Gene
VAV1
vav guanine nucleotide exchange factor 1
Explore in graph →CI-GENE-00038309HGNC:12657 ENSG00000141968 NCBI 7409 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (5)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 22561520
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Cholangiocarcinoma (National University of Singapore, Nat Genet 2012) chol_nus_2012 | Cholangiocarcinoma | Ssm | 1 | 8 | 12.5% | 175 | cbioportal |
| Stomach Adenocarcinoma (U Tokyo, Nat Genet 2014) stad_utokyo | Gastric Adenocarcinoma | Ssm | 2 | 30 | 6.7% | 156 | cbioportal |
| Prostate Cancer Brain Metastases (Bern, Nat Commun. 2022) prostate_pcbm_swiss_2019 | unmapped | Ssm | 11 | 168 | 6.5% | 174 | cbioportal |
| Mature T and NK Neoplasms (MSK, Blood Adv 2023) mtnn_msk_2022 | T-Cell Non-Hodgkin Lymphoma | Ssm | 5 | 102 | 4.9% | 16 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.