Gene

FOXO1

forkhead box O1

Explore in graph →CI-GENE-00002181HGNC:3819 ENSG00000150907 NCBI 2308 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (11)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–11 of 11 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FOXO1 mutation2
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11934 This study used a combination of RNA-seq, whole genome and targeted sequencing to identify recurrently mutated genes in follicular and diffuse large B-cell lymphoma. They reported 30 genes that had si… (full text at CIViC) PMID 21796119 · Morin et al., 2011 · Open in CIViC	civic
〃	Burkitt Lymphoma	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11819 FOXO1 mutations are associated with multiple B-cell lymphomas including BL as described in the referenced study PMID 30617194 · Grande et al., 2019 · Open in CIViC

Cohorts

Alteration frequency by cohort (47)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved47 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Mature B-Cell Neoplasms (Simon Fraser University, Blood 2023) mbn_sfu_2023	B-Cell Non-Hodgkin Lymphoma	Ssm	72

Literature

Linked publications (4)

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group.
· J Clin Oncol · 2002 · PMID 12039929 · validated civic_curation pubmed
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.
· Cancer Discov · 2014 · PMID 24436047 · validated civic_curation pubmed
Evolving classification of rhabdomyosarcoma.
· Histopathology · 2022 · PMID 34958505 · validated civic_curation pubmed
PAX3-FOXO1 Establishes Myogenic Super Enhancers and Confers BET Bromodomain Vulnerability.
· Cancer Discov · 2017 · PMID 28446439 · validated civic_curation

FOXO1 Fusion5
(diagnostic)	Alveolar Rhabdomyosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID7009 In a cohort of 171 pediatric rhabdomyosarcoma patients, the PAX3::FOXO1 fusion transcript was detected in 55% of patients with centrally reviewed ARMS. Critically, this fusion, along with the related … (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC	civic
〃	Alveolar Rhabdomyosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID11684 In this study, a total of 147 rhabdomyosarcomas/normal pairs were analyzed, 44 by whole genome sequencing and 103 tumors by whole exome sequencing. 50 cases classified as alveolar rhabdomyosarcoma his… (full text at CIViC) PMID 24436047 · Shern et al., 2014 · Open in CIViC	civic
〃	Alveolar Rhabdomyosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID11687 This study summarizes the evolution of the classification of rhabdomyosarcomas which now includes embryonal, alveolar, spindle cell/sclerosing and pleomorphic rhabdomyosarcoma. Genetically, alveolar r… (full text at CIViC) PMID 34958505 · Agaram, 2022 · Open in CIViC	civic
(prognostic)	Alveolar Rhabdomyosarcoma	Prognostic	B	Supports Poor Outcome	3	accepted	EID8885 In a cohort of 171 uniformly treated pediatric rhabdomyosarcoma (RMS) patients, 78 patients had alveolar rhabdomyosarcoma (ARMS). Of ARMS patients, 55% harbored a PAX3-FOXO1 fusion, 22% harbored a PAX… (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC	civic
BET Inhibitor	Alveolar Rhabdomyosarcoma	Predictive	D	Supports Sensitivity Response	3	accepted	EID7011 5 PAX3-FOXO1 fusion positive rhabdomyosarcoma cell lines exhibited greater sensitivity to BET bromodomain inhibitors than fusion negative lines and introduction of the PAX3-FOXO1 fusion to fibroblasts… (full text at CIViC) PMID 28446439 · Gryder et al., 2017 · Open in CIViC	civic

FOXO1 Fusion5

(diagnostic)

Alveolar Rhabdomyosarcoma

Diagnostic

Supports Positive

accepted

EID7009

In a cohort of 171 pediatric rhabdomyosarcoma patients, the PAX3::FOXO1 fusion transcript was detected in 55% of patients with centrally reviewed ARMS. Critically, this fusion, along with the related … (full text at CIViC)

