Pancreaticobiliary Neoplasm — Genomics

Pancreaticobiliary Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

36 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Acinar Cell Carcinoma of the Pancreas (JHU, J Pathol 2014) paac_jhu_2014JHU

23 cases with simple somatic mutation data · 23 cases total · 2026-01-12 · mapped to Pancreatic Acinar Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMAD4

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Biliary Tract Tumors (MSK, 2026) biliary_tract_adc_targets_msk_2026MSK

33 cases with simple somatic mutation data · 33 cases total · 2026-08-24 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	11	33	33.3%	cbioportal
2	ELF3	Ssm	8	33	24.2%	cbioportal
3	SMAD4	Ssm	7	33	21.2%	cbioportal
6	CDKN2A	Ssm	5	33	15.2%	cbioportal
4	ARID1A	Ssm	5	33	15.2%	cbioportal
5	BAP1	Ssm	5	33	15.2%	cbioportal
7	FGFR2	Ssm	4	33	12.1%	cbioportal
12	TCF7L2	Ssm	3	33	9.1%	cbioportal
8	BRAF	Ssm	3	33	9.1%	cbioportal
10	KRAS	Ssm	3	33	9.1%	cbioportal
11	SF3B1	Ssm	3	33	9.1%	cbioportal
9	KMT2C	Ssm	3	33	9.1%	cbioportal
16	ERBB3	Ssm	2	33	6.1%	cbioportal
15	CDK12	Ssm	2	33	6.1%	cbioportal
14	ATM	Ssm	2	33	6.1%	cbioportal
13	APC	Ssm	2	33	6.1%	cbioportal
31	TSC1	Ssm	2	33	6.1%	cbioportal
30	TET1	Ssm	2	33	6.1%	cbioportal
29	RTEL1	Ssm	2	33	6.1%	cbioportal
28	RRAS2	Ssm	2	33	6.1%	cbioportal
27	PIK3CG	Ssm	2	33	6.1%	cbioportal
26	PIK3CB	Ssm	2	33	6.1%	cbioportal
23	MAP3K13	Ssm	2	33	6.1%	cbioportal
24	NTRK1	Ssm	2	33	6.1%	cbioportal
20	IDH2	Ssm	2	33	6.1%	cbioportal
19	FAT1	Ssm	2	33	6.1%	cbioportal
18	EZH1	Ssm	2	33	6.1%	cbioportal
17	ERBB4	Ssm	2	33	6.1%	cbioportal
21	KMT2A	Ssm	2	33	6.1%	cbioportal
22	KMT2D	Ssm	2	33	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-08-24

Cholangiocarcinoma TCGA-CHOLTCGA

51 cases with simple somatic mutation data · 51 cases total · Data Release 46.0 · mapped to Cholangiocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ARID1A	Ssm	43	51	84.3%	gdc
4	KLHDC7A	Ssm	42	51	82.4%	gdc
2	TAS1R2	Ssm	42	51	82.4%	gdc
6	HTR6	Ssm	42	51	82.4%	gdc
5	TMCO4	Ssm	42	51	82.4%	gdc
3	MRTO4	Ssm	42	51	82.4%	gdc
33	MFAP2	Ssm	41	51	80.4%	gdc
32	RNF186	Ssm	41	51	80.4%	gdc
31	ZNF436	Ssm	41	51	80.4%	gdc
30	RPL11	Ssm	41	51	80.4%	gdc
29	THAP3	Ssm	41	51	80.4%	gdc
28	PRAMEF27	Ssm	41	51	80.4%	gdc
27	PADI4	Ssm	41	51	80.4%	gdc
26	PRAMEF12	Ssm	41	51	80.4%	gdc
25	ACTL8	Ssm	41	51	80.4%	gdc
24	CAMK2N1	Ssm	41	51	80.4%	gdc
23	TEX46	Ssm	41	51	80.4%	gdc
22	EIF4G3	Ssm	41	51	80.4%	gdc
21	VWA5B1	Ssm	41	51	80.4%	gdc
20	LACTBL1	Ssm	41	51	80.4%	gdc
19	DNAJC11	Ssm	41	51	80.4%	gdc
18	PITHD1	Ssm	41	51	80.4%	gdc
17	HTR1D	Ssm	41	51	80.4%	gdc
16	AADACL4	Ssm	41	51	80.4%	gdc
15	NBL1	Ssm	41	51	80.4%	gdc
14	OTUD3	Ssm	41	51	80.4%	gdc
13	PADI6	Ssm	41	51	80.4%	gdc
12	RPL22	Ssm	41	51	80.4%	gdc
34	CAPZB	Ssm	41	51	80.4%	gdc
35	PRAMEF20	Ssm	41	51	80.4%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Cholangiocarcinoma (ICGC, Cancer Discov 2017) chol_icgc_2017ICGC

417 cases with simple somatic mutation data · 489 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	147	417	35.3%	cbioportal
2	ARID1A	Ssm	80	417	19.2%	cbioportal
3	KRAS	Ssm	76	417	18.2%	cbioportal
4	SMAD4	Ssm	60	417	14.4%	cbioportal
5	SYNE1	Ssm	46	417	11%	cbioportal
6	MUC16	Ssm	44	417	10.6%	cbioportal
7	BAP1	Ssm	39	417	9.4%	cbioportal
8	LRP1B	Ssm	39	417	9.4%	cbioportal
9	FSIP2	Ssm	37	417	8.9%	cbioportal
10	EPHA2	Ssm	36	417	8.6%	cbioportal
11	PCLO	Ssm	36	417	8.6%	cbioportal
12	CSMD3	Ssm	34	417	8.2%	cbioportal
13	SACS	Ssm	34	417	8.2%	cbioportal
14	APC	Ssm	33	417	7.9%	cbioportal
15	RYR2	Ssm	32	417	7.7%	cbioportal
16	OBSCN	Ssm	31	417	7.4%	cbioportal
17	HMCN1	Ssm	30	417	7.2%	cbioportal
18	KMT2D	Ssm	30	417	7.2%	cbioportal
19	ELF3	Ssm	29	417	7%	cbioportal
20	KMT2C	Ssm	29	417	7%	cbioportal
21	PBRM1	Ssm	29	417	7%	cbioportal
22	LRP2	Ssm	28	417	6.7%	cbioportal
23	MUC6	Ssm	28	417	6.7%	cbioportal
24	FAT3	Ssm	27	417	6.5%	cbioportal
25	ARID2	Ssm	25	417	6%	cbioportal
30	SPTA1	Ssm	24	417	5.8%	cbioportal
27	CSMD1	Ssm	24	417	5.8%	cbioportal
26	ADGRV1	Ssm	24	417	5.8%	cbioportal
28	NEB	Ssm	24	417	5.8%	cbioportal
29	PLEC	Ssm	24	417	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Cholangiocarcinoma (MSK, Clin Cancer Res 2018) chol_msk_2018MSK

195 cases with simple somatic mutation data · 195 cases total · 2026-04-07 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	48	195	24.6%	cbioportal
2	TP53	Ssm	46	195	23.6%	cbioportal
3	ARID1A	Ssm	40	195	20.5%	cbioportal
4	BAP1	Ssm	26	195	13.3%	cbioportal
5	KRAS	Ssm	23	195	11.8%	cbioportal
6	PBRM1	Ssm	20	195	10.3%	cbioportal
7	SMAD4	Ssm	16	195	8.2%	cbioportal
8	ATM	Ssm	15	195	7.7%	cbioportal
9	KMT2C	Ssm	13	195	6.7%	cbioportal
10	PIK3CA	Ssm	13	195	6.7%	cbioportal
11	RASA1	Ssm	10	195	5.1%	cbioportal
14	NF1	Ssm	9	195	4.6%	cbioportal
13	KMT2D	Ssm	9	195	4.6%	cbioportal
12	BRAF	Ssm	9	195	4.6%	cbioportal
15	TERT	Ssm	8	195	4.1%	cbioportal
17	NRAS	Ssm	7	195	3.6%	cbioportal
16	ERBB3	Ssm	7	195	3.6%	cbioportal
18	SMARCA4	Ssm	6	195	3.1%	cbioportal
27	SF3B1	Ssm	5	195	2.6%	cbioportal
25	KMT2A	Ssm	5	195	2.6%	cbioportal
26	PTPRS	Ssm	5	195	2.6%	cbioportal
24	DOT1L	Ssm	5	195	2.6%	cbioportal
23	CTNNB1	Ssm	5	195	2.6%	cbioportal
22	ASXL1	Ssm	5	195	2.6%	cbioportal
21	ARID2	Ssm	5	195	2.6%	cbioportal
20	ARID1B	Ssm	5	195	2.6%	cbioportal
19	ABL1	Ssm	5	195	2.6%	cbioportal
28	STK11	Ssm	5	195	2.6%	cbioportal
63	PGR	Ssm	3	141	2.1%	cbioportal
43	ANKRD11	Ssm	3	141	2.1%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Cholangiocarcinoma (National Cancer Centre of Singapore, Nat Genet 2013) chol_nccs_2013National Cancer Centre of Singapore

