Gene

RHOA

ras homolog family member A

Explore in graph →CI-GENE-00023504HGNC:667 ENSG00000067560 NCBI 387 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RHOA MUTATION3
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11981 One of the first genes found to be affected by aberrant somatic hypermutation in DLBCL PMID 11460166 · Pasqualucci et al., 2001 · Open in CIViC	civic
〃	Burkitt Lymphoma	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11830 Described in multiple genome-wide studies of BL PMID 30617194 · Grande et al., 2019 · Open in CIViC	civic
(prognostic)	Gastric Carcinoma

Cohorts

Alteration frequency by cohort (46)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved46 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	8

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Comprehensive mutation profiling of mucinous gastric carcinoma.
· J Pathol · 2016 · PMID 27313181 · validated civic_curation pubmed