Malignant Reproductive System Neoplasm — Genomics

Malignant Reproductive System Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

64 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma TCGA-CESCTCGA

306 cases with simple somatic mutation data · 307 cases total · Data Release 46.0 · mapped to Cervical Carcinoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA, Firehose Legacy) cesc_tcgaTCGA

194 cases with simple somatic mutation data · 310 cases total · 2026-01-05 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	62	194	32%	cbioportal
2	PIK3CA	Ssm	53	194	27.3%	cbioportal
3	MUC4	Ssm	37	194	19.1%	cbioportal
4	KMT2C	Ssm	29	194	14.9%	cbioportal
5	MUC16	Ssm	28	194	14.4%	cbioportal
6	ADGRV1	Ssm	26	194	13.4%	cbioportal
7	SYNE1	Ssm	23	194	11.9%	cbioportal
8	KMT2D	Ssm	22	194	11.3%	cbioportal
9	EP300	Ssm	21	194	10.8%	cbioportal
10	RYR2	Ssm	21	194	10.8%	cbioportal
11	DMD	Ssm	20	194	10.3%	cbioportal
12	FLG	Ssm	20	194	10.3%	cbioportal
13	SYNE2	Ssm	20	194	10.3%	cbioportal
14	FBXW7	Ssm	19	194	9.8%	cbioportal
15	USH2A	Ssm	18	194	9.3%	cbioportal
16	OBSCN	Ssm	17	194	8.8%	cbioportal
22	MUC5B	Ssm	16	194	8.2%	cbioportal
19	MACF1	Ssm	16	194	8.2%	cbioportal
17	HLA-A	Ssm	16	194	8.2%	cbioportal
18	HMCN1	Ssm	16	194	8.2%	cbioportal
20	MDN1	Ssm	16	194	8.2%	cbioportal
21	MUC12	Ssm	16	194	8.2%	cbioportal
24	APOB	Ssm	15	194	7.7%	cbioportal
29	PTEN	Ssm	15	194	7.7%	cbioportal
28	PCLO	Ssm	15	194	7.7%	cbioportal
27	NEB	Ssm	15	194	7.7%	cbioportal
26	DNAH6	Ssm	15	194	7.7%	cbioportal
25	ARID1A	Ssm	15	194	7.7%	cbioportal
23	ABCA12	Ssm	15	194	7.7%	cbioportal
30	CREBBP	Ssm	14	194	7.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Cervical Squamous Cell Carcinoma (TCGA GDC, 2025) cesc_tcga_gdcTCGA GDC

289 cases with simple somatic mutation data · 309 cases total · 2026-01-13 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	87	289	30.1%	cbioportal
2	PIK3CA	Ssm	81	289	28%	cbioportal
3	KMT2C	Ssm	54	289	18.7%	cbioportal
4	MUC16	Ssm	49	289	17%	cbioportal
5	KMT2D	Ssm	39	289	13.5%	cbioportal
6	FLG	Ssm	37	289	12.8%	cbioportal
7	EP300	Ssm	36	289	12.5%	cbioportal
8	DMD	Ssm	35	289	12.1%	cbioportal
9	SYNE1	Ssm	35	289	12.1%	cbioportal
10	FBXW7	Ssm	34	289	11.8%	cbioportal
11	LRP1B	Ssm	33	289	11.4%	cbioportal
12	RYR2	Ssm	32	289	11.1%	cbioportal
13	DST	Ssm	31	289	10.7%	cbioportal
15	USH2A	Ssm	29	289	10%	cbioportal
14	ADGRV1	Ssm	29	289	10%	cbioportal
16	HUWE1	Ssm	28	289	9.7%	cbioportal
17	MUC17	Ssm	28	289	9.7%	cbioportal
18	LRP2	Ssm	24	289	8.3%	cbioportal
21	SYNE2	Ssm	24	289	8.3%	cbioportal
19	NAV3	Ssm	24	289	8.3%	cbioportal
20	NEB	Ssm	24	289	8.3%	cbioportal
22	PCLO	Ssm	23	289	8%	cbioportal
23	CREBBP	Ssm	22	289	7.6%	cbioportal
28	MUC5B	Ssm	22	289	7.6%	cbioportal
27	MDN1	Ssm	22	289	7.6%	cbioportal
26	HMCN1	Ssm	22	289	7.6%	cbioportal
25	FAT1	Ssm	22	289	7.6%	cbioportal
24	DNAH2	Ssm	22	289	7.6%	cbioportal
30	HYDIN	Ssm	21	289	7.3%	cbioportal
29	CSMD1	Ssm	21	289	7.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Cervical Squamous Cell Carcinoma (TCGA, PanCancer Atlas) cesc_tcga_pan_can_atlas_2018TCGA

291 cases with simple somatic mutation data · 297 cases total · 2026-06-05 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	91	291	31.3%	cbioportal
2	PIK3CA	Ssm	83	291	28.5%	cbioportal
3	KMT2C	Ssm	54	291	18.6%	cbioportal
4	MUC4	Ssm	50	291	17.2%	cbioportal
5	MUC16	Ssm	48	291	16.5%	cbioportal
6	KMT2D	Ssm	41	291	14.1%	cbioportal
7	FLG	Ssm	38	291	13.1%	cbioportal
9	SYNE1	Ssm	37	291	12.7%	cbioportal
8	DMD	Ssm	37	291	12.7%	cbioportal
11	FBXW7	Ssm	35	291	12%	cbioportal
10	EP300	Ssm	35	291	12%	cbioportal
12	RYR2	Ssm	35	291	12%	cbioportal
13	LRP1B	Ssm	33	291	11.3%	cbioportal
14	USH2A	Ssm	33	291	11.3%	cbioportal
16	MUC17	Ssm	30	291	10.3%	cbioportal
15	ADGRV1	Ssm	30	291	10.3%	cbioportal
17	HUWE1	Ssm	28	291	9.6%	cbioportal
18	CSMD1	Ssm	27	291	9.3%	cbioportal
19	NEB	Ssm	26	291	8.9%	cbioportal
20	NAV3	Ssm	25	291	8.6%	cbioportal
25	SYNE2	Ssm	24	291	8.2%	cbioportal
23	LRP2	Ssm	24	291	8.2%	cbioportal
22	HMCN1	Ssm	24	291	8.2%	cbioportal
21	AHNAK2	Ssm	24	291	8.2%	cbioportal
24	PCLO	Ssm	24	291	8.2%	cbioportal
28	DST	Ssm	23	291	7.9%	cbioportal
27	DNAH2	Ssm	23	291	7.9%	cbioportal
26	CREBBP	Ssm	23	291	7.9%	cbioportal
30	FAT1	Ssm	23	291	7.9%	cbioportal
29	EYS	Ssm	23	291	7.9%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Count Me In (CMI): The Metastatic Prostate Cancer (MPC) Project CMI-MPCCMI

60 cases with simple somatic mutation data · 63 cases total · Data Release 46.0 · mapped to Malignant Prostate Neoplasm CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	17	60	28.3%	gdc
2	RIMS2	Ssm	9	60	15%	gdc
4	FOXA1	Ssm	8	60	13.3%	gdc
3	SPOP	Ssm	8	60	13.3%	gdc
5	TTN	Ssm	7	60	11.7%	gdc
10	FAM161A	Ssm	5	60	8.3%	gdc
8	HMCN1	Ssm	5	60	8.3%	gdc
7	PTEN	Ssm	5	60	8.3%	gdc
6	XIAP	Ssm	5	60	8.3%	gdc
9	XPO5	Ssm	5	60	8.3%	gdc
18	KMT2D	Ssm	4	60	6.7%	gdc
11	SDK1	Ssm	4	60	6.7%	gdc
12	DNAH17	Ssm	4	60	6.7%	gdc
13	DNAH3	Ssm	4	60	6.7%	gdc
14	TYK2	Ssm	4	60	6.7%	gdc
15	MUC4	Ssm	4	60	6.7%	gdc
16	DCHS2	Ssm	4	60	6.7%	gdc
17	MUC16	Ssm	4	60	6.7%	gdc
19	MGA	Ssm	4	60	6.7%	gdc
20	OBSCN	Ssm	4	60	6.7%	gdc
21	NOTCH1	Ssm	4	60	6.7%	gdc
30	PADI4	Ssm	3	60	5%	gdc
28	ABCC12	Ssm	3	60	5%	gdc
27	RBBP8NL	Ssm	3	60	5%	gdc
26	MYH7B	Ssm	3	60	5%	gdc
25	YIPF3	Ssm	3	60	5%	gdc
24	WDFY4	Ssm	3	60	5%	gdc
23	C4orf54	Ssm	3	60	5%	gdc
22	ANAPC5	Ssm	3	60	5%	gdc
29	OR4C13	Ssm	3	60	5%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Endometrial cancer HR-positive (MSK, 2024) uec_msk_2024MSK

23 cases with simple somatic mutation data · 24 cases total · 2026-01-20 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	15	24	62.5%	cbioportal
2	ARID1A	Ssm	14	24	58.3%	cbioportal
3	PIK3CA	Ssm	12	24	50%	cbioportal
4	PIK3R1	Ssm	10	24	41.7%	cbioportal
5	CTNNB1	Ssm	9	24	37.5%	cbioportal
6	KRAS	Ssm	6	24	25%	cbioportal
7	BCOR	Ssm	5	24	20.8%	cbioportal
9	KMT2D	Ssm	4	24	16.7%	cbioportal
8	FGFR2	Ssm	4	24	16.7%	cbioportal
10	PIK3CG	Ssm	4	24	16.7%	cbioportal
11	ZFHX3	Ssm	4	24	16.7%	cbioportal
15	KMT2B	Ssm	3	23	13%	cbioportal
17	NOTCH1	Ssm	3	24	12.5%	cbioportal
12	CCND1	Ssm	3	24	12.5%	cbioportal
13	CTCF	Ssm	3	24	12.5%	cbioportal
16	MAP3K1	Ssm	3	24	12.5%	cbioportal
19	TP53	Ssm	3	24	12.5%	cbioportal
18	SPOP	Ssm	3	24	12.5%	cbioportal
14	JAK1	Ssm	3	24	12.5%	cbioportal
108	REST	Ssm	1	9	11.1%	cbioportal
68	ETAA1	Ssm	1	9	11.1%	cbioportal
78	GAB1	Ssm	1	9	11.1%	cbioportal
124	SPRTN	Ssm	1	9	11.1%	cbioportal
120	SMARCE1	Ssm	1	9	11.1%	cbioportal
27	INPPL1	Ssm	2	23	8.7%	cbioportal
39	SLX4	Ssm	2	23	8.7%	cbioportal
38	RASA1	Ssm	2	24	8.3%	cbioportal
40	SOX17	Ssm	2	24	8.3%	cbioportal
20	ACVR1	Ssm	2	24	8.3%	cbioportal
21	AKT1	Ssm	2	24	8.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Endometrial Cancer (MSK, 2018) ucec_msk_2018MSK

197 cases with simple somatic mutation data · 197 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	107	197	54.3%	cbioportal
2	PIK3CA	Ssm	80	197	40.6%	cbioportal
3	ARID1A	Ssm	59	197	29.9%	cbioportal
4	PTEN	Ssm	57	197	28.9%	cbioportal
5	PIK3R1	Ssm	46	197	23.4%	cbioportal
6	KRAS	Ssm	42	197	21.3%	cbioportal
7	KMT2D	Ssm	32	197	16.2%	cbioportal
8	CTNNB1	Ssm	30	197	15.2%	cbioportal
9	PPP2R1A	Ssm	30	197	15.2%	cbioportal
10	FBXW7	Ssm	28	197	14.2%	cbioportal
18	ZFHX3	Ssm	16	128	12.5%	cbioportal
11	CTCF	Ssm	23	197	11.7%	cbioportal
12	BCOR	Ssm	20	197	10.2%	cbioportal
13	ATM	Ssm	19	197	9.6%	cbioportal
14	FAT1	Ssm	19	197	9.6%	cbioportal
15	JAK1	Ssm	19	197	9.6%	cbioportal
16	KMT2C	Ssm	17	197	8.6%	cbioportal
17	NOTCH3	Ssm	16	197	8.1%	cbioportal
20	MTOR	Ssm	15	197	7.6%	cbioportal
19	MED12	Ssm	15	197	7.6%	cbioportal
21	SMARCA4	Ssm	15	197	7.6%	cbioportal
22	EP300	Ssm	14	197	7.1%	cbioportal
23	SPEN	Ssm	14	197	7.1%	cbioportal
27	KDM5C	Ssm	13	197	6.6%	cbioportal
25	ARID1B	Ssm	13	197	6.6%	cbioportal
24	AKT1	Ssm	13	197	6.6%	cbioportal
26	FGFR2	Ssm	13	197	6.6%	cbioportal
28	TSC2	Ssm	13	197	6.6%	cbioportal
54	ANKRD11	Ssm	8	128	6.3%	cbioportal
29	ERBB3	Ssm	12	197	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Cancer (MSK, Cancer Discovery 2023) ucec_ancestry_cds_msk_2023MSK

1,882 cases with simple somatic mutation data · 1,882 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	941	1,882	50%	cbioportal
2	TP53	Ssm	850	1,882	45.2%	cbioportal
3	PIK3CA	Ssm	824	1,882	43.8%	cbioportal
4	ARID1A	Ssm	793	1,882	42.1%	cbioportal
5	PIK3R1	Ssm	484	1,882	25.7%	cbioportal
6	KRAS	Ssm	357	1,882	19%	cbioportal
7	CTCF	Ssm	305	1,882	16.2%	cbioportal
8	CTNNB1	Ssm	296	1,882	15.7%	cbioportal
9	FBXW7	Ssm	276	1,882	14.7%	cbioportal
10	ZFHX3	Ssm	237	1,824	13%	cbioportal
13	KMT2B	Ssm	208	1,661	12.5%	cbioportal
11	KMT2D	Ssm	231	1,882	12.3%	cbioportal
12	PPP2R1A	Ssm	226	1,882	12%	cbioportal
15	INPPL1	Ssm	171	1,661	10.3%	cbioportal
14	BCOR	Ssm	184	1,882	9.8%	cbioportal
16	JAK1	Ssm	171	1,882	9.1%	cbioportal
17	RNF43	Ssm	154	1,882	8.2%	cbioportal
18	FGFR2	Ssm	151	1,882	8%	cbioportal
19	ATM	Ssm	139	1,882	7.4%	cbioportal
20	NF1	Ssm	118	1,882	6.3%	cbioportal
21	NSD1	Ssm	103	1,882	5.5%	cbioportal
22	ARID1B	Ssm	102	1,882	5.4%	cbioportal
23	ARID5B	Ssm	96	1,882	5.1%	cbioportal
24	KMT2C	Ssm	96	1,882	5.1%	cbioportal
25	SOX17	Ssm	93	1,882	4.9%	cbioportal
26	CCND1	Ssm	92	1,882	4.9%	cbioportal
28	POLE	Ssm	91	1,882	4.8%	cbioportal
27	FAT1	Ssm	91	1,882	4.8%	cbioportal
29	MED12	Ssm	89	1,882	4.7%	cbioportal
30	RASA1	Ssm	88	1,882	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma cfDNA (MSK, Clin Cancer Res 2022) ucec_ccr_cfdna_msk_2022MSK