15 cases with simple somatic mutation data · 15 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ARID1A	Ssm	4	15	26.7%	cbioportal
2	BAP1	Ssm	4	15	26.7%	cbioportal
3	IDH1	Ssm	3	15	20%	cbioportal
5	TP53	Ssm	3	15	20%	cbioportal
4	KRAS	Ssm	3	15	20%	cbioportal
9	CCT8L2	Ssm	2	15	13.3%	cbioportal
10	GPAT4	Ssm	2	15	13.3%	cbioportal
11	HMCN1	Ssm	2	15	13.3%	cbioportal
6	ADGRG4	Ssm	2	15	13.3%	cbioportal
12	LRRIQ1	Ssm	2	15	13.3%	cbioportal
7	ATP10A	Ssm	2	15	13.3%	cbioportal
8	BRPF3	Ssm	2	15	13.3%	cbioportal
167	RNF25	Ssm	1	15	6.7%	cbioportal
168	RPL3L	Ssm	1	15	6.7%	cbioportal
169	RTEL1	Ssm	1	15	6.7%	cbioportal
170	RTP5	Ssm	1	15	6.7%	cbioportal
171	RWDD1	Ssm	1	15	6.7%	cbioportal
172	SAE1	Ssm	1	15	6.7%	cbioportal
173	SBNO1	Ssm	1	15	6.7%	cbioportal
160	RABEP2	Ssm	1	15	6.7%	cbioportal
161	RB1	Ssm	1	15	6.7%	cbioportal
162	RBM10	Ssm	1	15	6.7%	cbioportal
163	RBM19	Ssm	1	15	6.7%	cbioportal
164	RGS18	Ssm	1	15	6.7%	cbioportal
165	RGS7	Ssm	1	15	6.7%	cbioportal
166	RHOBTB3	Ssm	1	15	6.7%	cbioportal
156	PRR16	Ssm	1	15	6.7%	cbioportal
157	PRRT1	Ssm	1	15	6.7%	cbioportal
158	PTPN6	Ssm	1	15	6.7%	cbioportal
159	PTPRC	Ssm	1	15	6.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Cholangiocarcinoma (National University of Singapore, Nat Genet 2012) chol_nus_2012National University of Singapore

8 cases with simple somatic mutation data · 8 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	TP53	Ssm	4	8	50%	cbioportal
1	SMAD4	Ssm	4	8	50%	cbioportal
4	RNF43	Ssm	3	8	37.5%	cbioportal
3	KRAS	Ssm	3	8	37.5%	cbioportal
5	GNAS	Ssm	2	8	25%	cbioportal
8	NDC80	Ssm	2	8	25%	cbioportal
9	PCDHA13	Ssm	2	8	25%	cbioportal
10	PEG3	Ssm	2	8	25%	cbioportal
12	ROBO2	Ssm	2	8	25%	cbioportal
11	RADIL	Ssm	2	8	25%	cbioportal
13	XIRP2	Ssm	2	8	25%	cbioportal
7	LAMA2	Ssm	2	8	25%	cbioportal
6	KMT2C	Ssm	2	8	25%	cbioportal
23	ARL6IP5	Ssm	1	8	12.5%	cbioportal
128	PREX2	Ssm	1	8	12.5%	cbioportal
14	ADAM12	Ssm	1	8	12.5%	cbioportal
15	AFF1	Ssm	1	8	12.5%	cbioportal
16	AGO1	Ssm	1	8	12.5%	cbioportal
17	ALPP	Ssm	1	8	12.5%	cbioportal
18	ANK2	Ssm	1	8	12.5%	cbioportal
19	ANKRD35	Ssm	1	8	12.5%	cbioportal
20	ANO4	Ssm	1	8	12.5%	cbioportal
21	ARAF	Ssm	1	8	12.5%	cbioportal
22	ARID1A	Ssm	1	8	12.5%	cbioportal
24	ASAP3	Ssm	1	8	12.5%	cbioportal
25	BBS4	Ssm	1	8	12.5%	cbioportal
26	BCAS2	Ssm	1	8	12.5%	cbioportal
27	CALML5	Ssm	1	8	12.5%	cbioportal
28	CALN1	Ssm	1	8	12.5%	cbioportal
29	CCDC183	Ssm	1	8	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Cholangiocarcinoma (TCGA, Firehose Legacy) chol_tcgaTCGA

35 cases with simple somatic mutation data · 51 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	14	35	40%	cbioportal
2	TTN	Ssm	10	35	28.6%	cbioportal
4	PBRM1	Ssm	8	35	22.9%	cbioportal
3	BAP1	Ssm	8	35	22.9%	cbioportal
5	ANKRD36C	Ssm	7	35	20%	cbioportal
6	CDC27	Ssm	7	35	20%	cbioportal
7	KMT2C	Ssm	7	35	20%	cbioportal
8	MUC2	Ssm	7	35	20%	cbioportal
11	TCHH	Ssm	6	35	17.1%	cbioportal
9	DNAH5	Ssm	6	35	17.1%	cbioportal
10	MUC5B	Ssm	6	35	17.1%	cbioportal
17	BIRC6	Ssm	5	35	14.3%	cbioportal
12	ABCA13	Ssm	5	35	14.3%	cbioportal
16	ATM	Ssm	5	35	14.3%	cbioportal
13	ADGRV1	Ssm	5	35	14.3%	cbioportal
14	AHNAK	Ssm	5	35	14.3%	cbioportal
15	ARID1A	Ssm	5	35	14.3%	cbioportal
24	TP53	Ssm	5	35	14.3%	cbioportal
23	RYR3	Ssm	5	35	14.3%	cbioportal
22	POLE	Ssm	5	35	14.3%	cbioportal
21	PLXNA4	Ssm	5	35	14.3%	cbioportal
20	MUC16	Ssm	5	35	14.3%	cbioportal
19	HLA-B	Ssm	5	35	14.3%	cbioportal
18	BLTP1	Ssm	5	35	14.3%	cbioportal
26	ANKRD17	Ssm	4	35	11.4%	cbioportal
28	ARID1B	Ssm	4	35	11.4%	cbioportal
29	CLIP4	Ssm	4	35	11.4%	cbioportal
30	COL6A3	Ssm	4	35	11.4%	cbioportal
25	AHNAK2	Ssm	4	35	11.4%	cbioportal
27	APC	Ssm	4	35	11.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Cholangiocarcinoma (TCGA GDC, 2025) chol_tcga_gdcTCGA GDC

51 cases with simple somatic mutation data · 51 cases total · 2026-01-13 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PBRM1	Ssm	10	51	19.6%	cbioportal
2	ARID1A	Ssm	9	51	17.6%	cbioportal
3	BAP1	Ssm	8	51	15.7%	cbioportal
5	IDH1	Ssm	7	51	13.7%	cbioportal
4	EPHA2	Ssm	7	51	13.7%	cbioportal
8	MUC16	Ssm	5	51	9.8%	cbioportal
6	KRAS	Ssm	5	51	9.8%	cbioportal
9	TP53	Ssm	5	51	9.8%	cbioportal
7	LRP1B	Ssm	5	51	9.8%	cbioportal
13	DNAH8	Ssm	4	51	7.8%	cbioportal
10	CHD7	Ssm	4	51	7.8%	cbioportal
11	CSMD3	Ssm	4	51	7.8%	cbioportal
12	DNAH5	Ssm	4	51	7.8%	cbioportal
14	ELF3	Ssm	4	51	7.8%	cbioportal
15	FGFR2	Ssm	4	51	7.8%	cbioportal
16	KMT2C	Ssm	4	51	7.8%	cbioportal
17	MUC5B	Ssm	4	51	7.8%	cbioportal
18	NEB	Ssm	4	51	7.8%	cbioportal
19	PCLO	Ssm	4	51	7.8%	cbioportal
20	PIK3CA	Ssm	4	51	7.8%	cbioportal
21	TENM1	Ssm	4	51	7.8%	cbioportal
24	ALB	Ssm	3	51	5.9%	cbioportal
23	AHNAK	Ssm	3	51	5.9%	cbioportal
22	ADAM30	Ssm	3	51	5.9%	cbioportal
46	RABGAP1	Ssm	3	51	5.9%	cbioportal
27	BIRC6	Ssm	3	51	5.9%	cbioportal
26	APOB	Ssm	3	51	5.9%	cbioportal
25	ANK2	Ssm	3	51	5.9%	cbioportal
29	CTNNA2	Ssm	3	51	5.9%	cbioportal
28	C3	Ssm	3	51	5.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Cholangiocarcinoma (TCGA, PanCancer Atlas) chol_tcga_pan_can_atlas_2018TCGA

