FPGS

folylpolyglutamate synthase

Explore in graph →CI-GENE-00002203HGNC:3824 ENSG00000136877 NCBI 2356 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FPGS Decreased RNA expression1
Fluorouracil	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	D	Supports Sensitivity Response	3	submitted	EID13312 shRNA-mediated reduction of FPGS expression increased fluorouracil sensitivity in colorectal cancer cells, producing approximately threefold and sixfold decreases in IC50 in HCT-116 and HT-29 cells, r… (full text at CIViC) PMID 21449674 · Muhale et al., 2011 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (3)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved3 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Adrenocortical Carcinoma (TCGA, Firehose Legacy) acc_tcga	Adrenal Cortical Carcinoma	Ssm	14	90	15.6%	49

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.