Gene

STAT3

signal transducer and activator of transcription 3

Explore in graph →CI-GENE-00034019HGNC:11364 ENSG00000168610 NCBI 6774 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
STAT3 Mutation1
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11988 The authors sequenced exons 19–24 of STAT3 (the region where the hot spot has been reported in other malignancies) in 48 diffuse large B-cell lymphoma samples. PMID 24837465 · Ohgami et al., 2014 · Open in CIViC	civic
STAT3 SH2 DOMAIN MUTATION1
(diagnostic)	T-Cell Large Granular Lymphocyte Leukemia	Diagnostic	B	Supports Positive	4	accepted	EID957 Mutations in the Src homology 2 (SH2) domain (exon 21) of STAT3 were found in 31 of 77 patients (40%) with large granular lymphocytic leukemia. Recurrent mutational hot spots included Y640F, D661V, D6… (full text at CIViC)

Cohorts

Alteration frequency by cohort (38)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved38 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	10

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Somatic STAT3 mutations in large granular lymphocytic leukemia.
· N Engl J Med · 2012 · PMID 22591296 · validated civic_curation pubmed