36 cases with simple somatic mutation data · 36 cases total · 2026-06-05 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	PBRM1	Ssm	7	36	19.4%	cbioportal
1	BAP1	Ssm	7	36	19.4%	cbioportal
3	IDH1	Ssm	5	36	13.9%	cbioportal
6	EPHA2	Ssm	4	36	11.1%	cbioportal
4	ARID1A	Ssm	4	36	11.1%	cbioportal
5	DNAH5	Ssm	4	36	11.1%	cbioportal
7	KMT2C	Ssm	4	36	11.1%	cbioportal
8	TP53	Ssm	4	36	11.1%	cbioportal
9	TTN	Ssm	4	36	11.1%	cbioportal
27	PLXNA4	Ssm	3	36	8.3%	cbioportal
26	MUC5B	Ssm	3	36	8.3%	cbioportal
25	MUC16	Ssm	3	36	8.3%	cbioportal
17	BIRC6	Ssm	3	36	8.3%	cbioportal
16	BCOR	Ssm	3	36	8.3%	cbioportal
15	ARID1B	Ssm	3	36	8.3%	cbioportal
12	AHNAK	Ssm	3	36	8.3%	cbioportal
13	ALB	Ssm	3	36	8.3%	cbioportal
14	APOB	Ssm	3	36	8.3%	cbioportal
28	RYR1	Ssm	3	36	8.3%	cbioportal
24	MPDZ	Ssm	3	36	8.3%	cbioportal
23	MACF1	Ssm	3	36	8.3%	cbioportal
22	LRP1	Ssm	3	36	8.3%	cbioportal
21	FMN2	Ssm	3	36	8.3%	cbioportal
20	CSMD2	Ssm	3	36	8.3%	cbioportal
19	COL6A3	Ssm	3	36	8.3%	cbioportal
10	ADAM30	Ssm	3	36	8.3%	cbioportal
11	ADGRV1	Ssm	3	36	8.3%	cbioportal
18	CHD7	Ssm	3	36	8.3%	cbioportal
86	LRP1B	Ssm	2	36	5.6%	cbioportal
29	ABCA13	Ssm	2	36	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Cystic Tumor of the Pancreas (Johns Hopkins, PNAS 2011) pact_jhu_2011Johns Hopkins

32 cases with simple somatic mutation data · 32 cases total · 2026-01-12 · mapped to Pancreatic Mucinous Cystic Neoplasm EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	11	32	34.4%	cbioportal
2	RNF43	Ssm	9	32	28.1%	cbioportal
3	CTNNB1	Ssm	8	32	25%	cbioportal
4	GNAS	Ssm	5	32	15.6%	cbioportal
5	VHL	Ssm	4	32	12.5%	cbioportal
6	TBC1D3F	Ssm	3	32	9.4%	cbioportal
16	TTN	Ssm	2	32	6.3%	cbioportal
7	ADGRV1	Ssm	2	32	6.3%	cbioportal
8	APC	Ssm	2	32	6.3%	cbioportal
9	CACNA1I	Ssm	2	32	6.3%	cbioportal
10	MUC4	Ssm	2	32	6.3%	cbioportal
11	POTEJ	Ssm	2	32	6.3%	cbioportal
12	RYR1	Ssm	2	32	6.3%	cbioportal
13	STN1	Ssm	2	32	6.3%	cbioportal
14	TEX2	Ssm	2	32	6.3%	cbioportal
15	TP53	Ssm	2	32	6.3%	cbioportal
28	AMER1	Ssm	1	32	3.1%	cbioportal
128	FAM27C	Ssm	1	32	3.1%	cbioportal
17	ABCA1	Ssm	1	32	3.1%	cbioportal
18	ABCA13	Ssm	1	32	3.1%	cbioportal
19	ACTBL2	Ssm	1	32	3.1%	cbioportal
20	ADAMTS19	Ssm	1	32	3.1%	cbioportal
21	ADAMTS8	Ssm	1	32	3.1%	cbioportal
22	ADAMTSL3	Ssm	1	32	3.1%	cbioportal
23	ADAT3	Ssm	1	32	3.1%	cbioportal
24	AGK	Ssm	1	32	3.1%	cbioportal
25	AK8	Ssm	1	32	3.1%	cbioportal
26	AKAP6	Ssm	1	32	3.1%	cbioportal
27	ALPL	Ssm	1	32	3.1%	cbioportal
29	AMER3	Ssm	1	32	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Gallbladder Cancer (MSK, 2022) gbc_mskcc_2022MSK

244 cases with simple somatic mutation data · 244 cases total · 2026-04-07 · mapped to Gallbladder Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	154	244	63.1%	cbioportal
2	SMAD4	Ssm	52	244	21.3%	cbioportal
3	ARID1A	Ssm	50	244	20.5%	cbioportal
7	ELF3	Ssm	21	191	11%	cbioportal
4	CDKN2A	Ssm	26	244	10.7%	cbioportal
5	PIK3CA	Ssm	26	244	10.7%	cbioportal
6	STK11	Ssm	22	244	9%	cbioportal
8	ARID2	Ssm	20	244	8.2%	cbioportal
9	KMT2C	Ssm	20	244	8.2%	cbioportal
10	ERBB2	Ssm	19	244	7.8%	cbioportal
152	SMARCA2	Ssm	3	40	7.5%	cbioportal
11	KRAS	Ssm	18	244	7.4%	cbioportal
13	ERBB3	Ssm	16	244	6.6%	cbioportal
12	ATM	Ssm	16	244	6.6%	cbioportal
14	KMT2D	Ssm	16	244	6.6%	cbioportal
16	TERT	Ssm	15	244	6.1%	cbioportal
15	CTNNB1	Ssm	15	244	6.1%	cbioportal
17	BRCA2	Ssm	13	244	5.3%	cbioportal
30	SLX4	Ssm	9	191	4.7%	cbioportal
28	PREX2	Ssm	9	191	4.7%	cbioportal
18	RBM10	Ssm	11	244	4.5%	cbioportal
20	NF1	Ssm	10	244	4.1%	cbioportal
21	PBRM1	Ssm	10	244	4.1%	cbioportal
22	RB1	Ssm	10	244	4.1%	cbioportal
19	KMT2A	Ssm	10	244	4.1%	cbioportal
26	IKZF1	Ssm	9	244	3.7%	cbioportal
29	RASA1	Ssm	9	244	3.7%	cbioportal
25	FBXW7	Ssm	9	244	3.7%	cbioportal
24	AXIN1	Ssm	9	244	3.7%	cbioportal
23	ATRX	Ssm	9	244	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Gallbladder Cancer (MSK, Cancer 2018) gbc_msk_2018MSK

103 cases with simple somatic mutation data · 103 cases total · 2026-01-07 · mapped to Gallbladder Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	60	103	58.3%	cbioportal
2	SMAD4	Ssm	27	103	26.2%	cbioportal
3	ARID1A	Ssm	26	103	25.2%	cbioportal
4	ATM	Ssm	16	103	15.5%	cbioportal
5	PIK3CA	Ssm	11	103	10.7%	cbioportal
6	KMT2D	Ssm	9	103	8.7%	cbioportal
7	TERT	Ssm	9	103	8.7%	cbioportal
8	KRAS	Ssm	8	103	7.8%	cbioportal
11	CDKN2A	Ssm	7	103	6.8%	cbioportal
10	ARID2	Ssm	7	103	6.8%	cbioportal
9	ARID1B	Ssm	7	103	6.8%	cbioportal
13	PBRM1	Ssm	7	103	6.8%	cbioportal
12	NF1	Ssm	7	103	6.8%	cbioportal
16	ERBB3	Ssm	6	103	5.8%	cbioportal
15	CTNNB1	Ssm	6	103	5.8%	cbioportal
14	BRCA2	Ssm	6	103	5.8%	cbioportal
24	PLCG2	Ssm	5	95	5.3%	cbioportal
19	KEAP1	Ssm	5	103	4.9%	cbioportal
20	KMT2C	Ssm	5	103	4.9%	cbioportal
21	MED12	Ssm	5	103	4.9%	cbioportal
22	NCOR1	Ssm	5	103	4.9%	cbioportal
23	NOTCH3	Ssm	5	103	4.9%	cbioportal
25	RB1	Ssm	5	103	4.9%	cbioportal
17	AR	Ssm	5	103	4.9%	cbioportal
26	SMARCA4	Ssm	5	103	4.9%	cbioportal
18	BRAF	Ssm	5	103	4.9%	cbioportal
29	EP300	Ssm	4	103	3.9%	cbioportal
28	AXIN1	Ssm	4	103	3.9%	cbioportal
27	APC	Ssm	4	103	3.9%	cbioportal
35	PTCH1	Ssm	4	103	3.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Gallbladder Carcinoma (Shanghai, Nat Genet 2014) gbc_shanghai_2014Shanghai

32 cases with simple somatic mutation data · 32 cases total · 2026-01-07 · mapped to Gallbladder Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	8	32	25%	cbioportal
2	MUC16	Ssm	6	32	18.8%	cbioportal
3	TTN	Ssm	5	32	15.6%	cbioportal
4	CS	Ssm	4	32	12.5%	cbioportal
5	KMT2C	Ssm	4	32	12.5%	cbioportal
6	ZNF521	Ssm	4	32	12.5%	cbioportal
7	CHD8	Ssm	3	32	9.4%	cbioportal
8	DNAH7	Ssm	3	32	9.4%	cbioportal
9	ERBB2	Ssm	3	32	9.4%	cbioportal
10	ERBB3	Ssm	3	32	9.4%	cbioportal
11	FCGBP	Ssm	3	32	9.4%	cbioportal
12	LILRA1	Ssm	3	32	9.4%	cbioportal
16	ZNF814	Ssm	3	32	9.4%	cbioportal
15	ZNF804B	Ssm	3	32	9.4%	cbioportal
14	PPIG	Ssm	3	32	9.4%	cbioportal
13	NPEPPS	Ssm	3	32	9.4%	cbioportal
20	AHNAK	Ssm	2	32	6.3%	cbioportal
17	ABCA13	Ssm	2	32	6.3%	cbioportal
18	ABLIM3	Ssm	2	32	6.3%	cbioportal
19	ADAMTSL3	Ssm	2	32	6.3%	cbioportal
21	AKAP11	Ssm	2	32	6.3%	cbioportal
22	ARHGEF7	Ssm	2	32	6.3%	cbioportal
23	ARID1A	Ssm	2	32	6.3%	cbioportal
24	ARID2	Ssm	2	32	6.3%	cbioportal
25	ATM	Ssm	2	32	6.3%	cbioportal
26	ATRX	Ssm	2	32	6.3%	cbioportal
27	BAG3	Ssm	2	32	6.3%	cbioportal
28	BAZ2B	Ssm	2	32	6.3%	cbioportal
29	BPTF	Ssm	2	32	6.3%	cbioportal
30	BRCA1	Ssm	2	32	6.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Insulinoma (Shanghai, Nat Commun 2013) panet_shanghai_2013Shanghai

