Gene
SORCS3
sortilin related VPS10 domain containing receptor 3
Explore in graph →CI-GENE-00033316HGNC:16699 ENSG00000156395 NCBI 22986 Cancer geneApproved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (26)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
gdcProvenance
- Source
- NCI Genomic Data Commons (open aggregated data)
- Dataset
- GDC top mutated genes by project
- Version
- Data Release 46.0
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- Open-access GDC data (NCI); citation of GDC and originating program requested
- Run
- ING-GDC-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Skin Cutaneous Melanoma TCGA-SKCM | Cutaneous Melanoma | Ssm | 322 | 470 | 68.5% | 80 | gdc |
| Cutaneous Squamous Cell Carcinoma (UCSF, NPJ Genom Med 2021) |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.