Gene

P2RY8

P2Y receptor family member 8

Explore in graph →CI-GENE-00018709HGNC:15524 ENSG00000182162 NCBI 286530 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
P2RY8 mutation2
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11973 This study performed exome sequencing on 55 DLBCL tumor samples and identified several significantly mutated genes including. PMID 22343534 · Lohr et al., 2012 · Open in CIViC	civic
〃	Burkitt Lymphoma	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11834 Mutations in this gene are common in BL according to several studies PMID 25274307 · Muppidi et al., 2014 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (13)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved13 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Diffuse Large B-Cell Lymphoma, NOS (TCGA GDC, 2025) dlbclnos_tcga_gdc	Diffuse Large B-Cell Lymphoma Unclassifiable	Ssm	6	36	16.7%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.