10 cases with simple somatic mutation data · 10 cases total · 2026-01-12 · mapped to Pancreatic Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	YY1	Ssm	3	10	30%	cbioportal
10	FPGS	Ssm	1	10	10%	cbioportal
2	ABHD18	Ssm	1	10	10%	cbioportal
3	AMOTL1	Ssm	1	10	10%	cbioportal
4	BLTP2	Ssm	1	10	10%	cbioportal
5	CBLL2	Ssm	1	10	10%	cbioportal
6	CKAP2L	Ssm	1	10	10%	cbioportal
7	CLDN14	Ssm	1	10	10%	cbioportal
8	CPNE3	Ssm	1	10	10%	cbioportal
9	CRYBB1	Ssm	1	10	10%	cbioportal
11	H3-3A	Ssm	1	10	10%	cbioportal
12	HERC6	Ssm	1	10	10%	cbioportal
13	HNRNPK	Ssm	1	10	10%	cbioportal
14	HSPA5	Ssm	1	10	10%	cbioportal
15	IRAG1	Ssm	1	10	10%	cbioportal
16	ITGA1	Ssm	1	10	10%	cbioportal
17	ITGAM	Ssm	1	10	10%	cbioportal
18	KLHL17	Ssm	1	10	10%	cbioportal
19	KPNA2	Ssm	1	10	10%	cbioportal
20	KRTAP4-3	Ssm	1	10	10%	cbioportal
21	LMO2	Ssm	1	10	10%	cbioportal
22	MICAL2	Ssm	1	10	10%	cbioportal
23	MTRF1	Ssm	1	10	10%	cbioportal
24	MTUS1	Ssm	1	10	10%	cbioportal
25	MYOZ1	Ssm	1	10	10%	cbioportal
26	NELL2	Ssm	1	10	10%	cbioportal
27	NLRC3	Ssm	1	10	10%	cbioportal
28	NOTCH1	Ssm	1	10	10%	cbioportal
29	NRXN1	Ssm	1	10	10%	cbioportal
30	NTAQ1	Ssm	1	10	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Intrahepatic Cholangiocarcinoma (JHU, Nat Genet 2013) chol_jhu_2013JHU

40 cases with simple somatic mutation data · 40 cases total · 2026-01-06 · mapped to Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BAP1	Ssm	8	40	20%	cbioportal
2	TP53	Ssm	8	40	20%	cbioportal
3	PBRM1	Ssm	7	40	17.5%	cbioportal
4	ARID1A	Ssm	6	40	15%	cbioportal
5	FGFR2	Ssm	4	40	10%	cbioportal
6	IDH1	Ssm	4	40	10%	cbioportal
7	TTN	Ssm	4	40	10%	cbioportal
13	EPHA2	Ssm	3	40	7.5%	cbioportal
14	FAT1	Ssm	3	40	7.5%	cbioportal
15	FAT4	Ssm	3	40	7.5%	cbioportal
16	HRNR	Ssm	3	40	7.5%	cbioportal
17	NIPBL	Ssm	3	40	7.5%	cbioportal
18	PIK3CA	Ssm	3	40	7.5%	cbioportal
19	SORCS3	Ssm	3	40	7.5%	cbioportal
20	UBE2O	Ssm	3	40	7.5%	cbioportal
10	DNAH11	Ssm	3	40	7.5%	cbioportal
11	DNAH6	Ssm	3	40	7.5%	cbioportal
12	DNAH9	Ssm	3	40	7.5%	cbioportal
8	CSMD1	Ssm	3	40	7.5%	cbioportal
9	CSMD3	Ssm	3	40	7.5%	cbioportal
21	ADAMTS18	Ssm	2	40	5%	cbioportal
26	AHNAK	Ssm	2	40	5%	cbioportal
25	AGK	Ssm	2	40	5%	cbioportal
24	ADRA2B	Ssm	2	40	5%	cbioportal
23	ADAMTSL3	Ssm	2	40	5%	cbioportal
29	APOE	Ssm	2	40	5%	cbioportal
22	ADAMTS5	Ssm	2	40	5%	cbioportal
28	ALB	Ssm	2	40	5%	cbioportal
106	ZNF613	Ssm	2	40	5%	cbioportal
27	AKAP9	Ssm	2	40	5%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Intrahepatic Cholangiocarcinoma (Mount Sinai 2015) ihch_ismms_2015

8 cases with simple somatic mutation data · 8 cases total · 2026-01-07 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ACAN	Ssm	2	8	25%	cbioportal
3	MUC16	Ssm	2	8	25%	cbioportal
2	ARAF	Ssm	2	8	25%	cbioportal
94	PLIN4	Ssm	1	8	12.5%	cbioportal
110	SERPING1	Ssm	1	8	12.5%	cbioportal
109	SERPINB13	Ssm	1	8	12.5%	cbioportal
108	SEC61A2	Ssm	1	8	12.5%	cbioportal
107	RYR3	Ssm	1	8	12.5%	cbioportal
106	RP1	Ssm	1	8	12.5%	cbioportal
105	RGS8	Ssm	1	8	12.5%	cbioportal
104	RBM47	Ssm	1	8	12.5%	cbioportal
103	RALGAPA2	Ssm	1	8	12.5%	cbioportal
102	RAD51AP2	Ssm	1	8	12.5%	cbioportal
101	RAB3C	Ssm	1	8	12.5%	cbioportal
100	PRRG1	Ssm	1	8	12.5%	cbioportal
99	PRPF40A	Ssm	1	8	12.5%	cbioportal
98	PREX2	Ssm	1	8	12.5%	cbioportal
97	PRAMEF22	Ssm	1	8	12.5%	cbioportal
96	PRAMEF19	Ssm	1	8	12.5%	cbioportal
95	PRAMEF14	Ssm	1	8	12.5%	cbioportal
93	PLEKHB2	Ssm	1	8	12.5%	cbioportal
92	PKHD1L1	Ssm	1	8	12.5%	cbioportal
91	PKD2L1	Ssm	1	8	12.5%	cbioportal
90	PIWIL2	Ssm	1	8	12.5%	cbioportal
89	PEG3	Ssm	1	8	12.5%	cbioportal
88	PDE4D	Ssm	1	8	12.5%	cbioportal
87	PAX8	Ssm	1	8	12.5%	cbioportal
113	SLC16A2	Ssm	1	8	12.5%	cbioportal
112	SKOR1	Ssm	1	8	12.5%	cbioportal
111	SEZ6	Ssm	1	8	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Intrahepatic Cholangiocarcinoma (MSK, Clin Cancer Res 2021) ihch_mskcc_2020MSK

199 cases with simple somatic mutation data · 219 cases total · 2026-04-07 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	45	199	22.6%	cbioportal
2	BAP1	Ssm	39	199	19.6%	cbioportal
3	ARID1A	Ssm	35	199	17.6%	cbioportal
4	TP53	Ssm	32	199	16.1%	cbioportal
5	PBRM1	Ssm	25	199	12.6%	cbioportal
6	KRAS	Ssm	19	199	9.5%	cbioportal
7	RASA1	Ssm	10	199	5%	cbioportal
8	BRAF	Ssm	9	199	4.5%	cbioportal
10	IDH2	Ssm	8	199	4%	cbioportal
11	PIK3CA	Ssm	8	199	4%	cbioportal
9	FGFR2	Ssm	8	199	4%	cbioportal
16	PTPRT	Ssm	7	199	3.5%	cbioportal
15	NRAS	Ssm	7	199	3.5%	cbioportal
12	ARID2	Ssm	7	199	3.5%	cbioportal
13	ATM	Ssm	7	199	3.5%	cbioportal
14	CDKN2A	Ssm	7	199	3.5%	cbioportal
68	SOS1	Ssm	3	89	3.4%	cbioportal
69	TP53BP1	Ssm	3	89	3.4%	cbioportal
61	PREX2	Ssm	3	89	3.4%	cbioportal
43	ELF3	Ssm	3	89	3.4%	cbioportal
17	ATRX	Ssm	6	199	3%	cbioportal
20	TERT	Ssm	6	199	3%	cbioportal
18	KMT2D	Ssm	6	199	3%	cbioportal
19	PTEN	Ssm	6	199	3%	cbioportal
23	RB1	Ssm	5	199	2.5%	cbioportal
21	DOT1L	Ssm	5	199	2.5%	cbioportal
22	RARA	Ssm	5	199	2.5%	cbioportal
24	SMARCA4	Ssm	5	199	2.5%	cbioportal
37	ZFHX3	Ssm	4	174	2.3%	cbioportal
105	MSH3	Ssm	2	89	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Intrahepatic Cholangiocarcinoma (MSK, Hepatology 2021) ihch_msk_2021MSK

