	cbioportal
22	ABCA13	Ssm	66	429	15.4%	cbioportal
23	ADGRV1	Ssm	65	429	15.2%	cbioportal
24	FAT3	Ssm	63	429	14.7%	cbioportal
25	NEB	Ssm	62	429	14.5%	cbioportal
29	SOX9	Ssm	61	429	14.2%	cbioportal
28	LRP2	Ssm	61	429	14.2%	cbioportal
27	DST	Ssm	61	429	14.2%	cbioportal
26	BRAF	Ssm	61	429	14.2%	cbioportal
30	MDN1	Ssm	60	429	14%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Colon Cancer (CPTAC-2 Prospective, Cell 2019) coad_cptac_2019CPTAC-2 Prospective

106 cases with simple somatic mutation data · 110 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	79	106	74.5%	cbioportal
2	TTN	Ssm	58	106	54.7%	cbioportal
3	TP53	Ssm	56	106	52.8%	cbioportal
4	MUC16	Ssm	39	106	36.8%	cbioportal
5	KRAS	Ssm	35	106	33%	cbioportal
6	OBSCN	Ssm	29	106	27.4%	cbioportal
7	SYNE1	Ssm	28	106	26.4%	cbioportal
8	DNAH5	Ssm	27	106	25.5%	cbioportal
9	FAT3	Ssm	27	106	25.5%	cbioportal
12	MUC5B	Ssm	26	106	24.5%	cbioportal
10	CSMD3	Ssm	26	106	24.5%	cbioportal
11	FAT4	Ssm	26	106	24.5%	cbioportal
13	RYR1	Ssm	25	106	23.6%	cbioportal
14	PCLO	Ssm	24	106	22.6%	cbioportal
15	ZNF469	Ssm	24	106	22.6%	cbioportal
20	PLEC	Ssm	23	106	21.7%	cbioportal
16	ACVR2A	Ssm	23	106	21.7%	cbioportal
18	HMCN1	Ssm	23	106	21.7%	cbioportal
19	PIK3CA	Ssm	23	106	21.7%	cbioportal
17	COL5A1	Ssm	23	106	21.7%	cbioportal
21	ARID1A	Ssm	22	106	20.8%	cbioportal
22	FSIP2	Ssm	22	106	20.8%	cbioportal
25	NBEA	Ssm	21	106	19.8%	cbioportal
23	AHNAK2	Ssm	21	106	19.8%	cbioportal
27	TCF7L2	Ssm	21	106	19.8%	cbioportal
26	RYR2	Ssm	21	106	19.8%	cbioportal
24	HERC2	Ssm	21	106	19.8%	cbioportal
29	DOCK3	Ssm	20	106	18.9%	cbioportal
30	MUC4	Ssm	20	106	18.9%	cbioportal
28	DMD	Ssm	20	106	18.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colon Cancer (Sidra-LUMC AC-ICAM, Nat Med 2023) coad_silu_2022Sidra-LUMC AC-ICAM

281 cases with simple somatic mutation data · 348 cases total · 2026-01-06 · mapped to Colon Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	196	281	69.8%	cbioportal
2	TTN	Ssm	142	281	50.5%	cbioportal
3	TP53	Ssm	119	281	42.3%	cbioportal
4	KRAS	Ssm	100	281	35.6%	cbioportal
5	SYNE1	Ssm	90	281	32%	cbioportal
6	MUC16	Ssm	76	281	27%	cbioportal
7	FAT4	Ssm	74	281	26.3%	cbioportal
8	OBSCN	Ssm	72	281	25.6%	cbioportal
9	RYR2	Ssm	66	281	23.5%	cbioportal
10	BRAF	Ssm	65	281	23.1%	cbioportal
11	LRP1B	Ssm	65	281	23.1%	cbioportal
12	ACVR2A	Ssm	64	281	22.8%	cbioportal
13	RYR1	Ssm	64	281	22.8%	cbioportal
14	CSMD1	Ssm	63	281	22.4%	cbioportal
15	DNAH5	Ssm	62	281	22.1%	cbioportal
16	PCLO	Ssm	61	281	21.7%	cbioportal
17	CSMD3	Ssm	60	281	21.4%	cbioportal
19	ZFHX4	Ssm	57	281	20.3%	cbioportal
18	MUC5B	Ssm	57	281	20.3%	cbioportal
21	FSIP2	Ssm	56	281	19.9%	cbioportal
20	FAT2	Ssm	56	281	19.9%	cbioportal
22	RYR3	Ssm	55	281	19.6%	cbioportal
23	USH2A	Ssm	55	281	19.6%	cbioportal
25	FAT3	Ssm	54	281	19.2%	cbioportal
24	DMD	Ssm	54	281	19.2%	cbioportal
26	ABCA13	Ssm	52	281	18.5%	cbioportal
28	ZNF469	Ssm	52	281	18.5%	cbioportal
27	SACS	Ssm	52	281	18.5%	cbioportal
29	APOB	Ssm	51	281	18.1%	cbioportal
30	PLEC	Ssm	51	281	18.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Adenocarcinoma (DFCI, Cell Reports 2016) coadread_dfci_2016DFCI

619 cases with simple somatic mutation data · 619 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	361	619	58.3%	cbioportal
2	TP53	Ssm	320	619	51.7%	cbioportal
3	TTN	Ssm	295	619	47.7%	cbioportal
4	KRAS	Ssm	173	619	27.9%	cbioportal
5	SYNE1	Ssm	167	619	27%	cbioportal
6	FLG	Ssm	154	619	24.9%	cbioportal
7	MUC16	Ssm	150	619	24.2%	cbioportal
8	PIK3CA	Ssm	132	619	21.3%	cbioportal
9	MUC17	Ssm	129	619	20.8%	cbioportal
10	BRAF	Ssm	127	619	20.5%	cbioportal
11	OBSCN	Ssm	116	619	18.7%	cbioportal
12	RYR1	Ssm	111	619	17.9%	cbioportal
13	FAT4	Ssm	109	619	17.6%	cbioportal
14	AHNAK2	Ssm	106	619	17.1%	cbioportal
15	NEB	Ssm	106	619	17.1%	cbioportal
16	CSMD3	Ssm	104	619	16.8%	cbioportal
17	LRP1B	Ssm	100	619	16.2%	cbioportal
18	PLEC	Ssm	99	619	16%	cbioportal
19	DNAH5	Ssm	98	619	15.8%	cbioportal
20	SDK1	Ssm	93	619	15%	cbioportal
21	KMT2C	Ssm	92	619	14.9%	cbioportal
22	UBR4	Ssm	91	619	14.7%	cbioportal
23	FAT3	Ssm	90	619	14.5%	cbioportal
24	HRNR	Ssm	90	619	14.5%	cbioportal
25	DIDO1	Ssm	89	619	14.4%	cbioportal
26	AHNAK	Ssm	87	619	14.1%	cbioportal
27	FBXW7	Ssm	86	619	13.9%	cbioportal
28	USH2A	Ssm	84	619	13.6%	cbioportal
29	HMCN1	Ssm	81	619	13.1%	cbioportal
30	RNF213	Ssm	80	619	12.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Adenocarcinoma (Genentech, Nature 2012) coadread_genentechGenentech

72 cases with simple somatic mutation data · 74 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	40	72	55.6%	cbioportal
2	KRAS	Ssm	37	72	51.4%	cbioportal
3	APC	Ssm	29	72	40.3%	cbioportal
4	TTN	Ssm	29	72	40.3%	cbioportal
5	PIK3CA	Ssm	22	72	30.6%	cbioportal
6	SYNE1	Ssm	19	72	26.4%	cbioportal
7	DNAH5	Ssm	18	72	25%	cbioportal
8	CSMD1	Ssm	17	72	23.6%	cbioportal
9	FAT3	Ssm	17	72	23.6%	cbioportal
10	FAT4	Ssm	17	72	23.6%	cbioportal
11	SMAD4	Ssm	17	72	23.6%	cbioportal
12	RYR2	Ssm	16	72	22.2%	cbioportal
16	PLEC	Ssm	15	72	20.8%	cbioportal
13	FBXW7	Ssm	15	72	20.8%	cbioportal
14	NEB	Ssm	15	72	20.8%	cbioportal
15	OBSCN	Ssm	15	72	20.8%	cbioportal
23	RYR1	Ssm	14	72	19.4%	cbioportal
22	PCLO	Ssm	14	72	19.4%	cbioportal
17	HERC2	Ssm	14	72	19.4%	cbioportal
18	LAMA5	Ssm	14	72	19.4%	cbioportal
19	LRP2	Ssm	14	72	19.4%	cbioportal
20	MYO15A	Ssm	14	72	19.4%	cbioportal
21	NRXN1	Ssm	14	72	19.4%	cbioportal
28	DNAH11	Ssm	13	72	18.1%	cbioportal
29	DNHD1	Ssm	13	72	18.1%	cbioportal
30	LRP1B	Ssm	13	72	18.1%	cbioportal
27	CSMD3	Ssm	13	72	18.1%	cbioportal
26	ATP10A	Ssm	13	72	18.1%	cbioportal
25	ATM	Ssm	13	72	18.1%	cbioportal
24	ADGRV1	Ssm	13	72	18.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Adenocarcinoma (MSK, 2026) crc_msk_2026MSK

7,237 cases with simple somatic mutation data · 7,237 cases total · 2026-09-01 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	5,400	7,237	74.6%	cbioportal
2	TP53	Ssm	5,295	7,237	73.2%	cbioportal
3	KRAS	Ssm	3,096	7,237	42.8%	cbioportal
4	PIK3CA	Ssm	1,486	7,237	20.5%	cbioportal
5	FBXW7	Ssm	1,127	7,237	15.6%	cbioportal
6	TCF7L2	Ssm	1,088	7,035	15.5%	cbioportal
7	SMAD4	Ssm	1,078	7,237	14.9%	cbioportal
8	ARID1A	Ssm	912	7,237	12.6%	cbioportal
9	SOX9	Ssm	869	7,237	12%	cbioportal
10	BRAF	Ssm	813	7,237	11.2%	cbioportal
11	KMT2D	Ssm	805	7,237	11.1%	cbioportal
15	KMT2B	Ssm	653	6,120	10.7%	cbioportal
12	RNF43	Ssm	734	7,237	10.1%	cbioportal
13	PTPRS	Ssm	708	7,237	9.8%	cbioportal
14	ZFHX3	Ssm	658	7,035	9.4%	cbioportal
16	ATM	Ssm	646	7,237	8.9%	cbioportal
17	PTPRT	Ssm	636	7,237	8.8%	cbioportal
18	KMT2C	Ssm	605	7,237	8.4%	cbioportal
19	NOTCH3	Ssm	571	7,237	7.9%	cbioportal
21	FAT1	Ssm	550	7,237	7.6%	cbioportal
20	AMER1	Ssm	550	7,237	7.6%	cbioportal
29	MSH3	Ssm	453	6,120	7.4%	cbioportal
22	CREBBP	Ssm	517	7,237	7.1%	cbioportal
23	CTNNB1	Ssm	503	7,237	7%	cbioportal
26	ANKRD11	Ssm	468	7,035	6.7%	cbioportal
44	PREX2	Ssm	404	6,120	6.6%	cbioportal
24	GRIN2A	Ssm	470	7,237	6.5%	cbioportal
25	CARD11	Ssm	469	7,237	6.5%	cbioportal
27	NOTCH1	Ssm	459	7,237	6.3%	cbioportal
28	BRCA2	Ssm	454	7,237	6.3%	cbioportal

Data updated 22 days agoSource updated 2026-09-01

Colorectal Adenocarcinoma (TCGA, Firehose Legacy) coadread_tcgaTCGA

223 cases with simple somatic mutation data · 640 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	160	223	71.7%	cbioportal
2	TP53	Ssm	120	223	53.8%	cbioportal
3	KRAS	Ssm	96	223	43%	cbioportal
4	TTN	Ssm	80	223	35.9%	cbioportal
5	SYNE1	Ssm	47	223	21.1%	cbioportal
6	LRP1B	Ssm	40	223	17.9%	cbioportal
8	MUC16	Ssm	39	223	17.5%	cbioportal
7	FAT4	Ssm	39	223	17.5%	cbioportal
9	FBXW7	Ssm	38	223	17%	cbioportal
10	LRP2	Ssm	35	223	15.7%	cbioportal
11	DMD	Ssm	34	223	15.2%	cbioportal
12	DNAH5	Ssm	34	223	15.2%	cbioportal
13	PIK3CA	Ssm	33	223	14.8%	cbioportal
14	FLG	Ssm	32	223	14.3%	cbioportal
16	FAT2	Ssm	30	223	13.5%	cbioportal
17	HMCN1	Ssm	30	223	13.5%	cbioportal
15	ANK2	Ssm	30	223	13.5%	cbioportal
18	RYR2	Ssm	29	223	13%	cbioportal
19	COL6A3	Ssm	28	223	12.6%	cbioportal
20	CSMD1	Ssm	28	223	12.6%	cbioportal
21	CSMD3	Ssm	28	223	12.6%	cbioportal
22	SDK1	Ssm	27	223	12.1%	cbioportal
23	DNAH2	Ssm	26	223	11.7%	cbioportal
24	PKHD1	Ssm	26	223	11.7%	cbioportal
25	SMAD4	Ssm	26	223	11.7%	cbioportal
26	USH2A	Ssm	26	223	11.7%	cbioportal
27	AMER1	Ssm	25	223	11.2%	cbioportal
29	HYDIN	Ssm	25	223	11.2%	cbioportal
28	ATM	Ssm	25	223	11.2%	cbioportal
30	CSMD2	Ssm	24	223	10.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Adenocarcinoma (TCGA, Nature 2012) coadread_tcga_pubTCGA

224 cases with simple somatic mutation data · 276 cases total · 2026-02-19 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	168	224	75%	cbioportal
2	TP53	Ssm	121	224	54%	cbioportal
3	KRAS	Ssm	94	224	42%	cbioportal
4	TTN	Ssm	80	224	35.7%	cbioportal
5	SYNE1	Ssm	47	224	21%	cbioportal
6	PIK3CA	Ssm	45	224	20.1%	cbioportal
7	LRP1B	Ssm	40	224	17.9%	cbioportal
8	FAT4	Ssm	39	224	17.4%	cbioportal
9	MUC16	Ssm	39	224	17.4%	cbioportal
10	FBXW7	Ssm	37	224	16.5%	cbioportal
11	DNAH5	Ssm	34	224	15.2%	cbioportal
12	LRP2	Ssm	34	224	15.2%	cbioportal
13	DMD	Ssm	33	224	14.7%	cbioportal
14	FLG	Ssm	32	224	14.3%	cbioportal
16	FAT2	Ssm	30	224	13.4%	cbioportal
15	ANK2	Ssm	30	224	13.4%	cbioportal
17	HMCN1	Ssm	29	224	12.9%	cbioportal
20	CSMD3	Ssm	28	224	12.5%	cbioportal
18	COL6A3	Ssm	28	224	12.5%	cbioportal
21	RYR2	Ssm	28	224	12.5%	cbioportal
19	CSMD1	Ssm	28	224	12.5%	cbioportal
23	TCF7L2	Ssm	27	224	12.1%	cbioportal
22	SDK1	Ssm	27	224	12.1%	cbioportal
27	USH2A	Ssm	26	224	11.6%	cbioportal
25	PKHD1	Ssm	26	224	11.6%	cbioportal
24	DNAH2	Ssm	26	224	11.6%	cbioportal
26	SMAD4	Ssm	26	224	11.6%	cbioportal
29	AMER1	Ssm	25	224	11.2%	cbioportal
28	ACVR2A	Ssm	25	224	11.2%	cbioportal
30	ATM	Ssm	25	224	11.2%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Colorectal Adenocarcinoma (TCGA, PanCancer Atlas) coadread_tcga_pan_can_atlas_2018TCGA

534 cases with simple somatic mutation data · 594 cases total · 2026-06-05 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	387	534	72.5%	cbioportal
2	TP53	Ssm	314	534	58.8%	cbioportal
3	TTN	Ssm	257	534	48.1%	cbioportal
4	KRAS	Ssm	218	534	40.8%	cbioportal
5	PIK3CA	Ssm	147	534	27.5%	cbioportal
6	MUC16	Ssm	146	534	27.3%	cbioportal
7	SYNE1	Ssm	144	534	27%	cbioportal
8	FAT4	Ssm	124	534	23.2%	cbioportal
9	RYR2	Ssm	105	534	19.7%	cbioportal
10	OBSCN	Ssm	99	534	18.5%	cbioportal
11	ZFHX4	Ssm	95	534	17.8%	cbioportal
12	FLG	Ssm	94	534	17.6%	cbioportal
13	LRP1B	Ssm	94	534	17.6%	cbioportal
15	DNAH5	Ssm	92	534	17.2%	cbioportal
14	CSMD1	Ssm	92	534	17.2%	cbioportal
16	FBXW7	Ssm	90	534	16.9%	cbioportal
17	CSMD3	Ssm	89	534	16.7%	cbioportal
18	DNAH11	Ssm	85	534	15.9%	cbioportal
19	RYR1	Ssm	83	534	15.5%	cbioportal
20	FAT3	Ssm	81	534	15.2%	cbioportal
21	PCLO	Ssm	80	534	15%	cbioportal
22	USH2A	Ssm	79	534	14.8%	cbioportal
23	ABCA13	Ssm	77	534	14.4%	cbioportal
24	RYR3	Ssm	77	534	14.4%	cbioportal
25	HYDIN	Ssm	76	534	14.2%	cbioportal
26	NEB	Ssm	74	534	13.9%	cbioportal
28	DMD	Ssm	72	534	13.5%	cbioportal
27	ADGRV1	Ssm	72	534	13.5%	cbioportal
30	LRP2	Ssm	70	534	13.1%	cbioportal
29	ATM	Ssm	70	534	13.1%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Colorectal Adenocarcinoma Triplets (MSK, Genome Biol 2014) coadread_mskccMSK

138 cases with simple somatic mutation data · 138 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	125	138	90.6%	cbioportal
2	TP53	Ssm	111	138	80.4%	cbioportal
3	KRAS	Ssm	76	138	55.1%	cbioportal
4	PIK3CA	Ssm	27	138	19.6%	cbioportal
5	SMAD4	Ssm	17	138	12.3%	cbioportal
6	AMER1	Ssm	12	138	8.7%	cbioportal
7	FBXW7	Ssm	12	138	8.7%	cbioportal
8	CTNNB1	Ssm	10	138	7.2%	cbioportal
9	ERBB3	Ssm	8	138	5.8%	cbioportal
10	EPHA5	Ssm	7	138	5.1%	cbioportal
11	PTPRS	Ssm	7	138	5.1%	cbioportal
13	BRAF	Ssm	6	138	4.3%	cbioportal
14	CREBBP	Ssm	6	138	4.3%	cbioportal
12	ASXL1	Ssm	6	138	4.3%	cbioportal
15	AR	Ssm	5	138	3.6%	cbioportal
18	ERBB2	Ssm	5	138	3.6%	cbioportal
19	GRIN2A	Ssm	5	138	3.6%	cbioportal
17	EPHB1	Ssm	5	138	3.6%	cbioportal
16	ATRX	Ssm	5	138	3.6%	cbioportal
21	EPHA7	Ssm	4	138	2.9%	cbioportal
39	PREX2	Ssm	4	138	2.9%	cbioportal
40	PTCH1	Ssm	4	138	2.9%	cbioportal
41	PTPRD	Ssm	4	138	2.9%	cbioportal
42	RARA	Ssm	4	138	2.9%	cbioportal
43	SMO	Ssm	4	138	2.9%	cbioportal
44	TERT	Ssm	4	138	2.9%	cbioportal
45	TET1	Ssm	4	138	2.9%	cbioportal
46	TSHR	Ssm	4	138	2.9%	cbioportal
38	PIK3CG	Ssm	4	138	2.9%	cbioportal
20	EPHA6	Ssm	4	138	2.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Cancer (CAS Shanghai, Cancer Cell 2020) coadread_cass_2020CAS Shanghai

