Gene

JUN

Jun proto-oncogene, AP-1 transcription factor subunit

Explore in graph →CI-GENE-00006555HGNC:6204 ENSG00000177606 NCBI 3725 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
JUN Overexpression1
Irbesartan	Colorectal Adenocarcinoma	Predictive	C	Supports Sensitivity Response	2	accepted	EID1633 A 67-year-old female presents with recurrent metastatic colonic adenocarcinoma. Immunohistochemical and genetic workup showed overexpression of c-JUN and FOS, which presumably signals through the RAA… (full text at CIViC) PMID 27022066 · Jones et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (35)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved35 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	8

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer.
· Ann Oncol · 2016 · PMID 27022066 · validated civic_curation pubmed