PMID 12039929 · Sorensen et al., 2002 · Open in CIViC

civic

〃

Alveolar Rhabdomyosarcoma

Diagnostic

Supports Positive

accepted

EID11684

In this study, a total of 147 rhabdomyosarcomas/normal pairs were analyzed, 44 by whole genome sequencing and 103 tumors by whole exome sequencing. 50 cases classified as alveolar rhabdomyosarcoma his… (full text at CIViC)

PMID 24436047 · Shern et al., 2014 · Open in CIViC

civic

〃

Alveolar Rhabdomyosarcoma

Diagnostic

Supports Positive

accepted

EID11687

This study summarizes the evolution of the classification of rhabdomyosarcomas which now includes embryonal, alveolar, spindle cell/sclerosing and pleomorphic rhabdomyosarcoma. Genetically, alveolar r… (full text at CIViC)

PMID 34958505 · Agaram, 2022 · Open in CIViC

civic

(prognostic)

Alveolar Rhabdomyosarcoma

Prognostic

Supports Poor Outcome

accepted

EID8885

In a cohort of 171 uniformly treated pediatric rhabdomyosarcoma (RMS) patients, 78 patients had alveolar rhabdomyosarcoma (ARMS). Of ARMS patients, 55% harbored a PAX3-FOXO1 fusion, 22% harbored a PAX… (full text at CIViC)

PMID 12039929 · Sorensen et al., 2002 · Open in CIViC

civic

BET Inhibitor

Alveolar Rhabdomyosarcoma

Predictive

Supports Sensitivity Response

accepted

EID7011

5 PAX3-FOXO1 fusion positive rhabdomyosarcoma cell lines exhibited greater sensitivity to BET bromodomain inhibitors than fusion negative lines and introduction of the PAX3-FOXO1 fusion to fibroblasts… (full text at CIViC)

PMID 28446439 · Gryder et al., 2017 · Open in CIViC

civic

FOXO1 Fusion4
(diagnostic)	Alveolar Rhabdomyosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID7010 In a cohort of 171 uniformly treated pediatric rhabdomyosarcoma (RMS) patients, 78 patients had alveolar rhabdomyosarcoma (ARMS). Of ARMS patients, 55% harbored a PAX3-FOXO1 fusion, 22% harbored a PAX… (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC	civic
〃	Alveolar Rhabdomyosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID11685 In this study, a total of 147 rhabdomyosarcomas/normal pairs were analyzed, 44 by whole genome sequencing and 103 tumors by whole exome sequencing. 50 cases classified as alveolar rhabdomyosarcoma his… (full text at CIViC) PMID 24436047 · Shern et al., 2014 · Open in CIViC	civic
〃	Alveolar Rhabdomyosarcoma	Diagnostic	B	Supports Positive	4	accepted	EID11686 This study summarizes the evolution of the classification of rhabdomyosarcomas which now includes embryonal, alveolar, spindle cell/sclerosing and pleomorphic rhabdomyosarcoma. Genetically, alveolar r… (full text at CIViC) PMID 34958505 · Agaram, 2022 · Open in CIViC	civic
(prognostic)	Alveolar Rhabdomyosarcoma	Prognostic	B	Supports Better Outcome	3	accepted	EID8886 In a cohort of 171 uniformly treated pediatric rhabdomyosarcoma (RMS) patients, 78 patients had alveolar rhabdomyosarcoma (ARMS). Of ARMS patients, 55% harbored a PAX3-FOXO1 fusion, 22% harbored a PAX… (full text at CIViC) PMID 12039929 · Sorensen et al., 2002 · Open in CIViC	civic

FOXO1 Fusion4

(diagnostic)

Alveolar Rhabdomyosarcoma

Diagnostic

Supports Positive

accepted

EID7010

PMID 12039929 · Sorensen et al., 2002 · Open in CIViC

civic

〃

Alveolar Rhabdomyosarcoma

Diagnostic