44 cases with simple somatic mutation data · 44 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	22	44	50%	cbioportal
2	PIK3CA	Ssm	21	44	47.7%	cbioportal
3	PTEN	Ssm	21	44	47.7%	cbioportal
4	ARID1A	Ssm	15	44	34.1%	cbioportal
5	FBXW7	Ssm	12	44	27.3%	cbioportal
6	KRAS	Ssm	11	44	25%	cbioportal
7	PIK3R1	Ssm	9	44	20.5%	cbioportal
8	CTCF	Ssm	8	44	18.2%	cbioportal
9	KMT2A	Ssm	8	44	18.2%	cbioportal
10	KMT2B	Ssm	8	44	18.2%	cbioportal
11	KMT2D	Ssm	7	44	15.9%	cbioportal
12	JAK1	Ssm	6	44	13.6%	cbioportal
17	POLD1	Ssm	5	44	11.4%	cbioportal
16	NFE2L2	Ssm	5	44	11.4%	cbioportal
13	BCOR	Ssm	5	44	11.4%	cbioportal
19	ZFHX3	Ssm	5	44	11.4%	cbioportal
18	RNF43	Ssm	5	44	11.4%	cbioportal
14	EP300	Ssm	5	44	11.4%	cbioportal
15	INPPL1	Ssm	5	44	11.4%	cbioportal
24	NOTCH4	Ssm	4	44	9.1%	cbioportal
21	ATR	Ssm	4	44	9.1%	cbioportal
22	CREBBP	Ssm	4	44	9.1%	cbioportal
23	ERF	Ssm	4	44	9.1%	cbioportal
25	PBRM1	Ssm	4	44	9.1%	cbioportal
26	PGR	Ssm	4	44	9.1%	cbioportal
27	PPP2R1A	Ssm	4	44	9.1%	cbioportal
28	RRAS2	Ssm	4	44	9.1%	cbioportal
20	AR	Ssm	4	44	9.1%	cbioportal
29	ANKRD11	Ssm	3	44	6.8%	cbioportal
45	NOTCH3	Ssm	3	44	6.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma (CPTAC, Cell 2020) ucec_cptac_2020CPTAC

95 cases with simple somatic mutation data · 81 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	75	95	78.9%	cbioportal
2	PIK3CA	Ssm	47	95	49.5%	cbioportal
3	ARID1A	Ssm	43	95	45.3%	cbioportal
4	PIK3R1	Ssm	36	95	37.9%	cbioportal
5	KRAS	Ssm	31	95	32.6%	cbioportal
6	CTNNB1	Ssm	29	95	30.5%	cbioportal
7	CTCF	Ssm	27	95	28.4%	cbioportal
8	KMT2B	Ssm	23	95	24.2%	cbioportal
10	ZFHX3	Ssm	21	95	22.1%	cbioportal
9	TP53	Ssm	21	95	22.1%	cbioportal
12	INPPL1	Ssm	19	95	20%	cbioportal
13	ZFHX4	Ssm	19	95	20%	cbioportal
11	DOCK3	Ssm	19	95	20%	cbioportal
14	FBXW7	Ssm	18	95	18.9%	cbioportal
15	MUC16	Ssm	18	95	18.9%	cbioportal
17	KMT2D	Ssm	17	95	17.9%	cbioportal
16	HERC2	Ssm	17	95	17.9%	cbioportal
25	SYNE1	Ssm	16	95	16.8%	cbioportal
22	RBM27	Ssm	16	95	16.8%	cbioportal
18	JAK1	Ssm	16	95	16.8%	cbioportal
19	LRTM3	Ssm	16	95	16.8%	cbioportal
20	NSD1	Ssm	16	95	16.8%	cbioportal
21	PCLO	Ssm	16	95	16.8%	cbioportal
23	RPL22	Ssm	16	95	16.8%	cbioportal
24	SCAF4	Ssm	16	95	16.8%	cbioportal
26	AHNAK	Ssm	15	95	15.8%	cbioportal
27	DNAH17	Ssm	15	95	15.8%	cbioportal
30	OBSCN	Ssm	15	95	15.8%	cbioportal
29	LMAN1	Ssm	15	95	15.8%	cbioportal
28	HUWE1	Ssm	15	95	15.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma MSI (MSK, Clin Cancer Res 2022) ucec_ccr_msk_2022MSK

181 cases with simple somatic mutation data · 181 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ARID1A	Ssm	160	181	88.4%	cbioportal
2	PTEN	Ssm	156	181	86.2%	cbioportal
3	KMT2D	Ssm	122	181	67.4%	cbioportal
5	KMT2B	Ssm	106	169	62.7%	cbioportal
4	PIK3CA	Ssm	112	181	61.9%	cbioportal
6	CTCF	Ssm	101	181	55.8%	cbioportal
8	INPPL1	Ssm	86	169	50.9%	cbioportal
7	ZFHX3	Ssm	90	180	50%	cbioportal
9	JAK1	Ssm	76	181	42%	cbioportal
10	RNF43	Ssm	76	181	42%	cbioportal
11	ARID1B	Ssm	67	181	37%	cbioportal
12	FAT1	Ssm	62	181	34.3%	cbioportal
13	PIK3R1	Ssm	62	181	34.3%	cbioportal
14	CIC	Ssm	54	181	29.8%	cbioportal
15	NOTCH3	Ssm	53	181	29.3%	cbioportal
16	ANKRD11	Ssm	51	180	28.3%	cbioportal
17	BCOR	Ssm	51	181	28.2%	cbioportal
18	KMT2C	Ssm	51	181	28.2%	cbioportal
19	CREBBP	Ssm	50	181	27.6%	cbioportal
21	SMARCA4	Ssm	48	181	26.5%	cbioportal
20	MSH6	Ssm	48	181	26.5%	cbioportal
23	POLD1	Ssm	47	180	26.1%	cbioportal
22	KRAS	Ssm	47	181	26%	cbioportal
26	SPEN	Ssm	46	181	25.4%	cbioportal
24	FGFR2	Ssm	46	181	25.4%	cbioportal
25	PTPRS	Ssm	46	181	25.4%	cbioportal
27	IRS2	Ssm	45	181	24.9%	cbioportal
28	FBXW7	Ssm	44	181	24.3%	cbioportal
29	ATM	Ssm	43	181	23.8%	cbioportal
30	CCND1	Ssm	43	181	23.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024MSK

69 cases with simple somatic mutation data · 69 cases total · 2026-03-09 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ERBB2	Ssm	69	69	100%	cbioportal
2	ARID1A	Ssm	47	69	68.1%	cbioportal
3	PIK3CA	Ssm	41	69	59.4%	cbioportal
4	PTEN	Ssm	40	69	58%	cbioportal
6	TP53	Ssm	35	69	50.7%	cbioportal
5	KMT2D	Ssm	35	69	50.7%	cbioportal
7	FBXW7	Ssm	27	69	39.1%	cbioportal
15	KMT2B	Ssm	20	57	35.1%	cbioportal
8	FAT1	Ssm	24	69	34.8%	cbioportal
9	NOTCH3	Ssm	24	69	34.8%	cbioportal
10	ZFHX3	Ssm	23	68	33.8%	cbioportal
104	ARHGAP35	Ssm	8	25	32%	cbioportal
11	NOTCH1	Ssm	22	69	31.9%	cbioportal
12	ERBB3	Ssm	21	69	30.4%	cbioportal
13	KMT2C	Ssm	21	69	30.4%	cbioportal
14	ATM	Ssm	20	69	29%	cbioportal
16	POLE	Ssm	20	69	29%	cbioportal
17	ARID1B	Ssm	19	69	27.5%	cbioportal
18	CREBBP	Ssm	19	69	27.5%	cbioportal
19	SMARCA4	Ssm	19	69	27.5%	cbioportal
20	ANKRD11	Ssm	18	68	26.5%	cbioportal
33	DROSHA	Ssm	15	57	26.3%	cbioportal
34	INPPL1	Ssm	15	57	26.3%	cbioportal
24	PIK3R1	Ssm	18	69	26.1%	cbioportal
23	NSD1	Ssm	18	69	26.1%	cbioportal
21	BCOR	Ssm	18	69	26.1%	cbioportal
22	MSH2	Ssm	18	69	26.1%	cbioportal
27	SPEN	Ssm	17	69	24.6%	cbioportal
26	PPP2R1A	Ssm	17	69	24.6%	cbioportal
25	CTCF	Ssm	17	69	24.6%	cbioportal

Data updated 22 days agoSource updated 2026-03-09

Endometrial Carcinoma (TCGA GDC, 2025) ucec_tcga_gdcTCGA GDC

511 cases with simple somatic mutation data · 547 cases total · 2026-01-14 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	334	511	65.4%	cbioportal
2	PIK3CA	Ssm	252	511	49.3%	cbioportal
3	ARID1A	Ssm	235	511	46%	cbioportal
4	TTN	Ssm	194	511	38%	cbioportal
5	TP53	Ssm	190	511	37.2%	cbioportal
6	PIK3R1	Ssm	166	511	32.5%	cbioportal
7	KMT2D	Ssm	140	511	27.4%	cbioportal
8	CTNNB1	Ssm	130	511	25.4%	cbioportal
9	MUC16	Ssm	127	511	24.9%	cbioportal
10	CTCF	Ssm	126	511	24.7%	cbioportal
11	CSMD3	Ssm	121	511	23.7%	cbioportal
12	ZFHX3	Ssm	118	511	23.1%	cbioportal
13	RYR2	Ssm	116	511	22.7%	cbioportal
14	KMT2B	Ssm	114	511	22.3%	cbioportal
15	OBSCN	Ssm	111	511	21.7%	cbioportal
16	DST	Ssm	109	511	21.3%	cbioportal
18	ZFHX4	Ssm	105	511	20.5%	cbioportal
17	MUC5B	Ssm	105	511	20.5%	cbioportal
19	CHD4	Ssm	104	511	20.4%	cbioportal
20	FAT1	Ssm	104	511	20.4%	cbioportal
21	SYNE1	Ssm	103	511	20.2%	cbioportal
23	MACF1	Ssm	102	511	20%	cbioportal
22	DNAH7	Ssm	102	511	20%	cbioportal
24	FAT4	Ssm	101	511	19.8%	cbioportal
25	TAF1	Ssm	101	511	19.8%	cbioportal
26	ARHGAP35	Ssm	98	511	19.2%	cbioportal
27	PCLO	Ssm	98	511	19.2%	cbioportal
29	DMD	Ssm	96	511	18.8%	cbioportal
30	DNAH5	Ssm	96	511	18.8%	cbioportal
28	ATM	Ssm	96	511	18.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Evolution and co-occurrence of PI3K pathway gene mutations in endometrial carcinoma molecular subtypes at the single-cell level ucec_msk_dacruzpaula_2025

11 cases with simple somatic mutation data · 11 cases total · 2026-01-20 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved25 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	10	11	90.9%	cbioportal
2	PIK3R1	Ssm	9	11	81.8%	cbioportal
3	PIK3CA	Ssm	7	11	63.6%	cbioportal
4	CTCF	Ssm	5	11	45.5%	cbioportal
5	FGFR2	Ssm	4	11	36.4%	cbioportal
8	TP53	Ssm	3	11	27.3%	cbioportal
7	KRAS	Ssm	3	11	27.3%	cbioportal
6	ARID1A	Ssm	3	11	27.3%	cbioportal
12	ERBB4	Ssm	2	11	18.2%	cbioportal
13	FBXW7	Ssm	2	11	18.2%	cbioportal
14	PDGFRA	Ssm	2	11	18.2%	cbioportal
9	ATM	Ssm	2	11	18.2%	cbioportal
10	CTNNB1	Ssm	2	11	18.2%	cbioportal
11	EGFR	Ssm	2	11	18.2%	cbioportal
25	VHL	Ssm	1	11	9.1%	cbioportal
21	NOTCH1	Ssm	1	11	9.1%	cbioportal
20	MTOR	Ssm	1	11	9.1%	cbioportal
19	MET	Ssm	1	11	9.1%	cbioportal
18	HRAS	Ssm	1	11	9.1%	cbioportal
17	HNF1A	Ssm	1	11	9.1%	cbioportal
16	GNAQ	Ssm	1	11	9.1%	cbioportal
15	BRAF	Ssm	1	11	9.1%	cbioportal
22	RB1	Ssm	1	11	9.1%	cbioportal
23	SMAD4	Ssm	1	11	9.1%	cbioportal
24	SMARCB1	Ssm	1	11	9.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

High-Grade Serous Ovarian Cancer (MSK, NPJ Genome Med 2021) hgsoc_msk_2021MSK

45 cases with simple somatic mutation data · 45 cases total · 2026-01-07 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	44	45	97.8%	cbioportal
2	BRCA2	Ssm	5	45	11.1%	cbioportal
3	KMT2D	Ssm	4	45	8.9%	cbioportal
9	AGO2	Ssm	2	28	7.1%	cbioportal
4	BRCA1	Ssm	3	45	6.7%	cbioportal
7	KMT2C	Ssm	3	45	6.7%	cbioportal
8	NTRK3	Ssm	3	45	6.7%	cbioportal
5	BRD4	Ssm	3	45	6.7%	cbioportal
6	KDM5A	Ssm	3	45	6.7%	cbioportal
18	MGA	Ssm	2	36	5.6%	cbioportal
24	PPP2R1A	Ssm	2	45	4.4%	cbioportal
17	KIT	Ssm	2	45	4.4%	cbioportal
16	INPP4B	Ssm	2	45	4.4%	cbioportal
15	FLT1	Ssm	2	45	4.4%	cbioportal
22	PIK3CA	Ssm	2	45	4.4%	cbioportal
23	PIK3R2	Ssm	2	45	4.4%	cbioportal
21	PDGFRA	Ssm	2	45	4.4%	cbioportal
14	EPHA5	Ssm	2	45	4.4%	cbioportal
13	CDK12	Ssm	2	45	4.4%	cbioportal
12	ATRX	Ssm	2	45	4.4%	cbioportal
11	AR	Ssm	2	45	4.4%	cbioportal
10	APC	Ssm	2	45	4.4%	cbioportal
20	NCOR1	Ssm	2	45	4.4%	cbioportal
19	MRE11	Ssm	2	45	4.4%	cbioportal
79	PREX2	Ssm	1	28	3.6%	cbioportal
90	RRAGC	Ssm	1	28	3.6%	cbioportal
61	INPPL1	Ssm	1	28	3.6%	cbioportal
80	PRKCI	Ssm	1	28	3.6%	cbioportal
45	EZH1	Ssm	1	28	3.6%	cbioportal
93	SESN1	Ssm	1	28	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

High-Grade Serous Ovarian Cancer (TCGA GDC, 2025) hgsoc_tcga_gdcTCGA GDC

405 cases with simple somatic mutation data · 604 cases total · 2026-01-13 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	369	405	91.1%	cbioportal
2	TTN	Ssm	96	405	23.7%	cbioportal
3	CSMD3	Ssm	36	405	8.9%	cbioportal
4	USH2A	Ssm	31	405	7.7%	cbioportal
5	NF1	Ssm	29	405	7.2%	cbioportal
6	RYR2	Ssm	28	405	6.9%	cbioportal
7	HMCN1	Ssm	26	405	6.4%	cbioportal
8	MUC16	Ssm	26	405	6.4%	cbioportal
9	FAT3	Ssm	23	405	5.7%	cbioportal
11	SI	Ssm	22	405	5.4%	cbioportal
10	MACF1	Ssm	22	405	5.4%	cbioportal
13	APOB	Ssm	21	405	5.2%	cbioportal
12	AHNAK	Ssm	21	405	5.2%	cbioportal
14	FLG2	Ssm	21	405	5.2%	cbioportal
15	MUC17	Ssm	21	405	5.2%	cbioportal
16	CDK12	Ssm	20	405	4.9%	cbioportal
18	FLG	Ssm	20	405	4.9%	cbioportal
17	DNAH3	Ssm	20	405	4.9%	cbioportal
19	LRP1B	Ssm	20	405	4.9%	cbioportal
20	BRCA1	Ssm	19	405	4.7%	cbioportal
21	DNAH5	Ssm	19	405	4.7%	cbioportal
22	DST	Ssm	19	405	4.7%	cbioportal
23	LRP1	Ssm	19	405	4.7%	cbioportal
27	SYNE2	Ssm	18	405	4.4%	cbioportal
25	FCGBP	Ssm	18	405	4.4%	cbioportal
24	COL6A3	Ssm	18	405	4.4%	cbioportal
28	TG	Ssm	18	405	4.4%	cbioportal
26	SYNE1	Ssm	18	405	4.4%	cbioportal
29	DNAH10	Ssm	17	405	4.2%	cbioportal
30	DNAH8	Ssm	17	405	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

