Lymphoid Neoplasm — Genomics

Lymphoid Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

35 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Acute Lymphoblastic Leukemia (St Jude, Nat Genet 2015) all_stjude_2015St Jude

93 cases with simple somatic mutation data · 93 cases total · 2026-01-05 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Acute Lymphoblastic Leukemia (St Jude, Nat Genet 2016) all_stjude_2016St Jude

73 cases with simple somatic mutation data · 73 cases total · 2026-01-05 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NRAS	Ssm	18	73	24.7%	cbioportal
2	KMT2D	Ssm	14	73	19.2%	cbioportal
3	SETD2	Ssm	10	73	13.7%	cbioportal
4	TBL1XR1	Ssm	8	73	11%	cbioportal
5	ZFP36L2	Ssm	6	73	8.2%	cbioportal
7	NCOR1	Ssm	5	73	6.8%	cbioportal
6	KRAS	Ssm	5	73	6.8%	cbioportal
8	ZEB2	Ssm	5	73	6.8%	cbioportal
10	PTPN11	Ssm	4	73	5.5%	cbioportal
9	PAX5	Ssm	4	73	5.5%	cbioportal
11	TP53	Ssm	4	73	5.5%	cbioportal
18	PIK3R1	Ssm	3	73	4.1%	cbioportal
12	CTCF	Ssm	3	73	4.1%	cbioportal
13	ERG	Ssm	3	73	4.1%	cbioportal
14	KDM6A	Ssm	3	73	4.1%	cbioportal
15	MED12	Ssm	3	73	4.1%	cbioportal
16	MYC	Ssm	3	73	4.1%	cbioportal
17	MYCBP2	Ssm	3	73	4.1%	cbioportal
19	TTN	Ssm	3	73	4.1%	cbioportal
30	FNDC1	Ssm	2	73	2.7%	cbioportal
29	FLT3	Ssm	2	73	2.7%	cbioportal
28	ETV6	Ssm	2	73	2.7%	cbioportal
27	EHMT2	Ssm	2	73	2.7%	cbioportal
26	EGFR	Ssm	2	73	2.7%	cbioportal
25	DNAH9	Ssm	2	73	2.7%	cbioportal
24	DACT2	Ssm	2	73	2.7%	cbioportal
23	CCN3	Ssm	2	73	2.7%	cbioportal
22	BRWD1	Ssm	2	73	2.7%	cbioportal
21	ADGRV1	Ssm	2	73	2.7%	cbioportal
20	ABCC8	Ssm	2	73	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

B-Lymphoblastic Leukemia/Lymphoma (TARGET GDC, 2025) bll_target_gdcTARGET GDC

739 cases with simple somatic mutation data · 989 cases total · 2026-01-14 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NOTCH1	Ssm	159	739	21.5%	cbioportal
2	KRAS	Ssm	90	739	12.2%	cbioportal
3	NRAS	Ssm	88	739	11.9%	cbioportal
4	FBXW7	Ssm	59	739	8%	cbioportal
5	PHF6	Ssm	44	739	6%	cbioportal
6	TTN	Ssm	35	739	4.7%	cbioportal
7	PAX5	Ssm	33	739	4.5%	cbioportal
8	KMT2D	Ssm	32	739	4.3%	cbioportal
9	PTEN	Ssm	29	739	3.9%	cbioportal
10	FLT3	Ssm	28	739	3.8%	cbioportal
11	USP7	Ssm	28	739	3.8%	cbioportal
12	DNM2	Ssm	26	739	3.5%	cbioportal
13	CREBBP	Ssm	25	739	3.4%	cbioportal
14	BCL11B	Ssm	24	739	3.2%	cbioportal
16	PTPN11	Ssm	23	739	3.1%	cbioportal
15	NSD2	Ssm	23	739	3.1%	cbioportal
17	JAK2	Ssm	22	739	3%	cbioportal
18	ETV6	Ssm	19	739	2.6%	cbioportal
19	SETD2	Ssm	19	739	2.6%	cbioportal
21	FSIP2	Ssm	17	739	2.3%	cbioportal
23	TP53	Ssm	17	739	2.3%	cbioportal
20	CTCF	Ssm	17	739	2.3%	cbioportal
22	IKZF1	Ssm	17	739	2.3%	cbioportal
24	JAK3	Ssm	16	739	2.2%	cbioportal
25	USH2A	Ssm	16	739	2.2%	cbioportal
27	JAK1	Ssm	15	739	2%	cbioportal
26	IL7R	Ssm	15	739	2%	cbioportal
28	ZFHX4	Ssm	15	739	2%	cbioportal
29	EZH2	Ssm	14	739	1.9%	cbioportal
30	MUC16	Ssm	14	739	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Burkitt Lymphoma Genome Sequencing Project CGCI-BLGSPCGCI

263 cases with simple somatic mutation data · 324 cases total · Data Release 46.0 · mapped to Burkitt Lymphoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SHCBP1	Ssm	73	263	27.8%	gdc
2	VPS35	Ssm	67	263	25.5%	gdc
4	TPTE	Ssm	66	263	25.1%	gdc
3	ORC6	Ssm	66	263	25.1%	gdc
5	MYLK3	Ssm	62	263	23.6%	gdc
6	IGLL5	Ssm	60	263	22.8%	gdc
7	C16orf87	Ssm	56	263	21.3%	gdc
8	PTPRC	Ssm	50	263	19%	gdc
9	ZNF280B	Ssm	48	263	18.3%	gdc
10	ZNF280A	Ssm	47	263	17.9%	gdc
12	PRAME	Ssm	46	263	17.5%	gdc
11	GGTLC2	Ssm	46	263	17.5%	gdc
13	MYC	Ssm	45	263	17.1%	gdc
14	OR11H12	Ssm	44	263	16.7%	gdc
15	ATP6V1G3	Ssm	43	263	16.3%	gdc
16	SLAMF6	Ssm	43	263	16.3%	gdc
17	ENSA	Ssm	40	263	15.2%	gdc
18	CD84	Ssm	40	263	15.2%	gdc
22	ADAMTSL4	Ssm	39	263	14.8%	gdc
23	GABPB2	Ssm	39	263	14.8%	gdc
24	TARS2	Ssm	39	263	14.8%	gdc
25	CD48	Ssm	39	263	14.8%	gdc
26	C1orf56	Ssm	39	263	14.8%	gdc
19	GOLPH3L	Ssm	39	263	14.8%	gdc
20	MLLT11	Ssm	39	263	14.8%	gdc
21	CDC42SE1	Ssm	39	263	14.8%	gdc
43	FAM243B	Ssm	38	263	14.4%	gdc
31	MINDY1	Ssm	38	263	14.4%	gdc
29	ECM1	Ssm	38	263	14.4%	gdc
30	CTSK	Ssm	38	263	14.4%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Chronic Lymphocytic Leukemia (Broad, Cell 2013) lcll_broad_2013Broad

160 cases with simple somatic mutation data · 160 cases total · 2026-01-07 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	23	160	14.4%	cbioportal
2	TP53	Ssm	19	160	11.9%	cbioportal
3	NOTCH1	Ssm	15	160	9.4%	cbioportal
4	MYD88	Ssm	12	160	7.5%	cbioportal
5	ATM	Ssm	9	160	5.6%	cbioportal
6	CHD2	Ssm	6	160	3.8%	cbioportal
7	MUC16	Ssm	6	160	3.8%	cbioportal
8	FAT3	Ssm	5	160	3.1%	cbioportal
12	XPO1	Ssm	5	160	3.1%	cbioportal
11	TTN	Ssm	5	160	3.1%	cbioportal
10	POT1	Ssm	5	160	3.1%	cbioportal
9	H1-4	Ssm	5	160	3.1%	cbioportal
14	FAT4	Ssm	4	160	2.5%	cbioportal
13	CSMD1	Ssm	4	160	2.5%	cbioportal
16	NRAS	Ssm	4	160	2.5%	cbioportal
23	WDR72	Ssm	4	160	2.5%	cbioportal
22	SRCAP	Ssm	4	160	2.5%	cbioportal
21	SLIT3	Ssm	4	160	2.5%	cbioportal
20	SCN2A	Ssm	4	160	2.5%	cbioportal
19	SAMHD1	Ssm	4	160	2.5%	cbioportal
18	RIPK1	Ssm	4	160	2.5%	cbioportal
17	PCLO	Ssm	4	160	2.5%	cbioportal
15	NAV2	Ssm	4	160	2.5%	cbioportal
30	CECR2	Ssm	3	160	1.9%	cbioportal
24	ADCY2	Ssm	3	160	1.9%	cbioportal
25	ALMS1	Ssm	3	160	1.9%	cbioportal
26	BCR	Ssm	3	160	1.9%	cbioportal
27	BLTP1	Ssm	3	160	1.9%	cbioportal
28	CDH10	Ssm	3	160	1.9%	cbioportal
29	CDH9	Ssm	3	160	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Chronic Lymphocytic Leukemia (Broad, Nature 2015) cll_broad_2015Broad

