SOCS1

suppressor of cytokine signaling 1

Explore in graph →CI-GENE-00033278HGNC:19383 ENSG00000185338 NCBI 8651 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SOCS1 Mutation1
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11986 The authors found that approximately 25% of diffuse large B-cell lymphoma and follicular lymphomas had SOCS1 mutations and they concluded these were likely caused by aberrant somatic hypermutation PMID 19734449 · Mottok et al., 2009 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (21)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved21 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Classical Hodgkins Lymphoma (SCCC, Blood Cancer Discov 2023) chl_sccc_2023	Classic Hodgkin Lymphoma	Ssm	38

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.