SOS1

SOS Ras/Rac guanine nucleotide exchange factor 1

Explore in graph →CI-GENE-00033325HGNC:11187 ENSG00000115904 NCBI 6654 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SOS1 E846K1
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	3	submitted	EID10542 The SOS1 mutation E846K commonly associated with Noonan syndrome was introduced into mouse ES cells using the Cre-Lox recombination system. ES cells expressing mutant SOS1 showed increased levels of p… (full text at CIViC) PMID 21041952 · Chen et al., 2010 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (34)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved34 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	8

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.