537 cases with simple somatic mutation data · 537 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	113	537	21%	cbioportal
2	ATM	Ssm	82	537	15.3%	cbioportal
3	TP53	Ssm	39	537	7.3%	cbioportal
4	NOTCH1	Ssm	38	537	7.1%	cbioportal
5	POT1	Ssm	35	537	6.5%	cbioportal
6	PCLO	Ssm	28	537	5.2%	cbioportal
7	CHD2	Ssm	26	537	4.8%	cbioportal
8	XPO1	Ssm	24	537	4.5%	cbioportal
9	RPS15	Ssm	22	537	4.1%	cbioportal
11	TTN	Ssm	21	537	3.9%	cbioportal
10	MUC16	Ssm	21	537	3.9%	cbioportal
12	BRAF	Ssm	20	537	3.7%	cbioportal
14	CSMD3	Ssm	19	537	3.5%	cbioportal
13	BIRC3	Ssm	19	537	3.5%	cbioportal
16	MGA	Ssm	17	537	3.2%	cbioportal
15	EGR2	Ssm	17	537	3.2%	cbioportal
18	MYD88	Ssm	16	537	3%	cbioportal
17	LRP1B	Ssm	16	537	3%	cbioportal
19	FAT4	Ssm	15	537	2.8%	cbioportal
20	USH2A	Ssm	15	537	2.8%	cbioportal
21	FAT3	Ssm	14	537	2.6%	cbioportal
22	KRAS	Ssm	14	537	2.6%	cbioportal
24	PCDH15	Ssm	13	537	2.4%	cbioportal
23	DDX3X	Ssm	13	537	2.4%	cbioportal
25	BCOR	Ssm	12	537	2.2%	cbioportal
26	CSMD1	Ssm	12	537	2.2%	cbioportal
27	FBXW7	Ssm	12	537	2.2%	cbioportal
28	IGLL5	Ssm	12	537	2.2%	cbioportal
29	DST	Ssm	11	537	2%	cbioportal
30	IKZF3	Ssm	11	537	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Chronic Lymphocytic Leukemia (Broad, Nature Genetics 2022) cll_broad_2022Broad

1,075 cases with simple somatic mutation data · 1,154 cases total · 2026-02-19 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	174	1,075	16.2%	cbioportal
2	ATM	Ssm	111	1,075	10.3%	cbioportal
3	TP53	Ssm	91	1,075	8.5%	cbioportal
4	TTN	Ssm	76	1,075	7.1%	cbioportal
5	POT1	Ssm	60	1,075	5.6%	cbioportal
6	PCLO	Ssm	58	1,075	5.4%	cbioportal
7	CHD2	Ssm	55	1,075	5.1%	cbioportal
8	NOTCH1	Ssm	54	1,075	5%	cbioportal
9	XPO1	Ssm	51	1,075	4.7%	cbioportal
10	MUC16	Ssm	49	1,075	4.6%	cbioportal
11	LRP1B	Ssm	48	1,075	4.5%	cbioportal
12	CSMD3	Ssm	42	1,075	3.9%	cbioportal
13	USH2A	Ssm	37	1,075	3.4%	cbioportal
14	FAT4	Ssm	35	1,075	3.3%	cbioportal
16	MGA	Ssm	34	1,075	3.2%	cbioportal
15	BRAF	Ssm	34	1,075	3.2%	cbioportal
17	RYR2	Ssm	34	1,075	3.2%	cbioportal
21	ZFHX4	Ssm	33	1,075	3.1%	cbioportal
20	MYD88	Ssm	33	1,075	3.1%	cbioportal
19	FAT1	Ssm	33	1,075	3.1%	cbioportal
18	EGR2	Ssm	33	1,075	3.1%	cbioportal
22	HMCN1	Ssm	32	1,075	3%	cbioportal
23	BIRC3	Ssm	30	1,075	2.8%	cbioportal
24	ZNF292	Ssm	30	1,075	2.8%	cbioportal
25	DST	Ssm	28	1,075	2.6%	cbioportal
26	CSMD1	Ssm	27	1,075	2.5%	cbioportal
27	DDX3X	Ssm	27	1,075	2.5%	cbioportal
28	FBXW7	Ssm	27	1,075	2.5%	cbioportal
29	KRAS	Ssm	27	1,075	2.5%	cbioportal
30	WDFY3	Ssm	27	1,075	2.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Chronic lymphocytic leukemia (ICGC, Nature Genetics 2011) cllsll_icgc_2011ICGC

105 cases with simple somatic mutation data · 105 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	10	105	9.5%	cbioportal
2	LRP1B	Ssm	5	105	4.8%	cbioportal
6	MUC2	Ssm	4	105	3.8%	cbioportal
4	CHD2	Ssm	4	105	3.8%	cbioportal
3	ATM	Ssm	4	105	3.8%	cbioportal
7	SI	Ssm	4	105	3.8%	cbioportal
5	CSMD3	Ssm	4	105	3.8%	cbioportal
10	CDH23	Ssm	3	105	2.9%	cbioportal
14	SLC4A10	Ssm	3	105	2.9%	cbioportal
13	RIMS2	Ssm	3	105	2.9%	cbioportal
12	POT1	Ssm	3	105	2.9%	cbioportal
8	ADGRL3	Ssm	3	105	2.9%	cbioportal
9	ASXL1	Ssm	3	105	2.9%	cbioportal
11	NXF1	Ssm	3	105	2.9%	cbioportal
22	CD36	Ssm	2	105	1.9%	cbioportal
15	ABCA4	Ssm	2	105	1.9%	cbioportal
16	ADAM2	Ssm	2	105	1.9%	cbioportal
17	ADAMTS18	Ssm	2	105	1.9%	cbioportal
18	ADGRL2	Ssm	2	105	1.9%	cbioportal
19	AKAP6	Ssm	2	105	1.9%	cbioportal
20	ARID1A	Ssm	2	105	1.9%	cbioportal
21	BRAF	Ssm	2	105	1.9%	cbioportal
23	CELF4	Ssm	2	105	1.9%	cbioportal
24	COL22A1	Ssm	2	105	1.9%	cbioportal
25	COL25A1	Ssm	2	105	1.9%	cbioportal
26	DCAF1	Ssm	2	105	1.9%	cbioportal
27	DDX3X	Ssm	2	105	1.9%	cbioportal
28	DLC1	Ssm	2	105	1.9%	cbioportal
29	DOCK4	Ssm	2	105	1.9%	cbioportal
30	DPP6	Ssm	2	105	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Chronic Lymphocytic Leukemia (IUOPA, Nature 2015) cll_iuopa_2015IUOPA

506 cases with simple somatic mutation data · 506 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NOTCH1	Ssm	48	506	9.5%	cbioportal
2	SF3B1	Ssm	41	506	8.1%	cbioportal
3	ATM	Ssm	31	506	6.1%	cbioportal
4	IGLL5	Ssm	26	506	5.1%	cbioportal
5	CHD2	Ssm	24	506	4.7%	cbioportal
6	LRP1B	Ssm	23	506	4.5%	cbioportal
7	MUC16	Ssm	20	506	4%	cbioportal
8	MYD88	Ssm	18	506	3.6%	cbioportal
9	POT1	Ssm	17	506	3.4%	cbioportal
10	PCLO	Ssm	15	506	3%	cbioportal
11	TP53	Ssm	15	506	3%	cbioportal
12	KLHL6	Ssm	14	506	2.8%	cbioportal
13	CSMD3	Ssm	13	506	2.6%	cbioportal
14	ZNF292	Ssm	13	506	2.6%	cbioportal
16	DDX3X	Ssm	12	506	2.4%	cbioportal
17	MGA	Ssm	12	506	2.4%	cbioportal
15	CSMD1	Ssm	12	506	2.4%	cbioportal
18	ADGRL3	Ssm	11	506	2.2%	cbioportal
22	USH2A	Ssm	10	506	2%	cbioportal
19	BRAF	Ssm	10	506	2%	cbioportal
20	FAT4	Ssm	10	506	2%	cbioportal
21	TTN	Ssm	10	506	2%	cbioportal
30	XPO1	Ssm	9	506	1.8%	cbioportal
28	SYNE1	Ssm	9	506	1.8%	cbioportal
29	TENM1	Ssm	9	506	1.8%	cbioportal
27	RYR2	Ssm	9	506	1.8%	cbioportal
25	DTX1	Ssm	9	506	1.8%	cbioportal
24	DNAH9	Ssm	9	506	1.8%	cbioportal
23	BIRC3	Ssm	9	506	1.8%	cbioportal
26	EGR2	Ssm	9	506	1.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Chronic Lymphocytic Leukemia (MSK, 2026) cllsll_msk_2026MSK