HIV+ Tumor Molecular Characterization Project - Cervical Cancer CGCI-HTMCP-CCCGCI

208 cases with simple somatic mutation data · 212 cases total · Data Release 46.0 · mapped to Cervical Carcinoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	112	208	53.8%	gdc
2	MUC4	Ssm	100	208	48.1%	gdc
3	LRCH3	Ssm	98	208	47.1%	gdc
6	NCBP2AS2	Ssm	97	208	46.6%	gdc
7	DLG1	Ssm	97	208	46.6%	gdc
5	PIGX	Ssm	97	208	46.6%	gdc
8	NRROS	Ssm	97	208	46.6%	gdc
13	PAK2	Ssm	97	208	46.6%	gdc
12	MUC20	Ssm	97	208	46.6%	gdc
9	NCBP2	Ssm	97	208	46.6%	gdc
11	PIGZ	Ssm	97	208	46.6%	gdc
10	CEP19	Ssm	97	208	46.6%	gdc
4	SENP5	Ssm	97	208	46.6%	gdc
19	UBXN7	Ssm	96	208	46.2%	gdc
15	RUBCN	Ssm	96	208	46.2%	gdc
14	SLC51A	Ssm	96	208	46.2%	gdc
31	ZDHHC19	Ssm	96	208	46.2%	gdc
23	TFRC	Ssm	96	208	46.2%	gdc
22	BDH1	Ssm	96	208	46.2%	gdc
21	TM4SF19	Ssm	96	208	46.2%	gdc
20	TM4SF19-TCTEX1D2	Ssm	96	208	46.2%	gdc
18	FYTTD1	Ssm	96	208	46.2%	gdc
16	WDR53	Ssm	96	208	46.2%	gdc
29	SI	Ssm	96	208	46.2%	gdc
28	SMCO1	Ssm	96	208	46.2%	gdc
27	AC069257.3	Ssm	96	208	46.2%	gdc
26	TCTEX1D2	Ssm	96	208	46.2%	gdc
25	PCYT1A	Ssm	96	208	46.2%	gdc
24	MELTF	Ssm	96	208	46.2%	gdc
17	RNF168	Ssm	96	208	46.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Low-Grade Serous Ovarian Cancer (MSK, Clin Cancer Res 2022) lgsoc_mapk_msk_2022MSK

119 cases with simple somatic mutation data · 119 cases total · 2026-01-16 · mapped to Low-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	38	119	31.9%	cbioportal
2	NRAS	Ssm	13	119	10.9%	cbioportal
3	BRAF	Ssm	11	119	9.2%	cbioportal
4	EIF1AX	Ssm	11	119	9.2%	cbioportal
5	KMT2D	Ssm	5	119	4.2%	cbioportal
6	ERBB2	Ssm	4	119	3.4%	cbioportal
7	ANKRD11	Ssm	3	111	2.7%	cbioportal
8	ARID1B	Ssm	3	119	2.5%	cbioportal
12	KMT2A	Ssm	2	119	1.7%	cbioportal
18	PTPRS	Ssm	2	119	1.7%	cbioportal
9	ATRX	Ssm	2	119	1.7%	cbioportal
10	BARD1	Ssm	2	119	1.7%	cbioportal
24	TP53	Ssm	2	119	1.7%	cbioportal
23	TERT	Ssm	2	119	1.7%	cbioportal
22	TBX3	Ssm	2	119	1.7%	cbioportal
21	RUNX1	Ssm	2	119	1.7%	cbioportal
20	ROS1	Ssm	2	119	1.7%	cbioportal
19	RB1	Ssm	2	119	1.7%	cbioportal
17	NF2	Ssm	2	119	1.7%	cbioportal
16	NF1	Ssm	2	119	1.7%	cbioportal
15	MET	Ssm	2	119	1.7%	cbioportal
14	MAP3K1	Ssm	2	119	1.7%	cbioportal
13	KMT2C	Ssm	2	119	1.7%	cbioportal
11	CTCF	Ssm	2	119	1.7%	cbioportal
48	EPAS1	Ssm	1	88	1.1%	cbioportal
36	CARM1	Ssm	1	88	1.1%	cbioportal
52	ERF	Ssm	1	88	1.1%	cbioportal
71	MSH3	Ssm	1	88	1.1%	cbioportal
88	RTEL1	Ssm	1	88	1.1%	cbioportal
82	PPM1D	Ssm	1	111	0.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic castration-sensitive prostate cancer (MSK, Clin Cancer Res 2020) prad_mcspc_mskcc_2020MSK

424 cases with simple somatic mutation data · 424 cases total · 2026-04-07 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	129	424	30.4%	cbioportal
2	SPOP	Ssm	53	424	12.5%	cbioportal
3	FOXA1	Ssm	50	424	11.8%	cbioportal
4	PTEN	Ssm	46	424	10.8%	cbioportal
5	APC	Ssm	36	424	8.5%	cbioportal
6	KMT2C	Ssm	34	424	8%	cbioportal
7	KMT2D	Ssm	30	424	7.1%	cbioportal
8	ZFHX3	Ssm	25	387	6.5%	cbioportal
9	ATM	Ssm	24	424	5.7%	cbioportal
10	CDK12	Ssm	24	424	5.7%	cbioportal
11	PIK3CA	Ssm	24	424	5.7%	cbioportal
12	CTNNB1	Ssm	23	424	5.4%	cbioportal
13	BRCA2	Ssm	19	424	4.5%	cbioportal
15	MGA	Ssm	14	387	3.6%	cbioportal
14	SPEN	Ssm	15	424	3.5%	cbioportal
16	NCOR1	Ssm	13	424	3.1%	cbioportal
57	TP53BP1	Ssm	7	233	3%	cbioportal
19	JAK1	Ssm	12	424	2.8%	cbioportal
18	CREBBP	Ssm	12	424	2.8%	cbioportal
17	BRAF	Ssm	12	424	2.8%	cbioportal
21	GRIN2A	Ssm	11	424	2.6%	cbioportal
22	PTPRT	Ssm	11	424	2.6%	cbioportal
20	FAT1	Ssm	11	424	2.6%	cbioportal
27	KMT2A	Ssm	10	424	2.4%	cbioportal
24	ARID1B	Ssm	10	424	2.4%	cbioportal
25	ASXL1	Ssm	10	424	2.4%	cbioportal
26	ASXL2	Ssm	10	424	2.4%	cbioportal
28	NF1	Ssm	10	424	2.4%	cbioportal
23	ARID1A	Ssm	10	424	2.4%	cbioportal
29	NOTCH1	Ssm	10	424	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Metastatic Prostate Adenocarcinoma (MCTP, Nature 2012) prad_michMCTP

61 cases with simple somatic mutation data · 121 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	25	61	41%	cbioportal
2	TTN	Ssm	8	61	13.1%	cbioportal
3	ZFHX3	Ssm	8	61	13.1%	cbioportal
5	RYR3	Ssm	7	61	11.5%	cbioportal
4	ABCA13	Ssm	7	61	11.5%	cbioportal
11	RB1	Ssm	6	61	9.8%	cbioportal
10	PTEN	Ssm	6	61	9.8%	cbioportal
6	APC	Ssm	6	61	9.8%	cbioportal
7	DNAH11	Ssm	6	61	9.8%	cbioportal
8	KMT2D	Ssm	6	61	9.8%	cbioportal
9	MUC16	Ssm	6	61	9.8%	cbioportal
13	CSMD1	Ssm	5	61	8.2%	cbioportal
14	USH2A	Ssm	5	61	8.2%	cbioportal
12	AR	Ssm	5	61	8.2%	cbioportal
15	ASXL2	Ssm	4	61	6.6%	cbioportal
30	RYR1	Ssm	4	61	6.6%	cbioportal
29	PLEC	Ssm	4	61	6.6%	cbioportal
28	NEB	Ssm	4	61	6.6%	cbioportal
27	NAALADL2	Ssm	4	61	6.6%	cbioportal
23	HSPG2	Ssm	4	61	6.6%	cbioportal
16	ATM	Ssm	4	61	6.6%	cbioportal
17	CDC42EP1	Ssm	4	61	6.6%	cbioportal
18	COL6A3	Ssm	4	61	6.6%	cbioportal
19	DGKB	Ssm	4	61	6.6%	cbioportal
20	FAT4	Ssm	4	61	6.6%	cbioportal
21	FREM2	Ssm	4	61	6.6%	cbioportal
22	GRIA1	Ssm	4	61	6.6%	cbioportal
26	MAGI3	Ssm	4	61	6.6%	cbioportal
25	LPAR1	Ssm	4	61	6.6%	cbioportal
24	JARID2	Ssm	4	61	6.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, PNAS 2019) prad_su2c_2019SU2C/PCF Dream Team

444 cases with simple somatic mutation data · 444 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	163	444	36.7%	cbioportal
2	TTN	Ssm	88	444	19.8%	cbioportal
3	MUC16	Ssm	67	444	15.1%	cbioportal
4	AR	Ssm	61	444	13.7%	cbioportal
5	SYNE1	Ssm	49	444	11%	cbioportal
6	CSMD3	Ssm	43	444	9.7%	cbioportal
7	FOXA1	Ssm	41	444	9.2%	cbioportal
8	KMT2C	Ssm	40	444	9%	cbioportal
9	BRCA2	Ssm	37	444	8.3%	cbioportal
10	KMT2D	Ssm	37	444	8.3%	cbioportal
11	AHNAK2	Ssm	35	444	7.9%	cbioportal
12	HMCN1	Ssm	32	444	7.2%	cbioportal
13	APC	Ssm	31	444	7%	cbioportal
14	USH2A	Ssm	31	444	7%	cbioportal
15	CACNA1E	Ssm	29	444	6.5%	cbioportal
16	OBSCN	Ssm	29	444	6.5%	cbioportal
19	PTEN	Ssm	28	444	6.3%	cbioportal
17	LRP1B	Ssm	28	444	6.3%	cbioportal
18	PLEC	Ssm	28	444	6.3%	cbioportal
20	RYR1	Ssm	28	444	6.3%	cbioportal
21	ATM	Ssm	27	444	6.1%	cbioportal
22	DCHS2	Ssm	27	444	6.1%	cbioportal
23	FAT3	Ssm	27	444	6.1%	cbioportal
24	CDK12	Ssm	26	444	5.9%	cbioportal
25	MUC4	Ssm	26	444	5.9%	cbioportal
26	RYR3	Ssm	26	444	5.9%	cbioportal
30	SPOP	Ssm	25	444	5.6%	cbioportal
28	MACF1	Ssm	25	444	5.6%	cbioportal
27	ABCA13	Ssm	25	444	5.6%	cbioportal
29	RYR2	Ssm	25	444	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Prostate Cancer (SU2C/PCF Dream Team, Cell 2015) prad_su2c_2015SU2C/PCF Dream Team

150 cases with simple somatic mutation data · 150 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	60	150	40%	cbioportal
2	TP53	Ssm	58	150	38.7%	cbioportal
3	TTN	Ssm	41	150	27.3%	cbioportal
4	MUC16	Ssm	35	150	23.3%	cbioportal
5	AR	Ssm	27	150	18%	cbioportal
6	KMT2C	Ssm	23	150	15.3%	cbioportal
7	SYNE1	Ssm	21	150	14%	cbioportal
8	KMT2D	Ssm	18	150	12%	cbioportal
9	FOXA1	Ssm	16	150	10.7%	cbioportal
10	MUC2	Ssm	15	150	10%	cbioportal
14	USH2A	Ssm	14	150	9.3%	cbioportal
11	CSMD3	Ssm	14	150	9.3%	cbioportal
12	FAT4	Ssm	14	150	9.3%	cbioportal
13	PIEZO1	Ssm	14	150	9.3%	cbioportal
16	PLEC	Ssm	13	150	8.7%	cbioportal
15	CSMD1	Ssm	13	150	8.7%	cbioportal
17	APC	Ssm	12	150	8%	cbioportal
18	LRP1B	Ssm	12	150	8%	cbioportal
19	SPOP	Ssm	12	150	8%	cbioportal
28	PREX2	Ssm	11	150	7.3%	cbioportal
29	PTEN	Ssm	11	150	7.3%	cbioportal
30	RYR1	Ssm	11	150	7.3%	cbioportal
27	PKHD1L1	Ssm	11	150	7.3%	cbioportal
26	OBSCN	Ssm	11	150	7.3%	cbioportal
25	MUC5B	Ssm	11	150	7.3%	cbioportal
24	HMCN1	Ssm	11	150	7.3%	cbioportal
23	DNAH3	Ssm	11	150	7.3%	cbioportal
22	DCHS2	Ssm	11	150	7.3%	cbioportal
21	CNTNAP5	Ssm	11	150	7.3%	cbioportal
20	ABCA13	Ssm	11	150	7.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Neuroendocrine Prostate Cancer (Multi-Institute, Nat Med 2016) nepc_wcm_2016Multi-Institute

114 cases with simple somatic mutation data · 114 cases total · 2026-01-08 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	27	114	23.7%	cbioportal
2	TTN	Ssm	21	114	18.4%	cbioportal
3	SPOP	Ssm	13	114	11.4%	cbioportal
4	MUC16	Ssm	11	114	9.6%	cbioportal
5	OBSCN	Ssm	10	114	8.8%	cbioportal
6	FOXA1	Ssm	9	114	7.9%	cbioportal
7	HMCN1	Ssm	9	114	7.9%	cbioportal
9	TMC8	Ssm	9	114	7.9%	cbioportal
8	SHANK1	Ssm	9	114	7.9%	cbioportal
10	ZNF208	Ssm	9	114	7.9%	cbioportal
11	ZNF626	Ssm	9	114	7.9%	cbioportal
12	ZNF729	Ssm	9	114	7.9%	cbioportal
19	METTL24	Ssm	8	114	7%	cbioportal
20	RB1	Ssm	8	114	7%	cbioportal
21	ZNFX1	Ssm	8	114	7%	cbioportal
15	DYNC1H1	Ssm	8	114	7%	cbioportal
16	FSIP2	Ssm	8	114	7%	cbioportal
17	KMO	Ssm	8	114	7%	cbioportal
18	LTBP1	Ssm	8	114	7%	cbioportal
13	CPD	Ssm	8	114	7%	cbioportal
14	DNAH3	Ssm	8	114	7%	cbioportal
30	SLC44A5	Ssm	7	114	6.1%	cbioportal
26	NBPF3	Ssm	7	114	6.1%	cbioportal
25	CSMD3	Ssm	7	114	6.1%	cbioportal
28	OR9A4	Ssm	7	114	6.1%	cbioportal
29	PIWIL2	Ssm	7	114	6.1%	cbioportal
27	NR2E1	Ssm	7	114	6.1%	cbioportal
24	COL14A1	Ssm	7	114	6.1%	cbioportal
23	CHRNA3	Ssm	7	114	6.1%	cbioportal
22	ADRM1	Ssm	7	114	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Ovarian Serous Cystadenocarcinoma TCGA-OVTCGA

