IRF8

interferon regulatory factor 8

Explore in graph →CI-GENE-00006332HGNC:5358 ENSG00000140968 NCBI 3394 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
IRF8 Mutation1
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11920 mutated genes in follicular and diffuse large B-cell lymphoma. They reported 30 genes that had significant evidence for recurrent mutation and positive selective pressure (Table 1). This is one of tho… (full text at CIViC) PMID 21796119 · Morin et al., 2011 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (16)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved16 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Non-Hodgkin Lymphoma (BCGSC, Nature 2011) nhl_bcgsc_2011	Non-Hodgkin Lymphoma	Ssm	2	14

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.