21 cases with simple somatic mutation data · 21 cases total · 2026-03-25 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SF3B1	Ssm	14	21	66.7%	cbioportal
2	TP53	Ssm	13	21	61.9%	cbioportal
3	BTK	Ssm	12	21	57.1%	cbioportal
7	MYO18A	Ssm	6	19	31.6%	cbioportal
9	SETD2	Ssm	6	21	28.6%	cbioportal
6	FAT1	Ssm	6	21	28.6%	cbioportal
8	RB1	Ssm	6	21	28.6%	cbioportal
4	ATM	Ssm	6	21	28.6%	cbioportal
5	CBFB	Ssm	6	21	28.6%	cbioportal
11	FANCL	Ssm	5	19	26.3%	cbioportal
12	LRP1B	Ssm	5	19	26.3%	cbioportal
10	ATXN2	Ssm	5	21	23.8%	cbioportal
13	TRAF3	Ssm	4	21	19%	cbioportal
26	ZNF292	Ssm	2	19	10.5%	cbioportal
14	ARID1A	Ssm	2	21	9.5%	cbioportal
16	BCL2	Ssm	2	21	9.5%	cbioportal
15	ARID1B	Ssm	2	21	9.5%	cbioportal
17	BCOR	Ssm	2	21	9.5%	cbioportal
18	CXCR4	Ssm	2	21	9.5%	cbioportal
20	DIS3	Ssm	2	21	9.5%	cbioportal
19	DDX3X	Ssm	2	21	9.5%	cbioportal
21	GRIN2A	Ssm	2	21	9.5%	cbioportal
22	KRAS	Ssm	2	21	9.5%	cbioportal
23	MGA	Ssm	2	21	9.5%	cbioportal
24	MYD88	Ssm	2	21	9.5%	cbioportal
25	TERT	Ssm	2	21	9.5%	cbioportal
35	PPM1D	Ssm	1	19	5.3%	cbioportal
33	PIK3CD	Ssm	1	19	5.3%	cbioportal
28	CARD11	Ssm	1	21	4.8%	cbioportal
27	ARHGEF28	Ssm	1	21	4.8%	cbioportal

Data updated 22 days agoSource updated 2026-03-25

Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023) chl_sccc_2023SCCC

61 cases with simple somatic mutation data · 61 cases total · 2026-01-06 · mapped to Classic Hodgkin Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SOCS1	Ssm	38	61	62.3%	cbioportal
2	TNFAIP3	Ssm	22	61	36.1%	cbioportal
3	B2M	Ssm	20	61	32.8%	cbioportal
4	ITPKB	Ssm	17	61	27.9%	cbioportal
5	GNA13	Ssm	16	61	26.2%	cbioportal
6	IGLL5	Ssm	15	61	24.6%	cbioportal
7	CENPB	Ssm	12	61	19.7%	cbioportal
9	STAT6	Ssm	12	61	19.7%	cbioportal
8	MUC16	Ssm	12	61	19.7%	cbioportal
11	CSF2RB	Ssm	11	61	18%	cbioportal
10	BCL7A	Ssm	11	61	18%	cbioportal
13	OBSCN	Ssm	11	61	18%	cbioportal
12	FAM230A	Ssm	11	61	18%	cbioportal
14	AHNAK2	Ssm	10	61	16.4%	cbioportal
15	FLG	Ssm	9	61	14.8%	cbioportal
17	NFKBIE	Ssm	9	61	14.8%	cbioportal
16	LRP1B	Ssm	9	61	14.8%	cbioportal
19	KMT2D	Ssm	8	61	13.1%	cbioportal
18	H1-4	Ssm	8	61	13.1%	cbioportal
22	TTN	Ssm	8	61	13.1%	cbioportal
20	MFHAS1	Ssm	8	61	13.1%	cbioportal
21	NFKB2	Ssm	8	61	13.1%	cbioportal
24	LRRN3	Ssm	7	61	11.5%	cbioportal
27	ZFP36L1	Ssm	7	61	11.5%	cbioportal
26	SDK2	Ssm	7	61	11.5%	cbioportal
25	MUC17	Ssm	7	61	11.5%	cbioportal
23	ACTB	Ssm	7	61	11.5%	cbioportal
29	CSMD3	Ssm	6	61	9.8%	cbioportal
30	DNAH11	Ssm	6	61	9.8%	cbioportal
28	BTG1	Ssm	6	61	9.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-06

Cutaneous T Cell Lymphoma (Columbia U, Nat Genet 2015) ctcl_columbia_2015Columbia U

43 cases with simple somatic mutation data · 43 cases total · 2026-01-07 · mapped to Non-Hodgkin Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PCLO	Ssm	8	43	18.6%	cbioportal
3	MUC5B	Ssm	6	43	14%	cbioportal
2	DNAH5	Ssm	6	43	14%	cbioportal
6	TENM4	Ssm	5	43	11.6%	cbioportal
4	AHNAK2	Ssm	5	43	11.6%	cbioportal
5	LRP1B	Ssm	5	43	11.6%	cbioportal
11	SLC8A1	Ssm	4	43	9.3%	cbioportal
12	SPATA31D1	Ssm	4	43	9.3%	cbioportal
8	FBN2	Ssm	4	43	9.3%	cbioportal
7	DNAH9	Ssm	4	43	9.3%	cbioportal
13	TP53	Ssm	4	43	9.3%	cbioportal
9	MMP16	Ssm	4	43	9.3%	cbioportal
10	RELN	Ssm	4	43	9.3%	cbioportal
19	COL24A1	Ssm	3	43	7%	cbioportal
28	FLNC	Ssm	3	43	7%	cbioportal
27	FAT4	Ssm	3	43	7%	cbioportal
26	FAM47C	Ssm	3	43	7%	cbioportal
25	F9	Ssm	3	43	7%	cbioportal
24	ERBB2	Ssm	3	43	7%	cbioportal
23	DYSF	Ssm	3	43	7%	cbioportal
22	DST	Ssm	3	43	7%	cbioportal
21	DSPP	Ssm	3	43	7%	cbioportal
46	TET2	Ssm	3	43	7%	cbioportal
17	CNTN6	Ssm	3	43	7%	cbioportal
18	COL12A1	Ssm	3	43	7%	cbioportal
14	ABCA6	Ssm	3	43	7%	cbioportal
15	ARHGEF17	Ssm	3	43	7%	cbioportal
16	CLSTN2	Ssm	3	43	7%	cbioportal
45	SULF1	Ssm	3	43	7%	cbioportal
20	CR1	Ssm	3	43	7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Diffuse Large B-cell Lymphoma (BCGSC, Blood 2013) nhl_bcgsc_2013BCGSC

53 cases with simple somatic mutation data · 53 cases total · 2026-01-08 · mapped to Non-Hodgkin Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC16	Ssm	17	53	32.1%	cbioportal
2	MUC4	Ssm	16	53	30.2%	cbioportal
3	TTN	Ssm	12	53	22.6%	cbioportal
5	KMT2D	Ssm	11	53	20.8%	cbioportal
4	EZH2	Ssm	11	53	20.8%	cbioportal
7	RP1L1	Ssm	11	53	20.8%	cbioportal
6	MUC17	Ssm	11	53	20.8%	cbioportal
8	USH2A	Ssm	10	53	18.9%	cbioportal
10	PKD1	Ssm	9	53	17%	cbioportal
9	LRP1B	Ssm	9	53	17%	cbioportal
12	TP53	Ssm	9	53	17%	cbioportal
11	SYNE2	Ssm	9	53	17%	cbioportal
17	MUC5B	Ssm	8	53	15.1%	cbioportal
16	HRNR	Ssm	8	53	15.1%	cbioportal
15	FAT4	Ssm	8	53	15.1%	cbioportal
14	DSEL	Ssm	8	53	15.1%	cbioportal
13	DNAH5	Ssm	8	53	15.1%	cbioportal
19	SYNE1	Ssm	8	53	15.1%	cbioportal
18	PCLO	Ssm	8	53	15.1%	cbioportal
28	ZFHX4	Ssm	7	53	13.2%	cbioportal
25	MPDZ	Ssm	7	53	13.2%	cbioportal
24	GOLGA6L2	Ssm	7	53	13.2%	cbioportal
23	FCGBP	Ssm	7	53	13.2%	cbioportal
22	FBN2	Ssm	7	53	13.2%	cbioportal
21	CARD11	Ssm	7	53	13.2%	cbioportal
20	ADGRV1	Ssm	7	53	13.2%	cbioportal
27	TDRD15	Ssm	7	53	13.2%	cbioportal
26	MYD88	Ssm	7	53	13.2%	cbioportal
30	BCL2	Ssm	6	53	11.3%	cbioportal
29	AGBL1	Ssm	6	53	11.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Diffuse Large B-Cell Lymphoma (Broad, PNAS 2012) dlbc_broad_2012Broad

