Gene
CDK8
cyclin dependent kinase 8
Explore in graph →CI-GENE-00040750HGNC:1779 ENSG00000132964 NCBI 1024 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (38)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 35121644
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Metastatic Triple Negative Breast Cancer (UNC Phase II Trial, J Immunother Cancer 2022) - iAtlas Harmonized brca_iatlas_anders_2022 | Invasive Breast Carcinoma | Ssm | 3 | 25 | 12% | 74 | cbioportal |
| Pancreatic Adenocarcinoma (MSK, 2025) paad_msk_2025 | Pancreatic Adenocarcinoma | Ssm | 3 | 29 | 10.3% | 4 | cbioportal |
| Colorectal Cancer (MSK, JCO Precis Oncol 2022) crc_dd_2022 | Colorectal Adenocarcinoma | Ssm | 4 | 47 | 8.5% | 94 | cbioportal |
| Bladder Cancer (MSK, Nat Genet 2016) blca_plasmacytoid_mskcc_2016 | Bladder Urothelial Carcinoma | Ssm | 2 | 34 | 5.9% | 41 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.