412 cases with simple somatic mutation data · 412 cases total · 2026-01-07 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	85	412	20.6%	cbioportal
2	ARID1A	Ssm	78	412	18.9%	cbioportal
3	BAP1	Ssm	72	412	17.5%	cbioportal
4	TP53	Ssm	70	412	17%	cbioportal
5	PBRM1	Ssm	44	412	10.7%	cbioportal
6	KRAS	Ssm	39	412	9.5%	cbioportal
7	BRAF	Ssm	26	412	6.3%	cbioportal
9	TERT	Ssm	20	412	4.9%	cbioportal
8	ATM	Ssm	20	412	4.9%	cbioportal
19	PREX2	Ssm	10	225	4.4%	cbioportal
10	FGFR2	Ssm	18	412	4.4%	cbioportal
11	IDH2	Ssm	18	412	4.4%	cbioportal
13	RASA1	Ssm	17	412	4.1%	cbioportal
12	PIK3CA	Ssm	17	412	4.1%	cbioportal
14	SMARCA4	Ssm	15	412	3.6%	cbioportal
15	ARID2	Ssm	14	412	3.4%	cbioportal
17	NRAS	Ssm	13	412	3.2%	cbioportal
16	KMT2D	Ssm	13	412	3.2%	cbioportal
18	KMT2C	Ssm	12	412	2.9%	cbioportal
21	ZFHX3	Ssm	10	372	2.7%	cbioportal
52	ELF3	Ssm	6	225	2.7%	cbioportal
20	PTEN	Ssm	10	412	2.4%	cbioportal
75	KMT2B	Ssm	5	225	2.2%	cbioportal
30	SF3B1	Ssm	9	412	2.2%	cbioportal
31	SMAD4	Ssm	9	412	2.2%	cbioportal
24	ARID1B	Ssm	9	412	2.2%	cbioportal
22	ABL1	Ssm	9	412	2.2%	cbioportal
25	ATRX	Ssm	9	412	2.2%	cbioportal
23	ARAF	Ssm	9	412	2.2%	cbioportal
29	PTPRT	Ssm	9	412	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Intrahepatic Cholangiocarcinoma (Shanghai, Nat Commun 2014) ihch_smmu_2014Shanghai

103 cases with simple somatic mutation data · 103 cases total · 2026-01-07 · mapped to Intrahepatic Cholangiocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	42	103	40.8%	cbioportal
2	HLA-A	Ssm	18	103	17.5%	cbioportal
3	KRAS	Ssm	17	103	16.5%	cbioportal
4	GAS8-AS1	Ssm	16	103	15.5%	cbioportal
5	TTN	Ssm	15	103	14.6%	cbioportal
8	MUC16	Ssm	13	103	12.6%	cbioportal
6	FAM230A	Ssm	13	103	12.6%	cbioportal
7	HLA-C	Ssm	13	103	12.6%	cbioportal
9	AHNAK2	Ssm	12	103	11.7%	cbioportal
10	MUC21	Ssm	11	103	10.7%	cbioportal
13	MUC3A	Ssm	10	103	9.7%	cbioportal
11	HLA-B	Ssm	10	103	9.7%	cbioportal
12	MUC2	Ssm	10	103	9.7%	cbioportal
14	ODF1	Ssm	10	103	9.7%	cbioportal
16	CDC27	Ssm	9	103	8.7%	cbioportal
15	ARSD	Ssm	9	103	8.7%	cbioportal
17	FAM135B	Ssm	9	103	8.7%	cbioportal
18	HMCN1	Ssm	9	103	8.7%	cbioportal
19	LILRA6	Ssm	9	103	8.7%	cbioportal
20	OBSCN	Ssm	9	103	8.7%	cbioportal
21	CEP89	Ssm	8	103	7.8%	cbioportal
25	PER3	Ssm	8	103	7.8%	cbioportal
24	MAGEC1	Ssm	8	103	7.8%	cbioportal
23	HRNR	Ssm	8	103	7.8%	cbioportal
22	GGT2P	Ssm	8	103	7.8%	cbioportal
28	BPTF	Ssm	7	103	6.8%	cbioportal
26	ADAMTS7	Ssm	7	103	6.8%	cbioportal
27	ARID1A	Ssm	7	103	6.8%	cbioportal
30	EPPK1	Ssm	7	103	6.8%	cbioportal
29	DLC1	Ssm	7	103	6.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Metastatic Pancreatic Adenocarcinoma (PRINCE Trial, Nat Med. 2022) - iAtlas Harmonized paad_iatlas_prince_2022

93 cases with simple somatic mutation data · 93 cases total · 2026-02-16 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	68	93	73.1%	cbioportal
2	TP53	Ssm	64	93	68.8%	cbioportal
3	NBPF14	Ssm	30	93	32.3%	cbioportal
4	CDKN2A	Ssm	25	93	26.9%	cbioportal
5	MUC17	Ssm	21	93	22.6%	cbioportal
6	TTN	Ssm	20	93	21.5%	cbioportal
7	DEAF1	Ssm	18	93	19.4%	cbioportal
8	AHNAK	Ssm	17	93	18.3%	cbioportal
9	NBPF1	Ssm	16	93	17.2%	cbioportal
10	PHLPP1	Ssm	14	93	15.1%	cbioportal
12	CENPB	Ssm	13	93	14%	cbioportal
11	AHNAK2	Ssm	13	93	14%	cbioportal
14	SMAD4	Ssm	12	93	12.9%	cbioportal
13	MUC5AC	Ssm	12	93	12.9%	cbioportal
15	ZNF208	Ssm	12	93	12.9%	cbioportal
16	MUC16	Ssm	11	93	11.8%	cbioportal
17	TCHH	Ssm	11	93	11.8%	cbioportal
19	NBPF10	Ssm	10	93	10.8%	cbioportal
20	RAMP2	Ssm	10	93	10.8%	cbioportal
18	FLG2	Ssm	10	93	10.8%	cbioportal
21	DGKZ	Ssm	9	93	9.7%	cbioportal
22	ZNF594	Ssm	9	93	9.7%	cbioportal
27	OBSCN	Ssm	8	93	8.6%	cbioportal
26	HRNR	Ssm	8	93	8.6%	cbioportal
25	FLG	Ssm	8	93	8.6%	cbioportal
24	EPAS1	Ssm	8	93	8.6%	cbioportal
23	EIF3J	Ssm	8	93	8.6%	cbioportal
30	USH2A	Ssm	8	93	8.6%	cbioportal
29	STUM	Ssm	8	93	8.6%	cbioportal
28	SAAL1	Ssm	8	93	8.6%	cbioportal

Data updated 22 days agoSource updated 2026-02-16

Metastatic Pancreatic Neuroendocrine Tumor (MSK, JCO Precis Oncol 2018) panet_msk_2018MSK