603 cases with simple somatic mutation data · 608 cases total · Data Release 46.0 · mapped to Ovarian Serous Cystadenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	483	603	80.1%	gdc
2	MYC	Ssm	455	603	75.5%	gdc
3	POU5F1B	Ssm	449	603	74.5%	gdc
4	FAM135B	Ssm	449	603	74.5%	gdc
5	ACTRT3	Ssm	447	603	74.1%	gdc
8	MYNN	Ssm	446	603	74%	gdc
9	PTK2	Ssm	446	603	74%	gdc
7	ADCY8	Ssm	446	603	74%	gdc
6	AGO2	Ssm	446	603	74%	gdc
10	LRRC34	Ssm	446	603	74%	gdc
12	PTP4A3	Ssm	445	603	73.8%	gdc
11	GSDMC	Ssm	445	603	73.8%	gdc
13	LRRC31	Ssm	445	603	73.8%	gdc
14	GPR20	Ssm	445	603	73.8%	gdc
15	LRRIQ4	Ssm	445	603	73.8%	gdc
16	LRATD2	Ssm	445	603	73.8%	gdc
18	SLC45A4	Ssm	444	603	73.6%	gdc
17	SAMD7	Ssm	444	603	73.6%	gdc
19	AC138647.1	Ssm	444	603	73.6%	gdc
24	TG	Ssm	444	603	73.6%	gdc
23	CHRAC1	Ssm	444	603	73.6%	gdc
22	SEC62	Ssm	444	603	73.6%	gdc
21	ASAP1	Ssm	444	603	73.6%	gdc
20	TRIB1	Ssm	444	603	73.6%	gdc
26	COL22A1	Ssm	443	603	73.5%	gdc
25	GPR160	Ssm	443	603	73.5%	gdc
27	KHDRBS3	Ssm	443	603	73.5%	gdc
29	MECOM	Ssm	443	603	73.5%	gdc
30	SCRIB	Ssm	443	603	73.5%	gdc
28	KCNK9	Ssm	443	603	73.5%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Ovarian Serous Cystadenocarcinoma (TCGA, Firehose Legacy) ov_tcgaTCGA

316 cases with simple somatic mutation data · 617 cases total · 2026-01-12 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	277	316	87.7%	cbioportal
2	TTN	Ssm	56	316	17.7%	cbioportal
3	USH2A	Ssm	20	316	6.3%	cbioportal
4	FAT3	Ssm	19	316	6%	cbioportal
6	MUC16	Ssm	18	316	5.7%	cbioportal
5	CSMD3	Ssm	18	316	5.7%	cbioportal
8	LRP2	Ssm	15	316	4.7%	cbioportal
7	HMCN1	Ssm	15	316	4.7%	cbioportal
9	NF1	Ssm	14	316	4.4%	cbioportal
10	RYR2	Ssm	14	316	4.4%	cbioportal
11	DNAH5	Ssm	13	316	4.1%	cbioportal
12	LRP1B	Ssm	13	316	4.1%	cbioportal
15	BRCA1	Ssm	12	316	3.8%	cbioportal
13	AHNAK	Ssm	12	316	3.8%	cbioportal
14	AHNAK2	Ssm	12	316	3.8%	cbioportal
16	COL6A3	Ssm	12	316	3.8%	cbioportal
23	MUC17	Ssm	11	316	3.5%	cbioportal
24	RYR1	Ssm	11	316	3.5%	cbioportal
17	APOB	Ssm	11	316	3.5%	cbioportal
18	BRCA2	Ssm	11	316	3.5%	cbioportal
19	DNAH3	Ssm	11	316	3.5%	cbioportal
20	FAT1	Ssm	11	316	3.5%	cbioportal
21	HUWE1	Ssm	11	316	3.5%	cbioportal
22	HYDIN	Ssm	11	316	3.5%	cbioportal
28	TENM1	Ssm	10	316	3.2%	cbioportal
26	PKHD1	Ssm	10	316	3.2%	cbioportal
27	SI	Ssm	10	316	3.2%	cbioportal
25	LRRK2	Ssm	10	316	3.2%	cbioportal
30	COL22A1	Ssm	9	316	2.8%	cbioportal
29	CDK12	Ssm	9	316	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Ovarian Serous Cystadenocarcinoma (TCGA, Nature 2011) ov_tcga_pubTCGA

316 cases with simple somatic mutation data · 489 cases total · 2026-01-21 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	303	316	95.9%	cbioportal
2	TTN	Ssm	55	316	17.4%	cbioportal
3	BRCA1	Ssm	37	316	11.7%	cbioportal
4	BRCA2	Ssm	34	316	10.8%	cbioportal
5	USH2A	Ssm	20	316	6.3%	cbioportal
6	CSMD3	Ssm	19	316	6%	cbioportal
8	MUC16	Ssm	18	316	5.7%	cbioportal
7	FAT3	Ssm	18	316	5.7%	cbioportal
9	LRP2	Ssm	15	316	4.7%	cbioportal
10	HMCN1	Ssm	14	316	4.4%	cbioportal
11	RYR2	Ssm	14	316	4.4%	cbioportal
12	LRP1B	Ssm	13	316	4.1%	cbioportal
14	DNAH3	Ssm	12	316	3.8%	cbioportal
16	NF1	Ssm	12	316	3.8%	cbioportal
15	DNAH5	Ssm	12	316	3.8%	cbioportal
13	AHNAK	Ssm	12	316	3.8%	cbioportal
22	TENM1	Ssm	11	316	3.5%	cbioportal
17	AHNAK2	Ssm	11	316	3.5%	cbioportal
18	APOB	Ssm	11	316	3.5%	cbioportal
19	FAT1	Ssm	11	316	3.5%	cbioportal
20	HYDIN	Ssm	11	316	3.5%	cbioportal
21	MUC17	Ssm	11	316	3.5%	cbioportal
25	LRRK2	Ssm	10	316	3.2%	cbioportal
24	HUWE1	Ssm	10	316	3.2%	cbioportal
23	COL6A3	Ssm	10	316	3.2%	cbioportal
26	RYR1	Ssm	10	316	3.2%	cbioportal
27	ADGRB3	Ssm	9	316	2.8%	cbioportal
29	COL22A1	Ssm	9	316	2.8%	cbioportal
28	CDK12	Ssm	9	316	2.8%	cbioportal
30	DST	Ssm	9	316	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-21

Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas) ov_tcga_pan_can_atlas_2018TCGA

523 cases with simple somatic mutation data · 585 cases total · 2026-06-04 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	373	523	71.3%	cbioportal
2	TTN	Ssm	110	523	21%	cbioportal
4	MUC16	Ssm	41	523	7.8%	cbioportal
3	FLG2	Ssm	41	523	7.8%	cbioportal
5	CSMD3	Ssm	38	523	7.3%	cbioportal
6	HMCN1	Ssm	34	523	6.5%	cbioportal
7	USH2A	Ssm	32	523	6.1%	cbioportal
10	NF1	Ssm	30	523	5.7%	cbioportal
8	AHNAK2	Ssm	30	523	5.7%	cbioportal
9	FLG	Ssm	30	523	5.7%	cbioportal
11	MACF1	Ssm	29	523	5.5%	cbioportal
12	RYR2	Ssm	28	523	5.4%	cbioportal
13	AHNAK	Ssm	26	523	5%	cbioportal
14	SYNE1	Ssm	26	523	5%	cbioportal
19	LRP2	Ssm	24	523	4.6%	cbioportal
20	MUC17	Ssm	24	523	4.6%	cbioportal
18	KMT2C	Ssm	24	523	4.6%	cbioportal
17	FAT3	Ssm	24	523	4.6%	cbioportal
16	DNAH3	Ssm	24	523	4.6%	cbioportal
15	APOB	Ssm	24	523	4.6%	cbioportal
21	RYR1	Ssm	23	523	4.4%	cbioportal
23	DST	Ssm	22	523	4.2%	cbioportal
24	MDN1	Ssm	22	523	4.2%	cbioportal
22	COL6A3	Ssm	22	523	4.2%	cbioportal
25	SI	Ssm	22	523	4.2%	cbioportal
28	LRP1B	Ssm	21	523	4%	cbioportal
27	FCGBP	Ssm	21	523	4%	cbioportal
29	MYH1	Ssm	21	523	4%	cbioportal
26	DNAH5	Ssm	21	523	4%	cbioportal
30	FAT4	Ssm	20	523	3.8%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Prostate Adenocarcinoma TCGA-PRADTCGA

500 cases with simple somatic mutation data · 500 cases total · Data Release 46.0 · mapped to Prostate Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CCAR2	Ssm	298	500	59.6%	gdc
3	BIN3	Ssm	297	500	59.4%	gdc
2	XPO7	Ssm	297	500	59.4%	gdc
4	C8orf58	Ssm	297	500	59.4%	gdc
9	PPP3CC	Ssm	296	500	59.2%	gdc
12	PEBP4	Ssm	296	500	59.2%	gdc
11	AC037459.1	Ssm	296	500	59.2%	gdc
10	TNFRSF10C	Ssm	296	500	59.2%	gdc
8	BMP1	Ssm	296	500	59.2%	gdc
7	PIWIL2	Ssm	296	500	59.2%	gdc
6	RHOBTB2	Ssm	296	500	59.2%	gdc
5	SORBS3	Ssm	296	500	59.2%	gdc
16	REEP4	Ssm	295	500	59%	gdc
23	TNFRSF10A	Ssm	295	500	59%	gdc
22	PDLIM2	Ssm	295	500	59%	gdc
20	TNFRSF10D	Ssm	295	500	59%	gdc
19	POLR3D	Ssm	295	500	59%	gdc
18	DOK2	Ssm	295	500	59%	gdc
21	FAM160B2	Ssm	295	500	59%	gdc
13	HR	Ssm	295	500	59%	gdc
17	DMTN	Ssm	295	500	59%	gdc
14	AC107959.5	Ssm	295	500	59%	gdc
15	EGR3	Ssm	295	500	59%	gdc
25	TNFRSF10B	Ssm	294	500	58.8%	gdc
26	NKX3-1	Ssm	294	500	58.8%	gdc
27	LGI3	Ssm	294	500	58.8%	gdc
28	NPM2	Ssm	294	500	58.8%	gdc
30	SLC25A37	Ssm	294	500	58.8%	gdc
29	R3HCC1	Ssm	294	500	58.8%	gdc
24	CHMP7	Ssm	294	500	58.8%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Prostate Adenocarcinoma (Broad/Cornell, Cell 2013) prad_broad_2013Broad/Cornell

57 cases with simple somatic mutation data · 82 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	7	57	12.3%	cbioportal
3	MUC16	Ssm	6	57	10.5%	cbioportal
2	ATM	Ssm	6	57	10.5%	cbioportal
4	TP53	Ssm	6	57	10.5%	cbioportal
5	FOXA1	Ssm	5	57	8.8%	cbioportal
7	MACF1	Ssm	5	57	8.8%	cbioportal
6	KMT2C	Ssm	5	57	8.8%	cbioportal
13	ZAN	Ssm	4	57	7%	cbioportal
9	FLG	Ssm	4	57	7%	cbioportal
8	BRINP2	Ssm	4	57	7%	cbioportal
12	TTN	Ssm	4	57	7%	cbioportal
11	SPOP	Ssm	4	57	7%	cbioportal
10	PLCB3	Ssm	4	57	7%	cbioportal
36	TNXB	Ssm	3	57	5.3%	cbioportal
19	CD8B	Ssm	3	57	5.3%	cbioportal
18	C10ORF90	Ssm	3	57	5.3%	cbioportal
27	FBN3	Ssm	3	57	5.3%	cbioportal
34	SIPA1L1	Ssm	3	57	5.3%	cbioportal
33	PRDM9	Ssm	3	57	5.3%	cbioportal
20	CLIC6	Ssm	3	57	5.3%	cbioportal
32	POTEF	Ssm	3	57	5.3%	cbioportal
31	NBPF1	Ssm	3	57	5.3%	cbioportal
30	MUC2	Ssm	3	57	5.3%	cbioportal
29	KRT8	Ssm	3	57	5.3%	cbioportal
35	SUZ12	Ssm	3	57	5.3%	cbioportal
28	IGSF10	Ssm	3	57	5.3%	cbioportal
23	CSMD3	Ssm	3	57	5.3%	cbioportal
24	DMD	Ssm	3	57	5.3%	cbioportal
25	DYNC2I1	Ssm	3	57	5.3%	cbioportal
26	FASN	Ssm	3	57	5.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (Broad/Cornell, Nat Genet 2012) prad_broadBroad/Cornell

112 cases with simple somatic mutation data · 123 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	14	112	12.5%	cbioportal
2	TTN	Ssm	11	112	9.8%	cbioportal
3	THSD7B	Ssm	7	112	6.3%	cbioportal
4	TP53	Ssm	7	112	6.3%	cbioportal
7	MED12	Ssm	6	112	5.4%	cbioportal
5	FAT4	Ssm	6	112	5.4%	cbioportal
9	SPTA1	Ssm	6	112	5.4%	cbioportal
8	SCN11A	Ssm	6	112	5.4%	cbioportal
6	HMCN1	Ssm	6	112	5.4%	cbioportal
16	PTEN	Ssm	5	112	4.5%	cbioportal
15	OBSCN	Ssm	5	112	4.5%	cbioportal
10	ABCA13	Ssm	5	112	4.5%	cbioportal
17	SYNE3	Ssm	5	112	4.5%	cbioportal
11	FAT1	Ssm	5	112	4.5%	cbioportal
12	FLG	Ssm	5	112	4.5%	cbioportal
13	MDN1	Ssm	5	112	4.5%	cbioportal
14	NBAS	Ssm	5	112	4.5%	cbioportal
24	FNDC1	Ssm	4	112	3.6%	cbioportal
30	MYO18B	Ssm	4	112	3.6%	cbioportal
29	MUC16	Ssm	4	112	3.6%	cbioportal
28	LRP1B	Ssm	4	112	3.6%	cbioportal
27	ITPR1	Ssm	4	112	3.6%	cbioportal
26	FRAS1	Ssm	4	112	3.6%	cbioportal
25	FOXA1	Ssm	4	112	3.6%	cbioportal
23	FMN2	Ssm	4	112	3.6%	cbioportal
22	DISP3	Ssm	4	112	3.6%	cbioportal
21	CUX1	Ssm	4	112	3.6%	cbioportal
20	CTNNA2	Ssm	4	112	3.6%	cbioportal
19	CD1A	Ssm	4	112	3.6%	cbioportal
18	CACNA1E	Ssm	4	112	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (CPC-GENE, Nature 2017) prad_cpcg_2017CPC-GENE