58 cases with simple somatic mutation data · 58 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PCLO	Ssm	19	58	32.8%	cbioportal
2	BCL2	Ssm	15	58	25.9%	cbioportal
3	CREBBP	Ssm	14	58	24.1%	cbioportal
5	TP53	Ssm	13	58	22.4%	cbioportal
4	FAT4	Ssm	13	58	22.4%	cbioportal
7	PIM1	Ssm	12	58	20.7%	cbioportal
6	KMT2D	Ssm	12	58	20.7%	cbioportal
8	CARD11	Ssm	11	58	19%	cbioportal
9	GNA13	Ssm	9	58	15.5%	cbioportal
10	TENM1	Ssm	9	58	15.5%	cbioportal
17	SGK1	Ssm	8	58	13.8%	cbioportal
11	BTG1	Ssm	8	58	13.8%	cbioportal
12	CSMD3	Ssm	8	58	13.8%	cbioportal
13	H1-4	Ssm	8	58	13.8%	cbioportal
14	MEF2B	Ssm	8	58	13.8%	cbioportal
15	MUC16	Ssm	8	58	13.8%	cbioportal
16	P2RY8	Ssm	8	58	13.8%	cbioportal
18	TNFRSF14	Ssm	8	58	13.8%	cbioportal
22	MYD88	Ssm	7	58	12.1%	cbioportal
19	CD79B	Ssm	7	58	12.1%	cbioportal
20	FAT1	Ssm	7	58	12.1%	cbioportal
21	LRRN3	Ssm	7	58	12.1%	cbioportal
23	UNC5D	Ssm	7	58	12.1%	cbioportal
27	BCR	Ssm	6	58	10.3%	cbioportal
28	BIRC6	Ssm	6	58	10.3%	cbioportal
30	H1-2	Ssm	6	58	10.3%	cbioportal
26	B2M	Ssm	6	58	10.3%	cbioportal
25	ATRX	Ssm	6	58	10.3%	cbioportal
24	ABCA13	Ssm	6	58	10.3%	cbioportal
29	EZH2	Ssm	6	58	10.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Diffuse Large B cell Lymphoma (DFCI, Nat Med 2018) dlbcl_dfci_2018DFCI

135 cases with simple somatic mutation data · 135 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	35	135	25.9%	cbioportal
2	PCLO	Ssm	32	135	23.7%	cbioportal
3	PIM1	Ssm	31	135	23%	cbioportal
4	TP53	Ssm	31	135	23%	cbioportal
5	BCL2	Ssm	30	135	22.2%	cbioportal
6	CREBBP	Ssm	28	135	20.7%	cbioportal
7	BTG1	Ssm	25	135	18.5%	cbioportal
8	MYD88	Ssm	22	135	16.3%	cbioportal
9	CD79B	Ssm	20	135	14.8%	cbioportal
10	FAT4	Ssm	20	135	14.8%	cbioportal
11	SGK1	Ssm	19	135	14.1%	cbioportal
12	CARD11	Ssm	18	135	13.3%	cbioportal
13	TTN	Ssm	18	135	13.3%	cbioportal
14	FAT1	Ssm	17	135	12.6%	cbioportal
15	TNFRSF14	Ssm	17	135	12.6%	cbioportal
18	USH2A	Ssm	16	135	11.9%	cbioportal
16	CSMD3	Ssm	16	135	11.9%	cbioportal
17	H1-2	Ssm	16	135	11.9%	cbioportal
20	ZFP36L1	Ssm	15	135	11.1%	cbioportal
19	ACTB	Ssm	15	135	11.1%	cbioportal
22	LRP1B	Ssm	14	135	10.4%	cbioportal
23	MUC16	Ssm	14	135	10.4%	cbioportal
21	H1-4	Ssm	14	135	10.4%	cbioportal
24	CD70	Ssm	13	135	9.6%	cbioportal
25	SYNE1	Ssm	13	135	9.6%	cbioportal
26	TBL1XR1	Ssm	13	135	9.6%	cbioportal
30	HLA-A	Ssm	12	135	8.9%	cbioportal
27	BCL6	Ssm	12	135	8.9%	cbioportal
28	EBF1	Ssm	12	135	8.9%	cbioportal
29	GNA13	Ssm	12	135	8.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Diffuse Large B-Cell Lymphoma (Duke, Cell 2017) dlbcl_duke_2017Duke

1,001 cases with simple somatic mutation data · 1,001 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	247	1,001	24.7%	cbioportal
2	MYD88	Ssm	172	1,001	17.2%	cbioportal
3	PIM1	Ssm	147	1,001	14.7%	cbioportal
4	CREBBP	Ssm	115	1,001	11.5%	cbioportal
5	H1-4	Ssm	105	1,001	10.5%	cbioportal
6	BCL2	Ssm	101	1,001	10.1%	cbioportal
7	SPEN	Ssm	101	1,001	10.1%	cbioportal
8	ARID1A	Ssm	96	1,001	9.6%	cbioportal
9	TP53	Ssm	93	1,001	9.3%	cbioportal
10	SOCS1	Ssm	92	1,001	9.2%	cbioportal
11	CARD11	Ssm	89	1,001	8.9%	cbioportal
12	ARID1B	Ssm	83	1,001	8.3%	cbioportal
13	GNA13	Ssm	83	1,001	8.3%	cbioportal
14	SETD1B	Ssm	83	1,001	8.3%	cbioportal
15	TNFRSF14	Ssm	79	1,001	7.9%	cbioportal
16	DUSP2	Ssm	76	1,001	7.6%	cbioportal
17	MGA	Ssm	75	1,001	7.5%	cbioportal
18	SMARCA4	Ssm	75	1,001	7.5%	cbioportal
19	NOTCH2	Ssm	73	1,001	7.3%	cbioportal
20	ATM	Ssm	72	1,001	7.2%	cbioportal
21	ZNF608	Ssm	68	1,001	6.8%	cbioportal
22	KLHL6	Ssm	67	1,001	6.7%	cbioportal
23	SGK1	Ssm	67	1,001	6.7%	cbioportal
26	MTOR	Ssm	64	1,001	6.4%	cbioportal
24	BIRC6	Ssm	64	1,001	6.4%	cbioportal
25	IRF8	Ssm	64	1,001	6.4%	cbioportal
27	PIK3CD	Ssm	63	1,001	6.3%	cbioportal
29	TET2	Ssm	62	1,001	6.2%	cbioportal
28	SETD2	Ssm	62	1,001	6.2%	cbioportal
30	EZH2	Ssm	61	1,001	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Diffuse Large B-Cell Lymphoma (MSK, Haematologica 2024) mbn_msk_2024MSK

396 cases with simple somatic mutation data · 396 cases total · 2026-01-08 · mapped to B-Cell Non-Hodgkin Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	125	396	31.6%	cbioportal
2	TP53	Ssm	112	396	28.3%	cbioportal
3	PIM1	Ssm	104	396	26.3%	cbioportal
4	MYD88	Ssm	91	396	23%	cbioportal
5	CREBBP	Ssm	86	396	21.7%	cbioportal
6	TNFRSF14	Ssm	73	396	18.4%	cbioportal
7	H1-4	Ssm	69	396	17.4%	cbioportal
8	BTG1	Ssm	67	396	16.9%	cbioportal
9	SETD1B	Ssm	64	396	16.2%	cbioportal
10	BCL2	Ssm	63	396	15.9%	cbioportal
11	SOCS1	Ssm	62	396	15.7%	cbioportal
12	B2M	Ssm	58	396	14.6%	cbioportal
13	HLA-A	Ssm	55	396	13.9%	cbioportal
14	CD79B	Ssm	54	396	13.6%	cbioportal
15	CARD11	Ssm	50	396	12.6%	cbioportal
16	IRF8	Ssm	48	396	12.1%	cbioportal
17	DTX1	Ssm	47	396	11.9%	cbioportal
18	FAT1	Ssm	44	396	11.1%	cbioportal
20	EZH2	Ssm	43	396	10.9%	cbioportal
19	ARID1A	Ssm	43	396	10.9%	cbioportal
21	TBL1XR1	Ssm	42	396	10.6%	cbioportal
23	TNFAIP3	Ssm	41	396	10.4%	cbioportal
22	EP300	Ssm	41	396	10.4%	cbioportal
24	FAS	Ssm	40	396	10.1%	cbioportal
27	SGK1	Ssm	39	396	9.8%	cbioportal
26	IRF4	Ssm	39	396	9.8%	cbioportal
25	CD58	Ssm	39	396	9.8%	cbioportal
28	GNA13	Ssm	37	396	9.3%	cbioportal
29	H1-2	Ssm	36	396	9.1%	cbioportal
30	CCND3	Ssm	35	396	8.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Diffuse Large B-Cell Lymphoma, NOS (TCGA GDC, 2025) dlbclnos_tcga_gdcTCGA GDC

