Gene

HSPA5

heat shock protein family A (Hsp70) member 5

Explore in graph →CI-GENE-00005128HGNC:5238 ENSG00000044574 NCBI 3309 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
HSPA5 EXPRESSION1
Fluorouracil	Malignant Colorectal NeoplasmCURATED_BROADER	Predictive	B	Supports Sensitivity Response	4	accepted	EID914 Expression of GRP78 (HSPA5) in colorectal cancer patients (n=396, by IHC) showed improved benefit from adjuvant chemotherapy in stage III patients (52% vs. 28%; p = 0.026). In vitro, GRP78 inhibition … (full text at CIViC) PMID 23456958 · Thornton et al., 2013 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (2)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved2 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Insulinoma (Shanghai, Nat Commun 2013) panet_shanghai_2013	Pancreatic Neuroendocrine Tumor	Ssm	1	10

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The unfolded protein response regulator GRP78 is a novel predictive biomarker in colorectal cancer.
· Int J Cancer · 2013 · PMID 23456958 · validated civic_curation pubmed