146 cases with simple somatic mutation data · 146 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	95	146	65.1%	cbioportal
2	TP53	Ssm	93	146	63.7%	cbioportal
3	TTN	Ssm	57	146	39%	cbioportal
4	KRAS	Ssm	47	146	32.2%	cbioportal
5	MUC16	Ssm	34	146	23.3%	cbioportal
6	FLG	Ssm	28	146	19.2%	cbioportal
7	OBSCN	Ssm	27	146	18.5%	cbioportal
8	PRRC2A	Ssm	26	146	17.8%	cbioportal
9	MUC5B	Ssm	25	146	17.1%	cbioportal
10	PLEC	Ssm	25	146	17.1%	cbioportal
12	LRP1B	Ssm	24	146	16.4%	cbioportal
11	FAT3	Ssm	24	146	16.4%	cbioportal
13	SOX9	Ssm	24	146	16.4%	cbioportal
14	FBXW7	Ssm	23	146	15.8%	cbioportal
15	PPFIA4	Ssm	23	146	15.8%	cbioportal
17	HYDIN	Ssm	22	146	15.1%	cbioportal
16	CPD	Ssm	22	146	15.1%	cbioportal
18	RYR1	Ssm	22	146	15.1%	cbioportal
21	MTUS2	Ssm	21	146	14.4%	cbioportal
19	AHNAK2	Ssm	21	146	14.4%	cbioportal
20	CACNA1H	Ssm	21	146	14.4%	cbioportal
24	NUPR2	Ssm	20	146	13.7%	cbioportal
22	FSIP2	Ssm	20	146	13.7%	cbioportal
23	MUC4	Ssm	20	146	13.7%	cbioportal
25	CSMD1	Ssm	19	146	13%	cbioportal
27	SMAD4	Ssm	19	146	13%	cbioportal
28	ZNF469	Ssm	19	146	13%	cbioportal
26	HSPG2	Ssm	19	146	13%	cbioportal
30	CSMD2	Ssm	18	146	12.3%	cbioportal
29	COL5A1	Ssm	18	146	12.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Cancer- ChangKang Project (SYSUCC, Nat Commun 2022) crc_sysucc_2022SYSUCC

1,015 cases with simple somatic mutation data · 1,015 cases total · 2026-01-19 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	458	1,015	45.1%	cbioportal
2	APC	Ssm	451	1,015	44.4%	cbioportal
3	TTN	Ssm	278	1,015	27.4%	cbioportal
4	KRAS	Ssm	239	1,015	23.5%	cbioportal
5	MUC16	Ssm	167	1,015	16.5%	cbioportal
6	SYNE1	Ssm	147	1,015	14.5%	cbioportal
7	PIK3CA	Ssm	130	1,015	12.8%	cbioportal
8	OBSCN	Ssm	126	1,015	12.4%	cbioportal
9	FBXW7	Ssm	121	1,015	11.9%	cbioportal
10	FLG	Ssm	116	1,015	11.4%	cbioportal
12	RYR2	Ssm	112	1,015	11%	cbioportal
11	FAT4	Ssm	112	1,015	11%	cbioportal
13	ZFHX4	Ssm	108	1,015	10.6%	cbioportal
14	LRP1B	Ssm	105	1,015	10.3%	cbioportal
15	RYR1	Ssm	101	1,015	10%	cbioportal
16	CSMD3	Ssm	100	1,015	9.9%	cbioportal
18	PCLO	Ssm	97	1,015	9.6%	cbioportal
17	NEB	Ssm	97	1,015	9.6%	cbioportal
19	DNAH11	Ssm	96	1,015	9.5%	cbioportal
20	USH2A	Ssm	95	1,015	9.4%	cbioportal
21	ABCA13	Ssm	93	1,015	9.2%	cbioportal
22	MUC5B	Ssm	93	1,015	9.2%	cbioportal
23	DNAH5	Ssm	92	1,015	9.1%	cbioportal
24	APOB	Ssm	91	1,015	9%	cbioportal
26	TCF7L2	Ssm	90	1,015	8.9%	cbioportal
25	CSMD1	Ssm	90	1,015	8.9%	cbioportal
27	FAT3	Ssm	87	1,015	8.6%	cbioportal
28	RYR3	Ssm	83	1,015	8.2%	cbioportal
30	HMCN1	Ssm	82	1,015	8.1%	cbioportal
29	AHNAK2	Ssm	82	1,015	8.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Colorectal Cancer (HTAN MSK, Nature 2025) crc_hta8_htan_2024HTAN MSK

28 cases with simple somatic mutation data · 83 cases total · 2026-02-17 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	26	28	92.9%	cbioportal
2	APC	Ssm	23	28	82.1%	cbioportal
3	KRAS	Ssm	10	28	35.7%	cbioportal
4	FBXW7	Ssm	5	28	17.9%	cbioportal
5	TCF7L2	Ssm	5	28	17.9%	cbioportal
6	PIK3CA	Ssm	4	28	14.3%	cbioportal
8	SOX9	Ssm	3	28	10.7%	cbioportal
7	ATM	Ssm	3	28	10.7%	cbioportal
15	KMT2B	Ssm	2	28	7.1%	cbioportal
20	SMAD4	Ssm	2	28	7.1%	cbioportal
19	RB1	Ssm	2	28	7.1%	cbioportal
18	NRAS	Ssm	2	28	7.1%	cbioportal
16	KMT2C	Ssm	2	28	7.1%	cbioportal
17	MDC1	Ssm	2	28	7.1%	cbioportal
9	BARD1	Ssm	2	28	7.1%	cbioportal
10	CARD11	Ssm	2	28	7.1%	cbioportal
11	FLT4	Ssm	2	28	7.1%	cbioportal
12	GNA11	Ssm	2	28	7.1%	cbioportal
13	INHBA	Ssm	2	28	7.1%	cbioportal
14	JUN	Ssm	2	28	7.1%	cbioportal
25	AXL	Ssm	1	28	3.6%	cbioportal
34	DNMT1	Ssm	1	28	3.6%	cbioportal
21	AMER1	Ssm	1	28	3.6%	cbioportal
22	ARID1A	Ssm	1	28	3.6%	cbioportal
23	ASXL1	Ssm	1	28	3.6%	cbioportal
24	AXIN2	Ssm	1	28	3.6%	cbioportal
26	B2M	Ssm	1	28	3.6%	cbioportal
27	BCOR	Ssm	1	28	3.6%	cbioportal
28	BRAF	Ssm	1	28	3.6%	cbioportal
29	BRCA2	Ssm	1	28	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-02-17

Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022MSK

22 cases with simple somatic mutation data · 22 cases total · 2026-01-06 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	22	22	100%	cbioportal
2	APC	Ssm	21	22	95.5%	cbioportal
3	TP53	Ssm	21	22	95.5%	cbioportal
7	USP8	Ssm	13	19	68.4%	cbioportal
4	SMAD4	Ssm	14	22	63.6%	cbioportal
9	HLA-C	Ssm	12	19	63.2%	cbioportal
5	ATM	Ssm	13	22	59.1%	cbioportal
6	PDCD1	Ssm	13	22	59.1%	cbioportal
11	PIK3C2G	Ssm	12	22	54.5%	cbioportal
12	TET2	Ssm	12	22	54.5%	cbioportal
10	MGA	Ssm	12	22	54.5%	cbioportal
8	ABRAXAS1	Ssm	12	22	54.5%	cbioportal
13	HLA-A	Ssm	11	22	50%	cbioportal
14	TCF7L2	Ssm	11	22	50%	cbioportal
15	ZFHX3	Ssm	11	22	50%	cbioportal
50	SETDB1	Ssm	9	19	47.4%	cbioportal
42	GAB1	Ssm	9	19	47.4%	cbioportal
33	STAT3	Ssm	10	22	45.5%	cbioportal
29	PRKN	Ssm	10	22	45.5%	cbioportal
30	RAD54L	Ssm	10	22	45.5%	cbioportal
31	SDHD	Ssm	10	22	45.5%	cbioportal
32	SOX17	Ssm	10	22	45.5%	cbioportal
26	MYCN	Ssm	10	22	45.5%	cbioportal
28	NSD1	Ssm	10	22	45.5%	cbioportal
23	KMT2D	Ssm	10	22	45.5%	cbioportal
24	MLH1	Ssm	10	22	45.5%	cbioportal
25	MST1R	Ssm	10	22	45.5%	cbioportal
27	NEGR1	Ssm	10	22	45.5%	cbioportal
17	AMER1	Ssm	10	22	45.5%	cbioportal
18	BRCA1	Ssm	10	22	45.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Colorectal Cancer (MSK, Gastroenterology 2020) crc_apc_impact_2020MSK

471 cases with simple somatic mutation data · 471 cases total · 2026-01-07 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	345	471	73.2%	cbioportal
2	APC	Ssm	325	471	69%	cbioportal
3	KRAS	Ssm	238	471	50.5%	cbioportal
4	PIK3CA	Ssm	88	471	18.7%	cbioportal
5	SMAD4	Ssm	69	471	14.6%	cbioportal
6	BRAF	Ssm	58	471	12.3%	cbioportal
7	FBXW7	Ssm	51	471	10.8%	cbioportal
12	TCF7L2	Ssm	36	392	9.2%	cbioportal
8	SOX9	Ssm	39	471	8.3%	cbioportal
9	RNF43	Ssm	38	471	8.1%	cbioportal
11	KMT2D	Ssm	36	471	7.6%	cbioportal
10	ARID1A	Ssm	36	471	7.6%	cbioportal
13	PTPRS	Ssm	33	471	7%	cbioportal
102	KMT2B	Ssm	10	153	6.5%	cbioportal
14	CTNNB1	Ssm	28	471	5.9%	cbioportal
23	ZFHX3	Ssm	22	392	5.6%	cbioportal
15	ERBB4	Ssm	26	471	5.5%	cbioportal
17	PTPRT	Ssm	25	471	5.3%	cbioportal
16	ATM	Ssm	25	471	5.3%	cbioportal
19	NF1	Ssm	24	471	5.1%	cbioportal
18	AMER1	Ssm	24	471	5.1%	cbioportal
20	PTEN	Ssm	23	471	4.9%	cbioportal
21	SMARCA4	Ssm	23	471	4.9%	cbioportal
32	ANKRD11	Ssm	19	392	4.8%	cbioportal
22	ERBB3	Ssm	22	471	4.7%	cbioportal
151	INPPL1	Ssm	7	153	4.6%	cbioportal
162	PREX2	Ssm	7	153	4.6%	cbioportal
26	FLT4	Ssm	21	471	4.5%	cbioportal
25	BRCA2	Ssm	21	471	4.5%	cbioportal
24	BCOR	Ssm	21	471	4.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Colorectal Cancer (MSK, JCO Precis Oncol 2022) crc_dd_2022MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	45	47	95.7%	cbioportal
2	APC	Ssm	39	47	83%	cbioportal
3	TP53	Ssm	20	47	42.6%	cbioportal
5	TCF7L2	Ssm	17	45	37.8%	cbioportal
4	PIK3CA	Ssm	17	47	36.2%	cbioportal
6	NRAS	Ssm	14	47	29.8%	cbioportal
7	PTPRS	Ssm	14	47	29.8%	cbioportal
8	FBXW7	Ssm	13	47	27.7%	cbioportal
9	ARID1A	Ssm	12	47	25.5%	cbioportal
10	FLT4	Ssm	12	47	25.5%	cbioportal
12	SMAD4	Ssm	11	47	23.4%	cbioportal
11	CREBBP	Ssm	11	47	23.4%	cbioportal
13	SOX9	Ssm	11	47	23.4%	cbioportal
22	KMT2B	Ssm	9	40	22.5%	cbioportal
16	KMT2A	Ssm	10	47	21.3%	cbioportal
19	PTEN	Ssm	10	47	21.3%	cbioportal
18	POLE	Ssm	10	47	21.3%	cbioportal
15	FAT1	Ssm	10	47	21.3%	cbioportal
14	AMER1	Ssm	10	47	21.3%	cbioportal
17	NOTCH3	Ssm	10	47	21.3%	cbioportal
25	ZFHX3	Ssm	9	45	20%	cbioportal
24	SPEN	Ssm	9	47	19.1%	cbioportal
20	AXIN2	Ssm	9	47	19.1%	cbioportal
21	BCOR	Ssm	9	47	19.1%	cbioportal
23	KMT2D	Ssm	9	47	19.1%	cbioportal
39	INPPL1	Ssm	7	40	17.5%	cbioportal
31	PTPRT	Ssm	8	47	17%	cbioportal
27	CIC	Ssm	8	47	17%	cbioportal
30	PIK3R1	Ssm	8	47	17%	cbioportal
29	MSH6	Ssm	8	47	17%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Colorectal Cancer Radiation (MSK, 2024) rectal_radiation_msk_2024MSK

48 cases with simple somatic mutation data · 48 cases total · 2026-01-20 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	36	48	75%	cbioportal
5	TTN	Ssm	9	17	52.9%	cbioportal
2	APC	Ssm	23	48	47.9%	cbioportal
3	KRAS	Ssm	17	48	35.4%	cbioportal
13	SYNE1	Ssm	6	17	35.3%	cbioportal
9	BSN	Ssm	6	17	35.3%	cbioportal
12	SPTBN4	Ssm	6	17	35.3%	cbioportal
15	DNAH11	Ssm	5	17	29.4%	cbioportal
16	MAST4	Ssm	5	17	29.4%	cbioportal
4	SMAD4	Ssm	12	48	25%	cbioportal
19	ARHGAP24	Ssm	4	17	23.5%	cbioportal
23	FLG	Ssm	4	17	23.5%	cbioportal
33	TBL3	Ssm	4	17	23.5%	cbioportal
18	ACTA1	Ssm	4	17	23.5%	cbioportal
30	PAPLN	Ssm	4	17	23.5%	cbioportal
65	LRP4	Ssm	3	17	17.6%	cbioportal
62	ITIH5	Ssm	3	17	17.6%	cbioportal
63	JAKMIP1	Ssm	3	17	17.6%	cbioportal
67	MUC16	Ssm	3	17	17.6%	cbioportal
94	TSKS	Ssm	3	17	17.6%	cbioportal
93	TRPC3	Ssm	3	17	17.6%	cbioportal
92	TLN1	Ssm	3	17	17.6%	cbioportal
90	SUN2	Ssm	3	17	17.6%	cbioportal
88	SLFNL1	Ssm	3	17	17.6%	cbioportal
87	SLC13A1	Ssm	3	17	17.6%	cbioportal
86	SERPINB2	Ssm	3	17	17.6%	cbioportal
69	NEB	Ssm	3	17	17.6%	cbioportal
60	GALNT17	Ssm	3	17	17.6%	cbioportal
95	UCP1	Ssm	3	17	17.6%	cbioportal
66	MMP16	Ssm	3	17	17.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Combined Hepatocellular and Intrahepatic Cholangiocarcinoma (Peking University, Cancer Cell 2019) hccihch_pku_2019Peking University

173 cases with simple somatic mutation data · 173 cases total · 2026-01-07 · mapped to Combined Hepatocellular Carcinoma and Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	74	173	42.8%	cbioportal
2	TTN	Ssm	28	173	16.2%	cbioportal
3	MUC16	Ssm	25	173	14.5%	cbioportal
4	CSMD3	Ssm	21	173	12.1%	cbioportal
5	ADGRV1	Ssm	18	173	10.4%	cbioportal
6	LRP1B	Ssm	17	173	9.8%	cbioportal
7	ABCA13	Ssm	16	173	9.2%	cbioportal
8	KMT2D	Ssm	15	173	8.7%	cbioportal
9	ARID1A

Data updated 22 days agoSource updated 2026-01-07

Disparities in metastatic colorectal cancer between Africans and Americans (MSK, 2020) crc_nigerian_2020MSK

64 cases with simple somatic mutation data · 64 cases total · 2026-01-07 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	37	64	57.8%	cbioportal
2	KRAS	Ssm	35	64	54.7%	cbioportal
3	APC	Ssm	28	64	43.8%	cbioportal
4	PIK3CA	Ssm	16	64	25%	cbioportal
9	TCF7L2	Ssm	13	55	23.6%	cbioportal
5	ARID1A	Ssm	15	64	23.4%	cbioportal
6	CREBBP	Ssm	14	64	21.9%	cbioportal
8	PTPRS	Ssm	13	64	20.3%	cbioportal
7	KMT2C	Ssm	13	64	20.3%	cbioportal
18	ZFHX3	Ssm	10	55	18.2%	cbioportal
10	CIC	Ssm	11	64	17.2%	cbioportal
11	PTPRT	Ssm	11	64	17.2%	cbioportal
12	SOX9	Ssm	11	64	17.2%	cbioportal
13	SPEN	Ssm	11	64	17.2%	cbioportal
17	RNF43	Ssm	10	64	15.6%	cbioportal
15	FAT1	Ssm	10	64	15.6%	cbioportal
14	AMER1	Ssm	10	64	15.6%	cbioportal
16	KMT2D	Ssm	10	64	15.6%	cbioportal
19	ALK	Ssm	9	64	14.1%	cbioportal
23	POLE	Ssm	9	64	14.1%	cbioportal
22	NOTCH3	Ssm	9	64	14.1%	cbioportal
21	NOTCH1	Ssm	9	64	14.1%	cbioportal
20	FLT4	Ssm	9	64	14.1%	cbioportal
26	BRCA2	Ssm	8	64	12.5%	cbioportal
24	ABL1	Ssm	8	64	12.5%	cbioportal
25	ARID1B	Ssm	8	64	12.5%	cbioportal
27	MLH1	Ssm	8	64	12.5%	cbioportal
28	NOTCH4	Ssm	8	64	12.5%	cbioportal
29	PIK3R1	Ssm	8	64	12.5%	cbioportal
30	RPS6KA4	Ssm	8	64	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophageal Adenocarcinoma (DFCI, Nat Genet 2013) esca_broadDFCI

151 cases with simple somatic mutation data · 151 cases total · 2026-01-07 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	106	151	70.2%	cbioportal
2	TTN	Ssm	81	151	53.6%	cbioportal
3	MUC16	Ssm	41	151	27.2%	cbioportal
4	SYNE1	Ssm	36	151	23.8%	cbioportal
5	LRP1B	Ssm	34	151	22.5%	cbioportal
6	FLG	Ssm	33	151	21.9%	cbioportal
7	SPTA1	Ssm	32	151	21.2%	cbioportal
8	PCLO	Ssm	31	151	20.5%	cbioportal
9	CSMD3	Ssm	26	151	17.2%	cbioportal
10	FAT3	Ssm	24	151	15.9%	cbioportal
11	PCDH15	Ssm	24	151	15.9%	cbioportal
12	CNTN6	Ssm	22	151	14.6%	cbioportal
14	PTPRD	Ssm	22	151	14.6%	cbioportal
13	CSMD1	Ssm	22	151	14.6%	cbioportal
15	FAT4	Ssm	21	151	13.9%	cbioportal
17	LAMA1	Ssm	21	151	13.9%	cbioportal
18	USH2A	Ssm	21	151	13.9%	cbioportal
16	HMCN1	Ssm	21	151	13.9%	cbioportal
20	CDKN2A	Ssm	20	151	13.2%	cbioportal
19	APOB	Ssm	20	151	13.2%	cbioportal
21	ZNF804B	Ssm	19	151	12.6%	cbioportal
24	RIMS2	Ssm	18	151	11.9%	cbioportal
25	RYR2	Ssm	18	151	11.9%	cbioportal
22	DOCK2	Ssm	18	151	11.9%	cbioportal
23	PCDH17	Ssm	18	151	11.9%	cbioportal
26	ZFHX4	Ssm	18	151	11.9%	cbioportal
28	RYR3	Ssm	16	151	10.6%	cbioportal
27	CUBN	Ssm	16	151	10.6%	cbioportal
30	ERBB4	Ssm	15	151	9.9%	cbioportal
34	SACS	Ssm	15	151	9.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophageal Adenocarcinoma (TCGA GDC, 2025) esca_tcga_gdcTCGA GDC