36 cases with simple somatic mutation data · 48 cases total · 2026-01-13 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	11	36	30.6%	cbioportal
2	BTG2	Ssm	10	36	27.8%	cbioportal
3	CARD11	Ssm	8	36	22.2%	cbioportal
4	PIM1	Ssm	8	36	22.2%	cbioportal
13	PCLO	Ssm	7	36	19.4%	cbioportal
5	B2M	Ssm	7	36	19.4%	cbioportal
12	LRP1B	Ssm	7	36	19.4%	cbioportal
11	IGLC2	Ssm	7	36	19.4%	cbioportal
10	IGHV2-70	Ssm	7	36	19.4%	cbioportal
9	IGHG2	Ssm	7	36	19.4%	cbioportal
8	IGHG1	Ssm	7	36	19.4%	cbioportal
7	H1-4	Ssm	7	36	19.4%	cbioportal
6	FAT4	Ssm	7	36	19.4%	cbioportal
15	IGHM	Ssm	6	36	16.7%	cbioportal
14	H1-2	Ssm	6	36	16.7%	cbioportal
20	SOCS1	Ssm	6	36	16.7%	cbioportal
19	P2RY8	Ssm	6	36	16.7%	cbioportal
18	MUC16	Ssm	6	36	16.7%	cbioportal
17	ITPKB	Ssm	6	36	16.7%	cbioportal
16	IGLV3-1	Ssm	6	36	16.7%	cbioportal
22	BTG1	Ssm	5	36	13.9%	cbioportal
21	ASXL3	Ssm	5	36	13.9%	cbioportal
30	UBR4	Ssm	5	36	13.9%	cbioportal
25	PLCB1	Ssm	5	36	13.9%	cbioportal
24	IRF4	Ssm	5	36	13.9%	cbioportal
23	IGLC3	Ssm	5	36	13.9%	cbioportal
29	TP53	Ssm	5	36	13.9%	cbioportal
28	TMSB4X	Ssm	5	36	13.9%	cbioportal
27	SYNE1	Ssm	5	36	13.9%	cbioportal
26	STAT3	Ssm	5	36	13.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Diffuse Large B-Cell Lymphoma (TCGA, PanCancer Atlas) dlbc_tcga_pan_can_atlas_2018TCGA

41 cases with simple somatic mutation data · 48 cases total · 2026-06-05 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IGHV2-70	Ssm	18	41	43.9%	cbioportal
2	IGLV3-1	Ssm	14	41	34.1%	cbioportal
3	KMT2D	Ssm	12	41	29.3%	cbioportal
4	BTG2	Ssm	10	41	24.4%	cbioportal
5	IGLL5	Ssm	10	41	24.4%	cbioportal
7	IGHV1-69	Ssm	9	41	22%	cbioportal
6	B2M	Ssm	9	41	22%	cbioportal
10	IGHM	Ssm	8	41	19.5%	cbioportal
9	IGHG1	Ssm	8	41	19.5%	cbioportal
8	CARD11	Ssm	8	41	19.5%	cbioportal
11	PIM1	Ssm	8	41	19.5%	cbioportal
15	IGHG2	Ssm	7	41	17.1%	cbioportal
16	IGHV4-34	Ssm	7	41	17.1%	cbioportal
17	LRP1B	Ssm	7	41	17.1%	cbioportal
18	MYD88	Ssm	7	41	17.1%	cbioportal
19	TMSB4X	Ssm	7	41	17.1%	cbioportal
12	FAT4	Ssm	7	41	17.1%	cbioportal
13	H1-2	Ssm	7	41	17.1%	cbioportal
14	H1-4	Ssm	7	41	17.1%	cbioportal
24	ITPKB	Ssm	6	41	14.6%	cbioportal
22	IGLC2	Ssm	6	41	14.6%	cbioportal
21	IGKV1-5	Ssm	6	41	14.6%	cbioportal
23	IRF4	Ssm	6	41	14.6%	cbioportal
25	MUC16	Ssm	6	41	14.6%	cbioportal
26	P2RY8	Ssm	6	41	14.6%	cbioportal
27	PCLO	Ssm	6	41	14.6%	cbioportal
20	IGKJ4	Ssm	6	41	14.6%	cbioportal
28	SOCS1	Ssm	6	41	14.6%	cbioportal
29	STAT3	Ssm	6	41	14.6%	cbioportal
30	ZFHX4	Ssm	6	41	14.6%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

HIV+ Tumor Molecular Characterization Project - Diffuse Large B-Cell Lymphoma CGCI-HTMCP-DLBCLCGCI

50 cases with simple somatic mutation data · 70 cases total · Data Release 46.0 · mapped to Diffuse Large B-Cell Lymphoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TPTE	Ssm	27	50	54%	gdc
4	PRSS1	Ssm	22	50	44%	gdc
3	PRSS2	Ssm	22	50	44%	gdc
2	MTRNR2L6	Ssm	22	50	44%	gdc
5	FOXD4L5	Ssm	21	50	42%	gdc
8	OR11H12	Ssm	20	50	40%	gdc
7	B3GAT1	Ssm	20	50	40%	gdc
6	GLB1L2	Ssm	20	50	40%	gdc
30	FAM243B	Ssm	19

Data updated 22 days agoSource updated Data Release 46.0

Lymphoid Neoplasm Diffuse Large B-cell Lymphoma TCGA-DLBCTCGA

50 cases with simple somatic mutation data · 58 cases total · Data Release 46.0 · mapped to Diffuse Large B-Cell Lymphoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BTG2	Ssm	29	50	58%	gdc
3	TUBB8B	Ssm	23	50	46%	gdc
2	MTRNR2L6	Ssm	23	50	46%	gdc
6	GPR149	Ssm	22	50	44%	gdc
9	DSEL	Ssm	22	50	44%	gdc
8	CSMD1	Ssm	22	50	44%	gdc
7	KLHL6	Ssm	22	50	44%	gdc
4	LAMA1	Ssm	22	50	44%	gdc
5	BCL6	Ssm	22	50	44%	gdc
10	ASPM	Ssm	22	50	44%	gdc
19	BCL2	Ssm	21	50	42%	gdc
28	ADCYAP1	Ssm	21	50	42%	gdc
29	USP14	Ssm	21	50	42%	gdc
30	ASXL3	Ssm	21	50	42%	gdc
22	ENOSF1	Ssm	21	50	42%	gdc
16	COLEC12	Ssm	21	50	42%	gdc
20	YES1	Ssm	21	50	42%	gdc
17	CETN1	Ssm	21	50	42%	gdc
18	TPTE	Ssm	21	50	42%	gdc
11	POTEC	Ssm	21	50	42%	gdc
12	TBL1XR1	Ssm	21	50	42%	gdc
13	KALRN	Ssm	21	50	42%	gdc
14	SALL3	Ssm	21	50	42%	gdc
15	CLUL1	Ssm	21	50	42%	gdc
21	AHR	Ssm	21	50	42%	gdc
23	PRSS2	Ssm	21	50	42%	gdc
24	ABCA13	Ssm	21	50	42%	gdc
25	PRSS1	Ssm	21	50	42%	gdc
26	THOC1	Ssm	21	50	42%	gdc
27	TYMS	Ssm	21	50	42%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (TCGA, Firehose Legacy) dlbc_tcgaTCGA