477 cases with simple somatic mutation data · 477 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	38	477	8%	cbioportal
2	TTN	Ssm	21	477	4.4%	cbioportal
3	TP53	Ssm	16	477	3.4%	cbioportal
4	MUC16	Ssm	12	477	2.5%	cbioportal
6	MED12	Ssm	11	477	2.3%	cbioportal
5	FOXA1	Ssm	11	477	2.3%	cbioportal
9	QRICH2	Ssm	9	477	1.9%	cbioportal
8	PRB4	Ssm	9	477	1.9%	cbioportal
7	C6	Ssm	9	477	1.9%	cbioportal
10	RYR2	Ssm	9	477	1.9%	cbioportal
12	KMT2C	Ssm	8	477	1.7%	cbioportal
11	ATM	Ssm	8	477	1.7%	cbioportal
15	TPTE	Ssm	7	477	1.5%	cbioportal
14	SYNE1	Ssm	7	477	1.5%	cbioportal
13	PCDH15	Ssm	7	477	1.5%	cbioportal
20	FAT3	Ssm	6	477	1.3%	cbioportal
19	CSMD3	Ssm	6	477	1.3%	cbioportal
18	C9	Ssm	6	477	1.3%	cbioportal
17	AHNAK2	Ssm	6	477	1.3%	cbioportal
16	ADAMTS20	Ssm	6	477	1.3%	cbioportal
21	SPTA1	Ssm	6	477	1.3%	cbioportal
28	DCAF4L2	Ssm	5	477	1%	cbioportal
22	ANK2	Ssm	5	477	1%	cbioportal
23	C3	Ssm	5	477	1%	cbioportal
24	C7	Ssm	5	477	1%	cbioportal
25	CFAP65	Ssm	5	477	1%	cbioportal
26	CNTNAP5	Ssm	5	477	1%	cbioportal
27	COL11A1	Ssm	5	477	1%	cbioportal
29	FAT1	Ssm	5	477	1%	cbioportal
30	FNDC1	Ssm	5	477	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (Fred Hutchinson CRC, Nat Med 2016) prad_fhcrcFred Hutchinson CRC

141 cases with simple somatic mutation data · 176 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	57	141	40.4%	cbioportal
2	CSMD3	Ssm	18	141	12.8%	cbioportal
3	MUC16	Ssm	18	141	12.8%	cbioportal
5	TTN	Ssm	18	141	12.8%	cbioportal
4	RNF213	Ssm	18	141	12.8%	cbioportal
7	OBSCN	Ssm	17	141	12.1%	cbioportal
6	DCHS2	Ssm	17	141	12.1%	cbioportal
9	HERC2	Ssm	16	141	11.3%	cbioportal
11	RYR2	Ssm	16	141	11.3%	cbioportal
10	LRP1B	Ssm	16	141	11.3%	cbioportal
8	ATM	Ssm	16	141	11.3%	cbioportal
12	CDH11	Ssm	15	141	10.6%	cbioportal
13	DNAH6	Ssm	15	141	10.6%	cbioportal
14	TICRR	Ssm	15	141	10.6%	cbioportal
15	ZFHX3	Ssm	15	141	10.6%	cbioportal
19	PCDHA6	Ssm	14	141	9.9%	cbioportal
16	ABCA13	Ssm	14	141	9.9%	cbioportal
17	CENPF	Ssm	14	141	9.9%	cbioportal
18	KMT2D	Ssm	14	141	9.9%	cbioportal
20	PLCG1	Ssm	14	141	9.9%	cbioportal
21	SPTA1	Ssm	14	141	9.9%	cbioportal
26	SYNE1	Ssm	13	141	9.2%	cbioportal
22	DNAH1	Ssm	13	141	9.2%	cbioportal
23	HECTD1	Ssm	13	141	9.2%	cbioportal
24	LRRK2	Ssm	13	141	9.2%	cbioportal
25	SKIC3	Ssm	13	141	9.2%	cbioportal
30	DYNC2H1	Ssm	12	141	8.5%	cbioportal
27	APOBEC3G	Ssm	12	141	8.5%	cbioportal
28	C7	Ssm	12	141	8.5%	cbioportal
29	CDH12	Ssm	12	141	8.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (MSK, 2025) prad_msk_2025MSK

120 cases with simple somatic mutation data · 120 cases total · 2026-03-04 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	31	120	25.8%	cbioportal
2	BRCA2	Ssm	22	120	18.3%	cbioportal
3	ZFHX3	Ssm	15	116	12.9%	cbioportal
5	KMT2C	Ssm	14	120	11.7%	cbioportal
4	FOXA1	Ssm	14	120	11.7%	cbioportal
6	CDK12	Ssm	12	120	10%	cbioportal
7	ATM	Ssm	10	120	8.3%	cbioportal
8	KMT2D	Ssm	9	120	7.5%	cbioportal
9	SPOP	Ssm	9	120	7.5%	cbioportal
10	SPEN	Ssm	8	120	6.7%	cbioportal
14	MGA	Ssm	7	116	6%	cbioportal
11	APC	Ssm	7	120	5.8%	cbioportal
13	BRCA1	Ssm	7	120	5.8%	cbioportal
12	AR	Ssm	7	120	5.8%	cbioportal
27	TP53BP1	Ssm	5	90	5.6%	cbioportal
15	CTNNB1	Ssm	6	120	5%	cbioportal
20	PTPRD	Ssm	6	120	5%	cbioportal
19	PTEN	Ssm	6	120	5%	cbioportal
18	PTCH1	Ssm	6	120	5%	cbioportal
17	NCOR1	Ssm	6	120	5%	cbioportal
16	KMT2A	Ssm	6	120	5%	cbioportal
184	GNB1	Ssm	1	22	4.5%	cbioportal
150	ARHGAP35	Ssm	1	22	4.5%	cbioportal
35	ERF	Ssm	4	90	4.4%	cbioportal
31	CARM1	Ssm	4	90	4.4%	cbioportal
21	ANKRD11	Ssm	5	116	4.3%	cbioportal
26	SMARCA4	Ssm	5	120	4.2%	cbioportal
24	NOTCH2	Ssm	5	120	4.2%	cbioportal
23	MED12	Ssm	5	120	4.2%	cbioportal
22	KDM6A	Ssm	5	120	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-03-04

Prostate Adenocarcinoma (MSK, Cancer Cell 2010) prad_mskccMSK

182 cases with simple somatic mutation data · 240 cases total · 2026-02-19 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
66	ROS1	Ssm	2	9	22.2%	cbioportal
69	STAT5B	Ssm	2	9	22.2%	cbioportal
85	ETS2	Ssm	1	9	11.1%	cbioportal
80	EGF	Ssm	1	9	11.1%	cbioportal
78	CASP9	Ssm	1	9	11.1%	cbioportal
119	SRC	Ssm	1	9	11.1%	cbioportal
115	RAC3	Ssm	1	9	11.1%	cbioportal
97	LCK	Ssm	1	9	11.1%	cbioportal
114	PTPN6	Ssm	1	9	11.1%	cbioportal
100	MAPK7	Ssm	1	9	11.1%	cbioportal
103	MUTYH	Ssm	1	9	11.1%	cbioportal
106	NSD1	Ssm	1	9	11.1%	cbioportal
107	PDGFRB	Ssm	1	9	11.1%	cbioportal
110	PRKCZ	Ssm	1	9	11.1%	cbioportal
111	PTK2	Ssm	1	9	11.1%	cbioportal
121	TYK2	Ssm	1	9	11.1%	cbioportal
75	BLK	Ssm	1	9	11.1%	cbioportal
120	STAT1	Ssm	1	9	11.1%	cbioportal
90	IDH2	Ssm	1	9	11.1%	cbioportal
89	FGF1	Ssm	1	9	11.1%	cbioportal
88	FES	Ssm	1	9	11.1%	cbioportal
81	ELK1	Ssm	1	9	11.1%	cbioportal
92	JAK2	Ssm	1	9	11.1%	cbioportal
1	PTPRF	Ssm	9	106	8.5%	cbioportal
2	EP300	Ssm	7	106	6.6%	cbioportal
4	FLT4	Ssm	6	106	5.7%	cbioportal
3	AR	Ssm	6	106	5.7%	cbioportal
7	EPS15	Ssm	5	106	4.7%	cbioportal
8	JAK1	Ssm	5	106	4.7%	cbioportal
9	NCOR2	Ssm	5	106	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Prostate Adenocarcinoma (MSK, Clin Cancer Res. 2022) prad_pik3r1_msk_2021MSK

1,417 cases with simple somatic mutation data · 1,417 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	411	1,417	29%	cbioportal
2	SPOP	Ssm	200	1,417	14.1%	cbioportal
3	FOXA1	Ssm	197	1,417	13.9%	cbioportal
4	APC	Ssm	124	1,417	8.8%	cbioportal
5	PTEN	Ssm	119	1,417	8.4%	cbioportal
6	KMT2C	Ssm	81	1,417	5.7%	cbioportal
8	ZFHX3	Ssm	75	1,361	5.5%	cbioportal
7	KMT2D	Ssm	76	1,417	5.4%	cbioportal
9	CDK12	Ssm	67	1,417	4.7%	cbioportal
10	CTNNB1	Ssm	61	1,417	4.3%	cbioportal
11	PIK3CA	Ssm	60	1,417	4.2%	cbioportal
12	ATM	Ssm	59	1,417	4.2%	cbioportal
13	BRCA2	Ssm	56	1,417	4%	cbioportal
14	AR	Ssm	53	1,417	3.7%	cbioportal
15	PIK3R1	Ssm	48	1,417	3.4%	cbioportal
16	KDM6A	Ssm	44	1,417	3.1%	cbioportal
17	MGA	Ssm	39	1,361	2.9%	cbioportal
18	RB1	Ssm	36	1,417	2.5%	cbioportal
19	MED12	Ssm	35	1,417	2.5%	cbioportal
20	PTPRD	Ssm	31	1,417	2.2%	cbioportal
21	GRIN2A	Ssm	28	1,417	2%	cbioportal
22	ASXL2	Ssm	27	1,417	1.9%	cbioportal
25	SPEN	Ssm	26	1,417	1.8%	cbioportal
23	EPHB1	Ssm	26	1,417	1.8%	cbioportal
24	JAK1	Ssm	26	1,417	1.8%	cbioportal
26	NCOR1	Ssm	25	1,417	1.8%	cbioportal
27	SF3B1	Ssm	25	1,417	1.8%	cbioportal
28	ARID1A	Ssm	23	1,417	1.6%	cbioportal
29	ASXL1	Ssm	22	1,417	1.6%	cbioportal
30	BRAF	Ssm	22	1,417	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (MSK/DFCI, Nature Genetics 2018) prad_p1000MSK/DFCI

1,013 cases with simple somatic mutation data · 1,013 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	189	1,013	18.7%	cbioportal
2	TTN	Ssm	151	1,013	14.9%	cbioportal
3	MUC16	Ssm	113	1,013	11.2%	cbioportal
4	SPOP	Ssm	92	1,013	9.1%	cbioportal
5	SYNE1	Ssm	73	1,013	7.2%	cbioportal
6	FOXA1	Ssm	69	1,013	6.8%	cbioportal
7	KMT2C	Ssm	66	1,013	6.5%	cbioportal
8	KMT2D	Ssm	65	1,013	6.4%	cbioportal
9	CSMD3	Ssm	61	1,013	6%	cbioportal
10	HMCN1	Ssm	55	1,013	5.4%	cbioportal
11	LRP1B	Ssm	54	1,013	5.3%	cbioportal
12	OBSCN	Ssm	53	1,013	5.2%	cbioportal
13	AR	Ssm	48	1,013	4.7%	cbioportal
14	SPTA1	Ssm	47	1,013	4.6%	cbioportal
15	USH2A	Ssm	46	1,013	4.5%	cbioportal
16	RYR1	Ssm	45	1,013	4.4%	cbioportal
17	PTEN	Ssm	44	1,013	4.3%	cbioportal
18	RYR2	Ssm	44	1,013	4.3%	cbioportal
19	ABCA13	Ssm	43	1,013	4.2%	cbioportal
20	FAT3	Ssm	41	1,013	4%	cbioportal
21	ZFHX3	Ssm	41	1,013	4%	cbioportal
22	DCHS2	Ssm	40	1,013	3.9%	cbioportal
23	FAT4	Ssm	39	1,013	3.8%	cbioportal
24	ATM	Ssm	38	1,013	3.8%	cbioportal
25	CACNA1E	Ssm	37	1,013	3.7%	cbioportal
26	CSMD1	Ssm	37	1,013	3.7%	cbioportal
27	DNAH3	Ssm	36	1,013	3.6%	cbioportal
29	MYO15A	Ssm	34	1,013	3.4%	cbioportal
28	MUC4	Ssm	34	1,013	3.4%	cbioportal
30	XIRP2	Ssm	34	1,013	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (MSK, Eur Urol 2020) prad_cdk12_mskcc_2020MSK

1,465 cases with simple somatic mutation data · 1,465 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	391	1,465	26.7%	cbioportal
2	FOXA1	Ssm	179	1,465	12.2%	cbioportal
3	SPOP	Ssm	166	1,465	11.3%	cbioportal
4	PTEN	Ssm	97	1,465	6.6%	cbioportal
5	KMT2C	Ssm	89	1,465	6.1%	cbioportal
6	CDK12	Ssm	88	1,465	6%	cbioportal
7	APC	Ssm	86	1,465	5.9%	cbioportal
8	KMT2D	Ssm	74	1,465	5.1%	cbioportal
9	AR	Ssm	56	1,465	3.8%	cbioportal
13	ZFHX3	Ssm	51	1,337	3.8%	cbioportal
10	CTNNB1	Ssm	55	1,465	3.8%	cbioportal
12	PIK3CA	Ssm	52	1,465	3.5%	cbioportal
11	ATM	Ssm	52	1,465	3.5%	cbioportal
14	BRCA2	Ssm	45	1,465	3.1%	cbioportal
15	KDM6A	Ssm	38	1,465	2.6%	cbioportal
16	GRIN2A	Ssm	36	1,465	2.5%	cbioportal
17	MED12	Ssm	31	1,465	2.1%	cbioportal
18	PTPRD	Ssm	30	1,465	2%	cbioportal
19	SPEN	Ssm	28	1,465	1.9%	cbioportal
20	RB1	Ssm	27	1,465	1.8%	cbioportal
24	MGA	Ssm	24	1,337	1.8%	cbioportal
21	BRAF	Ssm	26	1,465	1.8%	cbioportal
48	ERF	Ssm	14	809	1.7%	cbioportal
22	PIK3R1	Ssm	25	1,465	1.7%	cbioportal
25	NCOR1	Ssm	24	1,465	1.6%	cbioportal
23	ASXL1	Ssm	24	1,465	1.6%	cbioportal
29	NF1	Ssm	23	1,465	1.6%	cbioportal
28	KMT2A	Ssm	23	1,465	1.6%	cbioportal
27	JAK1	Ssm	23	1,465	1.6%	cbioportal
26	ARID1A	Ssm	23	1,465	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma Organoids (MSK, Cell 2014) prad_mskcc_cheny1_organoids_2014MSK

12 cases with simple somatic mutation data · 12 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	12	58.3%	cbioportal
2	TBP	Ssm	6	12	50%	cbioportal
3	LCE4A	Ssm	4	12	33.3%	cbioportal
10	KRT1	Ssm	3	12	25%	cbioportal
12	NKX6-2	Ssm	3	12	25%	cbioportal
11	KRT72	Ssm	3	12	25%	cbioportal
13	SCN5A	Ssm	3	12	25%	cbioportal
14	SPATA3	Ssm	3	12	25%	cbioportal
8	GIT2	Ssm	3	12	25%	cbioportal
6	CRACD	Ssm	3	12	25%	cbioportal
5	ATXN1	Ssm	3	12	25%	cbioportal
4	ABHD15	Ssm	3	12	25%	cbioportal
16	TRIOBP	Ssm	3	12	25%	cbioportal
15	SPATA31D1	Ssm	3	12	25%	cbioportal
7	FOXA1	Ssm	3	12	25%	cbioportal
9	KIRREL1	Ssm	3	12	25%	cbioportal
72	HSPB8	Ssm	2	12	16.7%	cbioportal
60	FHOD3	Ssm	2	12	16.7%	cbioportal
61	FREM1	Ssm	2	12	16.7%	cbioportal
62	FREM3	Ssm	2	12	16.7%	cbioportal
63	G6PC2	Ssm	2	12	16.7%	cbioportal
64	GALNT8	Ssm	2	12	16.7%	cbioportal
65	GK	Ssm	2	12	16.7%	cbioportal
66	GRTP1	Ssm	2	12	16.7%	cbioportal
67	H2AC11	Ssm	2	12	16.7%	cbioportal
68	H3C3	Ssm	2	12	16.7%	cbioportal
69	HAS1	Ssm	2	12	16.7%	cbioportal
70	HK2	Ssm	2	12	16.7%	cbioportal
71	HNRNPR	Ssm	2	12	16.7%	cbioportal
73	IGSF10	Ssm	2	12	16.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (SMMU, Eur Urol 2017) prad_eururol_2017SMMU