185 cases with simple somatic mutation data · 186 cases total · 2026-01-13 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	156	185	84.3%	cbioportal
2	TTN	Ssm	75	185	40.5%	cbioportal
3	MUC16	Ssm	40	185	21.6%	cbioportal
4	CSMD3	Ssm	35	185	18.9%	cbioportal
5	SYNE1	Ssm	33	185	17.8%	cbioportal
6	FLG	Ssm	27	185	14.6%	cbioportal
7	LRP1B	Ssm	27	185	14.6%	cbioportal
8	DNAH5	Ssm	26	185	14.1%	cbioportal
9	PCLO	Ssm	25	185	13.5%	cbioportal
10	HMCN1	Ssm	24	185	13%	cbioportal
11	KMT2D	Ssm	22	185	11.9%	cbioportal
12	RYR2	Ssm	22	185	11.9%	cbioportal
13	CSMD1	Ssm	20	185	10.8%	cbioportal
15	ZNF804B	Ssm	19	185	10.3%	cbioportal
14	FAT3	Ssm	19	185	10.3%	cbioportal
17	SPTA1	Ssm	18	185	9.7%	cbioportal
18	UNC13C	Ssm	18	185	9.7%	cbioportal
16	SACS	Ssm	18	185	9.7%	cbioportal
19	NFE2L2	Ssm	17	185	9.2%	cbioportal
20	NOTCH1	Ssm	17	185	9.2%	cbioportal
21	RYR3	Ssm	17	185	9.2%	cbioportal
26	PCDH15	Ssm	16	185	8.6%	cbioportal
22	COL11A1	Ssm	16	185	8.6%	cbioportal
23	DYNC2H1	Ssm	16	185	8.6%	cbioportal
24	LAMA1	Ssm	16	185	8.6%	cbioportal
25	OBSCN	Ssm	16	185	8.6%	cbioportal
27	PIK3CA	Ssm	16	185	8.6%	cbioportal
28	ADGRV1	Ssm	15	185	8.1%	cbioportal
29	ARID1A	Ssm	15	185	8.1%	cbioportal
30	CNTNAP5	Ssm	15	185	8.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Esophageal Adenocarcinoma (TCGA, PanCancer Atlas) esca_tcga_pan_can_atlas_2018TCGA

182 cases with simple somatic mutation data · 182 cases total · 2026-06-05 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	158	182	86.8%	cbioportal
2	TTN	Ssm	75	182	41.2%	cbioportal
3	MUC16	Ssm	43	182	23.6%	cbioportal
4	SYNE1	Ssm	37	182	20.3%	cbioportal
5	CSMD3	Ssm	35	182	19.2%	cbioportal
6	FLG	Ssm	32	182	17.6%	cbioportal
8	LRP1B	Ssm	31	182	17%	cbioportal
7	HMCN1	Ssm	31	182	17%	cbioportal
9	DNAH5	Ssm	30	182	16.5%	cbioportal
10	PCLO	Ssm	27	182	14.8%	cbioportal
11	RYR2	Ssm	23	182	12.6%	cbioportal
12	EYS	Ssm	22	182	12.1%	cbioportal
13	KMT2D	Ssm	22	182	12.1%	cbioportal
14	CSMD1	Ssm	21	182	11.5%	cbioportal
18	UNC13C	Ssm	20	182	11%	cbioportal
15	FAT3	Ssm	20	182	11%	cbioportal
16	PKHD1L1	Ssm	20	182	11%	cbioportal
17	SPTA1	Ssm	20	182	11%	cbioportal
22	ZNF804B	Ssm	19	182	10.4%	cbioportal
21	PCDH15	Ssm	19	182	10.4%	cbioportal
20	OBSCN	Ssm	19	182	10.4%	cbioportal
19	DYNC2H1	Ssm	19	182	10.4%	cbioportal
25	USH2A	Ssm	18	182	9.9%	cbioportal
24	SACS	Ssm	18	182	9.9%	cbioportal
23	NFE2L2	Ssm	18	182	9.9%	cbioportal
30	PIK3CA	Ssm	17	182	9.3%	cbioportal
29	MUC4	Ssm	17	182	9.3%	cbioportal
26	CNTNAP5	Ssm	17	182	9.3%	cbioportal
27	LAMA1	Ssm	17	182	9.3%	cbioportal
28	LRRK2	Ssm	17	182	9.3%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Esophageal Cancer-TRAP Project (MSK, Lancet Oncol 2020) egc_trap_msk_2020MSK

63 cases with simple somatic mutation data · 68 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	45	63	71.4%	cbioportal
3	TTN	Ssm	11	31	35.5%	cbioportal
6	PCLO	Ssm	7	31	22.6%	cbioportal
5	LRP1B	Ssm	7	31	22.6%	cbioportal
7	SYNE1	Ssm	7	31	22.6%	cbioportal
10	CSMD2	Ssm	6	31	19.4%	cbioportal
11	OBSCN	Ssm	6	31	19.4%	cbioportal
2	CDKN2A	Ssm	11	63	17.5%	cbioportal
23	UNC13C	Ssm	5	31	16.1%	cbioportal
15	CUBN	Ssm	5	31	16.1%	cbioportal
21	TENM4	Ssm	5	31	16.1%	cbioportal
13	COL4A4	Ssm	5	31	16.1%	cbioportal
14	CSMD3	Ssm	5	31	16.1%	cbioportal
16	DNAH8	Ssm	5	31	16.1%	cbioportal
18	MUC16	Ssm	5	31	16.1%	cbioportal
19	MXRA5	Ssm	5	31	16.1%	cbioportal
4	PTPRT	Ssm	10	63	15.9%	cbioportal
37	GLI3	Ssm	4	31	12.9%	cbioportal
41	MAGEC1	Ssm	4	31	12.9%	cbioportal
35	FAT4	Ssm	4	31	12.9%	cbioportal
51	RIMS1	Ssm	4	31	12.9%	cbioportal
47	PLEC	Ssm	4	31	12.9%	cbioportal
36	FBN2	Ssm	4	31	12.9%	cbioportal
24	ABCA13	Ssm	4	31	12.9%	cbioportal
25	ANKS1B	Ssm	4	31	12.9%	cbioportal
46	PIEZO1	Ssm	4	31	12.9%	cbioportal
45	PABPC3	Ssm	4	31	12.9%	cbioportal
44	NRXN1	Ssm	4	31	12.9%	cbioportal
43	NRK	Ssm	4	31	12.9%	cbioportal
55	TTC6	Ssm	4	31	12.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophageal Carcinoma TCGA-ESCATCGA

185 cases with simple somatic mutation data · 185 cases total · Data Release 46.0 · mapped to Esophageal Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	167	185	90.3%	gdc
3	POU5F1B	Ssm	138	185	74.6%	gdc
4	TG	Ssm	138	185	74.6%	gdc
2	MYC	Ssm	138	185	74.6%	gdc
5	KCNQ3	Ssm	135	185	73%	gdc
9	LRATD2	Ssm	134	185	72.4%	gdc
6	GSDMC	Ssm	134	185	72.4%	gdc
7	ADCY8	Ssm	134	185	72.4%	gdc
8	CDKN2A	Ssm	134	185	72.4%	gdc
10	EFR3A	Ssm	133	185	71.9%	gdc
11	CDKN2B	Ssm	133	185	71.9%	gdc
18	ZFAT	Ssm	132	185	71.4%	gdc
16	HHLA1	Ssm	132	185	71.4%	gdc
15	ASAP1	Ssm	132	185	71.4%	gdc
14	TRIB1	Ssm	132	185	71.4%	gdc
13	KHDRBS3	Ssm	132	185	71.4%	gdc
12	NDRG1	Ssm	132	185	71.4%	gdc
20	AC100868.1	Ssm	132	185	71.4%	gdc
19	LRRC6	Ssm	132	185	71.4%	gdc
17	CCN4	Ssm	132	185	71.4%	gdc
22	OC90	Ssm	132	185	71.4%	gdc
21	SLA	Ssm	132	185	71.4%	gdc
29	ST3GAL1	Ssm	131	185	70.8%	gdc
24	PHF20L1	Ssm	131	185	70.8%	gdc
25	ZNF572	Ssm	131	185	70.8%	gdc
26	WASHC5	Ssm	131	185	70.8%	gdc
27	TMEM71	Ssm	131	185	70.8%	gdc
28	CYRIB	Ssm	131	185	70.8%	gdc
23	COL22A1	Ssm	131	185	70.8%	gdc
30	SAMD7	Ssm	130	185	70.3%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Esophageal Carcinoma (TCGA, Firehose Legacy) esca_tcgaTCGA

185 cases with simple somatic mutation data · 186 cases total · 2026-01-07 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	153	185	82.7%	cbioportal
2	TTN	Ssm	97	185	52.4%	cbioportal
3	MUC16	Ssm	51	185	27.6%	cbioportal
4	SYNE1	Ssm	44	185	23.8%	cbioportal
5	CSMD3	Ssm	40	185	21.6%	cbioportal
6	DNAH5	Ssm	35	185	18.9%	cbioportal
7	HMCN1	Ssm	34	185	18.4%	cbioportal
8	LRP1B	Ssm	33	185	17.8%	cbioportal
10	KMT2D	Ssm	32	185	17.3%	cbioportal
9	FLG	Ssm	32	185	17.3%	cbioportal
11	RYR2	Ssm	31	185	16.8%	cbioportal
13	PCLO	Ssm	29	185	15.7%	cbioportal
12	MUC4	Ssm	29	185	15.7%	cbioportal
14	USH2A	Ssm	29	185	15.7%	cbioportal
16	OBSCN	Ssm	27	185	14.6%	cbioportal
15	CSMD1	Ssm	27	185	14.6%	cbioportal
17	PKHD1L1	Ssm	26	185	14.1%	cbioportal
20	SPTA1	Ssm	25	185	13.5%	cbioportal
19	FAT4	Ssm	25	185	13.5%	cbioportal
18	FAT3	Ssm	25	185	13.5%	cbioportal
21	MUC12	Ssm	24	185	13%	cbioportal
22	DYNC2H1	Ssm	23	185	12.4%	cbioportal
24	XIRP2	Ssm	23	185	12.4%	cbioportal
23	RYR3	Ssm	23	185	12.4%	cbioportal
26	DST	Ssm	22	185	11.9%	cbioportal
25	ADGRV1	Ssm	22	185	11.9%	cbioportal
29	EYS	Ssm	21	185	11.4%	cbioportal
27	ATM	Ssm	21	185	11.4%	cbioportal
30	NEB	Ssm	21	185	11.4%	cbioportal
28	CDKN2A	Ssm	21	185	11.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophageal Carcinoma (TCGA, Nature 2017) stes_tcga_pubTCGA

518 cases with simple somatic mutation data · 559 cases total · 2026-01-13 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	309	518	59.7%	cbioportal
2	TTN	Ssm	276	518	53.3%	cbioportal
3	MUC16	Ssm	171	518	33%	cbioportal
4	SYNE1	Ssm	134	518	25.9%	cbioportal
5	LRP1B	Ssm	125	518	24.1%	cbioportal
6	CSMD3	Ssm	121	518	23.4%	cbioportal
7	FLG	Ssm	108	518	20.8%	cbioportal
8	ARID1A	Ssm	106	518	20.5%	cbioportal
10	OBSCN	Ssm	104	518	20.1%	cbioportal
9	CSMD1	Ssm	104	518	20.1%	cbioportal
11	PCLO	Ssm	103	518	19.9%	cbioportal
13	FAT4	Ssm	99	518	19.1%	cbioportal
12	DNAH5	Ssm	99	518	19.1%	cbioportal
14	RYR2	Ssm	98	518	18.9%	cbioportal
15	HMCN1	Ssm	92	518	17.8%	cbioportal
16	KMT2D	Ssm	91	518	17.6%	cbioportal
17	FAT3	Ssm	88	518	17%	cbioportal
18	SPTA1	Ssm	86	518	16.6%	cbioportal
19	ZFHX4	Ssm	80	518	15.4%	cbioportal
20	USH2A	Ssm	79	518	15.3%	cbioportal
21	PIK3CA	Ssm	77	518	14.9%	cbioportal
22	PCDH15	Ssm	76	518	14.7%	cbioportal
23	RYR3	Ssm	74	518	14.3%	cbioportal
25	SACS	Ssm	72	518	13.9%	cbioportal
24	LRRK2	Ssm	72	518	13.9%	cbioportal
26	DNAH11	Ssm	71	518	13.7%	cbioportal
27	DNAH7	Ssm	70	518	13.5%	cbioportal
30	MUC4	Ssm	67	518	12.9%	cbioportal
28	AHNAK2	Ssm	67	518	12.9%	cbioportal
29	DMD	Ssm	67	518	12.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Esophageal Squamous Cell Carcinoma (ICGC, Nature 2014) escc_icgcICGC

88 cases with simple somatic mutation data · 88 cases total · 2026-01-07 · mapped to Esophageal Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	73	88	83%	cbioportal
2	TTN	Ssm	28	88	31.8%	cbioportal
4	PCLO	Ssm	12	88	13.6%	cbioportal
3	MUC16	Ssm	12	88	13.6%	cbioportal
5	ZFHX4	Ssm	11	88	12.5%	cbioportal
6	LRP1B	Ssm	10	88	11.4%	cbioportal
8	NOTCH1	Ssm	8	88	9.1%	cbioportal
7	DMD	Ssm	8	88	9.1%	cbioportal
13	SYNE1	Ssm	7	88	8%	cbioportal
9	CSMD3	Ssm	7	88	8%	cbioportal
11	PKHD1L1	Ssm	7	88	8%	cbioportal
10	DNAH6	Ssm	7	88	8%	cbioportal
12	RB1	Ssm	7	88	8%	cbioportal
20	FAT4	Ssm	6	88	6.8%	cbioportal
21	MACF1	Ssm	6	88	6.8%	cbioportal
19	FAT3	Ssm	6	88	6.8%	cbioportal
18	FAM135B	Ssm	6	88	6.8%	cbioportal
17	DNAH17	Ssm	6	88	6.8%	cbioportal
16	DNAH14	Ssm	6	88	6.8%	cbioportal
15	CACNA1E	Ssm	6	88	6.8%	cbioportal
14	ADGRV1	Ssm	6	88	6.8%	cbioportal
24	USH2A	Ssm	6	88	6.8%	cbioportal
23	RYR2	Ssm	6	88	6.8%	cbioportal
22	RP1	Ssm	6	88	6.8%	cbioportal
35	THSD7A	Ssm	5	88	5.7%	cbioportal
32	GRIN2A	Ssm	5	88	5.7%	cbioportal
30	CREBBP	Ssm	5	88	5.7%	cbioportal
31	CSMD1	Ssm	5	88	5.7%	cbioportal
33	MAGEC3	Ssm	5	88	5.7%	cbioportal
29	COL6A3	Ssm	5	88	5.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophageal Squamous Cell Carcinoma (UCLA, Nat Genet 2014) escc_ucla_2014UCLA

139 cases with simple somatic mutation data · 139 cases total · 2026-01-07 · mapped to Esophageal Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	83	139	59.7%	cbioportal
2	TTN	Ssm	49	139	35.3%	cbioportal
180	ZNF676	Ssm	4	20	20%	cbioportal
152	MYH2	Ssm	4	20	20%	cbioportal
3	KMT2D	Ssm	25	139	18%	cbioportal
4	MUC16	Ssm	20	139	14.4%	cbioportal
5	SYNE1	Ssm	18	139	12.9%	cbioportal
6	FAT1	Ssm	16	139	11.5%	cbioportal
9	LRP1B	Ssm	15	139	10.8%	cbioportal
7	ADGRV1	Ssm	15	139	10.8%	cbioportal
8	CSMD3	Ssm	15	139	10.8%	cbioportal
10	PCLO	Ssm	14	139	10.1%	cbioportal
11	XIRP2	Ssm	13	139	9.4%	cbioportal
12	ABCA13	Ssm	12	139	8.6%	cbioportal
14	HMCN1	Ssm	12	139	8.6%	cbioportal
13	FAT2	Ssm	12	139	8.6%	cbioportal
15	MUC4	Ssm	12	139	8.6%	cbioportal
19	FSIP2	Ssm	11	139	7.9%	cbioportal
17	DNAH5	Ssm	11	139	7.9%	cbioportal
16	DMD	Ssm	11	139	7.9%	cbioportal
25	PIK3CA	Ssm	11	139	7.9%	cbioportal
26	RB1	Ssm	11	139	7.9%	cbioportal
23	MUC2	Ssm	11	139	7.9%	cbioportal
24	NOTCH1	Ssm	11	139	7.9%	cbioportal
18	EP300	Ssm	11	139	7.9%	cbioportal
21	LRP2	Ssm	11	139	7.9%	cbioportal
22	MUC17	Ssm	11	139	7.9%	cbioportal
20	KMT2C	Ssm	11	139	7.9%	cbioportal
28	FAT3	Ssm	10	139	7.2%	cbioportal
30	SYNE2	Ssm	10	139	7.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophagogastric Cancer (MSK, Clin Cancer Res 2022) egc_msk_tp53_ccr_2022MSK

237 cases with simple somatic mutation data · 237 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	185	237	78.1%	cbioportal
3	CDKN2A	Ssm	39	237	16.5%	cbioportal
2	ARID1A	Ssm	39	237	16.5%	cbioportal
5	PREX2	Ssm	24	198	12.1%	cbioportal
4	SMARCA4	Ssm	25	237	10.5%	cbioportal
6	PIK3CA	Ssm	22	237	9.3%	cbioportal
7	ERBB4	Ssm	21	237	8.9%	cbioportal
9	SMAD4	Ssm	21	237	8.9%	cbioportal
8	PTPRD	Ssm	21	237	8.9%	cbioportal
10	KMT2D	Ssm	20	237	8.4%	cbioportal
11	APC	Ssm	19	237	8%	cbioportal
14	ZFHX3	Ssm	17	228	7.5%	cbioportal
13	PTPRT	Ssm	17	237	7.2%	cbioportal
12	KRAS	Ssm	17	237	7.2%	cbioportal
15	EPHA5	Ssm	16	237	6.8%	cbioportal
16	BRCA2	Ssm	15	237	6.3%	cbioportal
22	KMT2B	Ssm	12	198	6.1%	cbioportal
17	ARID2	Ssm	13	237	5.5%	cbioportal
18	KMT2A	Ssm	13	237	5.5%	cbioportal
23	PTPRS	Ssm	12	237	5.1%	cbioportal
21	ERBB2	Ssm	12	237	5.1%	cbioportal
20	CREBBP	Ssm	12	237	5.1%	cbioportal
19	AR	Ssm	12	237	5.1%	cbioportal
30	NTRK3	Ssm	11	237	4.6%	cbioportal
26	FLT4	Ssm	11	237	4.6%	cbioportal
25	ERBB3	Ssm	11	237	4.6%	cbioportal
24	CIC	Ssm	11	237	4.6%	cbioportal
31	RNF43	Ssm	11	237	4.6%	cbioportal
28	NF1	Ssm	11	237	4.6%	cbioportal
27	IRS2	Ssm	11	237	4.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Esophagogastric Cancer (MSK, Clin Cancer Res 2023) egc_trap_ccr_msk_2023MSK

64 cases with simple somatic mutation data · 64 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	44	64	68.8%	cbioportal
2	TTN	Ssm	27	64	42.2%	cbioportal
3	PCLO	Ssm	17	64	26.6%	cbioportal
4	LRP1B	Ssm	14	64	21.9%	cbioportal
6	SYNE1	Ssm	14	64	21.9%	cbioportal
5	MUC16	Ssm	14	64	21.9%	cbioportal
7	CDKN2A	Ssm	12	64	18.8%	cbioportal
10	CUBN	Ssm	11	64	17.2%	cbioportal
11	OBSCN	Ssm	11	64	17.2%	cbioportal
9	CSMD2	Ssm	11	64	17.2%	cbioportal
8	COL4A4	Ssm	11	64	17.2%	cbioportal
16	TENM4	Ssm	10	64	15.6%	cbioportal
12	CNTNAP4	Ssm	10	64	15.6%	cbioportal
13	DNAH5	Ssm	10	64	15.6%	cbioportal
14	DNAH8	Ssm	10	64	15.6%	cbioportal
15	MYO18B	Ssm	10	64	15.6%	cbioportal
20	FLG	Ssm	9	64	14.1%	cbioportal
19	CSMD3	Ssm	9	64	14.1%	cbioportal
18	APOB	Ssm	9	64	14.1%	cbioportal
17	ABCA13	Ssm	9	64	14.1%	cbioportal
24	RYR3	Ssm	9	64	14.1%	cbioportal
23	RIMS2	Ssm	9	64	14.1%	cbioportal
22	MYT1L	Ssm	9	64	14.1%	cbioportal
21	MYH6	Ssm	9	64	14.1%	cbioportal
25	COL11A1	Ssm	8	64	12.5%	cbioportal
29	PTPRT	Ssm	8	64	12.5%	cbioportal
30	SDK1	Ssm	8	64	12.5%	cbioportal
31	TTC6	Ssm	8	64	12.5%	cbioportal
26	EPHA3	Ssm	8	64	12.5%	cbioportal
28	HMCN1	Ssm	8	64	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Gallbladder Cancer (MSK, 2022) gbc_mskcc_2022MSK

