CXCR4

C-X-C motif chemokine receptor 4

Explore in graph →CI-GENE-00042634HGNC:2561 ENSG00000121966 NCBI 7852 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CXCR4 EXPRESSION2
Cisplatin	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	D	Supports Resistance	3

Cohorts

Alteration frequency by cohort (24)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved24 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Lung Cancer (SMC, Cancer Research 2016) lung_smc_2016	unmapped	Ssm	4	22	18.2%

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

CXCR4, a potential predictive marker for docetaxel sensitivity in gastric cancer.
· Anticancer Res · 2010 · PMID 20651371 · validated civic_curation pubmed

CXCR4 Mutation1
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11939 Identified from whole genome sequencing of DLBCL PMID 23131835 · Khodabakhshi et al., 2012 · Open in CIViC	civic