65 cases with simple somatic mutation data · 65 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	11	65	16.9%	cbioportal
2	KDM6A	Ssm	5	65	7.7%	cbioportal
3	KMT2D	Ssm	4	65	6.2%	cbioportal
7	RYR1	Ssm	3	65	4.6%	cbioportal
9	TP53	Ssm	3	65	4.6%	cbioportal
4	COL22A1	Ssm	3	65	4.6%	cbioportal
5	MYH2	Ssm	3	65	4.6%	cbioportal
8	SEMA5A	Ssm	3	65	4.6%	cbioportal
6	PTEN	Ssm	3	65	4.6%	cbioportal
62	RBM46	Ssm	2	65	3.1%	cbioportal
61	PSAPL1	Ssm	2	65	3.1%	cbioportal
60	PREX2	Ssm	2	65	3.1%	cbioportal
59	PPP2R3C	Ssm	2	65	3.1%	cbioportal
58	PLXNA4	Ssm	2	65	3.1%	cbioportal
57	PKHD1L1	Ssm	2	65	3.1%	cbioportal
56	PKHD1	Ssm	2	65	3.1%	cbioportal
55	NUP133	Ssm	2	65	3.1%	cbioportal
54	NLRC5	Ssm	2	65	3.1%	cbioportal
53	NCOR2	Ssm	2	65	3.1%	cbioportal
71	TLR6	Ssm	2	65	3.1%	cbioportal
67	SERPINA11	Ssm	2	65	3.1%	cbioportal
68	SLC25A26	Ssm	2	65	3.1%	cbioportal
69	SLC2A6	Ssm	2	65	3.1%	cbioportal
70	SUOX	Ssm	2	65	3.1%	cbioportal
72	TRIP12	Ssm	2	65	3.1%	cbioportal
65	RYR2	Ssm	2	65	3.1%	cbioportal
64	RUNX1T1	Ssm	2	65	3.1%	cbioportal
63	RPTN	Ssm	2	65	3.1%	cbioportal
73	TTN	Ssm	2	65	3.1%	cbioportal
66	SCN5A	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (TCGA, Cell 2015) prad_tcga_pubTCGA

333 cases with simple somatic mutation data · 333 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	37	333	11.1%	cbioportal
2	TTN	Ssm	37	333	11.1%	cbioportal
3	TP53	Ssm	23	333	6.9%	cbioportal
4	MUC16	Ssm	20	333	6%	cbioportal
5	MUC17	Ssm	17	333	5.1%	cbioportal
6	SPTA1	Ssm	15	333	4.5%	cbioportal
9	KMT2C	Ssm	13	333	3.9%	cbioportal
8	FOXA1	Ssm	13	333	3.9%	cbioportal
7	ATM	Ssm	13	333	3.9%	cbioportal
10	AHNAK2	Ssm	12	333	3.6%	cbioportal
11	CSMD3	Ssm	12	333	3.6%	cbioportal
12	LRP1B	Ssm	12	333	3.6%	cbioportal
14	OBSCN	Ssm	11	333	3.3%	cbioportal
13	KMT2D	Ssm	11	333	3.3%	cbioportal
18	RP1	Ssm	10	333	3%	cbioportal
15	AHNAK	Ssm	10	333	3%	cbioportal
16	FAT3	Ssm	10	333	3%	cbioportal
17	HMCN1	Ssm	10	333	3%	cbioportal
22	PTEN	Ssm	9	333	2.7%	cbioportal
19	BRCA2	Ssm	9	333	2.7%	cbioportal
21	FLG2	Ssm	9	333	2.7%	cbioportal
20	DCHS2	Ssm	9	333	2.7%	cbioportal
28	FLG	Ssm	8	333	2.4%	cbioportal
30	PCDH18	Ssm	8	333	2.4%	cbioportal
26	CTNNB1	Ssm	8	333	2.4%	cbioportal
27	DNAH9	Ssm	8	333	2.4%	cbioportal
29	MACF1	Ssm	8	333	2.4%	cbioportal
23	ADGRB3	Ssm	8	333	2.4%	cbioportal
24	ADGRV1	Ssm	8	333	2.4%	cbioportal
25	BRAF	Ssm	8	333	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (TCGA, Firehose Legacy) prad_tcgaTCGA

499 cases with simple somatic mutation data · 501 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FRG1BP	Ssm	97	499	19.4%	cbioportal
2	TTN	Ssm	63	499	12.6%	cbioportal
3	TP53	Ssm	61	499	12.2%	cbioportal
4	SPOP	Ssm	57	499	11.4%	cbioportal
5	MUC16	Ssm	38	499	7.6%	cbioportal
6	MUC17	Ssm	33	499	6.6%	cbioportal
7	KMT2C	Ssm	30	499	6%	cbioportal
8	KMT2D	Ssm	29	499	5.8%	cbioportal
9	FOXA1	Ssm	28	499	5.6%	cbioportal
10	NBPF1	Ssm	27	499	5.4%	cbioportal
11	SYNE1	Ssm	27	499	5.4%	cbioportal
12	SPTA1	Ssm	26	499	5.2%	cbioportal
14	LRP1B	Ssm	24	499	4.8%	cbioportal
13	KRTAP4-11	Ssm	24	499	4.8%	cbioportal
15	NBPF10	Ssm	23	499	4.6%	cbioportal
17	CSMD3	Ssm	22	499	4.4%	cbioportal
16	ATM	Ssm	22	499	4.4%	cbioportal
18	ZAN	Ssm	22	499	4.4%	cbioportal
19	CHEK2	Ssm	21	499	4.2%	cbioportal
20	MUC4	Ssm	21	499	4.2%	cbioportal
21	FAT3	Ssm	19	499	3.8%	cbioportal
22	HMCN1	Ssm	19	499	3.8%	cbioportal
23	RYR1	Ssm	19	499	3.8%	cbioportal
24	CACNA1E	Ssm	18	499	3.6%	cbioportal
25	OBSCN	Ssm	18	499	3.6%	cbioportal
26	RGPD8	Ssm	18	499	3.6%	cbioportal
27	USH2A	Ssm	18	499	3.6%	cbioportal
28	MACF1	Ssm	17	499	3.4%	cbioportal
29	PTEN	Ssm	17	499	3.4%	cbioportal
30	RYR2	Ssm	17	499	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (TCGA GDC, 2025) prad_tcga_gdcTCGA GDC

491 cases with simple somatic mutation data · 501 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	55	491	11.2%	cbioportal
2	SPOP	Ssm	54	491	11%	cbioportal
3	TTN	Ssm	47	491	9.6%	cbioportal
4	FOXA1	Ssm	29	491	5.9%	cbioportal
5	KMT2D	Ssm	28	491	5.7%	cbioportal
6	MUC16	Ssm	26	491	5.3%	cbioportal
7	SYNE1	Ssm	22	491	4.5%	cbioportal
8	KMT2C	Ssm	21	491	4.3%	cbioportal
10	SPTA1	Ssm	20	491	4.1%	cbioportal
9	LRP1B	Ssm	20	491	4.1%	cbioportal
11	ATM	Ssm	18	491	3.7%	cbioportal
13	RYR2	Ssm	17	491	3.5%	cbioportal
12	CSMD3	Ssm	17	491	3.5%	cbioportal
14	PTEN	Ssm	16	491	3.3%	cbioportal
15	KDM6A	Ssm	15	491	3.1%	cbioportal
18	MUC17	Ssm	14	491	2.9%	cbioportal
17	HMCN1	Ssm	14	491	2.9%	cbioportal
16	CACNA1E	Ssm	14	491	2.9%	cbioportal
19	RP1	Ssm	13	491	2.6%	cbioportal
20	USH2A	Ssm	13	491	2.6%	cbioportal
21	FAT3	Ssm	12	491	2.4%	cbioportal
23	RYR1	Ssm	12	491	2.4%	cbioportal
22	MYO15A	Ssm	12	491	2.4%	cbioportal
28	MACF1	Ssm	11	491	2.2%	cbioportal
30	ZMYM3	Ssm	11	491	2.2%	cbioportal
29	OBSCN	Ssm	11	491	2.2%	cbioportal
25	ADGRB3	Ssm	11	491	2.2%	cbioportal
26	APC	Ssm	11	491	2.2%	cbioportal
27	CNTNAP5	Ssm	11	491	2.2%	cbioportal
24	ABCA13	Ssm	11	491	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (TCGA, PanCancer Atlas) prad_tcga_pan_can_atlas_2018TCGA

494 cases with simple somatic mutation data · 494 cases total · 2026-06-04 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	57	494	11.5%	cbioportal
2	SPOP	Ssm	55	494	11.1%	cbioportal
3	TTN	Ssm	54	494	10.9%	cbioportal
4	MUC16	Ssm	31	494	6.3%	cbioportal
5	FOXA1	Ssm	28	494	5.7%	cbioportal
6	KMT2D	Ssm	28	494	5.7%	cbioportal
7	KMT2C	Ssm	25	494	5.1%	cbioportal
8	SPTA1	Ssm	23	494	4.7%	cbioportal
9	SYNE1	Ssm	23	494	4.7%	cbioportal
10	LRP1B	Ssm	22	494	4.5%	cbioportal
11	ATM	Ssm	20	494	4%	cbioportal
12	CSMD3	Ssm	19	494	3.8%	cbioportal
14	PTEN	Ssm	18	494	3.6%	cbioportal
15	RYR2	Ssm	18	494	3.6%	cbioportal
13	FAT3	Ssm	18	494	3.6%	cbioportal
16	HMCN1	Ssm	16	494	3.2%	cbioportal
17	OBSCN	Ssm	16	494	3.2%	cbioportal
19	COL11A1	Ssm	15	494	3%	cbioportal
20	MUC17	Ssm	15	494	3%	cbioportal
21	RYR1	Ssm	15	494	3%	cbioportal
18	CACNA1E	Ssm	15	494	3%	cbioportal
22	USH2A	Ssm	15	494	3%	cbioportal
24	MYO15A	Ssm	14	494	2.8%	cbioportal
23	MACF1	Ssm	14	494	2.8%	cbioportal
25	RP1	Ssm	13	494	2.6%	cbioportal
26	ZFHX3	Ssm	13	494	2.6%	cbioportal
27	ABCA13	Ssm	12	494	2.4%	cbioportal
30	DNAH17	Ssm	12	494	2.4%	cbioportal
29	DCHS2	Ssm	12	494	2.4%	cbioportal
28	CSMD1	Ssm	12	494	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Prostate Cancer-IDH Driver Mutant Cohort (MSK, 2024) prad_idhmut_msk_2025MSK

99 cases with simple somatic mutation data · 99 cases total · 2026-08-20 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	29	99	29.3%	cbioportal
2	TP53	Ssm	17	99	17.2%	cbioportal
3	FOXA1	Ssm	12	99	12.1%	cbioportal
4	SPOP	Ssm	12	99	12.1%	cbioportal
6	CTNNB1	Ssm	6	99	6.1%	cbioportal
7	PIK3CA	Ssm	6	99	6.1%	cbioportal
5	BRCA2	Ssm	6	99	6.1%	cbioportal
9	KMT2D	Ssm	5	99	5.1%	cbioportal
8	ATM	Ssm	5	99	5.1%	cbioportal
12	IDH2	Ssm	4	99	4%	cbioportal
13	PTEN	Ssm	4	99	4%	cbioportal
11	CDK12	Ssm	4	99	4%	cbioportal
10	APC	Ssm	4	99	4%	cbioportal
19	MGA	Ssm	3	96	3.1%	cbioportal
22	ZFHX3	Ssm	3	96	3.1%	cbioportal
18	KMT2A	Ssm	3	99	3%	cbioportal
15	DNMT3B	Ssm	3	99	3%	cbioportal
16	JAK1	Ssm	3	99	3%	cbioportal
21	TSC2	Ssm	3	99	3%	cbioportal
20	PTPRD	Ssm	3	99	3%	cbioportal
17	KDM6A	Ssm	3	99	3%	cbioportal
14	BCOR	Ssm	3	99	3%	cbioportal
40	NSD2	Ssm	2	89	2.2%	cbioportal
117	LRP1B	Ssm	1	45	2.2%	cbioportal
93	FANCL	Ssm	1	45	2.2%	cbioportal
51	ACVR1B	Ssm	1	45	2.2%	cbioportal
124	MLH3	Ssm	1	45	2.2%	cbioportal
119	MAP3K7	Ssm	1	45	2.2%	cbioportal
43	POLD1	Ssm	2	96	2.1%	cbioportal
48	TBX3	Ssm	2	99	2%	cbioportal

Data updated 22 days agoSource updated 2026-08-20

Prostate Cancer (MSK, JCO Precis Oncol 2017) prad_mskcc_2017MSK

504 cases with simple somatic mutation data · 504 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	166	504	32.9%	cbioportal
2	FOXA1	Ssm	58	504	11.5%	cbioportal
3	SPOP	Ssm	47	504	9.3%	cbioportal
4	APC	Ssm	40	504	7.9%	cbioportal
5	KMT2C	Ssm	34	504	6.7%	cbioportal
6	PTEN	Ssm	28	504	5.6%	cbioportal
7	CDK12	Ssm	27	504	5.4%	cbioportal
8	AR	Ssm	25	504	5%	cbioportal
9	KMT2D	Ssm	25	504	5%	cbioportal
10	BRCA2	Ssm	24	504	4.8%	cbioportal
11	SPEN	Ssm	21	504	4.2%	cbioportal
12	GRIN2A	Ssm	19	504	3.8%	cbioportal
13	ATM	Ssm	18	504	3.6%	cbioportal
14	CTNNB1	Ssm	17	504	3.4%	cbioportal
15	PIK3CA	Ssm	17	504	3.4%	cbioportal
16	JAK1	Ssm	15	504	3%	cbioportal
27	MGA	Ssm	10	345	2.9%	cbioportal
30	ZFHX3	Ssm	10	345	2.9%	cbioportal
18	RB1	Ssm	14	504	2.8%	cbioportal
17	FAT1	Ssm	14	504	2.8%	cbioportal
19	KMT2A	Ssm	12	504	2.4%	cbioportal
20	MED12	Ssm	12	504	2.4%	cbioportal
21	NCOR1	Ssm	12	504	2.4%	cbioportal
23	KDM6A	Ssm	11	504	2.2%	cbioportal
22	ASXL1	Ssm	11	504	2.2%	cbioportal
24	NOTCH1	Ssm	11	504	2.2%	cbioportal
25	PTPRS	Ssm	11	504	2.2%	cbioportal
28	NSD1	Ssm	10	504	2%	cbioportal
29	PIK3R1	Ssm	10	504	2%	cbioportal
26	BRAF	Ssm	10	504	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Cancer (MSK, Science 2022) prad_organoids_msk_2022MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	32	47	68.1%	cbioportal
5	MUC16	Ssm	7	24	29.2%	cbioportal
7	AEBP1	Ssm	6	24	25%	cbioportal
10	TTN	Ssm	6	24	25%	cbioportal
20	MUC5B	Ssm	5	24	20.8%	cbioportal
17	HERC1	Ssm	5	24	20.8%	cbioportal
18	LRP1B	Ssm	5	24	20.8%	cbioportal
19	MACF1	Ssm	5	24	20.8%	cbioportal
11	ABHD15	Ssm	5	24	20.8%	cbioportal
26	TRIOBP	Ssm	5	24	20.8%	cbioportal
14	CDH23	Ssm	5	24	20.8%	cbioportal
16	DNAH2	Ssm	5	24	20.8%	cbioportal
21	OBSCN	Ssm	5	24	20.8%	cbioportal
2	FOXA1	Ssm	8	47	17%	cbioportal
71	SPATA31D1	Ssm	4	24	16.7%	cbioportal
69	RYR2	Ssm	4	24	16.7%	cbioportal
50	LAMA3	Ssm	4	24	16.7%	cbioportal
49	KCNQ5	Ssm	4	24	16.7%	cbioportal
48	ITPRID1	Ssm	4	24	16.7%	cbioportal
47	ITGA10	Ssm	4	24	16.7%	cbioportal
74	SYNE3	Ssm	4	24	16.7%	cbioportal
68	RYR1	Ssm	4	24	16.7%	cbioportal
75	TRIM67	Ssm	4	24	16.7%	cbioportal
53	MYO10	Ssm	4	24	16.7%	cbioportal
66	RNF213	Ssm	4	24	16.7%	cbioportal
28	AHNAK	Ssm	4	24	16.7%	cbioportal
70	RYR3	Ssm	4	24	16.7%	cbioportal
51	MCF2L2	Ssm	4	24	16.7%	cbioportal
29	ANK2	Ssm	4	24	16.7%	cbioportal
52	MUC6	Ssm	4	24	16.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Race Differences in Prostate Cancer (MSK, 2021) prad_msk_stopsack_2021MSK

