Gene

MEF2B

myocyte enhancer factor 2B

Explore in graph →CI-GENE-00012348HGNC:6995 ENSG00000213999 NCBI 100271849 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MEF2B mutation2
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11919 Multiple studies have demonstrated an enrichment for somatic missense mutations in MEF2B including multiple hot spots. PMID 21796119 · Morin et al., 2011 · Open in CIViC	civic
〃	Mantle Cell Lymphoma	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11872 [the study] identified 25 significantly mutated genes, including known drivers such as ataxia-telangectasia mutated (ATM), cyclin D1 (CCND1), and the tumor suppressor TP53; mutated genes encoding the … (full text at CIViC) PMID 24145436 · Beà et al., 2013 · Open in CIViC

Cohorts

Alteration frequency by cohort (43)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved43 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Primary Central Nervous System Lymphoma (Mayo Clinic, Clin Cancer Res 2015) pcnsl_mayo_2015	Primary Central Nervous System Lymphoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.