Gene

YAP1

Yes1 associated transcriptional regulator

Explore in graph →CI-GENE-00039033HGNC:16262 ENSG00000137693 NCBI 10413 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (5)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
YAP1 Fusion1
(oncogenic)	Lung Non-Small Cell CarcinomaCURATED_BROADER	Oncogenic	C	Supports Oncogenicity	1	submitted

Cohorts

Alteration frequency by cohort (19)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved19 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial and Ovarian Cancer (MSK, Nature Medicine 2024) ucec_msk_2024	unmapped	Ssm	6	33	18.2%

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
· Cancer Cell · 2015 · PMID 25965575 · validated civic_curation pubmed

YAP1 Overexpression3
Docetaxel + FluorouracilSubstitutes	Malignant Esophageal Neoplasm	Predictive	D	Supports Resistance	2	submitted	EID1982 YAP1 up-regulation of EGFR plays an important role in conferring therapy resistance to 5-FU or docetaxel in esophageal cancer (EC) cells. Inhibitor of YAP1, Verteporfin, can overcome the acquired chem… (full text at CIViC) PMID 25739674 · Song et al., 2015 · Open in CIViC	civic
Verteporfin	Malignant Esophageal Neoplasm	Predictive	D	Supports Sensitivity Response	2	submitted	EID1983 YAP1 up-regulation of EGFR plays an important role in conferring therapy resistance to 5-FU or docetaxel in esophageal cancer (EC) cells. Inhibitor of YAP1, Verteporfin, can overcome the acquired chem… (full text at CIViC) PMID 25739674 · Song et al., 2015 · Open in CIViC	civic
Docetaxel + VerteporfinCombination	Malignant Esophageal Neoplasm	Predictive	D	Supports Sensitivity Response	2	submitted	EID9329 YAP1 and EGFR were found to be highly expressed in esophageal cancer (EC) cells and play an important role in resistance to 5-FU or docetaxel. Treatment of the EC cell line JHESO with the YAP1 inhibit… (full text at CIViC) PMID 25739674 · Song et al., 2015 · Open in CIViC	civic

YAP1 Overexpression3

Docetaxel + FluorouracilSubstitutes

Malignant Esophageal Neoplasm

Predictive

Supports Resistance

submitted

EID1982

YAP1 up-regulation of EGFR plays an important role in conferring therapy resistance to 5-FU or docetaxel in esophageal cancer (EC) cells. Inhibitor of YAP1, Verteporfin, can overcome the acquired chem… (full text at CIViC)

PMID 25739674 · Song et al., 2015 · Open in CIViC

civic

Verteporfin

Malignant Esophageal Neoplasm

Predictive

Supports Sensitivity Response

submitted

EID1983

PMID 25739674 · Song et al., 2015 · Open in CIViC

civic

Docetaxel + VerteporfinCombination

Malignant Esophageal Neoplasm

Predictive

Supports Sensitivity Response

submitted

EID9329

YAP1 and EGFR were found to be highly expressed in esophageal cancer (EC) cells and play an important role in resistance to 5-FU or docetaxel. Treatment of the EC cell line JHESO with the YAP1 inhibit… (full text at CIViC)

PMID 25739674 · Song et al., 2015 · Open in CIViC

civic

YAP1 Fusion1
(diagnostic)	Supratentorial Ependymoma YAP1 Fusion-Positive	Diagnostic	B	Supports Positive	4	accepted	EID11890 DNA methylation profiling of 500 ependymal tumors identified 9 molecular profiles with 3 occurring in the supratentorial compartment (designated ST EPN). RNA sequencing performed in 7 of the 13 cases… (full text at CIViC) PMID 25965575 · Pajtler et al., 2015 · Open in CIViC	civic

YAP1 Fusion1

(diagnostic)

Supratentorial Ependymoma YAP1 Fusion-Positive

Diagnostic

Supports Positive

accepted

EID11890

DNA methylation profiling of 500 ependymal tumors identified 9 molecular profiles with 3 occurring in the supratentorial compartment (designated ST EPN). RNA sequencing performed in 7 of the 13 cases… (full text at CIViC)

PMID 25965575 · Pajtler et al., 2015 · Open in CIViC

civic