96 cases with simple somatic mutation data · 96 cases total · 2026-01-12 · mapped to Pancreatic Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MEN1	Ssm	50	96	52.1%	cbioportal
2	DAXX	Ssm	41	96	42.7%	cbioportal
3	ATRX	Ssm	21	96	21.9%	cbioportal
4	TSC2	Ssm	18	96	18.8%	cbioportal
5	SETD2	Ssm	17	96	17.7%	cbioportal
6	TP53	Ssm	12	96	12.5%	cbioportal
7	ARID1A	Ssm	11	96	11.5%	cbioportal
8	PTEN	Ssm	11	96	11.5%	cbioportal
9	BRAF	Ssm	10	96	10.4%	cbioportal
118	PTP4A1	Ssm	2	21	9.5%	cbioportal
10	KMT2C	Ssm	7	96	7.3%	cbioportal
11	NOTCH3	Ssm	7	96	7.3%	cbioportal
12	ATM	Ssm	6	96	6.3%	cbioportal
15	NOTCH1	Ssm	6	96	6.3%	cbioportal
13	KMT2D	Ssm	6	96	6.3%	cbioportal
16	TERT	Ssm	6	96	6.3%	cbioportal
14	MED12	Ssm	6	96	6.3%	cbioportal
20	FAT1	Ssm	5	96	5.2%	cbioportal
18	BRCA2	Ssm	5	96	5.2%	cbioportal
17	ARID2	Ssm	5	96	5.2%	cbioportal
19	CREBBP	Ssm	5	96	5.2%	cbioportal
193	KMT2B	Ssm	1	21	4.8%	cbioportal
194	LYN	Ssm	1	21	4.8%	cbioportal
26	LATS2	Ssm	4	96	4.2%	cbioportal
22	ERBB4	Ssm	4	96	4.2%	cbioportal
24	KMT2A	Ssm	4	96	4.2%	cbioportal
21	CBL	Ssm	4	96	4.2%	cbioportal
31	YAP1	Ssm	4	96	4.2%	cbioportal
23	IGF1R	Ssm	4	96	4.2%	cbioportal
29	TSC1	Ssm	4	96	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Acinar Cell Carcinoma (MSK, JCO 2023) paac_msk_jco_2023MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-12 · mapped to Pancreatic Acinar Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMAD4	Ssm	8	47	17%	cbioportal
3	CTNNB1	Ssm	6	47	12.8%	cbioportal
2	AXIN1	Ssm	6	47	12.8%	cbioportal
5	PRKAR1A	Ssm	5	47	10.6%	cbioportal
6	RB1	Ssm	5	47	10.6%	cbioportal
4	NF1	Ssm	5	47	10.6%	cbioportal
7	CREBBP	Ssm	4	47	8.5%	cbioportal
9	PTEN	Ssm	4	47	8.5%	cbioportal
8	PBRM1	Ssm	4	47	8.5%	cbioportal
93	GNB1	Ssm	1	13	7.7%	cbioportal
172	ZNRF3	Ssm	1	13	7.7%	cbioportal
154	SETDB1	Ssm	1	13	7.7%	cbioportal
155	SLFN11	Ssm	1	13	7.7%	cbioportal
19	MGA	Ssm	3	46	6.5%	cbioportal
10	ARID1A	Ssm	3	47	6.4%	cbioportal
12	ATM	Ssm	3	47	6.4%	cbioportal
11	ASXL1	Ssm	3	47	6.4%	cbioportal
13	BRAF	Ssm	3	47	6.4%	cbioportal
24	SETD2	Ssm	3	47	6.4%	cbioportal
23	RARA	Ssm	3	47	6.4%	cbioportal
22	POLE	Ssm	3	47	6.4%	cbioportal
21	PIK3CG	Ssm	3	47	6.4%	cbioportal
20	NRAS	Ssm	3	47	6.4%	cbioportal
18	MEN1	Ssm	3	47	6.4%	cbioportal
16	IKBKE	Ssm	3	47	6.4%	cbioportal
15	CDKN2A	Ssm	3	47	6.4%	cbioportal
14	BRCA2	Ssm	3	47	6.4%	cbioportal
25	TP53	Ssm	3	47	6.4%	cbioportal
26	TSC2	Ssm	3	47	6.4%	cbioportal
17	KMT2D	Ssm	3	47	6.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma TCGA-PAADTCGA

185 cases with simple somatic mutation data · 185 cases total · Data Release 46.0 · mapped to Pancreatic Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	124	185	67%	gdc
2	KRAS	Ssm	123	185	66.5%	gdc
3	SMAD4	Ssm	119	185	64.3%	gdc
4	CDKN2A	Ssm	117	185	63.2%	gdc
10	MBD1	Ssm	114	185	61.6%	gdc
9	CFAP53	Ssm	114	185	61.6%	gdc
8	MAPK4	Ssm	114	185	61.6%	gdc
7	CXXC1	Ssm	114	185	61.6%	gdc
5	ME2	Ssm	114	185	61.6%	gdc
6	SKA1	Ssm	114	185	61.6%	gdc
16	MYO5B	Ssm	113	185	61.1%	gdc
11	C18orf54	Ssm	113	185	61.1%	gdc
12	MRO	Ssm	113	185	61.1%	gdc
13	TCF4	Ssm	113	185	61.1%	gdc
14	DCC	Ssm	113	185	61.1%	gdc
15	MEX3C	Ssm	113	185	61.1%	gdc
17	STARD6	Ssm	113	185	61.1%	gdc
18	MBD2	Ssm	113	185	61.1%	gdc
19	POLI	Ssm	113	185	61.1%	gdc
26	AC091551.1	Ssm	112	185	60.5%	gdc
30	LIPG	Ssm	112	185	60.5%	gdc
29	CCDC68	Ssm	112	185	60.5%	gdc
20	DYM	Ssm	112	185	60.5%	gdc
21	RAB27B	Ssm	112	185	60.5%	gdc
22	SMAD7	Ssm	112	185	60.5%	gdc
23	ALPK2	Ssm	112	185	60.5%	gdc
24	DYNAP	Ssm	112	185	60.5%	gdc
25	SERPINB7	Ssm	112	185	60.5%	gdc
28	ELAC1	Ssm	112	185	60.5%	gdc
27	SERPINB10	Ssm	112	185	60.5%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Pancreatic Adenocarcinoma (ICGC, Nature 2012) paad_icgcICGC

99 cases with simple somatic mutation data · 99 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	94	99	94.9%	cbioportal
2	TP53	Ssm	33	99	33.3%	cbioportal
3	SMAD4	Ssm	16	99	16.2%	cbioportal
4	TTN	Ssm	12	99	12.1%	cbioportal
6	MUC16	Ssm	5	99	5.1%	cbioportal
5	CSMD1	Ssm	5	99	5.1%	cbioportal
8	DNAH5	Ssm	4	99	4%	cbioportal
14	TGFBR2	Ssm	4	99	4%	cbioportal
13	SF3B1	Ssm	4	99	4%	cbioportal
12	RYR3	Ssm	4	99	4%	cbioportal
11	PCDH15	Ssm	4	99	4%	cbioportal
10	NALCN	Ssm	4	99	4%	cbioportal
9	HMCN1	Ssm	4	99	4%	cbioportal
7	ARID1A	Ssm	4	99	4%	cbioportal
17	ARID2	Ssm	3	99	3%	cbioportal
18	COL6A5	Ssm	3	99	3%	cbioportal
29	THSD7A	Ssm	3	99	3%	cbioportal
28	SYNE1	Ssm	3	99	3%	cbioportal
27	SLIT2	Ssm	3	99	3%	cbioportal
26	PCDHB6	Ssm	3	99	3%	cbioportal
25	OR2M5	Ssm	3	99	3%	cbioportal
24	NBAS	Ssm	3	99	3%	cbioportal
23	MAP2K4	Ssm	3	99	3%	cbioportal
22	LRP1B	Ssm	3	99	3%	cbioportal
21	FLG	Ssm	3	99	3%	cbioportal
20	EPC1	Ssm	3	99	3%	cbioportal
19	DMD	Ssm	3	99	3%	cbioportal
31	ZFHX4	Ssm	3	99	3%	cbioportal
15	ABCA12	Ssm	3	99	3%	cbioportal
16	AFF2	Ssm	3	99	3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma (MSK, 2025) paad_msk_2025MSK

29 cases with simple somatic mutation data · 29 cases total · 2026-02-10 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	18	29	62.1%	cbioportal
2	TP53	Ssm	14	29	48.3%	cbioportal
8	ZNF676	Ssm	3	16	18.8%	cbioportal
35	MARCHF7	Ssm	2	16	12.5%	cbioportal
20	DAB2	Ssm	2	16	12.5%	cbioportal
24	FAM86C1P	Ssm	2	16	12.5%	cbioportal
32	HLA-G	Ssm	2	16	12.5%	cbioportal
33	KIF2B	Ssm	2	16	12.5%	cbioportal
53	SMOC1	Ssm	2	16	12.5%	cbioportal
38	NBPF12	Ssm	2	16	12.5%	cbioportal
40	NOTCH2NLA	Ssm	2	16	12.5%	cbioportal
43	OR4C46	Ssm	2	16	12.5%	cbioportal
48	PRDM5	Ssm	2	16	12.5%	cbioportal
52	SDHAP1	Ssm	2	16	12.5%	cbioportal
4	CDK8	Ssm	3	29	10.3%	cbioportal
3	APC	Ssm	3	29	10.3%	cbioportal
7	RNF43	Ssm	3	29	10.3%	cbioportal
6	KMT2C	Ssm	3	29	10.3%	cbioportal
5	CDKN2A	Ssm	3	29	10.3%	cbioportal
47	PRDM14	Ssm	2	28	7.1%	cbioportal
51	RTEL1	Ssm	2	28	7.1%	cbioportal
23	ETAA1	Ssm	2	28	7.1%	cbioportal
9	ALB	Ssm	2	28	7.1%	cbioportal
31	HLA-C	Ssm	2	28	7.1%	cbioportal
55	USP8	Ssm	2	28	7.1%	cbioportal
30	HLA-A	Ssm	2	29	6.9%	cbioportal
28	GNAS	Ssm	2	29	6.9%	cbioportal
29	H3-3A	Ssm	2	29	6.9%	cbioportal
17	CDKN1B	Ssm	2	29	6.9%	cbioportal
16	BRAF	Ssm	2	29	6.9%	cbioportal