244 cases with simple somatic mutation data · 244 cases total · 2026-04-07 · mapped to Gallbladder Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	154	244	63.1%	cbioportal
2	SMAD4	Ssm	52	244	21.3%	cbioportal
3	ARID1A	Ssm	50	244	20.5%	cbioportal
7	ELF3	Ssm	21	191	11%	cbioportal
5	PIK3CA	Ssm	26	244	10.7%	cbioportal
4	CDKN2A	Ssm	26	244	10.7%	cbioportal
6	STK11	Ssm	22	244	9%	cbioportal
8	ARID2	Ssm	20	244	8.2%	cbioportal
9	KMT2C	Ssm	20	244	8.2%	cbioportal
10	ERBB2	Ssm	19	244	7.8%	cbioportal
152	SMARCA2	Ssm	3	40	7.5%	cbioportal
11	KRAS	Ssm	18	244	7.4%	cbioportal
13	ERBB3	Ssm	16	244	6.6%	cbioportal
14	KMT2D	Ssm	16	244	6.6%	cbioportal
12	ATM	Ssm	16	244	6.6%	cbioportal
16	TERT	Ssm	15	244	6.1%	cbioportal
15	CTNNB1	Ssm	15	244	6.1%	cbioportal
17	BRCA2	Ssm	13	244	5.3%	cbioportal
30	SLX4	Ssm	9	191	4.7%	cbioportal
28	PREX2	Ssm	9	191	4.7%	cbioportal
18	RBM10	Ssm	11	244	4.5%	cbioportal
19	KMT2A	Ssm	10	244	4.1%	cbioportal
22	RB1	Ssm	10	244	4.1%	cbioportal
20	NF1	Ssm	10	244	4.1%	cbioportal
21	PBRM1	Ssm	10	244	4.1%	cbioportal
29	RASA1	Ssm	9	244	3.7%	cbioportal
27	KEAP1	Ssm	9	244	3.7%	cbioportal
26	IKZF1	Ssm	9	244	3.7%	cbioportal
23	ATRX	Ssm	9	244	3.7%	cbioportal
24	AXIN1	Ssm	9	244	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Gallbladder Cancer (MSK, Cancer 2018) gbc_msk_2018MSK

103 cases with simple somatic mutation data · 103 cases total · 2026-01-07 · mapped to Gallbladder Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	60	103	58.3%	cbioportal
2	SMAD4	Ssm	27	103	26.2%	cbioportal
3	ARID1A	Ssm	26	103	25.2%	cbioportal
4	ATM	Ssm	16	103	15.5%	cbioportal
5	PIK3CA	Ssm	11	103	10.7%	cbioportal
7	TERT	Ssm	9	103	8.7%	cbioportal
6	KMT2D	Ssm	9	103	8.7%	cbioportal
8	KRAS	Ssm	8	103	7.8%	cbioportal
13	PBRM1	Ssm	7	103	6.8%	cbioportal
9	ARID1B	Ssm	7	103	6.8%	cbioportal
12	NF1	Ssm	7	103	6.8%	cbioportal
11	CDKN2A	Ssm	7	103	6.8%	cbioportal
10	ARID2	Ssm	7	103	6.8%	cbioportal
15	CTNNB1	Ssm	6	103	5.8%	cbioportal
14	BRCA2	Ssm	6	103	5.8%	cbioportal
16	ERBB3	Ssm	6	103	5.8%	cbioportal
24	PLCG2	Ssm	5	95	5.3%	cbioportal
20	KMT2C	Ssm	5	103	4.9%	cbioportal
18	BRAF	Ssm	5	103	4.9%	cbioportal
26	SMARCA4	Ssm	5	103	4.9%	cbioportal
17	AR	Ssm	5	103	4.9%	cbioportal
25	RB1	Ssm	5	103	4.9%	cbioportal
23	NOTCH3	Ssm	5	103	4.9%	cbioportal
22	NCOR1	Ssm	5	103	4.9%	cbioportal
21	MED12	Ssm	5	103	4.9%	cbioportal
19	KEAP1	Ssm	5	103	4.9%	cbioportal
30	FBXW7	Ssm	4	103	3.9%	cbioportal
32	MTOR	Ssm	4	103	3.9%	cbioportal
31	JAK1	Ssm	4	103	3.9%	cbioportal
29	EP300	Ssm	4	103	3.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Gallbladder Carcinoma (Shanghai, Nat Genet 2014) gbc_shanghai_2014Shanghai

32 cases with simple somatic mutation data · 32 cases total · 2026-01-07 · mapped to Gallbladder Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	8	32	25%	cbioportal
2	MUC16	Ssm	6	32	18.8%	cbioportal
3	TTN	Ssm	5	32	15.6%	cbioportal
6	ZNF521	Ssm	4	32	12.5%	cbioportal
5	KMT2C	Ssm	4	32	12.5%	cbioportal
4	CS	Ssm	4	32	12.5%	cbioportal
10	ERBB3	Ssm	3	32	9.4%	cbioportal
9	ERBB2	Ssm	3	32	9.4%	cbioportal
16	ZNF814	Ssm	3	32	9.4%	cbioportal
7	CHD8	Ssm	3	32	9.4%	cbioportal
8	DNAH7	Ssm	3	32	9.4%	cbioportal
15	ZNF804B	Ssm	3	32	9.4%	cbioportal
14	PPIG	Ssm	3	32	9.4%	cbioportal
13	NPEPPS	Ssm	3	32	9.4%	cbioportal
12	LILRA1	Ssm	3	32	9.4%	cbioportal
11	FCGBP	Ssm	3	32	9.4%	cbioportal
27	BAG3	Ssm	2	32	6.3%	cbioportal
20	AHNAK	Ssm	2	32	6.3%	cbioportal
19	ADAMTSL3	Ssm	2	32	6.3%	cbioportal
18	ABLIM3	Ssm	2	32	6.3%	cbioportal
17	ABCA13	Ssm	2	32	6.3%	cbioportal
30	BRCA1	Ssm	2	32	6.3%	cbioportal
29	BPTF	Ssm	2	32	6.3%	cbioportal
28	BAZ2B	Ssm	2	32	6.3%	cbioportal
22	ARHGEF7	Ssm	2	32	6.3%	cbioportal
23	ARID1A	Ssm	2	32	6.3%	cbioportal
24	ARID2	Ssm	2	32	6.3%	cbioportal
25	ATM	Ssm	2	32	6.3%	cbioportal
26	ATRX	Ssm	2	32	6.3%	cbioportal
21	AKAP11	Ssm	2	32	6.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Gastric Adenocarcinoma (TMUCIH, PNAS 2015) egc_tmucih_2015TMUCIH

78 cases with simple somatic mutation data · 78 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	36	78	46.2%	cbioportal
2	TTN	Ssm	34	78	43.6%	cbioportal
3	ARID1A	Ssm	17	78	21.8%	cbioportal
4	MUC16	Ssm	14	78	17.9%	cbioportal
6	CSMD3	Ssm	13	78	16.7%	cbioportal
5	COL11A1	Ssm	13	78	16.7%	cbioportal
7	PCLO	Ssm	13	78	16.7%	cbioportal
8	ZFHX4	Ssm	13	78	16.7%	cbioportal
9	LRP1B	Ssm	12	78	15.4%	cbioportal
10	SYNE1	Ssm	12	78	15.4%	cbioportal
11	CDH1	Ssm	11	78	14.1%	cbioportal
12	HMCN1	Ssm	11	78	14.1%	cbioportal
13	DNAH5	Ssm	10	78	12.8%	cbioportal
14	FAT4	Ssm	10	78	12.8%	cbioportal
15	PIK3CA	Ssm	10	78	12.8%	cbioportal
16	APC	Ssm	9	78	11.5%	cbioportal
17	DNAH7	Ssm	9	78	11.5%	cbioportal
18	FAT3	Ssm	9	78	11.5%	cbioportal
19	FREM2	Ssm	9	78	11.5%	cbioportal
20	PCDH9	Ssm	9	78	11.5%	cbioportal
21	USH2A	Ssm	9	78	11.5%	cbioportal
24	DMD	Ssm	8	78	10.3%	cbioportal
30	NALCN	Ssm	8	78	10.3%	cbioportal
29	MAGEC1	Ssm	8	78	10.3%	cbioportal
28	LRP2	Ssm	8	78	10.3%	cbioportal
27	LRBA	Ssm	8	78	10.3%	cbioportal
26	FSIP2	Ssm	8	78	10.3%	cbioportal
25	DYNC2H1	Ssm	8	78	10.3%	cbioportal
23	DCHS2	Ssm	8	78	10.3%	cbioportal
22	AKAP6	Ssm	8	78	10.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Gastric Cancer (OncoSG, 2018) stad_oncosg_2018OncoSG

147 cases with simple somatic mutation data · 147 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	70	147	47.6%	cbioportal
2	TTN	Ssm	59	147	40.1%	cbioportal
3	SYNE1	Ssm	36	147	24.5%	cbioportal
4	LRP1B	Ssm	32	147	21.8%	cbioportal
5	MUC16	Ssm	29	147	19.7%	cbioportal
6	DNAH5	Ssm	25	147	17%	cbioportal
7	CSMD1	Ssm	22	147	15%	cbioportal
8	NEB	Ssm	21	147	14.3%	cbioportal
10	OBSCN	Ssm	20	147	13.6%	cbioportal
9	FAT3	Ssm	20	147	13.6%	cbioportal
11	MUC19	Ssm	19	147	12.9%	cbioportal
15	XIRP2	Ssm	18	147	12.2%	cbioportal
13	RYR2	Ssm	18	147	12.2%	cbioportal
12	CSMD3	Ssm	18	147	12.2%	cbioportal
14	USH2A	Ssm	18	147	12.2%	cbioportal
18	EYS	Ssm	17	147	11.6%	cbioportal
16	ABCA13	Ssm	17	147	11.6%	cbioportal
19	NBEA	Ssm	17	147	11.6%	cbioportal
20	PCLO	Ssm	17	147	11.6%	cbioportal
21	SACS	Ssm	17	147	11.6%	cbioportal
22	SPTA1	Ssm	17	147	11.6%	cbioportal
17	ARID1A	Ssm	17	147	11.6%	cbioportal
26	SYNE2	Ssm	16	147	10.9%	cbioportal
25	RYR1	Ssm	16	147	10.9%	cbioportal
24	RIMS2	Ssm	16	147	10.9%	cbioportal
23	PAPPA2	Ssm	16	147	10.9%	cbioportal
28	COL11A1	Ssm	15	147	10.2%	cbioportal
27	ANK2	Ssm	15	147	10.2%	cbioportal
30	HMCN1	Ssm	15	147	10.2%	cbioportal
29	FSIP2	Ssm	15	147	10.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Hepatocellular Carcinoma (CLCA, Nature 2024) hcc_clca_2024CLCA

494 cases with simple somatic mutation data · 494 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	255	494	51.6%	cbioportal
3	TTN	Ssm	177	494	35.8%	cbioportal
2	TERT	Ssm	177	494	35.8%	cbioportal
4	MUC16	Ssm	105	494	21.3%	cbioportal
5	CTNNB1	Ssm	102	494	20.6%	cbioportal
6	ALB	Ssm	73	494	14.8%	cbioportal
7	PCLO	Ssm	67	494	13.6%	cbioportal
8	CSMD3	Ssm	65	494	13.2%	cbioportal
9	SYNE1	Ssm	60	494	12.1%	cbioportal
10	LRP1B	Ssm	59	494	11.9%	cbioportal
11	OBSCN	Ssm	59	494	11.9%	cbioportal
12	HMCN1	Ssm	58	494	11.7%	cbioportal
13	AXIN1	Ssm	57	494	11.5%	cbioportal
14	RYR2	Ssm	57	494	11.5%	cbioportal
15	APOB	Ssm	54	494	10.9%	cbioportal
16	ABCA13	Ssm	53	494	10.7%	cbioportal
17	PKHD1L1	Ssm	52	494	10.5%	cbioportal
19	FBN2	Ssm	51	494	10.3%	cbioportal
18	ARID1A	Ssm	51	494	10.3%	cbioportal
20	FAT3	Ssm	50	494	10.1%	cbioportal
21	ADGRV1	Ssm	47	494	9.5%	cbioportal
22	RYR3	Ssm	47	494	9.5%	cbioportal
23	CSMD1	Ssm	43	494	8.7%	cbioportal
24	USH2A	Ssm	43	494	8.7%	cbioportal
25	CSMD2	Ssm	41	494	8.3%	cbioportal
27	XIRP2	Ssm	41	494	8.3%	cbioportal
26	RYR1	Ssm	41	494	8.3%	cbioportal
28	SPTA1	Ssm	40	494	8.1%	cbioportal
29	MUC17	Ssm	39	494	7.9%	cbioportal
31	EYS	Ssm	37	494	7.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Hepatocellular Carcinoma (MERiC/Basel, Nat Commun. 2022) hcc_meric_2021MERiC/Basel

122 cases with simple somatic mutation data · 122 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CTNNB1	Ssm	45	122	36.9%	cbioportal
2	TP53	Ssm	41	122	33.6%	cbioportal
3	TTN	Ssm	29	122	23.8%	cbioportal
5	PCLO	Ssm	24	122	19.7%	cbioportal
4	ARID1A	Ssm	24	122	19.7%	cbioportal
6	OBSCN	Ssm	19	122	15.6%	cbioportal
7	MUC16	Ssm	18	122	14.8%	cbioportal
8	ALB	Ssm	17	122	13.9%	cbioportal
9	FLG	Ssm	17	122	13.9%	cbioportal
10	APOB	Ssm	15	122	12.3%	cbioportal
11	CSMD3	Ssm	15	122	12.3%	cbioportal
12	MUC4	Ssm	13	122	10.7%	cbioportal
13	SYNE1	Ssm	13	122	10.7%	cbioportal
15	XIRP2	Ssm	12	122	9.8%	cbioportal
14	ADGRV1	Ssm	12	122	9.8%	cbioportal
16	ABCA13	Ssm	11	122	9%	cbioportal
17	HYDIN	Ssm	11	122	9%	cbioportal
18	LRP1B	Ssm	11	122	9%	cbioportal
20	FBN1	Ssm	10	122	8.2%	cbioportal
19	COL22A1	Ssm	10	122	8.2%	cbioportal
21	HMCN1	Ssm	10	122	8.2%	cbioportal
28	FASN	Ssm	9	122	7.4%	cbioportal
29	FAT3	Ssm	9	122	7.4%	cbioportal
27	DNAH5	Ssm	9	122	7.4%	cbioportal
25	CSMD2	Ssm	9	122	7.4%	cbioportal
30	GPAM	Ssm	9	122	7.4%	cbioportal
24	CDKN1A	Ssm	9	122	7.4%	cbioportal
23	APC	Ssm	9	122	7.4%	cbioportal
26	DNAH17	Ssm	9	122	7.4%	cbioportal
22	ANK3	Ssm	9	122	7.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Hepatocellular Carcinoma (MSK, Clin Cancer Res 2018) hcc_mskimpact_2018MSK

127 cases with simple somatic mutation data · 127 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	68	127	53.5%	cbioportal
2	CTNNB1	Ssm	44	127	34.6%	cbioportal
3	TP53	Ssm	39	127	30.7%	cbioportal
4	ARID1A	Ssm	17	127	13.4%	cbioportal
5	TSC2	Ssm	11	127	8.7%	cbioportal
50	PREX2	Ssm	3	36	8.3%	cbioportal
6	NFE2L2	Ssm	8	127	6.3%	cbioportal
8	AXIN1	Ssm	7	127	5.5%	cbioportal
10	KMT2D	Ssm	7	127	5.5%	cbioportal
7	APC	Ssm	7	127	5.5%	cbioportal
11	SF3B1	Ssm	7	127	5.5%	cbioportal
9	JAK1	Ssm	7	127	5.5%	cbioportal
12	ARID2	Ssm	6	127	4.7%	cbioportal
13	BAP1	Ssm	6	127	4.7%	cbioportal
23	ZRSR2	Ssm	5	106	4.7%	cbioportal
19	NOTCH1	Ssm	5	127	3.9%	cbioportal
22	SETD2	Ssm	5	127	3.9%	cbioportal
20	PTPRT	Ssm	5	127	3.9%	cbioportal
18	KMT2A	Ssm	5	127	3.9%	cbioportal
17	KDR	Ssm	5	127	3.9%	cbioportal
16	IGF1R	Ssm	5	127	3.9%	cbioportal
15	CDKN1A	Ssm	5	127	3.9%	cbioportal
14	ALK	Ssm	5	127	3.9%	cbioportal
21	RB1	Ssm	5	127	3.9%	cbioportal
35	ZFHX3	Ssm	4	106	3.8%	cbioportal
25	CREBBP	Ssm	4	127	3.1%	cbioportal
31	PBRM1	Ssm	4	127	3.1%	cbioportal
27	KIT	Ssm	4	127	3.1%	cbioportal
26	KDM5A	Ssm	4	127	3.1%	cbioportal
24	CDKN2A	Ssm	4	127	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Hepatocellular Carcinoma (MSK, Clin Cancer Res 2024) hcc_msk_2024MSK

1,370 cases with simple somatic mutation data · 1,370 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	466	1,370	34%	cbioportal
2	ARID1A	Ssm	226	1,370	16.5%	cbioportal
3	TERT	Ssm	225	1,370	16.4%	cbioportal
4	KRAS	Ssm	152	1,370	11.1%	cbioportal
5	IDH1	Ssm	141	1,370	10.3%	cbioportal
6	CTNNB1	Ssm	132	1,370	9.6%	cbioportal
7	BAP1	Ssm	117	1,370	8.5%	cbioportal
85	ALB	Ssm	18	221	8.1%	cbioportal
8	SMAD4	Ssm	103	1,370	7.5%	cbioportal
9	PBRM1	Ssm	95	1,370	6.9%	cbioportal
10	ATM	Ssm	74	1,370	5.4%	cbioportal
11	KMT2C	Ssm	69	1,370	5%	cbioportal
13	PIK3CA	Ssm	67	1,370	4.9%	cbioportal
12	ARID2	Ssm	67	1,370	4.9%	cbioportal
18	ELF3	Ssm	47	998	4.7%	cbioportal
14	KMT2D	Ssm	64	1,370	4.7%	cbioportal
15	CDKN2A	Ssm	62	1,370	4.5%	cbioportal
16	BRAF	Ssm	52	1,370	3.8%	cbioportal
32	PREX2	Ssm	35	998	3.5%	cbioportal
17	NF1	Ssm	48	1,370	3.5%	cbioportal
20	RB1	Ssm	44	1,370	3.2%	cbioportal
19	ERBB3	Ssm	44	1,370	3.2%	cbioportal
21	KMT2A	Ssm	42	1,370	3.1%	cbioportal
24	STK11	Ssm	41	1,370	3%	cbioportal
22	APC	Ssm	41	1,370	3%	cbioportal
23	FGFR2	Ssm	41	1,370	3%	cbioportal
41	KMT2B	Ssm	29	998	2.9%	cbioportal
28	ZFHX3	Ssm	37	1,284	2.9%	cbioportal
25	AXIN1	Ssm	39	1,370	2.8%	cbioportal
27	RASA1	Ssm	37	1,370	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Hepatocellular Carcinoma (MSK, JCO Precis Oncol 2023) hcc_jcopo_msk_2023MSK

90 cases with simple somatic mutation data · 90 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	54	90	60%	cbioportal
2	TP53	Ssm	45	90	50%	cbioportal
3	CTNNB1	Ssm	35	90	38.9%	cbioportal
4	TSC2	Ssm	26	90	28.9%	cbioportal
28	ALB	Ssm	2	7	28.6%	cbioportal
5	ARID1A	Ssm	20	90	22.2%	cbioportal
103	SETDB1	Ssm	1	7	14.3%	cbioportal
9	AXIN1	Ssm	5	37	13.5%	cbioportal
15	CDKN1A	Ssm	4	37	10.8%	cbioportal
6	PIK3CA	Ssm	9	90	10%	cbioportal
7	APC	Ssm	8	90	8.9%	cbioportal
25	PTPRD	Ssm	3	37	8.1%	cbioportal
23	KMT2D	Ssm	3	37	8.1%	cbioportal
8	NF1	Ssm	7	90	7.8%	cbioportal
42	KMT2B	Ssm	2	27	7.4%	cbioportal
54	ZFHX3	Ssm	2	35	5.7%	cbioportal
34	EPHA7	Ssm	2	35	5.7%	cbioportal
39	H3-4	Ssm	2	35	5.7%	cbioportal
55	ZRSR2	Ssm	2	35	5.7%	cbioportal
48	PPM1D	Ssm	2	35	5.7%	cbioportal
11	NFE2L2	Ssm	5	90	5.6%	cbioportal
10	KDM6A	Ssm	5	90	5.6%	cbioportal
12	PAK5	Ssm	5	90	5.6%	cbioportal
31	BAP1	Ssm	2	37	5.4%	cbioportal
32	CDK12	Ssm	2	37	5.4%	cbioportal
40	INPP4B	Ssm	2	37	5.4%	cbioportal
17	PTCH1	Ssm	4	90	4.4%	cbioportal
19	TSC1	Ssm	4	90	4.4%	cbioportal
16	DNMT3A	Ssm	4	90	4.4%	cbioportal
13	ATM	Ssm	4	90	4.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Hepatocellular Carcinomas (INSERM, Nat Genet 2015) hcc_inserm_fr_2015INSERM

