Gene
GNA11
G protein subunit alpha 11
Explore in graph →CI-GENE-00003181HGNC:4379 ENSG00000088256 NCBI 2767 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (9)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 32255239
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| GNA11 G209P1 | ||||||||
| (prognostic) | Congenital Hemangioma | Prognostic | C | Supports Poor Outcome | 3 | submitted | EID8640An infant was diagnosed prenatally at 20 weeks gestation with segmented vascular tumors involving her liver, umbilicus, and skin of the upper back and torso. She developed congestive heart failure imm… (full text at CIViC) PMID 32255239 · Smith et al., 2020 · Open in CIViC | civic |
| GNA11 Mutation4 | ||||||||
| Cabozantinib | Uveal Melanoma | Predictive | B | Supports Sensitivity Response | 3 | accepted | EID3049In total, 77 patients with metastatic melanoma (62% cutaneous, 30% uveal, 8% mucosal) were admitted into a randomized phase II trial assessing the efficacy of Cabozantinib. Patients received cabozanti… (full text at CIViC) PMID 28103611 · | |
Cohorts
Alteration frequency by cohort (25)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 26683228
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Uveal Melanoma (QIMR, Oncotarget 2016) um_qimr_2016 | Uveal Melanoma | Ssm | 15 | 26 | 57.7% |
Literature
Linked publications (7)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)