Data updated 22 days agoSource updated 2026-02-10

Pancreatic Adenocarcinoma (QCMG, Nature 2016) paad_qcmg_uq_2016QCMG

383 cases with simple somatic mutation data · 456 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	344	383	89.8%	cbioportal
2	TP53	Ssm	253	383	66.1%	cbioportal
3	SMAD4	Ssm	86	383	22.5%	cbioportal
4	CDKN2A	Ssm	71	383	18.5%	cbioportal
5	TTN	Ssm	56	383	14.6%	cbioportal
6	ARID1A	Ssm	29	383	7.6%	cbioportal
7	SYNE1	Ssm	27	383	7%	cbioportal
8	LRP1B	Ssm	22	383	5.7%	cbioportal
11	RYR1	Ssm	21	383	5.5%	cbioportal
9	KMT2C	Ssm	21	383	5.5%	cbioportal
10	RNF43	Ssm	21	383	5.5%	cbioportal
12	MUC16	Ssm	20	383	5.2%	cbioportal
14	HMCN1	Ssm	19	383	5%	cbioportal
13	FLG	Ssm	19	383	5%	cbioportal
15	KMT2D	Ssm	19	383	5%	cbioportal
18	OBSCN	Ssm	18	383	4.7%	cbioportal
16	FAT3	Ssm	18	383	4.7%	cbioportal
17	GLI3	Ssm	18	383	4.7%	cbioportal
19	TGFBR2	Ssm	18	383	4.7%	cbioportal
22	RYR3	Ssm	16	383	4.2%	cbioportal
20	DNAH11	Ssm	16	383	4.2%	cbioportal
21	MUC4	Ssm	16	383	4.2%	cbioportal
23	RYR2	Ssm	15	383	3.9%	cbioportal
26	WDFY4	Ssm	14	383	3.7%	cbioportal
24	ATM	Ssm	14	383	3.7%	cbioportal
25	CSMD1	Ssm	14	383	3.7%	cbioportal
30	TENM3	Ssm	13	383	3.4%	cbioportal
27	ADGRV1	Ssm	13	383	3.4%	cbioportal
28	CSMD3	Ssm	13	383	3.4%	cbioportal
29	DNAH5	Ssm	13	383	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma (TCGA, Firehose Legacy) paad_tcgaTCGA

150 cases with simple somatic mutation data · 186 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	136	150	90.7%	cbioportal
2	TP53	Ssm	104	150	69.3%	cbioportal
3	SMAD4	Ssm	37	150	24.7%	cbioportal
4	TTN	Ssm	35	150	23.3%	cbioportal
5	CDKN2A	Ssm	22	150	14.7%	cbioportal
7	OBSCN	Ssm	11	150	7.3%	cbioportal
6	MUC16	Ssm	11	150	7.3%	cbioportal
8	RYR1	Ssm	11	150	7.3%	cbioportal
11	GNAS	Ssm	10	150	6.7%	cbioportal
9	FAT2	Ssm	10	150	6.7%	cbioportal
10	FLG	Ssm	10	150	6.7%	cbioportal
18	MYO18B	Ssm	9	150	6%	cbioportal
20	USH2A	Ssm	9	150	6%	cbioportal
19	RNF43	Ssm	9	150	6%	cbioportal
17	LRP1B	Ssm	9	150	6%	cbioportal
16	HMCN1	Ssm	9	150	6%	cbioportal
15	FAT4	Ssm	9	150	6%	cbioportal
14	FAT3	Ssm	9	150	6%	cbioportal
13	CSMD2	Ssm	9	150	6%	cbioportal
12	ADAMTS16	Ssm	9	150	6%	cbioportal
27	RREB1	Ssm	8	150	5.3%	cbioportal
26	PLEC	Ssm	8	150	5.3%	cbioportal
21	ADAMTS12	Ssm	8	150	5.3%	cbioportal
22	ARID1A	Ssm	8	150	5.3%	cbioportal
23	CACNA1B	Ssm	8	150	5.3%	cbioportal
24	GLI3	Ssm	8	150	5.3%	cbioportal
30	TGFBR2	Ssm	8	150	5.3%	cbioportal
29	SCN5A	Ssm	8	150	5.3%	cbioportal
28	RYR3	Ssm	8	150	5.3%	cbioportal
25	HECW2	Ssm	8	150	5.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Adenocarcinoma (TCGA GDC, 2025) paad_tcga_gdcTCGA GDC

173 cases with simple somatic mutation data · 186 cases total · 2026-01-13 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	107	173	61.8%	cbioportal
2	TP53	Ssm	100	173	57.8%	cbioportal
3	SMAD4	Ssm	36	173	20.8%	cbioportal
4	CDKN2A	Ssm	30	173	17.3%	cbioportal
5	TTN	Ssm	25	173	14.5%	cbioportal
6	MUC16	Ssm	12	173	6.9%	cbioportal
7	RNF43	Ssm	11	173	6.4%	cbioportal
8	ARID1A	Ssm	8	173	4.6%	cbioportal
9	HECW2	Ssm	8	173	4.6%	cbioportal
10	RYR1	Ssm	8	173	4.6%	cbioportal
11	TGFBR2	Ssm	8	173	4.6%	cbioportal
16	GNAS	Ssm	7	173	4%	cbioportal
14	FAT2	Ssm	7	173	4%	cbioportal
13	CACNA1B	Ssm	7	173	4%	cbioportal
12	ATM	Ssm	7	173	4%	cbioportal
20	RNF213	Ssm	7	173	4%	cbioportal
21	TPO	Ssm	7	173	4%	cbioportal
19	PCDH15	Ssm	7	173	4%	cbioportal
18	LRP1B	Ssm	7	173	4%	cbioportal
17	KDM6A	Ssm	7	173	4%	cbioportal
15	GLI3	Ssm	7	173	4%	cbioportal
29	FLG	Ssm	6	173	3.5%	cbioportal
37	MYO18B	Ssm	6	173	3.5%	cbioportal
36	MYO16	Ssm	6	173	3.5%	cbioportal
35	MUC17	Ssm	6	173	3.5%	cbioportal
34	KMT2D	Ssm	6	173	3.5%	cbioportal
33	KMT2C	Ssm	6	173	3.5%	cbioportal
32	KCNB2	Ssm	6	173	3.5%	cbioportal
31	KCNA6	Ssm	6	173	3.5%	cbioportal
30	FLNC	Ssm	6	173	3.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Pancreatic Adenocarcinoma (TCGA, PanCancer Atlas) paad_tcga_pan_can_atlas_2018TCGA

179 cases with simple somatic mutation data · 184 cases total · 2026-06-04 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	117	179	65.4%	cbioportal
2	TP53	Ssm	107	179	59.8%	cbioportal
3	SMAD4	Ssm	37	179	20.7%	cbioportal
4	CDKN2A	Ssm	35	179	19.6%	cbioportal
5	TTN	Ssm	29	179	16.2%	cbioportal
6	MUC16	Ssm	13	179	7.3%	cbioportal
7	RNF43	Ssm	11	179	6.1%	cbioportal
8	CSMD2	Ssm	10	179	5.6%	cbioportal
9	RYR1	Ssm	10	179	5.6%	cbioportal
10	ARID1A	Ssm	9	179	5%	cbioportal
11	PCDH15	Ssm	9	179	5%	cbioportal
17	OBSCN	Ssm	8	179	4.5%	cbioportal
12	ATM	Ssm	8	179	4.5%	cbioportal
13	CACNA1B	Ssm	8	179	4.5%	cbioportal
14	FLG	Ssm	8	179	4.5%	cbioportal
15	HECW2	Ssm	8	179	4.5%	cbioportal
16	MYO18B	Ssm	8	179	4.5%	cbioportal
18	RNF213	Ssm	8	179	4.5%	cbioportal
19	TGFBR2	Ssm	8	179	4.5%	cbioportal
28	GLI3	Ssm	7	179	3.9%	cbioportal
27	FLNC	Ssm	7	179	3.9%	cbioportal
26	FAT3	Ssm	7	179	3.9%	cbioportal
25	FAT2	Ssm	7	179	3.9%	cbioportal
24	DSCAML1	Ssm	7	179	3.9%	cbioportal
23	DNAH11	Ssm	7	179	3.9%	cbioportal
22	COL6A2	Ssm	7	179	3.9%	cbioportal
21	APBA2	Ssm	7	179	3.9%	cbioportal
20	ADAMTS12	Ssm	7	179	3.9%	cbioportal
29	GNAS	Ssm	7	179	3.9%	cbioportal
30	KDM6A	Ssm	7	179	3.9%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Pancreatic Cancer cfDNA (MSK, J Natl Cancer Inst 2025) pancreas_ctdna_msk_2025MSK

412 cases with simple somatic mutation data · 412 cases total · 2026-01-28 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	168	412	40.8%	cbioportal
2	TP53	Ssm	149	412	36.2%	cbioportal
3	CDKN2A	Ssm	37	412	9%	cbioportal
4	SMAD4	Ssm	34	412	8.3%	cbioportal
5	ARID1A	Ssm	24	412	5.8%	cbioportal
6	ATM	Ssm	23	412	5.6%	cbioportal
7	GNAS	Ssm	9	412	2.2%	cbioportal
9	SF3B1	Ssm	9	412	2.2%	cbioportal
8	KDM6A	Ssm	9	412	2.2%	cbioportal
10	SMARCA4	Ssm	8	412	1.9%	cbioportal
14	NTRK2	Ssm	7	412	1.7%	cbioportal
15	PTCH1	Ssm	7	412	1.7%	cbioportal
11	BRCA2	Ssm	7	412	1.7%	cbioportal
13	NF1	Ssm	7	412	1.7%	cbioportal
12	FOXO1	Ssm	7	412	1.7%	cbioportal
16	APC	Ssm	6	412	1.5%	cbioportal
17	PTEN	Ssm	6	412	1.5%	cbioportal
19	TSC2	Ssm	5	412	1.2%	cbioportal
18	FBXW7	Ssm	5	412	1.2%	cbioportal
20	CTNNB1	Ssm	4	412	1%	cbioportal
26	U2AF1	Ssm	4	412	1%	cbioportal
25	TSC1	Ssm	4	412	1%	cbioportal
24	STK11	Ssm	4	412	1%	cbioportal
23	NTRK1	Ssm	4	412	1%	cbioportal
22	MSH6	Ssm	4	412	1%	cbioportal
21	KEAP1	Ssm	4	412	1%	cbioportal
27	AKT1	Ssm	3	412	0.7%	cbioportal
28	FGFR2	Ssm	3	412	0.7%	cbioportal
29	PIK3CA	Ssm	3	412	0.7%	cbioportal
30	RB1	Ssm	3	412	0.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-28