243 cases with simple somatic mutation data · 243 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	139	243	57.2%	cbioportal
2	CTNNB1	Ssm	88	243	36.2%	cbioportal
3	TP53	Ssm	54	243	22.2%	cbioportal
4	TTN	Ssm	52	243	21.4%	cbioportal
5	MUC16	Ssm	28	243	11.5%	cbioportal
6	ALB	Ssm	27	243	11.1%	cbioportal
7	ARID1A	Ssm	24	243	9.9%	cbioportal
8	APOB	Ssm	22	243	9.1%	cbioportal
10	PCLO	Ssm	21	243	8.6%	cbioportal
9	AXIN1	Ssm	21	243	8.6%	cbioportal
11	CSMD1	Ssm	20	243	8.2%	cbioportal
12	RYR2	Ssm	20	243	8.2%	cbioportal
13	OBSCN	Ssm	19	243	7.8%	cbioportal
14	COL11A1	Ssm	18	243	7.4%	cbioportal
15	DNAH7	Ssm	16	243	6.6%	cbioportal
19	PCDH15	Ssm	15	243	6.2%	cbioportal
16	ARID2	Ssm	15	243	6.2%	cbioportal
17	CSMD3	Ssm	15	243	6.2%	cbioportal
18	FBN2	Ssm	15	243	6.2%	cbioportal
20	RPS6KA3	Ssm	15	243	6.2%	cbioportal
21	DNAH9	Ssm	14	243	5.8%	cbioportal
22	KMT2D	Ssm	14	243	5.8%	cbioportal
23	LRP1B	Ssm	14	243	5.8%	cbioportal
24	NFE2L2	Ssm	14	243	5.8%	cbioportal
25	RYR1	Ssm	14	243	5.8%	cbioportal
26	SPTA1	Ssm	14	243	5.8%	cbioportal
27	USH2A	Ssm	14	243	5.8%	cbioportal
28	FRAS1	Ssm	13	243	5.3%	cbioportal
29	ATM	Ssm	12	243	4.9%	cbioportal
30	DNAH5	Ssm	12	243	4.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Hepatocellular Carcinoma (TCGA GDC, 2025) hcc_tcga_gdcTCGA GDC

370 cases with simple somatic mutation data · 379 cases total · 2026-01-13 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	107	370	28.9%	cbioportal
2	CTNNB1	Ssm	95	370	25.7%	cbioportal
3	TTN	Ssm	90	370	24.3%	cbioportal
4	MUC16	Ssm	59	370	15.9%	cbioportal
5	ALB	Ssm	48	370	13%	cbioportal
6	PCLO	Ssm	42	370	11.4%	cbioportal
7	RYR2	Ssm	34	370	9.2%	cbioportal
8	LRP1B	Ssm	32	370	8.6%	cbioportal
9	APOB	Ssm	31	370	8.4%	cbioportal
11	XIRP2	Ssm	29	370	7.8%	cbioportal
10	CSMD3	Ssm	29	370	7.8%	cbioportal
12	ARID1A	Ssm	28	370	7.6%	cbioportal
13	OBSCN	Ssm	28	370	7.6%	cbioportal
14	ABCA13	Ssm	27	370	7.3%	cbioportal
15	FLG	Ssm	27	370	7.3%	cbioportal
17	HMCN1	Ssm	26	370	7%	cbioportal
16	AXIN1	Ssm	26	370	7%	cbioportal
18	CACNA1E	Ssm	25	370	6.8%	cbioportal
19	CUBN	Ssm	24	370	6.5%	cbioportal
21	USH2A	Ssm	24	370	6.5%	cbioportal
20	SPTA1	Ssm	24	370	6.5%	cbioportal
23	DNAH7	Ssm	23	370	6.2%	cbioportal
24	DOCK2	Ssm	23	370	6.2%	cbioportal
22	ADGRV1	Ssm	23	370	6.2%	cbioportal
25	RYR1	Ssm	22	370	5.9%	cbioportal
26	COL11A1	Ssm	21	370	5.7%	cbioportal
27	CSMD1	Ssm	21	370	5.7%	cbioportal
28	DMD	Ssm	21	370	5.7%	cbioportal
29	FAT3	Ssm	21	370	5.7%	cbioportal
30	PRKDC	Ssm	21	370	5.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Intrahepatic Cholangiocarcinoma (JHU, Nat Genet 2013) chol_jhu_2013JHU

40 cases with simple somatic mutation data · 40 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	TP53	Ssm	8	40	20%	cbioportal
1	BAP1	Ssm	8	40	20%	cbioportal
3	PBRM1	Ssm	7	40	17.5%	cbioportal
4	ARID1A	Ssm	6	40	15%	cbioportal
6	IDH1	Ssm	4	40	10%	cbioportal
5	FGFR2	Ssm	4	40	10%	cbioportal
7	TTN	Ssm	4	40	10%	cbioportal
14	FAT1	Ssm	3	40	7.5%	cbioportal
13	EPHA2	Ssm	3	40	7.5%	cbioportal
12	DNAH9	Ssm	3	40	7.5%	cbioportal
11	DNAH6	Ssm	3	40	7.5%	cbioportal
10	DNAH11	Ssm	3	40	7.5%	cbioportal
9	CSMD3	Ssm	3	40	7.5%	cbioportal
8	CSMD1	Ssm	3	40	7.5%	cbioportal
19	SORCS3	Ssm	3	40	7.5%	cbioportal
20	UBE2O	Ssm	3	40	7.5%	cbioportal
18	PIK3CA	Ssm	3	40	7.5%	cbioportal
17	NIPBL	Ssm	3	40	7.5%	cbioportal
16	HRNR	Ssm	3	40	7.5%	cbioportal
15	FAT4	Ssm	3	40	7.5%	cbioportal
27	AKAP9	Ssm	2	40	5%	cbioportal
29	APOE	Ssm	2	40	5%	cbioportal
28	ALB	Ssm	2	40	5%	cbioportal
26	AHNAK	Ssm	2	40	5%	cbioportal
25	AGK	Ssm	2	40	5%	cbioportal
24	ADRA2B	Ssm	2	40	5%	cbioportal
23	ADAMTSL3	Ssm	2	40	5%	cbioportal
22	ADAMTS5	Ssm	2	40	5%	cbioportal
21	ADAMTS18	Ssm	2	40	5%	cbioportal
98	TSPOAP1	Ssm	2	40	5%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Intrahepatic Cholangiocarcinoma (Mount Sinai 2015) ihch_ismms_2015

8 cases with simple somatic mutation data · 8 cases total · 2026-01-07 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ACAN	Ssm	2	8	25%	cbioportal
2	ARAF	Ssm	2	8	25%	cbioportal
3	MUC16	Ssm	2	8	25%	cbioportal
29	CTDSP2	Ssm	1	8	12.5%	cbioportal
94	PLIN4	Ssm	1	8	12.5%	cbioportal
4	ABCD4	Ssm	1	8	12.5%	cbioportal
5	ACIN1	Ssm	1	8	12.5%	cbioportal
6	ADAMTS19	Ssm	1	8	12.5%	cbioportal
7	ADAMTSL1	Ssm	1	8	12.5%	cbioportal
8	ADCY2	Ssm	1	8	12.5%	cbioportal
9	ANKRD20A3P	Ssm	1	8	12.5%	cbioportal
10	ANKRD30A	Ssm	1	8	12.5%	cbioportal
26	CRIPAK	Ssm	1	8	12.5%	cbioportal
12	ANXA6	Ssm	1	8	12.5%	cbioportal
11	ANLN	Ssm	1	8	12.5%	cbioportal
27	CROT	Ssm	1	8	12.5%	cbioportal
28	CTC1	Ssm	1	8	12.5%	cbioportal
13	APPBP2	Ssm	1	8	12.5%	cbioportal
14	AQP5	Ssm	1	8	12.5%	cbioportal
15	ARID1A	Ssm	1	8	12.5%	cbioportal
16	ASRGL1	Ssm	1	8	12.5%	cbioportal
17	BPIFA1	Ssm	1	8	12.5%	cbioportal
18	CBLIF	Ssm	1	8	12.5%	cbioportal
19	CCDC181	Ssm	1	8	12.5%	cbioportal
20	CCL7	Ssm	1	8	12.5%	cbioportal
21	CEACAM5	Ssm	1	8	12.5%	cbioportal
22	CEP295	Ssm	1	8	12.5%	cbioportal
23	CFAP20	Ssm	1	8	12.5%	cbioportal
24	CFAP43	Ssm	1	8	12.5%	cbioportal
25	CIT	Ssm	1	8	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Intrahepatic Cholangiocarcinoma (MSK, Clin Cancer Res 2021) ihch_mskcc_2020MSK

199 cases with simple somatic mutation data · 219 cases total · 2026-04-07 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	45	199	22.6%	cbioportal
2	BAP1	Ssm	39	199	19.6%	cbioportal
3	ARID1A	Ssm	35	199	17.6%	cbioportal
4	TP53	Ssm	32	199	16.1%	cbioportal
5	PBRM1	Ssm	25	199	12.6%	cbioportal
6	KRAS	Ssm	19	199	9.5%	cbioportal
7	RASA1	Ssm	10	199	5%	cbioportal
8	BRAF	Ssm	9	199	4.5%	cbioportal
11	PIK3CA	Ssm	8	199	4%	cbioportal
9	FGFR2	Ssm	8	199	4%	cbioportal
10	IDH2	Ssm	8	199	4%	cbioportal
12	ARID2	Ssm	7	199	3.5%	cbioportal
16	PTPRT	Ssm	7	199	3.5%	cbioportal
15	NRAS	Ssm	7	199	3.5%	cbioportal
14	CDKN2A	Ssm	7	199	3.5%	cbioportal
13	ATM	Ssm	7	199	3.5%	cbioportal
69	TP53BP1	Ssm	3	89	3.4%	cbioportal
61	PREX2	Ssm	3	89	3.4%	cbioportal
43	ELF3	Ssm	3	89	3.4%	cbioportal
68	SOS1	Ssm	3	89	3.4%	cbioportal
20	TERT	Ssm	6	199	3%	cbioportal
19	PTEN	Ssm	6	199	3%	cbioportal
18	KMT2D	Ssm	6	199	3%	cbioportal
17	ATRX	Ssm	6	199	3%	cbioportal
23	RB1	Ssm	5	199	2.5%	cbioportal
24	SMARCA4	Ssm	5	199	2.5%	cbioportal
21	DOT1L	Ssm	5	199	2.5%	cbioportal
22	RARA	Ssm	5	199	2.5%	cbioportal
37	ZFHX3	Ssm	4	174	2.3%	cbioportal
101	KMT2B	Ssm	2	89	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021) ihch_msk_2021MSK

412 cases with simple somatic mutation data · 412 cases total · 2026-01-07 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	85	412	20.6%	cbioportal
2	ARID1A	Ssm	78	412	18.9%	cbioportal
3	BAP1	Ssm	72	412	17.5%	cbioportal
4	TP53	Ssm	70	412	17%	cbioportal
5	PBRM1	Ssm	44	412	10.7%	cbioportal
6	KRAS	Ssm	39	412	9.5%	cbioportal
7	BRAF	Ssm	26	412	6.3%	cbioportal
8	ATM	Ssm	20	412	4.9%	cbioportal
9	TERT	Ssm	20	412	4.9%	cbioportal
19	PREX2	Ssm	10	225	4.4%	cbioportal
11	IDH2	Ssm	18	412	4.4%	cbioportal
10	FGFR2	Ssm	18	412	4.4%	cbioportal
12	PIK3CA	Ssm	17	412	4.1%	cbioportal
13	RASA1	Ssm	17	412	4.1%	cbioportal
14	SMARCA4	Ssm	15	412	3.6%	cbioportal
15	ARID2	Ssm	14	412	3.4%	cbioportal
17	NRAS	Ssm	13	412	3.2%	cbioportal
16	KMT2D	Ssm	13	412	3.2%	cbioportal
18	KMT2C	Ssm	12	412	2.9%	cbioportal
21	ZFHX3	Ssm	10	372	2.7%	cbioportal
52	ELF3	Ssm	6	225	2.7%	cbioportal
20	PTEN	Ssm	10	412	2.4%	cbioportal
75	KMT2B	Ssm	5	225	2.2%	cbioportal
23	ARAF	Ssm	9	412	2.2%	cbioportal
26	CDKN2A	Ssm	9	412	2.2%	cbioportal
22	ABL1	Ssm	9	412	2.2%	cbioportal
24	ARID1B	Ssm	9	412	2.2%	cbioportal
25	ATRX	Ssm	9	412	2.2%	cbioportal
27	FAT1	Ssm	9	412	2.2%	cbioportal
28	NF1	Ssm	9	412	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Intrahepatic Cholangiocarcinoma (Shanghai, Nat Commun 2014) ihch_smmu_2014Shanghai

103 cases with simple somatic mutation data · 103 cases total · 2026-01-07 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	42	103	40.8%	cbioportal
2	HLA-A	Ssm	18	103	17.5%	cbioportal
3	KRAS	Ssm	17	103	16.5%	cbioportal
4	GAS8-AS1	Ssm	16	103	15.5%	cbioportal
5	TTN	Ssm	15	103	14.6%	cbioportal
6	FAM230A	Ssm	13	103	12.6%	cbioportal
7	HLA-C	Ssm	13	103	12.6%	cbioportal
8	MUC16	Ssm	13	103	12.6%	cbioportal
9	AHNAK2	Ssm	12	103	11.7%	cbioportal
10	MUC21	Ssm	11	103	10.7%	cbioportal
13	MUC3A	Ssm	10	103	9.7%	cbioportal
11	HLA-B	Ssm	10	103	9.7%	cbioportal
12	MUC2	Ssm	10	103	9.7%	cbioportal
14	ODF1	Ssm	10	103	9.7%	cbioportal
17	FAM135B	Ssm	9	103	8.7%	cbioportal
20	OBSCN	Ssm	9	103	8.7%	cbioportal
19	LILRA6	Ssm	9	103	8.7%	cbioportal
18	HMCN1	Ssm	9	103	8.7%	cbioportal
16	CDC27	Ssm	9	103	8.7%	cbioportal
15	ARSD	Ssm	9	103	8.7%	cbioportal
23	HRNR	Ssm	8	103	7.8%	cbioportal
22	GGT2P	Ssm	8	103	7.8%	cbioportal
25	PER3	Ssm	8	103	7.8%	cbioportal
24	MAGEC1	Ssm	8	103	7.8%	cbioportal
21	CEP89	Ssm	8	103	7.8%	cbioportal
29	DLC1	Ssm	7	103	6.8%	cbioportal
30	EPPK1	Ssm	7	103	6.8%	cbioportal
28	BPTF	Ssm	7	103	6.8%	cbioportal
27	ARID1A	Ssm	7	103	6.8%	cbioportal
26	ADAMTS7	Ssm	7	103	6.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Liver Hepatocellular Adenoma and Carcinomas (MSK, PLOS One 2018) hcc_msk_venturaa_2018MSK

19 cases with simple somatic mutation data · 19 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	7	19	36.8%	cbioportal
4	TP53	Ssm	3	19	15.8%	cbioportal
2	CTNNB1	Ssm	3	19	15.8%	cbioportal
3	HNF1A	Ssm	3	19	15.8%	cbioportal
5	APC	Ssm	2	19	10.5%	cbioportal
6	PIK3CA	Ssm	2	19	10.5%	cbioportal
30	LATS1	Ssm	1	19	5.3%	cbioportal
20	EED	Ssm	1	19	5.3%	cbioportal
21	EP300	Ssm	1	19	5.3%	cbioportal
22	ERG	Ssm	1	19	5.3%	cbioportal
23	FAT1	Ssm	1	19	5.3%	cbioportal
24	GNAS	Ssm	1	19	5.3%	cbioportal
25	HGF	Ssm	1	19	5.3%	cbioportal
26	KDM6A	Ssm	1	19	5.3%	cbioportal
27	KEAP1	Ssm	1	19	5.3%	cbioportal
28	KMT2C	Ssm	1	19	5.3%	cbioportal
19	DNMT3B	Ssm	1	19	5.3%	cbioportal
29	KMT2D	Ssm	1	19	5.3%	cbioportal
7	ARID1A	Ssm	1	19	5.3%	cbioportal
12	BRCA1	Ssm	1	19	5.3%	cbioportal
13	BTK	Ssm	1	19	5.3%	cbioportal
14	CDK12	Ssm	1	19	5.3%	cbioportal
15	CDKN1A	Ssm	1	19	5.3%	cbioportal
16	CDKN1B	Ssm	1	19	5.3%	cbioportal
17	CTCF	Ssm	1	19	5.3%	cbioportal
18	CUL3	Ssm	1	19	5.3%	cbioportal
8	ARID2	Ssm	1	19	5.3%	cbioportal
9	ASXL2	Ssm	1	19	5.3%	cbioportal
10	ATM	Ssm	1	19	5.3%	cbioportal
11	BCOR	Ssm	1	19	5.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Liver Hepatocellular Carcinoma TCGA-LIHCTCGA

377 cases with simple somatic mutation data · 377 cases total · Data Release 46.0 · mapped to Hepatocellular Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ASH1L	Ssm	279	377	74%	gdc
2	RUSC1	Ssm	277	377	73.5%	gdc
4	THBS3	Ssm	276	377	73.2%	gdc
5	SLC50A1	Ssm	276	377	73.2%	gdc
6	PKLR	Ssm	276	377	73.2%	gdc
7	FAM189B	Ssm	276	377	73.2%	gdc
3	EFNA3	Ssm	276	377	73.2%	gdc
11	TRIM46	Ssm	275	377	72.9%	gdc
10	CLK2	Ssm	275	377	72.9%	gdc
8	AL691442.1	Ssm	275	377	72.9%	gdc
12	ADAM15	Ssm	275	377	72.9%	gdc
13	INSRR	Ssm	275	377	72.9%	gdc
14	DCST2	Ssm	275	377	72.9%	gdc
15	EFNA1	Ssm	275	377	72.9%	gdc
16	ZBTB7B	Ssm	275	377	72.9%	gdc
17	MTX1	Ssm	275	377	72.9%	gdc
18	FDPS	Ssm	275	377	72.9%	gdc
9	SCAMP3	Ssm	275	377	72.9%	gdc
28	KRTCAP2	Ssm	274	377	72.7%	gdc
30	YY1AP1	Ssm	274	377	72.7%	gdc
29	ARHGEF2	Ssm	274	377	72.7%	gdc
21	AL713999.2	Ssm	274	377	72.7%	gdc
19	EFNA4	Ssm	274	377	72.7%	gdc
20	KHDC4	Ssm	274	377	72.7%	gdc
22	MUC1	Ssm	274	377	72.7%	gdc
23	DCST1	Ssm	274	377	72.7%	gdc
24	LENEP	Ssm	274	377	72.7%	gdc
25	GBA	Ssm	274	377	72.7%	gdc
26	HCN3	Ssm	274	377	72.7%	gdc
27	DPM3	Ssm	274	377	72.7%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Liver Hepatocellular Carcinoma (AMC, Hepatology 2014) lihc_amc_prvAMC

