Gene

RIT1

Ras like without CAAX 1

Explore in graph →CI-GENE-00023598HGNC:10023 ENSG00000143622 NCBI 6016 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (14)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–14 of 14 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RIT1 A77P2
(oncogenic)	Lung Adenocarcinoma	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9830 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 A77P was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 A… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	2	submitted	EID9832 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 A77P-transduced PC6 lung cancer cells showed activation o… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC

Cohorts

Alteration frequency by cohort (22)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved22 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Liver Hepatocellular Carcinoma TCGA-LIHC	Hepatocellular Carcinoma	Ssm

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Elevated expression of RIT1 correlates with poor prognosis in endometrial cancer.
· Int J Clin Exp Pathol · 2015 · PMID 26617739 · validated civic_curation pubmed
Oncogenic RIT1 mutations in lung adenocarcinoma.
· Oncogene · 2014 · PMID 24469055 · validated civic_curation pubmed

RIT1 A77S2
(oncogenic)	Lung Adenocarcinoma	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9831 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 A77S was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 A… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	2	submitted	EID9833 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 A77S-transduced PC6 lung cancer cells showed activation o… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic

RIT1 A77S2

(oncogenic)

Lung Adenocarcinoma

Oncogenic

Supports Oncogenicity

submitted

EID9831

RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 A77S was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 A… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic

(functional)

—UNRESOLVED

Functional

Supports Gain Of Function

submitted

EID9833

RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 A77S-transduced PC6 lung cancer cells showed activation o… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic

RIT1 F82L2
(oncogenic)	Lung Adenocarcinoma	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9834 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 F82L was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 F… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	2	submitted	EID9835 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 F82L-transduced PC6 lung cancer cells showed activation o… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic

RIT1 F82L2

(oncogenic)

Lung Adenocarcinoma

Oncogenic

Supports Oncogenicity

submitted

EID9834

RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 F82L was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 F… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic

(functional)

—UNRESOLVED

Functional

Supports Gain Of Function

submitted

EID9835

RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 F82L-transduced PC6 lung cancer cells showed activation o… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic

RIT1 M90I2
(oncogenic)	Lung Adenocarcinoma	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9825 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 M90I was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 M… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	3	submitted	EID9826 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from NCI-H2110 with endogenous RIT1 M90I and RIT1-transduced PC6 lu… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic

RIT1 M90I2

(oncogenic)

Lung Adenocarcinoma

Oncogenic

Supports Oncogenicity

submitted

EID9825

RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 M90I was expressed in NIH3T3 cells and induced colony formation in soft agar. Similarly, RIT1 M… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic

(functional)

—UNRESOLVED

Functional

Supports Gain Of Function

submitted

EID9826

RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from NCI-H2110 with endogenous RIT1 M90I and RIT1-transduced PC6 lu… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic

RIT1 Mutation1
Pictilisib + SelumetinibSubstitutes	Lung Adenocarcinoma	Predictive	D	Supports Sensitivity Response	3	accepted	EID742 RIT1 mutations were identified in approx. 2% of lung adenocarcinomas (5/87 in the "oncogene negative" samples of TCGA - no RIT1 mutations were observed in 143 samples with a known driver mutation). GD… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic

RIT1 Mutation1

Pictilisib + SelumetinibSubstitutes

Lung Adenocarcinoma

Predictive

Supports Sensitivity Response

accepted

EID742

RIT1 mutations were identified in approx. 2% of lung adenocarcinomas (5/87 in the "oncogene negative" samples of TCGA - no RIT1 mutations were observed in 143 samples with a known driver mutation). GD… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic

NF1 Mutation + RIT1 MutationRIT1 NF11
(diagnostic)	Lung Adenocarcinoma	Diagnostic	B	Supports Positive	5	submitted	EID11373 This study contained 230 patients with untreated lung adenocarcinoma. Whole-exome sequencing of tumor cells yielded that RTK/RAS/RAF based mutations to be 62%. However, analysis shows that NF1 mutatio… (full text at CIViC) PMID 25079552 · 2014, Nature · Open in CIViC	civic

NF1 Mutation + RIT1 MutationRIT1 NF11

(diagnostic)

Lung Adenocarcinoma

Diagnostic

Supports Positive

submitted

EID11373

This study contained 230 patients with untreated lung adenocarcinoma. Whole-exome sequencing of tumor cells yielded that RTK/RAS/RAF based mutations to be 62%. However, analysis shows that NF1 mutatio… (full text at CIViC)

PMID 25079552 · 2014, Nature · Open in CIViC

civic

RIT1 OVEREXPRESSION1
(prognostic)	Malignant Endometrial NeoplasmCURATED_BROADER	Prognostic	B	Supports Poor Outcome	3	accepted	EID741 After preliminary studies in cell lines, GEO datasets and fresh frozen tissues, RIT1 expression was determined in 257 tumors and 31 normal tissues. Elevated expression of RIT1 was correlated with poor… (full text at CIViC) PMID 26617739 · Xu et al., 2015 · Open in CIViC	civic

RIT1 OVEREXPRESSION1

(prognostic)

Malignant Endometrial NeoplasmCURATED_BROADER

Prognostic

Supports Poor Outcome

accepted

EID741

After preliminary studies in cell lines, GEO datasets and fresh frozen tissues, RIT1 expression was determined in 257 tumors and 31 normal tissues. Elevated expression of RIT1 was correlated with poor… (full text at CIViC)

PMID 26617739 · Xu et al., 2015 · Open in CIViC

civic

RIT1 Q40L1
(oncogenic)	Lung Adenocarcinoma	Oncogenic	D	Does Not Support Oncogenicity	3	submitted	EID9829 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 Q40L was expressed in NIH3T3 cells and did not induce colony formation in soft agar greater tha… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic

RIT1 Q40L1

(oncogenic)

Lung Adenocarcinoma

Oncogenic

Does Not Support Oncogenicity

submitted

EID9829

RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 Q40L was expressed in NIH3T3 cells and did not induce colony formation in soft agar greater tha… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic

RIT1 Q79L2
(oncogenic)	Lung Adenocarcinoma	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9827 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 Q79L, a known activating mutation, was expressed in NIH3T3 cells and induced colony formation i… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	3	submitted	EID9828 RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 Q79L-transduced PC6 lung cancer cells showed strong activ… (full text at CIViC) PMID 24469055 · Berger et al., 2014 · Open in CIViC	civic

RIT1 Q79L2

(oncogenic)

Lung Adenocarcinoma

Oncogenic

Supports Oncogenicity

submitted

EID9827

RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. RIT1 Q79L, a known activating mutation, was expressed in NIH3T3 cells and induced colony formation i… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic

(functional)

—UNRESOLVED

Functional

Supports Gain Of Function

submitted

EID9828

RIT1 mutations were identified in lung adenocarcinoma tumors lacking typical driver gene mutations. Western blot analysis of lysates from RIT1 Q79L-transduced PC6 lung cancer cells showed strong activ… (full text at CIViC)

PMID 24469055 · Berger et al., 2014 · Open in CIViC

civic