Gene

STAT6

signal transducer and activator of transcription 6

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
STAT6 Fusion1
(diagnostic)	Hemangiopericytoma	Diagnostic	C	Supports Positive	2	submitted	EID7504 Presence of NAB2::STAT6 fusion may supports diagnosis of Hemangiopericytoma (HPC) and Meningeal solitary fibrous tumor (SFT). For 30 meningeal-based tumors originally diagnosed as either SFT or HPC, … (full text at CIViC) PMID 26883114 · Fritchie et al., 2016 · Open in CIViC	civic
STAT6 Mutation1
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11989 The authors analyzed exome data from 38 relapsed DLBCLs and 138 diagnostic DLBCLs and identified genes enriched for mutations in the former relative to the latter.

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved10 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Adrenocortical Carcinoma TCGA-ACC	Adrenal Cortical CarcinomaALIAS

Literature

Data not yet available

No publication linked to this gene yet.