231 cases with simple somatic mutation data · 231 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	71	231	30.7%	cbioportal
3	TTN	Ssm	52	231	22.5%	cbioportal
2	CTNNB1	Ssm	52	231	22.5%	cbioportal
4	MUC16	Ssm	40	231	17.3%	cbioportal
6	PCLO	Ssm	26	231	11.3%	cbioportal
5	HMCN1	Ssm	26	231	11.3%	cbioportal
7	ADGRV1	Ssm	25	231	10.8%	cbioportal
8	HYDIN	Ssm	21	231	9.1%	cbioportal
9	LRP1B	Ssm	19	231	8.2%	cbioportal
10	SYNE1	Ssm	19	231	8.2%	cbioportal
13	MUC4	Ssm	18	231	7.8%	cbioportal
11	APOB	Ssm	18	231	7.8%	cbioportal
12	DNAH5	Ssm	18	231	7.8%	cbioportal
16	VCAN	Ssm	18	231	7.8%	cbioportal
15	RYR3	Ssm	18	231	7.8%	cbioportal
14	RYR2	Ssm	18	231	7.8%	cbioportal
17	FBN2	Ssm	17	231	7.4%	cbioportal
18	PKHD1L1	Ssm	16	231	6.9%	cbioportal
19	ABCA13	Ssm	15	231	6.5%	cbioportal
23	XIRP2	Ssm	15	231	6.5%	cbioportal
22	LIAT1	Ssm	15	231	6.5%	cbioportal
21	FLG	Ssm	15	231	6.5%	cbioportal
20	CSMD3	Ssm	15	231	6.5%	cbioportal
27	OBSCN	Ssm	14	231	6.1%	cbioportal
26	MDN1	Ssm	14	231	6.1%	cbioportal
25	BLTP1	Ssm	14	231	6.1%	cbioportal
24	AXIN1	Ssm	14	231	6.1%	cbioportal
30	COL6A6	Ssm	13	231	5.6%	cbioportal
28	AHNAK2	Ssm	13	231	5.6%	cbioportal
29	CENPF	Ssm	13	231	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Liver Hepatocellular Carcinoma (RIKEN, Nat Genet 2012) lihc_rikenRIKEN

27 cases with simple somatic mutation data · 27 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved14 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	13	27	48.1%	cbioportal
2	ATM	Ssm	4	27	14.8%	cbioportal
6	WWP1	Ssm	3	27	11.1%	cbioportal
5	CTNNB1	Ssm	3	27	11.1%	cbioportal
4	BAZ2B	Ssm	3	27	11.1%	cbioportal
3	ARID1A	Ssm	3	27	11.1%	cbioportal
8	ERRFI1	Ssm	2	27	7.4%	cbioportal
7	ALB	Ssm	2	27	7.4%	cbioportal
9	GXYLT1	Ssm	2	27	7.4%	cbioportal
10	IGSF10	Ssm	2	27	7.4%	cbioportal
11	OTOP1	Ssm	2	27	7.4%	cbioportal
12	USP25	Ssm	2	27	7.4%	cbioportal
13	ZIC3	Ssm	2	27	7.4%	cbioportal
14	UBR3	Ssm	1	27	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Liver Hepatocellular Carcinoma (TCGA, Firehose Legacy) lihc_tcgaTCGA

373 cases with simple somatic mutation data · 379 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	115	373	30.8%	cbioportal
2	TTN	Ssm	105	373	28.2%	cbioportal
3	CTNNB1	Ssm	97	373	26%	cbioportal
4	MUC16	Ssm	54	373	14.5%	cbioportal
5	ALB	Ssm	43	373	11.5%	cbioportal
6	APOB	Ssm	39	373	10.5%	cbioportal
7	RYR2	Ssm	39	373	10.5%	cbioportal
8	PCLO	Ssm	35	373	9.4%	cbioportal
9	CSMD3	Ssm	33	373	8.8%	cbioportal
11	OBSCN	Ssm	33	373	8.8%	cbioportal
10	LRP1B	Ssm	33	373	8.8%	cbioportal
12	ABCA13	Ssm	32	373	8.6%	cbioportal
13	ARID1A	Ssm	32	373	8.6%	cbioportal
14	CACNA1E	Ssm	31	373	8.3%	cbioportal
15	RYR1	Ssm	30	373	8%	cbioportal
16	XIRP2	Ssm	29	373	7.8%	cbioportal
17	SPTA1	Ssm	28	373	7.5%	cbioportal
18	HMCN1	Ssm	27	373	7.2%	cbioportal
19	AHNAK2	Ssm	26	373	7%	cbioportal
22	USH2A	Ssm	26	373	7%	cbioportal
21	FRAS1	Ssm	26	373	7%	cbioportal
20	FLG	Ssm	26	373	7%	cbioportal
24	MUC4	Ssm	25	373	6.7%	cbioportal
23	FAT3	Ssm	25	373	6.7%	cbioportal
25	ADGRV1	Ssm	24	373	6.4%	cbioportal
26	ALMS1	Ssm	24	373	6.4%	cbioportal
27	AXIN1	Ssm	24	373	6.4%	cbioportal
28	DNAH6	Ssm	24	373	6.4%	cbioportal
29	CSMD1	Ssm	23	373	6.2%	cbioportal
30	DNAH7	Ssm	23	373	6.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Liver Hepatocellular Carcinoma (TCGA, PanCancer Atlas) lihc_tcga_pan_can_atlas_2018TCGA

366 cases with simple somatic mutation data · 372 cases total · 2026-06-03 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	110	366	30.1%	cbioportal
2	TTN	Ssm	98	366	26.8%	cbioportal
3	CTNNB1	Ssm	95	366	26%	cbioportal
4	MUC16	Ssm	60	366	16.4%	cbioportal
5	ALB	Ssm	47	366	12.8%	cbioportal
6	PCLO	Ssm	39	366	10.7%	cbioportal
7	RYR2	Ssm	37	366	10.1%	cbioportal
8	APOB	Ssm	35	366	9.6%	cbioportal
9	OBSCN	Ssm	35	366	9.6%	cbioportal
10	LRP1B	Ssm	33	366	9%	cbioportal
11	FLG	Ssm	32	366	8.7%	cbioportal
12	ABCA13	Ssm	31	366	8.5%	cbioportal
13	CSMD3	Ssm	30	366	8.2%	cbioportal
14	ARID1A	Ssm	29	366	7.9%	cbioportal
15	CACNA1E	Ssm	29	366	7.9%	cbioportal
16	XIRP2	Ssm	29	366	7.9%	cbioportal
17	FAT3	Ssm	27	366	7.4%	cbioportal
18	ADGRV1	Ssm	26	366	7.1%	cbioportal
19	HMCN1	Ssm	26	366	7.1%	cbioportal
20	AXIN1	Ssm	25	366	6.8%	cbioportal
21	SPTA1	Ssm	25	366	6.8%	cbioportal
22	USH2A	Ssm	25	366	6.8%	cbioportal
23	PRKDC	Ssm	24	366	6.6%	cbioportal
24	RYR1	Ssm	24	366	6.6%	cbioportal
25	CSMD1	Ssm	23	366	6.3%	cbioportal
26	DNAH7	Ssm	23	366	6.3%	cbioportal
27	DOCK2	Ssm	23	366	6.3%	cbioportal
28	CUBN	Ssm	22	366	6%	cbioportal
29	HERC2	Ssm	22	366	6%	cbioportal
30	FBN2	Ssm	21	366	5.7%	cbioportal

Data updated 22 days agoSource updated 2026-06-03

Metastatic Colorectal Cancer (MSK, Cancer Cell 2018) crc_msk_2017MSK

1,134 cases with simple somatic mutation data · 1,134 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	867	1,134	76.5%	cbioportal
2	TP53	Ssm	824	1,134	72.7%	cbioportal
3	KRAS	Ssm	495	1,134	43.7%	cbioportal
4	PIK3CA	Ssm	229	1,134	20.2%	cbioportal
5	SMAD4	Ssm	173	1,134	15.3%	cbioportal
8	TCF7L2	Ssm	124	920	13.5%	cbioportal
6	FBXW7	Ssm	145	1,134	12.8%	cbioportal
7	BRAF	Ssm	133	1,134	11.7%	cbioportal
10	SOX9	Ssm	107	1,134	9.4%	cbioportal
9	KMT2D	Ssm	107	1,134	9.4%	cbioportal
11	ARID1A	Ssm	104	1,134	9.2%	cbioportal
12	PTPRS	Ssm	102	1,134	9%	cbioportal
13	RNF43	Ssm	95	1,134	8.4%	cbioportal
14	ATM	Ssm	85	1,134	7.5%	cbioportal
15	NOTCH3	Ssm	85	1,134	7.5%	cbioportal
16	CTNNB1	Ssm	84	1,134	7.4%	cbioportal
22	ZFHX3	Ssm	68	920	7.4%	cbioportal
17	FAT1	Ssm	78	1,134	6.9%	cbioportal
18	PTPRT	Ssm	78	1,134	6.9%	cbioportal
38	MGA	Ssm	57	920	6.2%	cbioportal
19	NOTCH1	Ssm	70	1,134	6.2%	cbioportal
21	PTEN	Ssm	68	1,134	6%	cbioportal
20	KMT2C	Ssm	68	1,134	6%	cbioportal
23	EPHA5	Ssm	66	1,134	5.8%	cbioportal
24	SMARCA4	Ssm	66	1,134	5.8%	cbioportal
25	AMER1	Ssm	65	1,134	5.7%	cbioportal
26	BRCA2	Ssm	65	1,134	5.7%	cbioportal
27	ERBB4	Ssm	64	1,134	5.6%	cbioportal
30	GRIN2A	Ssm	63	1,134	5.6%	cbioportal
29	EP300	Ssm	63	1,134	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Esophagogastric Cancer (MSK, Cancer Discovery 2017) egc_msk_2017MSK

341 cases with simple somatic mutation data · 341 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	253	341	74.2%	cbioportal
2	ARID1A	Ssm	44	341	12.9%	cbioportal
164	PREX2	Ssm	4	36	11.1%	cbioportal
3	CDKN2A	Ssm	37	341	10.9%	cbioportal
185	DROSHA	Ssm	3	28	10.7%	cbioportal
4	SMAD4	Ssm	33	341	9.7%	cbioportal
5	KRAS	Ssm	31	341	9.1%	cbioportal
6	KMT2D	Ssm	30	341	8.8%	cbioportal
14	ZFHX3	Ssm	17	206	8.3%	cbioportal
7	CDH1	Ssm	27	341	7.9%	cbioportal
8	PIK3CA	Ssm	26	341	7.6%	cbioportal
9	ERBB4	Ssm	25	341	7.3%	cbioportal
10	EPHA5	Ssm	24	341	7%	cbioportal
11	PTPRT	Ssm	23	341	6.7%	cbioportal
12	ERBB3	Ssm	21	341	6.2%	cbioportal
37	PGR	Ssm	12	206	5.8%	cbioportal
13	PTPRD	Ssm	19	341	5.6%	cbioportal
16	NF1	Ssm	16	341	4.7%	cbioportal
18	SMARCA4	Ssm	16	341	4.7%	cbioportal
17	PBRM1	Ssm	16	341	4.7%	cbioportal
15	APC	Ssm	16	341	4.7%	cbioportal
19	KMT2A	Ssm	15	341	4.4%	cbioportal
20	NOTCH1	Ssm	15	341	4.4%	cbioportal
52	INHBA	Ssm	9	206	4.4%	cbioportal
57	POLD1	Ssm	9	206	4.4%	cbioportal
25	RHOA	Ssm	14	333	4.2%	cbioportal
24	PTPRS	Ssm	14	341	4.1%	cbioportal
21	AR	Ssm	14	341	4.1%	cbioportal
22	CIC	Ssm	14	341	4.1%	cbioportal
23	CREBBP	Ssm	14	341	4.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Metastatic Pancreatic Adenocarcinoma (PRINCE Trial, Nat Med. 2022) - iAtlas Harmonized paad_iatlas_prince_2022

93 cases with simple somatic mutation data · 93 cases total · 2026-02-16 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	68	93	73.1%	cbioportal
2	TP53	Ssm	64	93	68.8%	cbioportal
3	NBPF14	Ssm	30	93	32.3%	cbioportal
4	CDKN2A	Ssm	25	93	26.9%	cbioportal
5	MUC17	Ssm	21	93	22.6%	cbioportal
6	TTN	Ssm	20	93	21.5%	cbioportal
7	DEAF1	Ssm	18	93	19.4%	cbioportal
8	AHNAK	Ssm	17	93	18.3%	cbioportal
9	NBPF1	Ssm	16	93	17.2%	cbioportal
10	PHLPP1	Ssm	14	93	15.1%	cbioportal
12	CENPB	Ssm	13	93	14%	cbioportal
11	AHNAK2	Ssm	13	93	14%	cbioportal
14	SMAD4	Ssm	12	93	12.9%	cbioportal
15	ZNF208	Ssm	12	93	12.9%	cbioportal
13	MUC5AC	Ssm	12	93	12.9%	cbioportal
16	MUC16	Ssm	11	93	11.8%	cbioportal
17	TCHH	Ssm	11	93	11.8%	cbioportal
19	NBPF10	Ssm	10	93	10.8%	cbioportal
18	FLG2	Ssm	10	93	10.8%	cbioportal
20	RAMP2	Ssm	10	93	10.8%	cbioportal
22	ZNF594	Ssm	9	93	9.7%	cbioportal
21	DGKZ	Ssm	9	93	9.7%	cbioportal
29	STUM	Ssm	8	93	8.6%	cbioportal
23	EIF3J	Ssm	8	93	8.6%	cbioportal
24	EPAS1	Ssm	8	93	8.6%	cbioportal
25	FLG	Ssm	8	93	8.6%	cbioportal
26	HRNR	Ssm	8	93	8.6%	cbioportal
27	OBSCN	Ssm	8	93	8.6%	cbioportal
28	SAAL1	Ssm	8	93	8.6%	cbioportal
30	USH2A	Ssm	8	93	8.6%	cbioportal

Data updated 22 days agoSource updated 2026-02-16

Pancreatic Acinar Cell Carcinoma (MSK, JCO 2023) paac_msk_jco_2023MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-12 · mapped to Pancreatic Acinar Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMAD4	Ssm	8	47	17%	cbioportal
3	CTNNB1	Ssm	6	47	12.8%	cbioportal
2	AXIN1	Ssm	6	47	12.8%	cbioportal
6	RB1	Ssm	5	47	10.6%	cbioportal
5	PRKAR1A	Ssm	5	47	10.6%	cbioportal
4	NF1	Ssm	5	47	10.6%	cbioportal
7	CREBBP	Ssm	4	47	8.5%	cbioportal
8	PBRM1	Ssm	4	47	8.5%	cbioportal
9	PTEN	Ssm	4	47	8.5%	cbioportal
172	ZNRF3	Ssm	1	13	7.7%	cbioportal
155	SLFN11	Ssm	1	13	7.7%	cbioportal
93	GNB1	Ssm	1	13	7.7%	cbioportal
154	SETDB1	Ssm	1	13	7.7%	cbioportal
19	MGA	Ssm	3	46	6.5%	cbioportal
18	MEN1	Ssm	3	47	6.4%	cbioportal
20	NRAS	Ssm	3	47	6.4%	cbioportal
21	PIK3CG	Ssm	3	47	6.4%	cbioportal
22	POLE	Ssm	3	47	6.4%	cbioportal
23	RARA	Ssm	3	47	6.4%	cbioportal
24	SETD2	Ssm	3	47	6.4%	cbioportal
25	TP53	Ssm	3	47	6.4%	cbioportal
26	TSC2	Ssm	3	47	6.4%	cbioportal
13	BRAF	Ssm	3	47	6.4%	cbioportal
10	ARID1A	Ssm	3	47	6.4%	cbioportal
16	IKBKE	Ssm	3	47	6.4%	cbioportal
17	KMT2D	Ssm	3	47	6.4%	cbioportal
14	BRCA2	Ssm	3	47	6.4%	cbioportal
11	ASXL1	Ssm	3	47	6.4%	cbioportal
15	CDKN2A	Ssm	3	47	6.4%	cbioportal
12	ATM	Ssm	3	47	6.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma TCGA-PAADTCGA

185 cases with simple somatic mutation data · 185 cases total · Data Release 46.0 · mapped to Pancreatic Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	124	185	67%	gdc
2	KRAS	Ssm	123	185	66.5%	gdc
3	SMAD4	Ssm	119	185	64.3%	gdc
4	CDKN2A	Ssm	117	185	63.2%	gdc
6	SKA1	Ssm	114	185	61.6%	gdc
5	ME2	Ssm	114	185	61.6%	gdc
7	CXXC1	Ssm	114	185	61.6%	gdc
8	MAPK4	Ssm	114	185	61.6%	gdc
9	CFAP53	Ssm	114	185	61.6%	gdc
10	MBD1	Ssm	114	185	61.6%	gdc
19	POLI	Ssm	113	185	61.1%	gdc
11	C18orf54	Ssm	113	185	61.1%	gdc
12	MRO	Ssm	113	185	61.1%	gdc
13	TCF4	Ssm	113	185	61.1%	gdc
14	DCC	Ssm	113	185	61.1%	gdc
15	MEX3C	Ssm	113	185	61.1%	gdc
16	MYO5B	Ssm	113	185	61.1%	gdc
17	STARD6	Ssm	113	185	61.1%	gdc
18	MBD2	Ssm	113	185	61.1%	gdc
25	SERPINB7	Ssm	112	185	60.5%	gdc
23	ALPK2	Ssm	112	185	60.5%	gdc
24	DYNAP	Ssm	112	185	60.5%	gdc
26	AC091551.1	Ssm	112	185	60.5%	gdc
20	DYM	Ssm	112	185	60.5%	gdc
30	LIPG	Ssm	112	185	60.5%	gdc
27	SERPINB10	Ssm	112	185	60.5%	gdc
28	ELAC1	Ssm	112	185	60.5%	gdc
29	CCDC68	Ssm	112	185	60.5%	gdc
21	RAB27B	Ssm	112	185	60.5%	gdc
22	SMAD7	Ssm	112	185	60.5%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Pancreatic Adenocarcinoma (ICGC, Nature 2012) paad_icgcICGC

99 cases with simple somatic mutation data · 99 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	94	99	94.9%	cbioportal
2	TP53	Ssm	33	99	33.3%	cbioportal
3	SMAD4	Ssm	16	99	16.2%	cbioportal
4	TTN	Ssm	12	99	12.1%	cbioportal
5	CSMD1	Ssm	5	99	5.1%	cbioportal
6	MUC16	Ssm	5	99	5.1%	cbioportal
9	HMCN1	Ssm	4	99	4%	cbioportal
14	TGFBR2	Ssm	4	99	4%	cbioportal
13	SF3B1	Ssm	4	99	4%	cbioportal
12	RYR3	Ssm	4	99	4%	cbioportal
11	PCDH15	Ssm	4	99	4%	cbioportal
10	NALCN	Ssm	4	99	4%	cbioportal
8	DNAH5	Ssm	4	99	4%	cbioportal
7	ARID1A	Ssm	4	99	4%	cbioportal
23	MAP2K4	Ssm	3	99	3%	cbioportal
25	OR2M5	Ssm	3	99	3%	cbioportal
26	PCDHB6	Ssm	3	99	3%	cbioportal
27	SLIT2	Ssm	3	99	3%	cbioportal
16	AFF2	Ssm	3	99	3%	cbioportal
15	ABCA12	Ssm	3	99	3%	cbioportal
21	FLG	Ssm	3	99	3%	cbioportal
22	LRP1B	Ssm	3	99	3%	cbioportal
24	NBAS	Ssm	3	99	3%	cbioportal
29	THSD7A	Ssm	3	99	3%	cbioportal
30	XIRP2	Ssm	3	99	3%	cbioportal
28	SYNE1	Ssm	3	99	3%	cbioportal
17	ARID2	Ssm	3	99	3%	cbioportal
18	COL6A5	Ssm	3	99	3%	cbioportal
19	DMD	Ssm	3	99	3%	cbioportal
20	EPC1	Ssm	3	99	3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma (MSK, 2025) paad_msk_2025MSK

