Gene
CYLD
CYLD lysine 63 deubiquitinase
Explore in graph →CI-GENE-00042729HGNC:2584 ENSG00000083799 NCBI 1540 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (41)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 31591597
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Rectal Cancer (MSK,Nature Medicine 2019) rectal_msk_2019 | Colorectal Adenocarcinoma | Ssm | 5 | 49 | 10.2% | 130 | cbioportal |
| Upper Tract Urothelial Carcinoma PDX (MSK, Nat Commun 2020) utuc_pdx_msk_2019 | Renal Pelvis and Ureter Urothelial Carcinoma | Ssm | 3 | 32 | 9.4% | 137 | cbioportal |
| Colorectal Cancer (MSK, JCO Precis Oncol 2022) crc_dd_2022 | Colorectal Adenocarcinoma | Ssm | 3 | 40 | 7.5% | 138 | cbioportal |
| Cholangiocarcinoma (National Cancer Centre of Singapore, Nat Genet 2013) chol_nccs_2013 | Cholangiocarcinoma | Ssm | 1 | 15 | 6.7% | 60 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.