Gene

PIM1

Pim-1 proto-oncogene, serine/threonine kinase

Explore in graph →CI-GENE-00019767HGNC:8986 ENSG00000137193 NCBI 5292 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (5)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–5 of 5 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PIM1 L2V1
Ibrutinib	Diffuse Large B-Cell Lymphoma Activated B-Cell Type	Predictive	D	Supports Resistance	3	accepted

Cohorts

Alteration frequency by cohort (22)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved22 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Primary Central Nervous System Lymphoma (Mayo Clinic, Clin Cancer Res 2015) pcnsl_mayo_2015	Primary Central Nervous System Lymphoma	Ssm

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Association of Nuclear PIM1 Expression with Lymph Node Metastasis and Poor Prognosis in Patients with Lung Adenocarcinoma and Squamous Cell Carcinoma.
· J Cancer · 2016 · PMID 26918046 · validated civic_curation pubmed
The role of PIM1 in the ibrutinib-resistant ABC subtype of diffuse large B-cell lymphoma.
· Am J Cancer Res · 2016 · PMID 27904766 · validated civic_curation pubmed

PIM1 Mutation1
(oncogenic)	Diffuse Large B-Cell LymphomaCURATED_BROADER	Oncogenic	E	Supports Oncogenicity	4	submitted	EID11974 This is one of the first of many genes identified as targets of aberrant somatic hypermutation in DLBCL PMID 11460166 · Pasqualucci et al., 2001 · Open in CIViC	civic

PIM1 Mutation1

(oncogenic)

Diffuse Large B-Cell LymphomaCURATED_BROADER

Oncogenic

Supports Oncogenicity

submitted

EID11974

This is one of the first of many genes identified as targets of aberrant somatic hypermutation in DLBCL

PMID 11460166 · Pasqualucci et al., 2001 · Open in CIViC

civic

PIM1 NUCLEAR EXPRESSION1
(prognostic)	Lung Non-Small Cell CarcinomaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	2	accepted	EID1168 The expression of PIM1, p-STAT3, and c-MYC was tested (IHC) in 194 NSCLC archival tumor samples. High nuclear expression of PIM1 was detected in 43.3% of cases and was significantly correlated with ad… (full text at CIViC) PMID 26918046 · Jiang et al., 2016 · Open in CIViC	civic

PIM1 NUCLEAR EXPRESSION1

(prognostic)

Lung Non-Small Cell CarcinomaCURATED_BROADER

Prognostic

Supports Poor Outcome

accepted

EID1168

The expression of PIM1, p-STAT3, and c-MYC was tested (IHC) in 194 NSCLC archival tumor samples. High nuclear expression of PIM1 was detected in 43.3% of cases and was significantly correlated with ad… (full text at CIViC)

PMID 26918046 · Jiang et al., 2016 · Open in CIViC

civic

PIM1 P81S1
Ibrutinib	Diffuse Large B-Cell Lymphoma Activated B-Cell Type	Predictive	D	Supports Resistance	3	accepted	EID9946 Foundation panel results of baseline tumour samples from 48 patients with diffuse large B cell lymphoma identified PIM1 mutations in 6 patient samples, 5 of which were the DLBCL-ABC subtype. Four out … (full text at CIViC) PMID 27904766 · Kuo et al., 2016 · Open in CIViC	civic

PIM1 P81S1

Ibrutinib

Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Predictive

Supports Resistance

accepted

EID9946

Foundation panel results of baseline tumour samples from 48 patients with diffuse large B cell lymphoma identified PIM1 mutations in 6 patient samples, 5 of which were the DLBCL-ABC subtype. Four out … (full text at CIViC)

PMID 27904766 · Kuo et al., 2016 · Open in CIViC

civic

PIM1 S97N1
Ibrutinib	Diffuse Large B-Cell Lymphoma Activated B-Cell Type	Predictive	D	Supports Resistance	3	accepted	EID9947 Foundation panel results of baseline tumour samples from 48 patients with diffuse large B cell lymphoma identified PIM1 mutations in 6 patient samples, 5 of which were the DLBCL-ABC subtype. Four out … (full text at CIViC) PMID 27904766 · Kuo et al., 2016 · Open in CIViC	civic

PIM1 S97N1

Ibrutinib

Diffuse Large B-Cell Lymphoma Activated B-Cell Type

Predictive

Supports Resistance

accepted

EID9947

PMID 27904766 · Kuo et al., 2016 · Open in CIViC

civic