29 cases with simple somatic mutation data · 29 cases total · 2026-02-10 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	18	29	62.1%	cbioportal
2	TP53	Ssm	14	29	48.3%	cbioportal
8	ZNF676	Ssm	3	16	18.8%	cbioportal
24	FAM86C1P	Ssm	2	16	12.5%	cbioportal
35	MARCHF7	Ssm	2	16	12.5%	cbioportal
52	SDHAP1	Ssm	2	16	12.5%	cbioportal
38	NBPF12	Ssm	2	16	12.5%	cbioportal
32	HLA-G	Ssm	2	16	12.5%	cbioportal
40	NOTCH2NLA	Ssm	2	16	12.5%	cbioportal
20	DAB2	Ssm	2	16	12.5%	cbioportal
43	OR4C46	Ssm	2	16	12.5%	cbioportal
33	KIF2B	Ssm	2	16	12.5%	cbioportal
53	SMOC1	Ssm	2	16	12.5%	cbioportal
48	PRDM5	Ssm	2	16	12.5%	cbioportal
4	CDK8	Ssm	3	29	10.3%	cbioportal
3	APC	Ssm	3	29	10.3%	cbioportal
5	CDKN2A	Ssm	3	29	10.3%	cbioportal
7	RNF43	Ssm	3	29	10.3%	cbioportal
6	KMT2C	Ssm	3	29	10.3%	cbioportal
31	HLA-C	Ssm	2	28	7.1%	cbioportal
47	PRDM14	Ssm	2	28	7.1%	cbioportal
23	ETAA1	Ssm	2	28	7.1%	cbioportal
9	ALB	Ssm	2	28	7.1%	cbioportal
55	USP8	Ssm	2	28	7.1%	cbioportal
51	RTEL1	Ssm	2	28	7.1%	cbioportal
13	BAP1	Ssm	2	29	6.9%	cbioportal
11	ASXL1	Ssm	2	29	6.9%	cbioportal
10	ARID2	Ssm	2	29	6.9%	cbioportal
17	CDKN1B	Ssm	2	29	6.9%	cbioportal
12	AXIN1	Ssm	2	29	6.9%	cbioportal

Data updated 22 days agoSource updated 2026-02-10

Pancreatic Adenocarcinoma (QCMG, Nature 2016) paad_qcmg_uq_2016QCMG

383 cases with simple somatic mutation data · 456 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	344	383	89.8%	cbioportal
2	TP53	Ssm	253	383	66.1%	cbioportal
3	SMAD4	Ssm	86	383	22.5%	cbioportal
4	CDKN2A	Ssm	71	383	18.5%	cbioportal
5	TTN	Ssm	56	383	14.6%	cbioportal
6	ARID1A	Ssm	29	383	7.6%	cbioportal
7	SYNE1	Ssm	27	383	7%	cbioportal
8	LRP1B	Ssm	22	383	5.7%	cbioportal
9	KMT2C	Ssm	21	383	5.5%	cbioportal
10	RNF43	Ssm	21	383	5.5%	cbioportal
11	RYR1	Ssm	21	383	5.5%	cbioportal
12	MUC16	Ssm	20	383	5.2%	cbioportal
13	FLG	Ssm	19	383	5%	cbioportal
15	KMT2D	Ssm	19	383	5%	cbioportal
14	HMCN1	Ssm	19	383	5%	cbioportal
19	TGFBR2	Ssm	18	383	4.7%	cbioportal
16	FAT3	Ssm	18	383	4.7%	cbioportal
17	GLI3	Ssm	18	383	4.7%	cbioportal
18	OBSCN	Ssm	18	383	4.7%	cbioportal
22	RYR3	Ssm	16	383	4.2%	cbioportal
20	DNAH11	Ssm	16	383	4.2%	cbioportal
21	MUC4	Ssm	16	383	4.2%	cbioportal
23	RYR2	Ssm	15	383	3.9%	cbioportal
24	ATM	Ssm	14	383	3.7%	cbioportal
25	CSMD1	Ssm	14	383	3.7%	cbioportal
26	WDFY4	Ssm	14	383	3.7%	cbioportal
27	ADGRV1	Ssm	13	383	3.4%	cbioportal
30	TENM3	Ssm	13	383	3.4%	cbioportal
29	DNAH5	Ssm	13	383	3.4%	cbioportal
28	CSMD3	Ssm	13	383	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma (TCGA, Firehose Legacy) paad_tcgaTCGA

150 cases with simple somatic mutation data · 186 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	136	150	90.7%	cbioportal
2	TP53	Ssm	104	150	69.3%	cbioportal
3	SMAD4	Ssm	37	150	24.7%	cbioportal
4	TTN	Ssm	35	150	23.3%	cbioportal
5	CDKN2A	Ssm	22	150	14.7%	cbioportal
7	OBSCN	Ssm	11	150	7.3%	cbioportal
8	RYR1	Ssm	11	150	7.3%	cbioportal
6	MUC16	Ssm	11	150	7.3%	cbioportal
9	FAT2	Ssm	10	150	6.7%	cbioportal
11	GNAS	Ssm	10	150	6.7%	cbioportal
10	FLG	Ssm	10	150	6.7%	cbioportal
18	MYO18B	Ssm	9	150	6%	cbioportal
16	HMCN1	Ssm	9	150	6%	cbioportal
15	FAT4	Ssm	9	150	6%	cbioportal
14	FAT3	Ssm	9	150	6%	cbioportal
13	CSMD2	Ssm	9	150	6%	cbioportal
12	ADAMTS16	Ssm	9	150	6%	cbioportal
20	USH2A	Ssm	9	150	6%	cbioportal
19	RNF43	Ssm	9	150	6%	cbioportal
17	LRP1B	Ssm	9	150	6%	cbioportal
26	PLEC	Ssm	8	150	5.3%	cbioportal
21	ADAMTS12	Ssm	8	150	5.3%	cbioportal
22	ARID1A	Ssm	8	150	5.3%	cbioportal
23	CACNA1B	Ssm	8	150	5.3%	cbioportal
24	GLI3	Ssm	8	150	5.3%	cbioportal
25	HECW2	Ssm	8	150	5.3%	cbioportal
27	RREB1	Ssm	8	150	5.3%	cbioportal
28	RYR3	Ssm	8	150	5.3%	cbioportal
29	SCN5A	Ssm	8	150	5.3%	cbioportal
30	TGFBR2	Ssm	8	150	5.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma (TCGA GDC, 2025) paad_tcga_gdcTCGA GDC

173 cases with simple somatic mutation data · 186 cases total · 2026-01-13 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	107	173	61.8%	cbioportal
2	TP53	Ssm	100	173	57.8%	cbioportal
3	SMAD4	Ssm	36	173	20.8%	cbioportal
4	CDKN2A	Ssm	30	173	17.3%	cbioportal
5	TTN	Ssm	25	173	14.5%	cbioportal
6	MUC16	Ssm	12	173	6.9%	cbioportal
7	RNF43	Ssm	11	173	6.4%	cbioportal
8	ARID1A	Ssm	8	173	4.6%	cbioportal
10	RYR1	Ssm	8	173	4.6%	cbioportal
11	TGFBR2	Ssm	8	173	4.6%	cbioportal
9	HECW2	Ssm	8	173	4.6%	cbioportal
15	GLI3	Ssm	7	173	4%	cbioportal
16	GNAS	Ssm	7	173	4%	cbioportal
17	KDM6A	Ssm	7	173	4%	cbioportal
18	LRP1B	Ssm	7	173	4%	cbioportal
19	PCDH15	Ssm	7	173	4%	cbioportal
20	RNF213	Ssm	7	173	4%	cbioportal
21	TPO	Ssm	7	173	4%	cbioportal
12	ATM	Ssm	7	173	4%	cbioportal
13	CACNA1B	Ssm	7	173	4%	cbioportal
14	FAT2	Ssm	7	173	4%	cbioportal
22	ADAMTS12	Ssm	6	173	3.5%	cbioportal
30	FLNC	Ssm	6	173	3.5%	cbioportal
29	FLG	Ssm	6	173	3.5%	cbioportal
28	FBN3	Ssm	6	173	3.5%	cbioportal
27	COL6A2	Ssm	6	173	3.5%	cbioportal
26	COL5A1	Ssm	6	173	3.5%	cbioportal
25	COL11A1	Ssm	6	173	3.5%	cbioportal
24	APBA2	Ssm	6	173	3.5%	cbioportal
23	ADAMTS16	Ssm	6	173	3.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas) paad_tcga_pan_can_atlas_2018TCGA

179 cases with simple somatic mutation data · 184 cases total · 2026-06-04 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	117	179	65.4%	cbioportal
2	TP53	Ssm	107	179	59.8%	cbioportal
3	SMAD4	Ssm	37	179	20.7%	cbioportal
4	CDKN2A	Ssm	35	179	19.6%	cbioportal
5	TTN	Ssm	29	179	16.2%	cbioportal
6	MUC16	Ssm	13	179	7.3%	cbioportal
7	RNF43	Ssm	11	179	6.1%	cbioportal
8	CSMD2	Ssm	10	179	5.6%	cbioportal
9	RYR1	Ssm	10	179	5.6%	cbioportal
10	ARID1A	Ssm	9	179	5%	cbioportal
11	PCDH15	Ssm	9	179	5%	cbioportal
16	MYO18B	Ssm	8	179	4.5%	cbioportal
14	FLG	Ssm	8	179	4.5%	cbioportal
15	HECW2	Ssm	8	179	4.5%	cbioportal
13	CACNA1B	Ssm	8	179	4.5%	cbioportal
12	ATM	Ssm	8	179	4.5%	cbioportal
19	TGFBR2	Ssm	8	179	4.5%	cbioportal
18	RNF213	Ssm	8	179	4.5%	cbioportal
17	OBSCN	Ssm	8	179	4.5%	cbioportal
22	COL6A2	Ssm	7	179	3.9%	cbioportal
26	FAT3	Ssm	7	179	3.9%	cbioportal
27	FLNC	Ssm	7	179	3.9%	cbioportal
28	GLI3	Ssm	7	179	3.9%	cbioportal
29	GNAS	Ssm	7	179	3.9%	cbioportal
30	KDM6A	Ssm	7	179	3.9%	cbioportal
24	DSCAML1	Ssm	7	179	3.9%	cbioportal
23	DNAH11	Ssm	7	179	3.9%	cbioportal
21	APBA2	Ssm	7	179	3.9%	cbioportal
20	ADAMTS12	Ssm	7	179	3.9%	cbioportal
25	FAT2	Ssm	7	179	3.9%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Pancreatic Cancer cfDNA (MSK, J Natl Cancer Inst 2025) pancreas_ctdna_msk_2025MSK

412 cases with simple somatic mutation data · 412 cases total · 2026-01-28 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	168	412	40.8%	cbioportal
2	TP53	Ssm	149	412	36.2%	cbioportal
3	CDKN2A	Ssm	37	412	9%	cbioportal
4	SMAD4	Ssm	34	412	8.3%	cbioportal
5	ARID1A	Ssm	24	412	5.8%	cbioportal
6	ATM	Ssm	23	412	5.6%	cbioportal
7	GNAS	Ssm	9	412	2.2%	cbioportal
9	SF3B1	Ssm	9	412	2.2%	cbioportal
8	KDM6A	Ssm	9	412	2.2%	cbioportal
10	SMARCA4	Ssm	8	412	1.9%	cbioportal
12	FOXO1	Ssm	7	412	1.7%	cbioportal
11	BRCA2	Ssm	7	412	1.7%	cbioportal
15	PTCH1	Ssm	7	412	1.7%	cbioportal
13	NF1	Ssm	7	412	1.7%	cbioportal
14	NTRK2	Ssm	7	412	1.7%	cbioportal
16	APC	Ssm	6	412	1.5%	cbioportal
17	PTEN	Ssm	6	412	1.5%	cbioportal
19	TSC2	Ssm	5	412	1.2%	cbioportal
18	FBXW7	Ssm	5	412	1.2%	cbioportal
21	KEAP1	Ssm	4	412	1%	cbioportal
22	MSH6	Ssm	4	412	1%	cbioportal
23	NTRK1	Ssm	4	412	1%	cbioportal
24	STK11	Ssm	4	412	1%	cbioportal
25	TSC1	Ssm	4	412	1%	cbioportal
26	U2AF1	Ssm	4	412	1%	cbioportal
20	CTNNB1	Ssm	4	412	1%	cbioportal
30	RB1	Ssm	3	412	0.7%	cbioportal
28	FGFR2	Ssm	3	412	0.7%	cbioportal
29	PIK3CA	Ssm	3	412	0.7%	cbioportal
27	AKT1	Ssm	3	412	0.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-28

Pancreatic Cancer (UTSW, Nat Commun 2015) paad_utsw_2015UTSW

109 cases with simple somatic mutation data · 109 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	100	109	91.7%	cbioportal
2	TP53	Ssm	55	109	50.5%	cbioportal
3	SMAD4	Ssm	21	109	19.3%	cbioportal
4	ZNF814	Ssm	20	109	18.3%	cbioportal
5	MUC16	Ssm	17	109	15.6%	cbioportal
6	TTN	Ssm	16	109	14.7%	cbioportal
7	MUC2	Ssm	12	109	11%	cbioportal
8	FLG	Ssm	11	109	10.1%	cbioportal
9	MIA2	Ssm	11	109	10.1%	cbioportal
10	MUC5B	Ssm	10	109	9.2%	cbioportal
11	OBSCN	Ssm	9	109	8.3%	cbioportal
12	ATXN1	Ssm	8	109	7.3%	cbioportal
13	COL18A1	Ssm	8	109	7.3%	cbioportal
14	HERC2	Ssm	8	109	7.3%	cbioportal
15	KRT4	Ssm	8	109	7.3%	cbioportal
16	NEBL	Ssm	8	109	7.3%	cbioportal
17	NF1	Ssm	8	109	7.3%	cbioportal
18	PCMTD1	Ssm	8	109	7.3%	cbioportal
28	MUC17	Ssm	7	109	6.4%	cbioportal
19	AHNAK2	Ssm	7	109	6.4%	cbioportal
20	ARID1A	Ssm	7	109	6.4%	cbioportal
21	COL14A1	Ssm	7	109	6.4%	cbioportal
22	DGKB	Ssm	7	109	6.4%	cbioportal
23	FAT3	Ssm	7	109	6.4%	cbioportal
24	FOLH1	Ssm	7	109	6.4%	cbioportal
25	KMT2C	Ssm	7	109	6.4%	cbioportal
26	LILRB3	Ssm	7	109	6.4%	cbioportal
27	MAGEC1	Ssm	7	109	6.4%	cbioportal
29	MUC4	Ssm	7	109	6.4%	cbioportal
30	NBPF9	Ssm	7	109	6.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Ductal Adenocarcinoma (CPTAC, Cell 2021) paad_cptac_2021CPTAC

140 cases with simple somatic mutation data · 140 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	135	140	96.4%	cbioportal
2	TP53	Ssm	105	140	75%	cbioportal
3	CDKN2A	Ssm	29	140	20.7%	cbioportal
4	SMAD4	Ssm	24	140	17.1%	cbioportal
5	CTNNA2	Ssm	13	140	9.3%	cbioportal
6	MUC4	Ssm	13	140	9.3%	cbioportal
7	TTN	Ssm	12	140	8.6%	cbioportal
8	RYR2	Ssm	10	140	7.1%	cbioportal
9	RNF43	Ssm	9	140	6.4%	cbioportal
10	ARID1A	Ssm	8	140	5.7%	cbioportal
11	KMT2D	Ssm	8	140	5.7%	cbioportal
16	RBMXL3	Ssm	7	140	5%	cbioportal
15	MUC16	Ssm	7	140	5%	cbioportal
17	SYNE1	Ssm	7	140	5%	cbioportal
12	DNAH9	Ssm	7	140	5%	cbioportal
13	FMN2	Ssm	7	140	5%	cbioportal
14	GNAS	Ssm	7	140	5%	cbioportal
18	ANKRD30B	Ssm	6	140	4.3%	cbioportal
22	GLI3	Ssm	6	140	4.3%	cbioportal
23	IRX2	Ssm	6	140	4.3%	cbioportal
24	KMT2C	Ssm	6	140	4.3%	cbioportal
25	LRP1B	Ssm	6	140	4.3%	cbioportal
26	PXDNL	Ssm	6	140	4.3%	cbioportal
27	RBM10	Ssm	6	140	4.3%	cbioportal
28	RYR3	Ssm	6	140	4.3%	cbioportal
29	TAF1L	Ssm	6	140	4.3%	cbioportal
30	ZFHX4	Ssm	6	140	4.3%	cbioportal
20	CSMD1	Ssm	6	140	4.3%	cbioportal
19	CDH10	Ssm	6	140	4.3%	cbioportal
21	DOCK2	Ssm	6	140	4.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pre-cancer Colorectal Polyps (HTAN Vanderbilt, Cell 2021) crc_hta11_htan_2021HTAN Vanderbilt

30 cases with simple somatic mutation data · 61 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	20	30	66.7%	cbioportal
2	MUC16	Ssm	17	30	56.7%	cbioportal
3	PCLO	Ssm	17	30	56.7%	cbioportal
4	MUC17	Ssm	16	30	53.3%	cbioportal
6	SYNE1	Ssm	16	30	53.3%	cbioportal
5	MUC19	Ssm	16	30	53.3%	cbioportal
8	FLG	Ssm	15	30	50%	cbioportal
7	APC	Ssm	15	30	50%	cbioportal
10	RNF213	Ssm	14	30	46.7%	cbioportal
9	FSIP2	Ssm	14	30	46.7%	cbioportal
22	TENM2	Ssm	13	30	43.3%	cbioportal
21	PRRC2C	Ssm	13	30	43.3%	cbioportal
15	HECTD4	Ssm	13	30	43.3%	cbioportal
16	HMCN1	Ssm	13	30	43.3%	cbioportal
20	MUC4	Ssm	13	30	43.3%	cbioportal
19	MUC12	Ssm	13	30	43.3%	cbioportal
18	MKI67	Ssm	13	30	43.3%	cbioportal
17	LAMA3	Ssm	13	30	43.3%	cbioportal
13	DNAH10	Ssm	13	30	43.3%	cbioportal
12	CUBN	Ssm	13	30	43.3%	cbioportal
11	CHD7	Ssm	13	30	43.3%	cbioportal
14	DNAH5	Ssm	13	30	43.3%	cbioportal
25	KMT2C	Ssm	12	30	40%	cbioportal
24	KMT2A	Ssm	12	30	40%	cbioportal
23	CEP350	Ssm	12	30	40%	cbioportal
27	MACF1	Ssm	12	30	40%	cbioportal
28	OBSCN	Ssm	12	30	40%	cbioportal
29	POGZ	Ssm	12	30	40%	cbioportal
30	UBR5	Ssm	12	30	40%	cbioportal
26	LRP2	Ssm	12	30	40%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Rectal Adenocarcinoma (TCGA GDC, 2025) read_tcga_gdcTCGA GDC

155 cases with simple somatic mutation data · 171 cases total · 2026-01-13 · mapped to Rectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	APC	Ssm	126	155	81.3%	cbioportal
2	TP53	Ssm	110	155	71%	cbioportal
3	KRAS	Ssm	63	155	40.6%	cbioportal
4	TTN	Ssm	61	155	39.4%	cbioportal
5	SYNE1	Ssm	35	155	22.6%	cbioportal
6	MUC16	Ssm	28	155	18.1%	cbioportal
7	FBXW7	Ssm	26	155	16.8%	cbioportal
8	FAT4	Ssm	25	155	16.1%	cbioportal
9	RYR2	Ssm	25	155	16.1%	cbioportal
10	LRP1B	Ssm	24	155	15.5%	cbioportal
12	SMAD4	Ssm	23	155	14.8%	cbioportal
11	CSMD1	Ssm	23	155	14.8%	cbioportal
13	PIK3CA	Ssm	22	155	14.2%	cbioportal
14	DNAH11	Ssm	19	155	12.3%	cbioportal
15	FAT3	Ssm	19	155	12.3%	cbioportal
16	SACS	Ssm	18	155	11.6%	cbioportal
19	ZFHX4	Ssm	17	155	11%	cbioportal
17	CSMD3	Ssm	17	155	11%	cbioportal
18	OBSCN	Ssm	17	155	11%	cbioportal
20	FLG	Ssm	16	155	10.3%	cbioportal
21	HYDIN	Ssm	16	155	10.3%	cbioportal
29	TCF7L2	Ssm	15	155	9.7%	cbioportal
22	ABCA13	Ssm	15	155	9.7%	cbioportal
23	ATM	Ssm	15	155	9.7%	cbioportal
24	DNAH7	Ssm	15	155	9.7%	cbioportal
25	NBEA	Ssm	15	155	9.7%	cbioportal
26	NRAS	Ssm	15	155	9.7%	cbioportal
27	RYR1	Ssm	15	155	9.7%	cbioportal
28	SPTA1	Ssm	15	155	9.7%	cbioportal
30	AHNAK2	Ssm	14	155	9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Rectal Cancer (MSK,Nature Medicine 2019) rectal_msk_2019MSK

