Gene

PPARG

peroxisome proliferator activated receptor gamma

Explore in graph →CI-GENE-00020499HGNC:9236 ENSG00000132170 NCBI 5468 Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PPARG Fusion1
(diagnostic)	Thyroid Gland Follicular CarcinomaALIAS	Diagnostic	B	Supports Positive	3	accepted	EID498 PAX8–PPARG gene fusions were found in 12/33 follicular thyroid carcinoma tumor samples, but were rarely found in thyroid Hürthle cell tumors. PMID 12727991 · Nikiforova et al., 2003 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (19)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved19 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	7

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.
· J Clin Endocrinol Metab · 2003 · PMID 12727991 · validated civic_curation pubmed