2,069 cases with simple somatic mutation data · 2,069 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	551	2,069	26.6%	cbioportal
2	FOXA1	Ssm	273	2,069	13.2%	cbioportal
3	SPOP	Ssm	260	2,069	12.6%	cbioportal
4	PTEN	Ssm	155	2,069	7.5%	cbioportal
5	KMT2C	Ssm	140	2,069	6.8%	cbioportal
6	APC	Ssm	138	2,069	6.7%	cbioportal
7	KMT2D	Ssm	133	2,069	6.4%	cbioportal
9	ZFHX3	Ssm	110	1,924	5.7%	cbioportal
8	CDK12	Ssm	118	2,069	5.7%	cbioportal
10	PIK3CA	Ssm	92	2,069	4.4%	cbioportal
11	ATM	Ssm	86	2,069	4.2%	cbioportal
12	AR	Ssm	80	2,069	3.9%	cbioportal
13	CTNNB1	Ssm	78	2,069	3.8%	cbioportal
14	BRCA2	Ssm	74	2,069	3.6%	cbioportal
15	SPEN	Ssm	70	2,069	3.4%	cbioportal
27	ERF	Ssm	47	1,402	3.4%	cbioportal
16	KDM6A	Ssm	69	2,069	3.3%	cbioportal
20	MGA	Ssm	61	1,924	3.2%	cbioportal
17	JAK1	Ssm	64	2,069	3.1%	cbioportal
18	RB1	Ssm	63	2,069	3%	cbioportal
19	GRIN2A	Ssm	61	2,069	2.9%	cbioportal
21	FAT1	Ssm	56	2,069	2.7%	cbioportal
22	KMT2A	Ssm	52	2,069	2.5%	cbioportal
23	MED12	Ssm	52	2,069	2.5%	cbioportal
25	NCOR1	Ssm	50	2,069	2.4%	cbioportal
24	ASXL1	Ssm	50	2,069	2.4%	cbioportal
26	PTPRD	Ssm	49	2,069	2.4%	cbioportal
44	KMT2B	Ssm	32	1,402	2.3%	cbioportal
28	ARID1A	Ssm	43	2,069	2.1%	cbioportal
29	PIK3R1	Ssm	41	2,069	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Small Cell Carcinoma of the Ovary (MSK, Nat Genet 2014) scco_mskccMSK

12 cases with simple somatic mutation data · 12 cases total · 2026-01-13 · mapped to Ovarian Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved5 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMARCA4	Ssm	11	12	91.7%	cbioportal
5	WT1	Ssm	1	12	8.3%	cbioportal
3	JAK3	Ssm	1	12	8.3%	cbioportal
2	ASXL1	Ssm	1	12	8.3%	cbioportal
4	NOTCH2	Ssm	1	12	8.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Squamous Cell Carcinoma of the Vulva (CUK, Exp Mol Med 2018) vsc_cuk_2018CUK

15 cases with simple somatic mutation data · 15 cases total · 2026-01-16 · mapped to Vaginal Squamous Cell Carcinoma, Not Otherwise Specified EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MAML2	Ssm	6	15	40%	cbioportal
4	SYNE1	Ssm	5	15	33.3%	cbioportal
5	TP53	Ssm	5	15	33.3%	cbioportal
3	SPTBN1	Ssm	5	15	33.3%	cbioportal
2	ODF1	Ssm	5	15	33.3%	cbioportal
6	FAT2	Ssm	4	15	26.7%	cbioportal
7	NRG3	Ssm	4	15	26.7%	cbioportal
31	SLC12A3	Ssm	3	15	20%	cbioportal
30	SHROOM3	Ssm	3	15	20%	cbioportal
29	SCAF4	Ssm	3	15	20%	cbioportal
28	PARD3B	Ssm	3	15	20%	cbioportal
27	NRG1	Ssm	3	15	20%	cbioportal
26	NLGN3	Ssm	3	15	20%	cbioportal
25	MDN1	Ssm	3	15	20%	cbioportal
17	DCHS1	Ssm	3	15	20%	cbioportal
18	F5	Ssm	3	15	20%	cbioportal
19	FAM193A	Ssm	3	15	20%	cbioportal
20	FAT1	Ssm	3	15	20%	cbioportal
16	CSMD1	Ssm	3	15	20%	cbioportal
22	KMT2C	Ssm	3	15	20%	cbioportal
8	AHNAK	Ssm	3	15	20%	cbioportal
24	MAML3	Ssm	3	15	20%	cbioportal
10	AMOTL2	Ssm	3	15	20%	cbioportal
11	ANP32E	Ssm	3	15	20%	cbioportal
21	KMT2B	Ssm	3	15	20%	cbioportal
32	ZBTB41	Ssm	3	15	20%	cbioportal
13	CACNA1B	Ssm	3	15	20%	cbioportal
14	CASP8	Ssm	3	15	20%	cbioportal
15	CREBBP	Ssm	3	15	20%	cbioportal
12	APC	Ssm	3	15	20%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Uterine Carcinosarcoma TCGA-UCSTCGA

57 cases with simple somatic mutation data · 57 cases total · Data Release 46.0 · mapped to Uterine Carcinosarcoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	gdc
2	PIK3CA	Ssm	46	57	80.7%	gdc
3	MELTF	Ssm	46	57	80.7%	gdc
14	EEF1AKMT4-ECE2	Ssm	45	57	78.9%	gdc
21	PSMA7	Ssm	45	57	78.9%	gdc
20	OPA1	Ssm	45	57	78.9%	gdc
19	FBXO45	Ssm	45	57	78.9%	gdc
7	ATP13A5	Ssm	45	57	78.9%	gdc
4	SENP5	Ssm	45	57	78.9%	gdc
5	LAMA5	Ssm	45	57	78.9%	gdc
18	GATA5	Ssm	45	57	78.9%	gdc
17	OSTN	Ssm	45	57	78.9%	gdc
16	TRA2B	Ssm	45	57	78.9%	gdc
6	ADRM1	Ssm	45	57	78.9%	gdc
8	YEATS2	Ssm	45	57	78.9%	gdc
9	MB21D2	Ssm	45	57	78.9%	gdc
10	ATP13A4	Ssm	45	57	78.9%	gdc
11	RNF168	Ssm	45	57	78.9%	gdc
12	FGF12	Ssm	45	57	78.9%	gdc
13	MUC4	Ssm	45	57	78.9%	gdc
15	APOD	Ssm	45	57	78.9%	gdc
30	OSBPL2	Ssm	44	57	77.2%	gdc
22	SS18L1	Ssm	44	57	77.2%	gdc
23	PIGX	Ssm	44	57	77.2%	gdc
24	DVL3	Ssm	44	57	77.2%	gdc
25	NCBP2AS2	Ssm	44	57	77.2%	gdc
26	TNK2	Ssm	44	57	77.2%	gdc
27	SLC51A	Ssm	44	57	77.2%	gdc
28	AHSG	Ssm	44	57	77.2%	gdc
29	RBBP8NL	Ssm	44	57	77.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Uterine Carcinosarcoma (Johns Hopkins, Nat Commun 2014) ucs_jhu_2014Johns Hopkins

22 cases with simple somatic mutation data · 22 cases total · 2026-01-16 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	16	22	72.7%	cbioportal
3	PTEN	Ssm	9	22	40.9%	cbioportal
2	PIK3CA	Ssm	9	22	40.9%	cbioportal
4	ARID1A	Ssm	8	22	36.4%	cbioportal
5	KMT2C	Ssm	6	22	27.3%	cbioportal
7	PXDNL	Ssm	6	22	27.3%	cbioportal
6	KRAS	Ssm	6	22	27.3%	cbioportal
8	TTN	Ssm	6	22	27.3%	cbioportal
15	FBXW7	Ssm	5	22	22.7%	cbioportal
24	URB1	Ssm	5	22	22.7%	cbioportal
23	TRRAP	Ssm	5	22	22.7%	cbioportal
22	SPTBN5	Ssm	5	22	22.7%	cbioportal
21	SPEG	Ssm	5	22	22.7%	cbioportal
20	PLEC	Ssm	5	22	22.7%	cbioportal
19	MDN1	Ssm	5	22	22.7%	cbioportal
18	LTBP2	Ssm	5	22	22.7%	cbioportal
17	LRP2	Ssm	5	22	22.7%	cbioportal
16	HMCN1	Ssm	5	22	22.7%	cbioportal
14	FAM135B	Ssm	5	22	22.7%	cbioportal
13	CNTNAP2	Ssm	5	22	22.7%	cbioportal
12	CDHR3	Ssm	5	22	22.7%	cbioportal
11	BLTP1	Ssm	5	22	22.7%	cbioportal
10	BCOR	Ssm	5	22	22.7%	cbioportal
9	APOB	Ssm	5	22	22.7%	cbioportal
27	ADAMTSL4	Ssm	4	22	18.2%	cbioportal
29	ADGRG4	Ssm	4	22	18.2%	cbioportal
28	ADGRF4	Ssm	4	22	18.2%	cbioportal
111	MED12L	Ssm	4	22	18.2%	cbioportal
26	ABI3BP	Ssm	4	22	18.2%	cbioportal
25	A2M	Ssm	4	22	18.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Uterine Carcinosarcoma (TCGA, Firehose Legacy) ucs_tcgaTCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-01-13 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	FRG1BP	Ssm	21	57	36.8%	cbioportal
4	PIK3CA	Ssm	20	57	35.1%	cbioportal
5	PPP2R1A	Ssm	16	57	28.1%	cbioportal
6	MUC4	Ssm	13	57	22.8%	cbioportal
7	PTEN	Ssm	11	57	19.3%	cbioportal
9	TTN	Ssm	10	57	17.5%	cbioportal
8	CHD4	Ssm	10	57	17.5%	cbioportal
10	ARID1A	Ssm	8	57	14%	cbioportal
13	MUC17	Ssm	7	57	12.3%	cbioportal
12	LRP1B	Ssm	7	57	12.3%	cbioportal
11	KRAS	Ssm	7	57	12.3%	cbioportal
24	ZNF814	Ssm	6	57	10.5%	cbioportal
18	MUC16	Ssm	6	57	10.5%	cbioportal
19	PIK3R1	Ssm	6	57	10.5%	cbioportal
20	RB1	Ssm	6	57	10.5%	cbioportal
21	SYNE1	Ssm	6	57	10.5%	cbioportal
22	VPS13B	Ssm	6	57	10.5%	cbioportal
23	ZBTB7B	Ssm	6	57	10.5%	cbioportal
17	MGAM	Ssm	6	57	10.5%	cbioportal
14	ARHGAP35	Ssm	6	57	10.5%	cbioportal
16	KMT2D	Ssm	6	57	10.5%	cbioportal
15	FLNA	Ssm	6	57	10.5%	cbioportal
32	NRXN1	Ssm	5	57	8.8%	cbioportal
33	PLEC	Ssm	5	57	8.8%	cbioportal
30	LRP2	Ssm	5	57	8.8%	cbioportal
29	FLG	Ssm	5	57	8.8%	cbioportal
28	FER1L6	Ssm	5	57	8.8%	cbioportal
27	FCGBP	Ssm	5	57	8.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Carcinosarcoma (TCGA, PanCancer Atlas) ucs_tcga_pan_can_atlas_2018TCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-06-05 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
6	TTN	Ssm	11	57	19.3%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
7	CHD4	Ssm	10	57	17.5%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
19	ZBTB7B	Ssm	6	57	10.5%	cbioportal
18	VPS13B	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
16	PIK3R1	Ssm	6	57	10.5%	cbioportal
15	MUC16	Ssm	6	57	10.5%	cbioportal
14	MGAM	Ssm	6	57	10.5%	cbioportal
12	FLNA	Ssm	6	57	10.5%	cbioportal
13	KMT2D	Ssm	6	57	10.5%	cbioportal
11	ARHGAP35	Ssm	6	57	10.5%	cbioportal
10	AHNAK	Ssm	6	57	10.5%	cbioportal
26	RB1	Ssm	5	57	8.8%	cbioportal
24	LRP2	Ssm	5	57	8.8%	cbioportal
23	LRP1B	Ssm	5	57	8.8%	cbioportal
22	FLG	Ssm	5	57	8.8%	cbioportal
21	FER1L6	Ssm	5	57	8.8%	cbioportal
20	DOP1A	Ssm	5	57	8.8%	cbioportal
25	MUC17	Ssm	5	57	8.8%	cbioportal
27	ABCA12	Ssm	4	57	7%	cbioportal
30	COL11A1	Ssm	4	57	7%	cbioportal
29	BRWD1	Ssm	4	57	7%	cbioportal
28	ADAMTSL1	Ssm	4	57	7%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor (TCGA GDC, 2025) ucs_tcga_gdcTCGA GDC

