Gene
COL1A1
collagen type I alpha 1 chain
Explore in graph →CI-GENE-00041838HGNC:2197 ENSG00000108821 NCBI 1277 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (17)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 27634761
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Lung Cancer (SMC, Cancer Research 2016) lung_smc_2016 | unmapped | Ssm | 6 | 22 | 27.3% | 31 | cbioportal |
| Metastatic Melanoma (UCLA, Cell 2016) mel_ucla_2016 | Melanoma | Ssm | 9 | 38 | 23.7% | 138 | cbioportal |
| Melanoma (MSK, Cell 2017) - iAtlas Harmonized mel_iatlas_riaz_nivolumab_2017 | Melanoma | Ssm | 10 | 73 | 13.7% | 72 | cbioportal |
| Cutaneous Squamous Cell Carcinoma (DFCI, Clin Cancer Res 2015) cscc_dfarber_2015 | Skin Squamous Cell Carcinoma | Ssm | 3 | 29 | 10.3% | 153 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.