Gene

BIRC3

baculoviral IAP repeat containing 3

Explore in graph →CI-GENE-00021826HGNC:591 ENSG00000023445 NCBI 330 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BIRC3 mutation1
(oncogenic)	Mantle Cell Lymphoma	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11843 BIRC3 mutations have been described in MCL in multiple studies PMID 32160292 · Pararajalingam et al., 2020 · Open in CIViC	civic
BIRC3 TRUNCATING MUTATION1
(prognostic)	Chronic Lymphocytic Leukemia	Prognostic	B	Supports Poor Outcome	2	accepted	EID1488 BIRC3 mutations were identified in 23 of 919 screened CLLs. They are strongly linked to non-mutated IGHV genes (18/23, P = 0.0001), a widely recognized prognostic signature for poor outcome. PMID 24943832 · Baliakas et al., 2015 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (36)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved36 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cutaneous Squamous Cell Carcinoma (DFCI, Clin Cancer Res 2015) cscc_dfarber_2015	Skin Squamous Cell Carcinoma	Ssm	4

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Recurrent mutations refine prognosis in chronic lymphocytic leukemia.
· Leukemia · 2015 · PMID 24943832 · validated civic_curation pubmed