Gene

TEK

TEK receptor tyrosine kinase

Explore in graph →CI-GENE-00034856HGNC:11724 ENSG00000120156 NCBI 7010 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (6)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–6 of 6 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
TEK Cis double mutants1
(diagnostic)	Multiple Cutaneous And Mucosal Venous MalformationsUNRESOLVED	Diagnostic	B	Supports Positive	4	submitted	EID9474 Sanger sequencing of cDNA followed by targeted deep sequencing detected TEK mutations in 15/17 unrelated Blue Rubber Bleb Nevus Syndrome (BRBN) patients and 5/6 patients with sporadically occurring mu… (full text at CIViC) PMID 27519652 · Soblet et al., 2017 · Open in CIViC	civic
TEK R849W1
Bosutinib	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	D	Supports Resistance	2	submitted	EID7517 In an in vitro kinase study, the recombinant TEK R849W mutant kinase demonstrated resistance to bosutinib treatment at concentrations of 1μM and 10μM (activity %: 77 and 35) when compared to wild type…

Cohorts

Alteration frequency by cohort (47)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved47 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Skin Cutaneous Melanoma TCGA-SKCM	Cutaneous Melanoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.

TEK R849W and R1108*1
(diagnostic)	Multiple Cutaneous And Mucosal Venous MalformationsUNRESOLVED	Diagnostic	C	Supports Positive	2	submitted	EID9477 Sanger sequencing of cDNA from two tissues samples derived from a patient with cutaneomucosal venous malformation (VMCM) known to harbor germline R849W revealed a distinct somatic mutation in each tis… (full text at CIViC) PMID 27519652 · Soblet et al., 2017 · Open in CIViC	civic

TEK R849W and R1108*1

(diagnostic)

Multiple Cutaneous And Mucosal Venous MalformationsUNRESOLVED

Diagnostic

Supports Positive

submitted

EID9477

Sanger sequencing of cDNA from two tissues samples derived from a patient with cutaneomucosal venous malformation (VMCM) known to harbor germline R849W revealed a distinct somatic mutation in each tis… (full text at CIViC)

PMID 27519652 · Soblet et al., 2017 · Open in CIViC

civic

TEK T1105N and T1106N2
(diagnostic)	Blue Rubber Bleb Nevus SyndromeUNRESOLVED	Diagnostic	C	Supports Positive	2	submitted	EID9475 Sanger sequencing of cDNA followed by targeted deep sequencing detected TEK mutations in 15/17 unrelated Blue Rubber Bleb Nevus Syndrome (BRBN) patients (32/35 lesions positive). Mutations were locate… (full text at CIViC) PMID 27519652 · Soblet et al., 2017 · Open in CIViC	civic
(oncogenic)	Blue Rubber Bleb Nevus SyndromeUNRESOLVED	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9478 TIE2 double mutant (T1105N plus T1106N) and wildtype were expressed through retrovirus in Human umbilical vein endothelial cells (HUVECs). Unlike wildtype cells, the double mutant demonstrated ligand-… (full text at CIViC) PMID 27519652 · Soblet et al., 2017 · Open in CIViC	civic

TEK T1105N and T1106N2

(diagnostic)

Blue Rubber Bleb Nevus SyndromeUNRESOLVED

Diagnostic

Supports Positive

submitted

EID9475

Sanger sequencing of cDNA followed by targeted deep sequencing detected TEK mutations in 15/17 unrelated Blue Rubber Bleb Nevus Syndrome (BRBN) patients (32/35 lesions positive). Mutations were locate… (full text at CIViC)

PMID 27519652 · Soblet et al., 2017 · Open in CIViC

civic

(oncogenic)

Blue Rubber Bleb Nevus SyndromeUNRESOLVED

Oncogenic

Supports Oncogenicity

submitted

EID9478

TIE2 double mutant (T1105N plus T1106N) and wildtype were expressed through retrovirus in Human umbilical vein endothelial cells (HUVECs). Unlike wildtype cells, the double mutant demonstrated ligand-… (full text at CIViC)

PMID 27519652 · Soblet et al., 2017 · Open in CIViC

civic

TEK Y897C and R915C1
(diagnostic)	Multiple Cutaneous And Mucosal Venous MalformationsUNRESOLVED	Diagnostic	C	Supports Positive	2	submitted	EID9476 Sanger sequencing of cDNA followed by targeted deep sequencing detected TEK mutations in ⅚ patients with sporadically occurring multifocal VMs. Mutations were located in exons 17 and/or 23. Furthermor… (full text at CIViC) PMID 27519652 · Soblet et al., 2017 · Open in CIViC	civic

TEK Y897C and R915C1

(diagnostic)

Multiple Cutaneous And Mucosal Venous MalformationsUNRESOLVED

Diagnostic

Supports Positive

submitted

EID9476

Sanger sequencing of cDNA followed by targeted deep sequencing detected TEK mutations in ⅚ patients with sporadically occurring multifocal VMs. Mutations were located in exons 17 and/or 23. Furthermor… (full text at CIViC)

PMID 27519652 · Soblet et al., 2017 · Open in CIViC

civic