48 cases with simple somatic mutation data · 48 cases total · 2026-01-07 · mapped to Diffuse Large B-Cell Lymphoma Unclassifiable EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IGLL5	Ssm	17	48	35.4%	cbioportal
2	MUC4	Ssm	15	48	31.3%	cbioportal
4	MUC2	Ssm	14	48	29.2%	cbioportal
3	KMT2D	Ssm	14	48	29.2%	cbioportal
5	B2M	Ssm	13	48	27.1%	cbioportal
6	BTG2	Ssm	13	48	27.1%	cbioportal
7	MUC16	Ssm	11	48	22.9%	cbioportal
8	CARD11	Ssm	10	48	20.8%	cbioportal
10	PIM1	Ssm	10	48	20.8%	cbioportal
9	FAT4	Ssm	10	48	20.8%	cbioportal
12	TTN	Ssm	10	48	20.8%	cbioportal
11	SYNE1	Ssm	10	48	20.8%	cbioportal
13	H1-4	Ssm	9	48	18.8%	cbioportal
14	MUC5B	Ssm	9	48	18.8%	cbioportal
16	P2RY8	Ssm	8	48	16.7%	cbioportal
17	PCLO	Ssm	8	48	16.7%	cbioportal
15	CSMD3	Ssm	8	48	16.7%	cbioportal
21	FAT1	Ssm	7	48	14.6%	cbioportal
22	H1-2	Ssm	7	48	14.6%	cbioportal
23	HLA-C	Ssm	7	48	14.6%	cbioportal
24	KLHL6	Ssm	7	48	14.6%	cbioportal
25	LRP1B	Ssm	7	48	14.6%	cbioportal
26	LRP2	Ssm	7	48	14.6%	cbioportal
27	MUC17	Ssm	7	48	14.6%	cbioportal
28	MYD88	Ssm	7	48	14.6%	cbioportal
29	OBSCN	Ssm	7	48	14.6%	cbioportal
30	RHPN2	Ssm	7	48	14.6%	cbioportal
19	BTG1	Ssm	7	48	14.6%	cbioportal
18	ATM	Ssm	7	48	14.6%	cbioportal
20	DMBT1	Ssm	7	48	14.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Mantle Cell Lymphoma (IDIBIPS, PNAS 2013) mcl_idibips_2013IDIBIPS

29 cases with simple somatic mutation data · 29 cases total · 2026-01-08 · mapped to Mantle Cell Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ATM	Ssm	12	29	41.4%	cbioportal
2	CCND1	Ssm	10	29	34.5%	cbioportal
3	TP53	Ssm	6	29	20.7%	cbioportal
5	NSD2	Ssm	4	29	13.8%	cbioportal
4	KMT2D	Ssm	4	29	13.8%	cbioportal
25	TNRC6B	Ssm	2	29	6.9%	cbioportal
13	DNAJC6	Ssm	2	29	6.9%	cbioportal
12	DLGAP2	Ssm	2	29	6.9%	cbioportal
11	DCP1B	Ssm	2	29	6.9%	cbioportal
10	CSMD2	Ssm	2	29	6.9%	cbioportal
9	CRYBG3	Ssm	2	29	6.9%	cbioportal
8	CHMP4C	Ssm	2	29	6.9%	cbioportal
7	BIRC3	Ssm	2	29	6.9%	cbioportal
6	ABCC9	Ssm	2	29	6.9%	cbioportal
29	UNC80	Ssm	2	29	6.9%	cbioportal
28	UBR5	Ssm	2	29	6.9%	cbioportal
27	TTN	Ssm	2	29	6.9%	cbioportal
26	TRPM6	Ssm	2	29	6.9%	cbioportal
24	TLR2	Ssm	2	29	6.9%	cbioportal
23	TAS2R41	Ssm	2	29	6.9%	cbioportal
22	SYNE1	Ssm	2	29	6.9%	cbioportal
21	SP140	Ssm	2	29	6.9%	cbioportal
20	SLC17A6	Ssm	2	29	6.9%	cbioportal
19	RGS4	Ssm	2	29	6.9%	cbioportal
18	PCSK2	Ssm	2	29	6.9%	cbioportal
17	MEF2B	Ssm	2	29	6.9%	cbioportal
16	LUZP4	Ssm	2	29	6.9%	cbioportal
15	KIAA1671	Ssm	2	29	6.9%	cbioportal
14	FLNC	Ssm	2	29	6.9%	cbioportal
65	AZU1	Ssm	1	29	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Mature B-cell malignancies (MD Anderson Cancer Center) mbn_mdacc_2013MD Anderson Cancer Center

755 cases with simple somatic mutation data · 760 cases total · 2026-01-08 · mapped to B-Cell Non-Hodgkin Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	247	755	32.7%	cbioportal
2	CREBBP	Ssm	180	755	23.8%	cbioportal
3	BCL2	Ssm	153	755	20.3%	cbioportal
4	NEB	Ssm	123	755	16.3%	cbioportal
5	ATM	Ssm	116	755	15.4%	cbioportal
6	LRP1B	Ssm	96	755	12.7%	cbioportal
7	TP53	Ssm	91	755	12.1%	cbioportal
8	MYC	Ssm	82	755	10.9%	cbioportal
9	ARID1A	Ssm	80	755	10.6%	cbioportal
10	HERC2	Ssm	78	755	10.3%	cbioportal
11	TNFRSF14	Ssm	77	755	10.2%	cbioportal
12	CSMD1	Ssm	70	755	9.3%	cbioportal
13	CSMD3	Ssm	69	755	9.1%	cbioportal
14	PIM1	Ssm	66	755	8.7%	cbioportal
15	FAT1	Ssm	65	755	8.6%	cbioportal
16	EZH2	Ssm	64	755	8.5%	cbioportal
17	RYR2	Ssm	64	755	8.5%	cbioportal
18	PIEZO1	Ssm	63	755	8.3%	cbioportal
19	CARD11	Ssm	62	755	8.2%	cbioportal
20	IGLV5-45	Ssm	58	755	7.7%	cbioportal
21	CCND3	Ssm	56	755	7.4%	cbioportal
22	EP300	Ssm	56	755	7.4%	cbioportal
23	HMCN1	Ssm	56	755	7.4%	cbioportal
24	SMARCA4	Ssm	55	755	7.3%	cbioportal
25	HYDIN	Ssm	54	755	7.2%	cbioportal
26	RYR3	Ssm	54	755	7.2%	cbioportal
27	DCHS2	Ssm	53	755	7%	cbioportal
28	DST	Ssm	53	755	7%	cbioportal
29	BCL7A	Ssm	52	755	6.9%	cbioportal
30	EPPK1	Ssm	52	755	6.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Mature B-Cell Neoplasms (Simon Fraser University, Blood 2023) mbn_sfu_2023Simon Fraser University

297 cases with simple somatic mutation data · 297 cases total · 2026-02-10 · mapped to B-Cell Non-Hodgkin Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MYC	Ssm	156	297	52.5%	cbioportal
2	DDX3X	Ssm	124	297	41.8%	cbioportal
3	ID3	Ssm	115	297	38.7%	cbioportal
4	TP53	Ssm	110	297	37%	cbioportal
5	ARID1A	Ssm	95	297	32%	cbioportal
6	FOXO1	Ssm	72	297	24.2%	cbioportal
7	IGLL5	Ssm	71	297	23.9%	cbioportal
8	CNTNAP3B	Ssm	70	297	23.6%	cbioportal
9	CCND3	Ssm	68	297	22.9%	cbioportal
10	IGLV3-1	Ssm	60	297	20.2%	cbioportal
11	GNA13	Ssm	57	297	19.2%	cbioportal
12	GARIN4	Ssm	55	297	18.5%	cbioportal
13	FBXO11	Ssm	53	297	17.8%	cbioportal
14	TTN	Ssm	52	297	17.5%	cbioportal
15	GP6	Ssm	49	297	16.5%	cbioportal
16	AKAP10	Ssm	47	297	15.8%	cbioportal
17	MAP3K9	Ssm	47	297	15.8%	cbioportal
18	IGHV2-70D	Ssm	43	297	14.5%	cbioportal
23	ZNF701	Ssm	42	297	14.1%	cbioportal
21	SMPD1	Ssm	42	297	14.1%	cbioportal
20	SMARCA4	Ssm	42	297	14.1%	cbioportal
19	FRG2C	Ssm	42	297	14.1%	cbioportal
22	SPATA31A6	Ssm	42	297	14.1%	cbioportal
24	IGHV2-70	Ssm	41	297	13.8%	cbioportal
25	L1TD1	Ssm	41	297	13.8%	cbioportal
26	IGLV4-60	Ssm	39	297	13.1%	cbioportal
27	MUC16	Ssm	39	297	13.1%	cbioportal
28	LRRC4B	Ssm	38	297	12.8%	cbioportal
29	MPEG1	Ssm	38	297	12.8%	cbioportal
30	FAT4	Ssm	37	297	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-10

