Gene
A2M
alpha-2-macroglobulin
Explore in graph →CI-GENE-00000004HGNC:7 ENSG00000175899 NCBI 2 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (21)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 25233892
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Uterine Carcinosarcoma (Johns Hopkins, Nat Commun 2014) ucs_jhu_2014 | Uterine Malignant Mixed Mesodermal (Mullerian) Tumor | Ssm | 4 | 22 | 18.2% | 25 | cbioportal |
| Non-Small Cell Lung Cancer (MSK, Cancer Cell 2018) nsclc_mskcc_2018 | Lung Non-Small Cell Carcinoma | Ssm | 7 | 75 | 9.3% | 156 | cbioportal |
| Gastric Cancer (OncoSG, 2018) stad_oncosg_2018 | Gastric Adenocarcinoma | Ssm | 9 | 147 | 6.1% | 144 | cbioportal |
| Diffuse Glioma (GLASS Consortium, Nature 2019) difg_glass_2019 | Diffuse Glioma | Ssm | 22 | 444 | 5% | 146 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.