339 cases with simple somatic mutation data · 339 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	268	339	79.1%	cbioportal
2	APC	Ssm	257	339	75.8%	cbioportal
3	KRAS	Ssm	152	339	44.8%	cbioportal
4	FBXW7	Ssm	66	339	19.5%	cbioportal
5	SMAD4	Ssm	47	339	13.9%	cbioportal
130	CYLD	Ssm	5	49	10.2%	cbioportal
6	PIK3CA	Ssm	33	339	9.7%	cbioportal
8	TCF7L2	Ssm	28	300	9.3%	cbioportal
7	ARID1A	Ssm	28	339	8.3%	cbioportal
200	UPF1	Ssm	4	49	8.2%	cbioportal
196	SESN3	Ssm	4	49	8.2%	cbioportal
199	TP53BP1	Ssm	4	49	8.2%	cbioportal
181	KMT2B	Ssm	4	49	8.2%	cbioportal
192	PREX2	Ssm	4	49	8.2%	cbioportal
9	SOX9	Ssm	21	339	6.2%	cbioportal
10	ERBB3	Ssm	20	339	5.9%	cbioportal
11	NOTCH3	Ssm	20	339	5.9%	cbioportal
19	MGA	Ssm	17	300	5.7%	cbioportal
15	PTPRS	Ssm	19	339	5.6%	cbioportal
14	KMT2C	Ssm	19	339	5.6%	cbioportal
13	ATM	Ssm	19	339	5.6%	cbioportal
12	AMER1	Ssm	19	339	5.6%	cbioportal
16	BRAF	Ssm	18	339	5.3%	cbioportal
17	PTPRT	Ssm	18	339	5.3%	cbioportal
18	AR	Ssm	17	339	5%	cbioportal
22	ANKRD11	Ssm	15	300	5%	cbioportal
20	EPHA5	Ssm	16	339	4.7%	cbioportal
21	KMT2A	Ssm	16	339	4.7%	cbioportal
24	NRAS	Ssm	15	339	4.4%	cbioportal
23	CREBBP	Ssm	15	339	4.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Rectum Adenocarcinoma TCGA-READTCGA

171 cases with simple somatic mutation data · 172 cases total · Data Release 46.0 · mapped to Rectal Adenocarcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTPRT	Ssm	154	171	90.1%	gdc
2	TAF4	Ssm	152	171	88.9%	gdc
3	TOP1	Ssm	152	171	88.9%	gdc
9	STAU1	Ssm	151	171	88.3%	gdc
11	RALGAPB	Ssm	151	171	88.3%	gdc
10	DNMT3B	Ssm	151	171	88.3%	gdc
8	CHD6	Ssm	151	171	88.3%	gdc
7	ZNF831	Ssm	151	171	88.3%	gdc
6	EPB41L1	Ssm	151	171	88.3%	gdc
5	KCNB1	Ssm	151	171	88.3%	gdc
4	CD40	Ssm	151	171	88.3%	gdc
28	ZNFX1	Ssm	150	171	87.7%	gdc
29	ARFGEF2	Ssm	150	171	87.7%	gdc
14	MMP9	Ssm	150	171	87.7%	gdc
15	NCOA3	Ssm	150	171	87.7%	gdc
16	JPH2	Ssm	150	171	87.7%	gdc
17	FAM217B	Ssm	150	171	87.7%	gdc
18	PPP1R16B	Ssm	150	171	87.7%	gdc
19	SLC12A5	Ssm	150	171	87.7%	gdc
20	RIMS4	Ssm	150	171	87.7%	gdc
21	SOGA1	Ssm	150	171	87.7%	gdc
22	CEP250	Ssm	150	171	87.7%	gdc
23	HNF4A	Ssm	150	171	87.7%	gdc
24	KIAA1755	Ssm	150	171	87.7%	gdc
25	RBPJL	Ssm	150	171	87.7%	gdc
26	ZNF334	Ssm	150	171	87.7%	gdc
27	PREX1	Ssm	150	171	87.7%	gdc
30	GNAS	Ssm	150	171	87.7%	gdc
12	LAMA5	Ssm	150	171	87.7%	gdc
13	PCK1	Ssm	150	171	87.7%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Stomach Adenocarcinoma TCGA-STADTCGA

443 cases with simple somatic mutation data · 443 cases total · Data Release 46.0 · mapped to Gastric Adenocarcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CSMD3	Ssm	305	443	68.8%	gdc
2	RIMS2	Ssm	302	443	68.2%	gdc
3	FER1L6	Ssm	299	443	67.5%	gdc
4	TTN	Ssm	297	443	67%	gdc
5	MYC	Ssm	296	443	66.8%	gdc
7	TG	Ssm	295	443	66.6%	gdc
6	ADCY8	Ssm	295	443	66.6%	gdc
8	POU5F1B	Ssm	294	443	66.4%	gdc
11	UBR5	Ssm	293	443	66.1%	gdc
10	LRP12	Ssm	293	443	66.1%	gdc
9	ASAP1	Ssm	293	443	66.1%	gdc
12	DDX27	Ssm	292	443	65.9%	gdc
13	VPS13B	Ssm	290	443	65.5%	gdc
14	ZNF831	Ssm	290	443	65.5%	gdc
15	COL14A1	Ssm	290	443	65.5%	gdc
16	GSDMC	Ssm	289	443	65.2%	gdc
17	NFATC2	Ssm	289	443	65.2%	gdc
18	DIDO1	Ssm	289	443	65.2%	gdc
19	PLEC	Ssm	289	443	65.2%	gdc
23	KLHL38	Ssm	288	443	65%	gdc
20	PKHD1L1	Ssm	288	443	65%	gdc
22	ANXA13	Ssm	288	443	65%	gdc
21	WASHC5	Ssm	288	443	65%	gdc
26	ATAD2	Ssm	287	443	64.8%	gdc
28	SQLE	Ssm	287	443	64.8%	gdc
29	PTPRT	Ssm	287	443	64.8%	gdc
30	LRATD2	Ssm	287	443	64.8%	gdc
24	FAM91A1	Ssm	287	443	64.8%	gdc
27	FBXO32	Ssm	287	443	64.8%	gdc
25	EXT1	Ssm	287	443	64.8%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Stomach Adenocarcinoma (Pfizer and UHK, Nat Genet 2014) stad_pfizer_uhongkongPfizer and UHK

100 cases with simple somatic mutation data · 100 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	55	100	55%	cbioportal
2	TTN	Ssm	41	100	41%	cbioportal
3	MUC16	Ssm	24	100	24%	cbioportal
4	SYNE1	Ssm	22	100	22%	cbioportal
5	CSMD1	Ssm	19	100	19%	cbioportal
6	ARID1A	Ssm	18	100	18%	cbioportal
7	FLG	Ssm	17	100	17%	cbioportal
8	DNAH5	Ssm	16	100	16%	cbioportal
9	CDH1	Ssm	15	100	15%	cbioportal
10	FAT3	Ssm	14	100	14%	cbioportal
12	LRP1B	Ssm	14	100	14%	cbioportal
11	HYDIN	Ssm	14	100	14%	cbioportal
13	DNAH14	Ssm	13	100	13%	cbioportal
15	OBSCN	Ssm	13	100	13%	cbioportal
16	RYR3	Ssm	13	100	13%	cbioportal
14	KMT2C	Ssm	13	100	13%	cbioportal
17	SPTA1	Ssm	13	100	13%	cbioportal
18	SDK1	Ssm	12	100	12%	cbioportal
30	XIRP2	Ssm	11	100	11%	cbioportal
29	TGFBR2	Ssm	11	100	11%	cbioportal
28	SYNE2	Ssm	11	100	11%	cbioportal
27	RYR1	Ssm	11	100	11%	cbioportal
26	RNF43	Ssm	11	100	11%	cbioportal
25	PREX2	Ssm	11	100	11%	cbioportal
24	PCLO	Ssm	11	100	11%	cbioportal
23	MDN1	Ssm	11	100	11%	cbioportal
22	HRNR	Ssm	11	100	11%	cbioportal
20	CACNA1C	Ssm	11	100	11%	cbioportal
19	ABCA13	Ssm	11	100	11%	cbioportal
21	COBLL1	Ssm	11	100	11%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (TCGA, Firehose Legacy) stad_tcgaTCGA

478 cases with simple somatic mutation data · 478 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	217	478	45.4%	cbioportal
2	TP53	Ssm	190	478	39.7%	cbioportal
3	MUC16	Ssm	134	478	28%	cbioportal
4	LRP1B	Ssm	104	478	21.8%	cbioportal
5	ARID1A	Ssm	102	478	21.3%	cbioportal
6	SYNE1	Ssm	101	478	21.1%	cbioportal
7	OBSCN	Ssm	95	478	19.9%	cbioportal
8	FLG	Ssm	86	478	18%	cbioportal
9	FAT4	Ssm	85	478	17.8%	cbioportal
10	CSMD1	Ssm	84	478	17.6%	cbioportal
11	PCLO	Ssm	80	478	16.7%	cbioportal
12	RYR2	Ssm	77	478	16.1%	cbioportal
14	FAT3	Ssm	73	478	15.3%	cbioportal
13	DNAH5	Ssm	73	478	15.3%	cbioportal
15	HMCN1	Ssm	73	478	15.3%	cbioportal
18	ZFHX4	Ssm	69	478	14.4%	cbioportal
17	SPTA1	Ssm	69	478	14.4%	cbioportal
16	KMT2D	Ssm	69	478	14.4%	cbioportal
19	PIK3CA	Ssm	65	478	13.6%	cbioportal
20	HSPG2	Ssm	63	478	13.2%	cbioportal
21	DNAH7	Ssm	62	478	13%	cbioportal
23	RYR3	Ssm	61	478	12.8%	cbioportal
22	PCDH15	Ssm	61	478	12.8%	cbioportal
24	SACS	Ssm	60	478	12.6%	cbioportal
28	USH2A	Ssm	59	478	12.3%	cbioportal
26	DNAH11	Ssm	59	478	12.3%	cbioportal
25	ACVR2A	Ssm	59	478	12.3%	cbioportal
27	LRRK2	Ssm	59	478	12.3%	cbioportal
30	CUBN	Ssm	58	478	12.1%	cbioportal
29	AHNAK2	Ssm	58	478	12.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (TCGA GDC, 2025) stad_tcga_gdcTCGA GDC

431 cases with simple somatic mutation data · 443 cases total · 2026-01-14 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	221	431	51.3%	cbioportal
2	TP53	Ssm	198	431	45.9%	cbioportal
3	MUC16	Ssm	135	431	31.3%	cbioportal
4	ARID1A	Ssm	116	431	26.9%	cbioportal
5	LRP1B	Ssm	115	431	26.7%	cbioportal
7	SYNE1	Ssm	102	431	23.7%	cbioportal
6	CSMD3	Ssm	102	431	23.7%	cbioportal
8	FAT4	Ssm	92	431	21.3%	cbioportal
9	FLG	Ssm	85	431	19.7%	cbioportal
10	PCLO	Ssm	81	431	18.8%	cbioportal
11	HMCN1	Ssm	80	431	18.6%	cbioportal
13	ZFHX4	Ssm	77	431	17.9%	cbioportal
12	ACVR2A	Ssm	77	431	17.9%	cbioportal
14	DNAH5	Ssm	76	431	17.6%	cbioportal
16	SPTA1	Ssm	74	431	17.2%	cbioportal
15	OBSCN	Ssm	74	431	17.2%	cbioportal
17	RYR2	Ssm	73	431	16.9%	cbioportal
18	CSMD1	Ssm	71	431	16.5%	cbioportal
19	FAT3	Ssm	71	431	16.5%	cbioportal
20	KMT2D	Ssm	68	431	15.8%	cbioportal
21	PIK3CA	Ssm	67	431	15.5%	cbioportal
22	DST	Ssm	66	431	15.3%	cbioportal
23	SACS	Ssm	65	431	15.1%	cbioportal
24	PCDH15	Ssm	62	431	14.4%	cbioportal
25	PLEC	Ssm	62	431	14.4%	cbioportal
26	DMD	Ssm	61	431	14.2%	cbioportal
27	LRRK2	Ssm	60	431	13.9%	cbioportal
28	SYNE2	Ssm	59	431	13.7%	cbioportal
29	UBR5	Ssm	59	431	13.7%	cbioportal
30	COL12A1	Ssm	58	431	13.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Stomach Adenocarcinoma (TCGA, Nature 2014) stad_tcga_pubTCGA

295 cases with simple somatic mutation data · 295 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	166	295	56.3%	cbioportal
2	TP53	Ssm	138	295	46.8%	cbioportal
3	MUC16	Ssm	101	295	34.2%	cbioportal
4	ARID1A	Ssm	90	295	30.5%	cbioportal
5	LRP1B	Ssm	78	295	26.4%	cbioportal
6	SYNE1	Ssm	76	295	25.8%	cbioportal
7	FAT4	Ssm	70	295	23.7%	cbioportal
8	CSMD3	Ssm	68	295	23.1%	cbioportal
9	PCLO	Ssm	67	295	22.7%	cbioportal
10	HMCN1	Ssm	66	295	22.4%	cbioportal
11	CSMD1	Ssm	65	295	22%	cbioportal
12	KMT2D	Ssm	65	295	22%	cbioportal
13	FLG	Ssm	62	295	21%	cbioportal
14	RYR2	Ssm	59	295	20%	cbioportal
15	PIK3CA	Ssm	57	295	19.3%	cbioportal
16	SPTA1	Ssm	57	295	19.3%	cbioportal
17	DNAH5	Ssm	56	295	19%	cbioportal
18	FAT3	Ssm	56	295	19%	cbioportal
19	OBSCN	Ssm	55	295	18.6%	cbioportal
20	ZFHX4	Ssm	53	295	18%	cbioportal
21	RYR3	Ssm	50	295	16.9%	cbioportal
22	PCDH15	Ssm	49	295	16.6%	cbioportal
23	RNF43	Ssm	49	295	16.6%	cbioportal
24	ADGRV1	Ssm	48	295	16.3%	cbioportal
25	PLEC	Ssm	48	295	16.3%	cbioportal
26	DMD	Ssm	47	295	15.9%	cbioportal
27	SACS	Ssm	47	295	15.9%	cbioportal
28	COL12A1	Ssm	46	295	15.6%	cbioportal
29	RYR1	Ssm	46	295	15.6%	cbioportal
30	TSPOAP1	Ssm	46	295	15.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (TCGA, PanCancer Atlas) stad_tcga_pan_can_atlas_2018TCGA

436 cases with simple somatic mutation data · 440 cases total · 2026-06-04 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	235	436	53.9%	cbioportal
2	TP53	Ssm	213	436	48.9%	cbioportal
3	MUC16	Ssm	146	436	33.5%	cbioportal
4	LRP1B	Ssm	120	436	27.5%	cbioportal
5	SYNE1	Ssm	111	436	25.5%	cbioportal
6	ARID1A	Ssm	110	436	25.2%	cbioportal
7	CSMD3	Ssm	107	436	24.5%	cbioportal
8	FLG	Ssm	103	436	23.6%	cbioportal
9	FAT4	Ssm	94	436	21.6%	cbioportal
10	CSMD1	Ssm	88	436	20.2%	cbioportal
11	PCLO	Ssm	88	436	20.2%	cbioportal
12	HMCN1	Ssm	86	436	19.7%	cbioportal
13	OBSCN	Ssm	81	436	18.6%	cbioportal
14	DNAH5	Ssm	80	436	18.3%	cbioportal
16	ZFHX4	Ssm	79	436	18.1%	cbioportal
15	RYR2	Ssm	79	436	18.1%	cbioportal
17	FAT3	Ssm	77	436	17.7%	cbioportal
18	SPTA1	Ssm	77	436	17.7%	cbioportal
19	KMT2D	Ssm	73	436	16.7%	cbioportal
20	PCDH15	Ssm	72	436	16.5%	cbioportal
21	PIK3CA	Ssm	71	436	16.3%	cbioportal
22	AHNAK2	Ssm	68	436	15.6%	cbioportal
24	SACS	Ssm	64	436	14.7%	cbioportal
23	PLEC	Ssm	64	436	14.7%	cbioportal
29	RYR3	Ssm	62	436	14.2%	cbioportal
30	USH2A	Ssm	62	436	14.2%	cbioportal
28	LAMA1	Ssm	62	436	14.2%	cbioportal
27	DNAH11	Ssm	62	436	14.2%	cbioportal
26	CUBN	Ssm	62	436	14.2%	cbioportal
25	COL12A1	Ssm	62	436	14.2%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Stomach Adenocarcinoma (UHK, Nat Genet 2011) stad_uhongkongUHK

22 cases with simple somatic mutation data · 22 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	9	22	40.9%	cbioportal
2	DNAH7	Ssm	7	22	31.8%	cbioportal
5	LRP1B	Ssm	6	22	27.3%	cbioportal
3	ARID1A	Ssm	6	22	27.3%	cbioportal
7	SLCO6A1	Ssm	6	22	27.3%	cbioportal
4	CSMD3	Ssm	6	22	27.3%	cbioportal
6	PTEN	Ssm	6	22	27.3%	cbioportal
8	PCDH15	Ssm	5	22	22.7%	cbioportal
9	TTN	Ssm	5	22	22.7%	cbioportal
25	USP34	Ssm	4	22	18.2%	cbioportal
10	ACVR2A	Ssm	4	22	18.2%	cbioportal
11	BAZ2B	Ssm	4	22	18.2%	cbioportal
12	COPB2	Ssm	4	22	18.2%	cbioportal
13	DNAH3	Ssm	4	22	18.2%	cbioportal
14	EIF3A	Ssm	4	22	18.2%	cbioportal
15	FMN2	Ssm	4	22	18.2%	cbioportal
16	HERC2	Ssm	4	22	18.2%	cbioportal
17	HMCN1	Ssm	4	22	18.2%	cbioportal
18	LMAN1	Ssm	4	22	18.2%	cbioportal
19	PAPPA	Ssm	4	22	18.2%	cbioportal
20	SPTA1	Ssm	4	22	18.2%	cbioportal
21	SYNE2	Ssm	4	22	18.2%	cbioportal
22	TIAM1	Ssm	4	22	18.2%	cbioportal
23	TTK	Ssm	4	22	18.2%	cbioportal
24	USH2A	Ssm	4	22	18.2%	cbioportal
28	ABCB5	Ssm	3	22	13.6%	cbioportal
26	ABCA7	Ssm	3	22	13.6%	cbioportal
27	ABCA8	Ssm	3	22	13.6%	cbioportal
29	ADAMTS18	Ssm	3	22	13.6%	cbioportal
30	ANK3	Ssm	3	22	13.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (U Tokyo, Nat Genet 2014) stad_utokyoU Tokyo

30 cases with simple somatic mutation data · 30 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	10	30	33.3%	cbioportal
2	TTN	Ssm	8	30	26.7%	cbioportal
3	RHOA	Ssm	7	30	23.3%	cbioportal
4	ARID1A	Ssm	5	30	16.7%	cbioportal
5	CACNA1H	Ssm	4	30	13.3%	cbioportal
6	CDC27	Ssm	4	30	13.3%	cbioportal
7	CDH1	Ssm	4	30	13.3%	cbioportal
8	KIF2B	Ssm	4	30	13.3%	cbioportal
9	MUC16	Ssm	4	30	13.3%	cbioportal
11	SPTA1	Ssm	4	30	13.3%	cbioportal
10	MYT1L	Ssm	4	30	13.3%	cbioportal
14	CSMD1	Ssm	3	30	10%	cbioportal
26	STAB1	Ssm	3	30	10%	cbioportal
12	COL12A1	Ssm	3	30	10%	cbioportal
13	CRB1	Ssm	3	30	10%	cbioportal
27	SYNE1	Ssm	3	30	10%	cbioportal
28	TENM1	Ssm	3	30	10%	cbioportal
29	TLL1	Ssm	3	30	10%	cbioportal
30	TPRXL	Ssm	3	30	10%	cbioportal
25	SRRM4	Ssm	3	30	10%	cbioportal
24	RYR2	Ssm	3	30	10%	cbioportal
23	PLXNA4	Ssm	3	30	10%	cbioportal
22	NF1	Ssm	3	30	10%	cbioportal
21	NCKAP5	Ssm	3	30	10%	cbioportal
20	KCNT2	Ssm	3	30	10%	cbioportal
19	HEATR5B	Ssm	3	30	10%	cbioportal
18	GRM5	Ssm	3	30	10%	cbioportal
17	DYNC2H1	Ssm	3	30	10%	cbioportal
16	DMD	Ssm	3	30	10%	cbioportal
15	CYP7B1	Ssm	3	30	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-13