Mature T and NK Neoplasms (MSK, Blood Adv 2023) mtnn_msk_2022MSK

132 cases with simple somatic mutation data · 132 cases total · 2026-01-08 · mapped to T-Cell Non-Hodgkin Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TET2	Ssm	68	132	51.5%	cbioportal
2	RHOA	Ssm	40	131	30.5%	cbioportal
3	DNMT3A	Ssm	25	132	18.9%	cbioportal
4	TP53	Ssm	21	132	15.9%	cbioportal
5	IDH2	Ssm	15	132	11.4%	cbioportal
8	PLCG1	Ssm	8	102	7.8%	cbioportal
7	STAT3	Ssm	10	131	7.6%	cbioportal
6	FAT1	Ssm	10	131	7.6%	cbioportal
9	SETD2	Ssm	8	131	6.1%	cbioportal
10	FAS	Ssm	6	102	5.9%	cbioportal
12	POT1	Ssm	6	102	5.9%	cbioportal
16	VAV1	Ssm	5	102	4.9%	cbioportal
14	KSR2	Ssm	5	102	4.9%	cbioportal
11	KMT2D	Ssm	6	131	4.6%	cbioportal
20	DDX3X	Ssm	4	102	3.9%	cbioportal
29	TET3	Ssm	4	102	3.9%	cbioportal
27	ROBO1	Ssm	4	102	3.9%	cbioportal
15	STAT5B	Ssm	5	131	3.8%	cbioportal
13	JAK1	Ssm	5	132	3.8%	cbioportal
192	RIT1	Ssm	1	29	3.4%	cbioportal
158	LATS2	Ssm	1	29	3.4%	cbioportal
131	ERCC2	Ssm	1	29	3.4%	cbioportal
186	PTPRS	Ssm	1	29	3.4%	cbioportal
187	PTPRT	Ssm	1	29	3.4%	cbioportal
148	H3-4	Ssm	1	29	3.4%	cbioportal
168	NCOA3	Ssm	1	29	3.4%	cbioportal
26	RARA	Ssm	4	131	3.1%	cbioportal
23	HLA-A	Ssm	4	131	3.1%	cbioportal
17	ARID2	Ssm	4	131	3.1%	cbioportal
21	EPHA3	Ssm	4	131	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Multiple Myeloma (Broad, Cancer Cell 2014) mm_broadBroad

205 cases with simple somatic mutation data · 211 cases total · 2026-01-08 · mapped to Multiple Myeloma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	45	205	22%	cbioportal
2	NRAS	Ssm	37	205	18%	cbioportal
3	DIS3	Ssm	19	205	9.3%	cbioportal
5	ZNF717	Ssm	17	205	8.3%	cbioportal
4	TTN	Ssm	17	205	8.3%	cbioportal
7	TP53	Ssm	15	205	7.3%	cbioportal
6	TENT5C	Ssm	15	205	7.3%	cbioportal
8	BRAF	Ssm	13	205	6.3%	cbioportal
9	MUC16	Ssm	13	205	6.3%	cbioportal
11	RYR2	Ssm	11	205	5.4%	cbioportal
10	LRP1B	Ssm	11	205	5.4%	cbioportal
12	FAT3	Ssm	10	205	4.9%	cbioportal
17	TRIO	Ssm	9	205	4.4%	cbioportal
13	DNAH5	Ssm	9	205	4.4%	cbioportal
14	DNAH9	Ssm	9	205	4.4%	cbioportal
15	HYDIN	Ssm	9	205	4.4%	cbioportal
16	NEB	Ssm	9	205	4.4%	cbioportal
21	SVIL	Ssm	8	205	3.9%	cbioportal
18	CSMD2	Ssm	8	205	3.9%	cbioportal
19	GRIA2	Ssm	8	205	3.9%	cbioportal
20	KALRN	Ssm	8	205	3.9%	cbioportal
26	EGR1	Ssm	7	205	3.4%	cbioportal
22	ADAMTS9	Ssm	7	205	3.4%	cbioportal
23	CCND1	Ssm	7	205	3.4%	cbioportal
24	CHD3	Ssm	7	205	3.4%	cbioportal
30	SI	Ssm	7	205	3.4%	cbioportal
29	NRXN1	Ssm	7	205	3.4%	cbioportal
28	HMCN1	Ssm	7	205	3.4%	cbioportal
27	FBN2	Ssm	7	205	3.4%	cbioportal
25	COL21A1	Ssm	7	205	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Multiple Myeloma CoMMpass Study MMRF-COMMPASSMMRF

961 cases with simple somatic mutation data · 995 cases total · Data Release 46.0 · mapped to Multiple Myeloma CURATED_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IGHV2-70	Ssm	437	961	45.5%	gdc
2	IGLV3-1	Ssm	364	961	37.9%	gdc
3	IGHV2-70D	Ssm	238	961	24.8%	gdc
4	KRAS	Ssm	227	961	23.6%	gdc
5	BCL7A	Ssm	212	961	22.1%	gdc
6	IGLL5	Ssm	211	961	22%	gdc
7	LTB	Ssm	186	961	19.4%	gdc
8	NRAS	Ssm	183	961	19%	gdc
9	TTN	Ssm	181	961	18.8%	gdc
10	MIR5195	Ssm	143	961	14.9%	gdc
11	TENT5C	Ssm	115	961	12%	gdc
12	IGHV1-69D	Ssm	115	961	12%	gdc
13	MUC16	Ssm	102	961	10.6%	gdc
14	BMP6	Ssm	100	961	10.4%	gdc
15	IGKV4-1	Ssm	99	961	10.3%	gdc
16	DIS3	Ssm	97	961	10.1%	gdc
17	TMSB4X	Ssm	97	961	10.1%	gdc
18	TRAF3	Ssm	86	961	8.9%	gdc
20	FAT4	Ssm	84	961	8.7%	gdc
19	CSMD3	Ssm	84	961	8.7%	gdc
21	RYR2	Ssm	81	961	8.4%	gdc
22	PCDH15	Ssm	79	961	8.2%	gdc
23	FAT3	Ssm	78	961	8.1%	gdc
24	PCLO	Ssm	76	961	7.9%	gdc
25	NRXN1	Ssm	75	961	7.8%	gdc
26	LRP1B	Ssm	73	961	7.6%	gdc
27	USH2A	Ssm	71	961	7.4%	gdc
28	IGLV4-60	Ssm	71	961	7.4%	gdc
29	DUSP2	Ssm	70	961	7.3%	gdc
30	BRAF	Ssm	69	961	7.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Non-Hodgkin Lymphoma (BCGSC, Nature 2011) nhl_bcgsc_2011BCGSC

14 cases with simple somatic mutation data · 14 cases total · 2026-01-08 · mapped to Non-Hodgkin Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	EZH2	Ssm	4	14	28.6%	cbioportal
2	CMYA5	Ssm	3	14	21.4%	cbioportal
4	WDFY3	Ssm	3	14	21.4%	cbioportal
3	CNTNAP5	Ssm	3	14	21.4%	cbioportal
26	SEMA5A	Ssm	2	14	14.3%	cbioportal
27	SGK1	Ssm	2	14	14.3%	cbioportal
28	SPEF2	Ssm	2	14	14.3%	cbioportal
29	SPTBN5	Ssm	2	14	14.3%	cbioportal
31	SUSD4	Ssm	2	14	14.3%	cbioportal
17	IRF8	Ssm	2	14	14.3%	cbioportal
23	MPDZ	Ssm	2	14	14.3%	cbioportal
22	MEF2B	Ssm	2	14	14.3%	cbioportal
5	CARD11	Ssm	2	14	14.3%	cbioportal
6	CFAP43	Ssm	2	14	14.3%	cbioportal
7	CREBBP	Ssm	2	14	14.3%	cbioportal
8	CTNND2	Ssm	2	14	14.3%	cbioportal
9	CXCR5	Ssm	2	14	14.3%	cbioportal
10	DSEL	Ssm	2	14	14.3%	cbioportal
11	DSG4	Ssm	2	14	14.3%	cbioportal
12	FAS	Ssm	2	14	14.3%	cbioportal
13	FAT2	Ssm	2	14	14.3%	cbioportal
14	H1-2	Ssm	2	14	14.3%	cbioportal
15	H2AC6	Ssm	2	14	14.3%	cbioportal
16	H2BC5	Ssm	2	14	14.3%	cbioportal
21	MAGEB18	Ssm	2	14	14.3%	cbioportal
20	LINC02915	Ssm	2	14	14.3%	cbioportal
19	KMT2D	Ssm	2	14	14.3%	cbioportal
18	ITPR2	Ssm	2	14	14.3%	cbioportal
24	MUC16	Ssm	2	14	14.3%	cbioportal
25	P2RY8	Ssm	2	14	14.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Pediatric Acute Lymphoid Leukemia - Phase II (TARGET, 2018) all_phase2_target_2018_pubTARGET

