Gene

ERRFI1

ERBB receptor feedback inhibitor 1

Explore in graph →CI-GENE-00044973HGNC:18185 ENSG00000116285 NCBI 54206 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ERRFI1 E384*2
Erlotinib	Cholangiocarcinoma	Predictive	C	Supports Sensitivity Response	3	rejected	EID5869 A patient with cholangiocarcinoma who has initially undergone surgical resection progressed on gemcitabine and cisplatin. He subsequently received pegylated hyaluroniade (PEGPH20) in an investigationa… (full text at CIViC) PMID 24550739 · Borad et al., 2014 · Open in CIViC	civic
〃	Cholangiocarcinoma	Predictive	C	Supports Sensitivity Response	2	accepted	EID1724 An ERRFI1 (E384X) was detected in a patient with metastatic, recurrent/refractory cholangiocarcinoma (allelic fraction 11%) without any mutations or amplifications in other EGFR signaling members such… (full text at CIViC) PMID 24550739 · Borad et al., 2014 · Open in CIViC

Cohorts

Alteration frequency by cohort (37)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved37 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial and Ovarian Cancer (MSK, Nature Medicine 2024) ucec_msk_2024	unmapped	Ssm	6	33	18.2%

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Integrated genomic characterization reveals novel, therapeutically relevant drug targets in FGFR and EGFR pathways in sporadic intrahepatic cholangiocarcinoma.
· PLoS Genet · 2014 · PMID 24550739 · validated civic_curation pubmed