Pancreatic Cancer (UTSW, Nat Commun 2015) paad_utsw_2015UTSW

109 cases with simple somatic mutation data · 109 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	100	109	91.7%	cbioportal
2	TP53	Ssm	55	109	50.5%	cbioportal
3	SMAD4	Ssm	21	109	19.3%	cbioportal
4	ZNF814	Ssm	20	109	18.3%	cbioportal
5	MUC16	Ssm	17	109	15.6%	cbioportal
6	TTN	Ssm	16	109	14.7%	cbioportal
7	MUC2	Ssm	12	109	11%	cbioportal
8	FLG	Ssm	11	109	10.1%	cbioportal
9	MIA2	Ssm	11	109	10.1%	cbioportal
10	MUC5B	Ssm	10	109	9.2%	cbioportal
11	OBSCN	Ssm	9	109	8.3%	cbioportal
12	ATXN1	Ssm	8	109	7.3%	cbioportal
13	COL18A1	Ssm	8	109	7.3%	cbioportal
14	HERC2	Ssm	8	109	7.3%	cbioportal
15	KRT4	Ssm	8	109	7.3%	cbioportal
16	NEBL	Ssm	8	109	7.3%	cbioportal
17	NF1	Ssm	8	109	7.3%	cbioportal
18	PCMTD1	Ssm	8	109	7.3%	cbioportal
27	MAGEC1	Ssm	7	109	6.4%	cbioportal
28	MUC17	Ssm	7	109	6.4%	cbioportal
30	NBPF9	Ssm	7	109	6.4%	cbioportal
19	AHNAK2	Ssm	7	109	6.4%	cbioportal
29	MUC4	Ssm	7	109	6.4%	cbioportal
20	ARID1A	Ssm	7	109	6.4%	cbioportal
21	COL14A1	Ssm	7	109	6.4%	cbioportal
22	DGKB	Ssm	7	109	6.4%	cbioportal
23	FAT3	Ssm	7	109	6.4%	cbioportal
24	FOLH1	Ssm	7	109	6.4%	cbioportal
25	KMT2C	Ssm	7	109	6.4%	cbioportal
26	LILRB3	Ssm	7	109	6.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Ductal Adenocarcinoma (CPTAC, Cell 2021) paad_cptac_2021CPTAC

140 cases with simple somatic mutation data · 140 cases total · 2026-01-12 · mapped to Pancreatic Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	135	140	96.4%	cbioportal
2	TP53	Ssm	105	140	75%	cbioportal
3	CDKN2A	Ssm	29	140	20.7%	cbioportal
4	SMAD4	Ssm	24	140	17.1%	cbioportal
6	MUC4	Ssm	13	140	9.3%	cbioportal
5	CTNNA2	Ssm	13	140	9.3%	cbioportal
7	TTN	Ssm	12	140	8.6%	cbioportal
8	RYR2	Ssm	10	140	7.1%	cbioportal
9	RNF43	Ssm	9	140	6.4%	cbioportal
11	KMT2D	Ssm	8	140	5.7%	cbioportal
10	ARID1A	Ssm	8	140	5.7%	cbioportal
17	SYNE1	Ssm	7	140	5%	cbioportal
16	RBMXL3	Ssm	7	140	5%	cbioportal
15	MUC16	Ssm	7	140	5%	cbioportal
14	GNAS	Ssm	7	140	5%	cbioportal
13	FMN2	Ssm	7	140	5%	cbioportal
12	DNAH9	Ssm	7	140	5%	cbioportal
28	RYR3	Ssm	6	140	4.3%	cbioportal
26	PXDNL	Ssm	6	140	4.3%	cbioportal
25	LRP1B	Ssm	6	140	4.3%	cbioportal
24	KMT2C	Ssm	6	140	4.3%	cbioportal
23	IRX2	Ssm	6	140	4.3%	cbioportal
22	GLI3	Ssm	6	140	4.3%	cbioportal
21	DOCK2	Ssm	6	140	4.3%	cbioportal
20	CSMD1	Ssm	6	140	4.3%	cbioportal
19	CDH10	Ssm	6	140	4.3%	cbioportal
18	ANKRD30B	Ssm	6	140	4.3%	cbioportal
30	ZFHX4	Ssm	6	140	4.3%	cbioportal
29	TAF1L	Ssm	6	140	4.3%	cbioportal
27	RBM10	Ssm	6	140	4.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Neuroendocrine Tumors (Johns Hopkins University, Science 2011) panet_jhu_2011Johns Hopkins University

10 cases with simple somatic mutation data · 10 cases total · 2026-01-12 · mapped to Pancreatic Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MEN1	Ssm	5	10	50%	cbioportal
2	DAXX	Ssm	3	10	30%	cbioportal
4	TSC2	Ssm	2	10	20%	cbioportal
3	PTEN	Ssm	2	10	20%	cbioportal
23	CD1A	Ssm	1	10	10%	cbioportal
141	ZNF557	Ssm	1	10	10%	cbioportal
5	ABCA7	Ssm	1	10	10%	cbioportal
6	ABCB4	Ssm	1	10	10%	cbioportal
7	ADAMTS8	Ssm	1	10	10%	cbioportal
8	ADGRG4	Ssm	1	10	10%	cbioportal
9	AFMID	Ssm	1	10	10%	cbioportal
10	AHNAK	Ssm	1	10	10%	cbioportal
11	AKAP6	Ssm	1	10	10%	cbioportal
12	ALK	Ssm	1	10	10%	cbioportal
13	ANXA8L1	Ssm	1	10	10%	cbioportal
14	ARMC5	Ssm	1	10	10%	cbioportal
15	ATP6V0A1	Ssm	1	10	10%	cbioportal
16	ATRX	Ssm	1	10	10%	cbioportal
17	BCL9L	Ssm	1	10	10%	cbioportal
18	BRD1	Ssm	1	10	10%	cbioportal
19	C21ORF58	Ssm	1	10	10%	cbioportal
20	CABIN1	Ssm	1	10	10%	cbioportal
21	CAMSAP2	Ssm	1	10	10%	cbioportal
22	CCDC158	Ssm	1	10	10%	cbioportal
24	CD1C	Ssm	1	10	10%	cbioportal
25	CEP135	Ssm	1	10	10%	cbioportal
26	CES1	Ssm	1	10	10%	cbioportal
27	CILP	Ssm	1	10	10%	cbioportal
28	COL1A1	Ssm	1	10	10%	cbioportal
29	CPNE8	Ssm	1	10	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Neuroendocrine Tumors (Multi-Institute, Nature 2017) panet_arcnet_2017Multi-Institute

98 cases with simple somatic mutation data · 98 cases total · 2026-01-12 · mapped to Pancreatic Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MEN1	Ssm	36	98	36.7%	cbioportal
2	DAXX	Ssm	22	98	22.4%	cbioportal
3	ATRX	Ssm	10	98	10.2%	cbioportal
4	PTEN	Ssm	7	98	7.1%	cbioportal
5	SETD2	Ssm	5	98	5.1%	cbioportal
6	TTN	Ssm	5	98	5.1%	cbioportal
9	FREM3	Ssm	4	98	4.1%	cbioportal
10	MUC16	Ssm	4	98	4.1%	cbioportal
7	DNAH5	Ssm	4	98	4.1%	cbioportal
8	DYNC1I1	Ssm	4	98	4.1%	cbioportal
18	FLNC	Ssm	3	98	3.1%	cbioportal
37	ZSCAN1	Ssm	3	98	3.1%	cbioportal
20	HERC1	Ssm	3	98	3.1%	cbioportal
21	HSPG2	Ssm	3	98	3.1%	cbioportal
22	KMT2C	Ssm	3	98	3.1%	cbioportal
35	URB1	Ssm	3	98	3.1%	cbioportal
24	MED23	Ssm	3	98	3.1%	cbioportal
25	MTOR	Ssm	3	98	3.1%	cbioportal
26	NLRP2	Ssm	3	98	3.1%	cbioportal
27	NUMA1	Ssm	3	98	3.1%	cbioportal
23	LRP2	Ssm	3	98	3.1%	cbioportal
36	VWA3A	Ssm	3	98	3.1%	cbioportal
19	GBP2	Ssm	3	98	3.1%	cbioportal
11	A2M	Ssm	3	98	3.1%	cbioportal
12	ATM	Ssm	3	98	3.1%	cbioportal
13	CEP290	Ssm	3	98	3.1%	cbioportal
14	DNAH17	Ssm	3	98	3.1%	cbioportal
15	DST	Ssm	3	98	3.1%	cbioportal
16	EFTUD2	Ssm	3	98	3.1%	cbioportal
17	FLG	Ssm	3	98	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-12