150 cases with simple somatic mutation data · 1,978 cases total · 2026-01-05 · mapped to B Lymphoblastic Leukemia/Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NRAS	Ssm	16	150	10.7%	cbioportal
2	KRAS	Ssm	8	150	5.3%	cbioportal
3	CREBBP	Ssm	6	150	4%	cbioportal
5	TP53	Ssm	6	150	4%	cbioportal
4	PTPN11	Ssm	6	150	4%	cbioportal
8	NSD2	Ssm	5	150	3.3%	cbioportal
7	JAK2	Ssm	5	150	3.3%	cbioportal
6	FLT3	Ssm	5	150	3.3%	cbioportal
10	NOTCH2	Ssm	4	150	2.7%	cbioportal
9	CDK11A	Ssm	4	150	2.7%	cbioportal
16	TAS2R19	Ssm	3	150	2%	cbioportal
11	DOT1L	Ssm	3	150	2%	cbioportal
15	QRICH2	Ssm	3	150	2%	cbioportal
14	OVGP1	Ssm	3	150	2%	cbioportal
13	KMT2D	Ssm	3	150	2%	cbioportal
12	HLA-C	Ssm	3	150	2%	cbioportal
17	APOE	Ssm	2	150	1.3%	cbioportal
29	HDHD5	Ssm	2	150	1.3%	cbioportal
27	GCNA	Ssm	2	150	1.3%	cbioportal
26	FURIN	Ssm	2	150	1.3%	cbioportal
25	FHL3	Ssm	2	150	1.3%	cbioportal
24	FCGBP	Ssm	2	150	1.3%	cbioportal
23	EZH2	Ssm	2	150	1.3%	cbioportal
22	ELL	Ssm	2	150	1.3%	cbioportal
21	ECPAS	Ssm	2	150	1.3%	cbioportal
20	CEP162	Ssm	2	150	1.3%	cbioportal
19	CCDC186	Ssm	2	150	1.3%	cbioportal
18	ATF7IP	Ssm	2	150	1.3%	cbioportal
28	GNB1	Ssm	2	150	1.3%	cbioportal
30	HLA-DRB1	Ssm	2	150	1.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Primary Central Nervous System Lymphoma (Mayo Clinic, Clin Cancer Res 2015) pcnsl_mayo_2015Mayo Clinic

10 cases with simple somatic mutation data · 19 cases total · 2026-01-12 · mapped to Primary Central Nervous System Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MYD88	Ssm	7	10	70%	cbioportal
5	SMG5	Ssm	4	10	40%	cbioportal
2	CD79B	Ssm	4	10	40%	cbioportal
3	DLGAP2	Ssm	4	10	40%	cbioportal
4	PIM1	Ssm	4	10	40%	cbioportal
11	KLHL14	Ssm	3	10	30%	cbioportal
10	FAT4	Ssm	3	10	30%	cbioportal
9	DST	Ssm	3	10	30%	cbioportal
8	DSG4	Ssm	3	10	30%	cbioportal
7	CARD11	Ssm	3	10	30%	cbioportal
6	BTG2	Ssm	3	10	30%	cbioportal
15	TENM1	Ssm	3	10	30%	cbioportal
14	TCL1A	Ssm	3	10	30%	cbioportal
13	PRR12	Ssm	3	10	30%	cbioportal
12	LRP1B	Ssm	3	10	30%	cbioportal
29	CHPF2	Ssm	2	10	20%	cbioportal
30	CNTNAP5	Ssm	2	10	20%	cbioportal
19	APBA1	Ssm	2	10	20%	cbioportal
20	ARAF	Ssm	2	10	20%	cbioportal
21	BCL2	Ssm	2	10	20%	cbioportal
22	BSN	Ssm	2	10	20%	cbioportal
23	BTG1	Ssm	2	10	20%	cbioportal
24	C10ORF71	Ssm	2	10	20%	cbioportal
25	CCDC7	Ssm	2	10	20%	cbioportal
26	CDKN1B	Ssm	2	10	20%	cbioportal
27	CEP295	Ssm	2	10	20%	cbioportal
28	CFAP47	Ssm	2	10	20%	cbioportal
16	A2ML1	Ssm	2	10	20%	cbioportal
17	AHNAK	Ssm	2	10	20%	cbioportal
18	ANGPTL6	Ssm	2	10	20%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Primary CNS Lymphoma (MSK, Clin Cancer Res 2024) pcnsl_msk_2024MSK

86 cases with simple somatic mutation data · 86 cases total · 2026-01-12 · mapped to Primary Central Nervous System Lymphoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MYD88	Ssm	37	86	43%	cbioportal
2	PIM1	Ssm	33	86	38.4%	cbioportal
4	KMT2D	Ssm	20	86	23.3%	cbioportal
3	CD79B	Ssm	20	86	23.3%	cbioportal
5	DTX1	Ssm	18	86	20.9%	cbioportal
6	H1-4	Ssm	16	86	18.6%	cbioportal
7	BTG2	Ssm	15	86	17.4%	cbioportal
10	TBL1XR1	Ssm	14	86	16.3%	cbioportal
8	BTG1	Ssm	14	86	16.3%	cbioportal
9	ETV6	Ssm	14	86	16.3%	cbioportal
11	HLA-A	Ssm	13	86	15.1%	cbioportal
12	SETD1B	Ssm	12	86	14%	cbioportal
13	GNA13	Ssm	11	86	12.8%	cbioportal
14	SOCS1	Ssm	10	86	11.6%	cbioportal
16	CARD11	Ssm	9	86	10.5%	cbioportal
15	B2M	Ssm	9	86	10.5%	cbioportal
17	IRF4	Ssm	9	86	10.5%	cbioportal
18	MPEG1	Ssm	9	86	10.5%	cbioportal
20	H1-2	Ssm	8	86	9.3%	cbioportal
19	CREBBP	Ssm	8	86	9.3%	cbioportal
22	CXCR4	Ssm	7	86	8.1%	cbioportal
21	CCND3	Ssm	7	86	8.1%	cbioportal
29	TP53	Ssm	7	86	8.1%	cbioportal
28	PHOX2B	Ssm	7	86	8.1%	cbioportal
27	PCLO	Ssm	7	86	8.1%	cbioportal
26	PCBP1	Ssm	7	86	8.1%	cbioportal
25	LTB	Ssm	7	86	8.1%	cbioportal
24	KMT2C	Ssm	7	86	8.1%	cbioportal
23	FAT1	Ssm	7	86	8.1%	cbioportal
30	CD70	Ssm	6	86	7%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Refractory Cancers (RC) - Peripheral T-Cell Lymphoma (PTCL) RC-PTCLRC

58 cases with simple somatic mutation data · 58 cases total · Data Release 46.0 · mapped to Peripheral T-Cell Lymphoma, Not Otherwise Specified ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PRSS1	Ssm	42	58	72.4%	gdc
2	PRSS2	Ssm	41	58	70.7%	gdc
3	MTRNR2L6	Ssm	38	58	65.5%	gdc
4	POTEM	Ssm	20	58	34.5%	gdc
5	OR11H12	Ssm	20	58	34.5%	gdc
7	C8orf33	Ssm	18	58	31%	gdc
6	TPTE	Ssm	18	58	31%	gdc
14	POTEH	Ssm	17	58	29.3%	gdc
8	GIMAP2	Ssm	17	58	29.3%	gdc
9	ACTR3C	Ssm	17	58	29.3%	gdc
10	GIMAP7	Ssm	17	58	29.3%	gdc
11	GIMAP4	Ssm	17	58	29.3%	gdc
12	POTEG	Ssm	17	58	29.3%	gdc
13	GIMAP6	Ssm	17	58	29.3%	gdc
29	AC135068.4	Ssm	16	58	27.6%	gdc
30	REPIN1	Ssm	16	58	27.6%	gdc
28	FAM86B2	Ssm	16	58	27.6%	gdc
27	SPATA31A7	Ssm	16	58	27.6%	gdc
26	GIMAP8	Ssm	16	58	27.6%	gdc
25	AC135068.1	Ssm	16	58	27.6%	gdc
24	POTEB3	Ssm	16	58	27.6%	gdc
23	OR4M2	Ssm	16	58	27.6%	gdc
22	DPP6	Ssm	16	58	27.6%	gdc
21	OR4N4	Ssm	16	58	27.6%	gdc
20	AC073111.3	Ssm	16	58	27.6%	gdc
19	RARRES2	Ssm	16	58	27.6%	gdc
18	SPATA31A5	Ssm	16	58	27.6%	gdc
17	AL391987.1	Ssm	16	58	27.6%	gdc
16	CNTNAP3C	Ssm	16	58	27.6%	gdc
15	ZBED6CL	Ssm	16	58	27.6%	gdc

Data updated 22 days agoSource updated Data Release 46.0