57 cases with simple somatic mutation data · 57 cases total · 2026-01-14 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	49	57	86%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
6	CHD4	Ssm	10	57	17.5%	cbioportal
7	PIK3R1	Ssm	9	57	15.8%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
10	TTN	Ssm	7	57	12.3%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
14	KMT2D	Ssm	6	57	10.5%	cbioportal
18	ZBTB7B	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
16	MGAM	Ssm	6	57	10.5%	cbioportal
15	LRP2	Ssm	6	57	10.5%	cbioportal
11	AHNAK	Ssm	6	57	10.5%	cbioportal
12	ARHGAP35	Ssm	6	57	10.5%	cbioportal
13	FLNA	Ssm	6	57	10.5%	cbioportal
23	VPS13B	Ssm	5	57	8.8%	cbioportal
19	DOP1A	Ssm	5	57	8.8%	cbioportal
20	MUC16	Ssm	5	57	8.8%	cbioportal
21	MUC17	Ssm	5	57	8.8%	cbioportal
22	RB1	Ssm	5	57	8.8%	cbioportal
27	COPB1	Ssm	4	57	7%	cbioportal
26	BRWD1	Ssm	4	57	7%	cbioportal
25	ADAMTSL1	Ssm	4	57	7%	cbioportal
24	ABCA12	Ssm	4	57	7%	cbioportal
30	DPP10	Ssm	4	57	7%	cbioportal
29	DNAH2	Ssm	4	57	7%	cbioportal
28	CUBN	Ssm	4	57	7%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Uterine Clear Cell Carcinoma (NIH, Cancer 2017) uccc_nih_2017NIH

16 cases with simple somatic mutation data · 16 cases total · 2026-01-13 · mapped to Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	16	43.8%	cbioportal
2	KMT2C	Ssm	5	16	31.3%	cbioportal
4	ZNF717	Ssm	4	16	25%	cbioportal
3	TAF1	Ssm	4	16	25%	cbioportal
6	FAM136A	Ssm	3	16	18.8%	cbioportal
5	AGAP4	Ssm	3	16	18.8%	cbioportal
7	PIK3CA	Ssm	3	16	18.8%	cbioportal
13	CCDC178	Ssm	2	16	12.5%	cbioportal
14	CHL1	Ssm	2	16	12.5%	cbioportal
15	CHRM5	Ssm	2	16	12.5%	cbioportal
16	COIL	Ssm	2	16	12.5%	cbioportal
17	COL5A1	Ssm	2	16	12.5%	cbioportal
29	FRG2C	Ssm	2	16	12.5%	cbioportal
28	FRG1	Ssm	2	16	12.5%	cbioportal
27	FOXA2	Ssm	2	16	12.5%	cbioportal
26	FAT3	Ssm	2	16	12.5%	cbioportal
25	ERBB3	Ssm	2	16	12.5%	cbioportal
24	EPC2	Ssm	2	16	12.5%	cbioportal
20	DNAH11	Ssm	2	16	12.5%	cbioportal
11	ARID1A	Ssm	2	16	12.5%	cbioportal
10	AP3D1	Ssm	2	16	12.5%	cbioportal
9	AHNAK2	Ssm	2	16	12.5%	cbioportal
8	ABCD1	Ssm	2	16	12.5%	cbioportal
37	MAGEE1	Ssm	2	16	12.5%	cbioportal
18	DENND4A	Ssm	2	16	12.5%	cbioportal
19	DMAP1	Ssm	2	16	12.5%	cbioportal
23	DYSF	Ssm	2	16	12.5%	cbioportal
22	DST	Ssm	2	16	12.5%	cbioportal
21	DNAH3	Ssm	2	16	12.5%	cbioportal
12	ASTE1	Ssm	2	16	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Corpus Endometrial Carcinoma TCGA-UCECTCGA

559 cases with simple somatic mutation data · 560 cases total · Data Release 46.0 · mapped to Endometrial Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	418	559	74.8%	gdc
2	PIK3CA	Ssm	349	559	62.4%	gdc
3	ARID1A	Ssm	319	559	57.1%	gdc
4	TTN	Ssm	297	559	53.1%	gdc
5	OBSCN	Ssm	296	559	53%	gdc
6	RYR2	Ssm	291	559	52.1%	gdc
7	ASH1L	Ssm	289	559	51.7%	gdc
8	USH2A	Ssm	286	559	51.2%	gdc
9	FLG	Ssm	283	559	50.6%	gdc
10	CACNA1E	Ssm	281	559	50.3%	gdc
11	HMCN1	Ssm	278	559	49.7%	gdc
13	HRNR	Ssm	277	559	49.6%	gdc
12	CSMD3	Ssm	277	559	49.6%	gdc
14	CEP350	Ssm	277	559	49.6%	gdc
15	CTCF	Ssm	276	559	49.4%	gdc
18	ZFHX3	Ssm	275	559	49.2%	gdc
17	ASPM	Ssm	275	559	49.2%	gdc
16	GON4L	Ssm	275	559	49.2%	gdc
19	NFASC	Ssm	271	559	48.5%	gdc
20	CSMD1	Ssm	270	559	48.3%	gdc
21	PDE4DIP	Ssm	269	559	48.1%	gdc
22	SPTA1	Ssm	269	559	48.1%	gdc
23	INSRR	Ssm	269	559	48.1%	gdc
24	SETDB1	Ssm	267	559	47.8%	gdc
25	F5	Ssm	266	559	47.6%	gdc
26	MUC16	Ssm	266	559	47.6%	gdc
27	COPA	Ssm	266	559	47.6%	gdc
29	ARHGEF2	Ssm	265	559	47.4%	gdc
28	PRRC2C	Ssm	265	559	47.4%	gdc
30	LYST	Ssm	264	559	47.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Uterine Corpus Endometrial Carcinoma (TCGA, Firehose Legacy) ucec_tcgaTCGA

248 cases with simple somatic mutation data · 549 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	161	248	64.9%	cbioportal
2	PIK3CA	Ssm	132	248	53.2%	cbioportal
3	ARID1A	Ssm	83	248	33.5%	cbioportal
4	PIK3R1	Ssm	82	248	33.1%	cbioportal
5	TTN	Ssm	79	248	31.9%	cbioportal
6	CTNNB1	Ssm	74	248	29.8%	cbioportal
7	TP53	Ssm	69	248	27.8%	cbioportal
8	KRAS	Ssm	52	248	21%	cbioportal
9	MUC16	Ssm	48	248	19.4%	cbioportal
10	CSMD3	Ssm	47	248	19%	cbioportal
11	CTCF	Ssm	45	248	18.1%	cbioportal
12	ZFHX3	Ssm	44	248	17.7%	cbioportal
13	MUC5B	Ssm	43	248	17.3%	cbioportal
14	RYR2	Ssm	41	248	16.5%	cbioportal
15	FAT1	Ssm	40	248	16.1%	cbioportal
16	FAT4	Ssm	40	248	16.1%	cbioportal
17	OBSCN	Ssm	39	248	15.7%	cbioportal
19	FBXW7	Ssm	38	248	15.3%	cbioportal
18	DMD	Ssm	38	248	15.3%	cbioportal
20	NEB	Ssm	37	248	14.9%	cbioportal
22	FAT3	Ssm	36	248	14.5%	cbioportal
21	ARHGAP35	Ssm	36	248	14.5%	cbioportal
23	ZFHX4	Ssm	36	248	14.5%	cbioportal
27	USH2A	Ssm	35	248	14.1%	cbioportal
24	CHD4	Ssm	35	248	14.1%	cbioportal
25	DNAH5	Ssm	35	248	14.1%	cbioportal
26	TAF1	Ssm	35	248	14.1%	cbioportal
28	RYR3	Ssm	34	248	13.7%	cbioportal
29	ANK3	Ssm	33	248	13.3%	cbioportal
30	DNAH10	Ssm	33	248	13.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) ucec_tcga_pubTCGA

248 cases with simple somatic mutation data · 373 cases total · 2026-01-16 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	161	248	64.9%	cbioportal
2	PIK3CA	Ssm	132	248	53.2%	cbioportal
3	ARID1A	Ssm	83	248	33.5%	cbioportal
4	PIK3R1	Ssm	81	248	32.7%	cbioportal
5	TTN	Ssm	79	248	31.9%	cbioportal
6	CTNNB1	Ssm	74	248	29.8%	cbioportal
7	TP53	Ssm	69	248	27.8%	cbioportal
8	KRAS	Ssm	52	248	21%	cbioportal
9	MUC16	Ssm	48	248	19.4%	cbioportal
10	CSMD3	Ssm	47	248	19%	cbioportal
11	CTCF	Ssm	45	248	18.1%	cbioportal
12	ZFHX3	Ssm	44	248	17.7%	cbioportal
13	MUC5B	Ssm	43	248	17.3%	cbioportal
14	RYR2	Ssm	41	248	16.5%	cbioportal
16	FAT4	Ssm	40	248	16.1%	cbioportal
15	FAT1	Ssm	40	248	16.1%	cbioportal
17	OBSCN	Ssm	39	248	15.7%	cbioportal
19	FBXW7	Ssm	38	248	15.3%	cbioportal
18	DMD	Ssm	38	248	15.3%	cbioportal
20	NEB	Ssm	37	248	14.9%	cbioportal
23	ZFHX4	Ssm	36	248	14.5%	cbioportal
21	ARHGAP35	Ssm	36	248	14.5%	cbioportal
22	FAT3	Ssm	36	248	14.5%	cbioportal
25	DNAH5	Ssm	35	248	14.1%	cbioportal
24	CHD4	Ssm	35	248	14.1%	cbioportal
26	TAF1	Ssm	35	248	14.1%	cbioportal
27	USH2A	Ssm	35	248	14.1%	cbioportal
28	RYR3	Ssm	34	248	13.7%	cbioportal
29	ANK3	Ssm	33	248	13.3%	cbioportal
30	DNAH10	Ssm	33	248	13.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) ucec_tcga_pan_can_atlas_2018TCGA

517 cases with simple somatic mutation data · 529 cases total · 2026-06-04 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	337	517	65.2%	cbioportal
2	PIK3CA	Ssm	259	517	50.1%	cbioportal
3	ARID1A	Ssm	227	517	43.9%	cbioportal
4	TTN	Ssm	206	517	39.8%	cbioportal
5	TP53	Ssm	193	517	37.3%	cbioportal
6	PIK3R1	Ssm	159	517	30.8%	cbioportal
7	KMT2D	Ssm	143	517	27.7%	cbioportal
8	MUC16	Ssm	142	517	27.5%	cbioportal
9	CTNNB1	Ssm	133	517	25.7%	cbioportal
10	CTCF	Ssm	127	517	24.6%	cbioportal
11	RYR2	Ssm	125	517	24.2%	cbioportal
12	ZFHX3	Ssm	123	517	23.8%	cbioportal
13	CSMD3	Ssm	122	517	23.6%	cbioportal
14	MUC5B	Ssm	117	517	22.6%	cbioportal
15	OBSCN	Ssm	117	517	22.6%	cbioportal
16	SYNE1	Ssm	114	517	22.1%	cbioportal
17	CHD4	Ssm	113	517	21.9%	cbioportal
18	KMT2B	Ssm	113	517	21.9%	cbioportal
19	FLG	Ssm	112	517	21.7%	cbioportal
21	ZFHX4	Ssm	109	517	21.1%	cbioportal
20	MACF1	Ssm	109	517	21.1%	cbioportal
22	FAT4	Ssm	108	517	20.9%	cbioportal
23	NEB	Ssm	106	517	20.5%	cbioportal
24	USH2A	Ssm	105	517	20.3%	cbioportal
25	TAF1	Ssm	104	517	20.1%	cbioportal
28	DNAH7	Ssm	103	517	19.9%	cbioportal
29	FAT1	Ssm	103	517	19.9%	cbioportal
27	DMD	Ssm	103	517	19.9%	cbioportal
26	ARHGAP35	Ssm	103	517	19.9%	cbioportal
30	PCLO	Ssm	102	517	19.7%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Uterine Endometrioid Carcinoma (CPTAC GDC, 2025) uec_cptac_gdcCPTAC GDC

247 cases with simple somatic mutation data · 442 cases total · 2026-01-14 · mapped to Endometrial Endometrioid Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	194	247	78.5%	cbioportal
2	ARID1A	Ssm	136	247	55.1%	cbioportal
3	PIK3CA	Ssm	105	247	42.5%	cbioportal
4	PIK3R1	Ssm	91	247	36.8%	cbioportal
5	TTN	Ssm	89	247	36%	cbioportal
6	CTNNB1	Ssm	71	247	28.7%	cbioportal
7	KRAS	Ssm	67	247	27.1%	cbioportal
8	OBSCN	Ssm	65	247	26.3%	cbioportal
9	KMT2B	Ssm	62	247	25.1%	cbioportal
12	TP53	Ssm	61	247	24.7%	cbioportal
10	INPPL1	Ssm	61	247	24.7%	cbioportal
11	KMT2D	Ssm	61	247	24.7%	cbioportal
13	CTCF	Ssm	56	247	22.7%	cbioportal
14	SYNE1	Ssm	54	247	21.9%	cbioportal
15	ZFHX3	Ssm	54	247	21.9%	cbioportal
16	PCLO	Ssm	51	247	20.6%	cbioportal
17	MUC16	Ssm	49	247	19.8%	cbioportal
18	MUC5B	Ssm	48	247	19.4%	cbioportal
19	FSIP2	Ssm	47	247	19%	cbioportal
20	CSMD3	Ssm	46	247	18.6%	cbioportal
22	ZFHX4	Ssm	45	247	18.2%	cbioportal
21	RYR1	Ssm	45	247	18.2%	cbioportal
24	RYR2	Ssm	43	247	17.4%	cbioportal
23	JAK1	Ssm	43	247	17.4%	cbioportal
25	DNAH5	Ssm	42	247	17%	cbioportal
27	FAT3	Ssm	41	247	16.6%	cbioportal
26	CHD4	Ssm	41	247	16.6%	cbioportal
28	HERC2	Ssm	41	247	16.6%	cbioportal
29	DNAH17	Ssm	40	247	16.2%	cbioportal
30	FBXW7	Ssm	40	247	16.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Uterine Sarcoma/Mesenchymal (MSK, Clin Cancer Res 2020) usarc_msk_2020MSK

108 cases with simple somatic mutation data · 108 cases total · 2026-01-19 · mapped to Uterine Corpus Sarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	40	108	37%	cbioportal
2	ATRX	Ssm	25	108	23.1%	cbioportal
3	RB1	Ssm	12	108	11.1%	cbioportal
4	MED12	Ssm	11	108	10.2%	cbioportal
5	BRCA2	Ssm	7	108	6.5%	cbioportal
6	FAT1	Ssm	6	108	5.6%	cbioportal
7	PTEN	Ssm	6	108	5.6%	cbioportal
130	PPARG	Ssm	1	20	5%	cbioportal
57	AGO2	Ssm	1	20	5%	cbioportal
145	TEK	Ssm	1	20	5%	cbioportal
9	ROS1	Ssm	5	108	4.6%	cbioportal
8	AR	Ssm	5	108	4.6%	cbioportal
14	PIK3CA	Ssm	4	108	3.7%	cbioportal
11	KDR	Ssm	4	108	3.7%	cbioportal
12	NSD1	Ssm	4	108	3.7%	cbioportal
13	PDGFRB	Ssm	4	108	3.7%	cbioportal
10	ARID2	Ssm	4	108	3.7%	cbioportal
18	CARD11	Ssm	3	108	2.8%	cbioportal
21	KMT2A	Ssm	3	108	2.8%	cbioportal
20	ERBB4	Ssm	3	108	2.8%	cbioportal
19	DAXX	Ssm	3	108	2.8%	cbioportal
17	BRD4	Ssm	3	108	2.8%	cbioportal
15	ARID1A	Ssm	3	108	2.8%	cbioportal
16	ASXL1	Ssm	3	108	2.8%	cbioportal
24	TERT	Ssm	3	108	2.8%	cbioportal
23	NF1	Ssm	3	108	2.8%	cbioportal
22	MET	Ssm	3	108	2.8%	cbioportal
26	ATM	Ssm	2	108	1.9%	cbioportal
25	ARID1B	Ssm	2	108	1.9%	cbioportal
29	BRCA1	Ssm	2	108	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-19