Gene

ACTA1

actin alpha 1, skeletal muscle

Explore in graph →CI-GENE-00000286HGNC:129 ENSG00000143632 NCBI 58 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ACTA1 EXPRESSION1
(prognostic)	Lung Adenocarcinoma	Prognostic	B	Supports Poor Outcome	2	accepted	EID1161 ActA level was measured in serum and plasma samples of 64/87 lung adenocarcinoma patients and 46/66 age- and gender-matched controls (ELISA). ActA Levels were higher in patients than in controls and w… (full text at CIViC) PMID 26950277 · Hoda et al., 2016 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (3)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved3 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer Radiation (MSK, 2024) rectal_radiation_msk_2024	Rectal Adenocarcinoma	Ssm	4	17

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma.
· Oncotarget · 2016 · PMID 26950277 · validated civic_curation pubmed